Characterization of an Artificial Swine-Origin Influenza Virus with the Same Gene Combination as H1N1/2009 Virus: A Genesis Clue of Pandemic Strain
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{"title"=>"Characterization of an artificial Swine-Origin influenza virus with the same gene combination as h1n1/2009 virus: A genesis clue of pandemic strain", "type"=>"journal", "authors"=>[{"first_name"=>"Xueli", "last_name"=>"Zhao", "scopus_author_id"=>"43862143600"}, {"first_name"=>"Yipeng", "last_name"=>"Sun", "scopus_author_id"=>"55533882200"}, {"first_name"=>"Juan", "last_name"=>"Pu", "scopus_author_id"=>"13906484300"}, {"first_name"=>"Lihong", "last_name"=>"Fan", "scopus_author_id"=>"42961466400"}, {"first_name"=>"Weimin", "last_name"=>"Shi", "scopus_author_id"=>"35485431300"}, {"first_name"=>"Yanxin", "last_name"=>"Hu", "scopus_author_id"=>"15044694100"}, {"first_name"=>"Jun", "last_name"=>"Yang", "scopus_author_id"=>"57029455200"}, {"first_name"=>"Qi", "last_name"=>"Xu", "scopus_author_id"=>"36151534300"}, {"first_name"=>"Jingjing", "last_name"=>"Wang", "scopus_author_id"=>"36984512300"}, {"first_name"=>"Dongjun", "last_name"=>"Hou", "scopus_author_id"=>"48061096100"}, {"first_name"=>"Guangpeng", "last_name"=>"Ma", "scopus_author_id"=>"8532553700"}, {"first_name"=>"Jinhua", "last_name"=>"Liu", "scopus_author_id"=>"36165045800"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-79960747392", "sgr"=>"79960747392", "pui"=>"362208614", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21799774", "doi"=>"10.1371/journal.pone.0022091"}, "id"=>"a3cb9936-8e7b-3229-a6be-3584d85a6038", "abstract"=>"Pandemic H1N1/2009 influenza virus, derived from a reassortment of avian, human, and swine influenza viruses, possesses a unique gene segment combination that had not been detected previously in animal and human populations. Whether such a gene combination could result in the pathogenicity and transmission as H1N1/2009 virus remains unclear. In the present study, we used reverse genetics to construct a reassortant virus (rH1N1) with the same gene combination as H1N1/2009 virus (NA and M genes from a Eurasian avian-like H1N1 swine virus and another six genes from a North American triple-reassortant H1N2 swine virus). Characterization of rH1N1 in mice showed that this virus had higher replicability and pathogenicity than those of the seasonal human H1N1 and Eurasian avian-like swine H1N1 viruses, but was similar to the H1N1/2009 and triple-reassortant H1N2 viruses. Experiments performed on guinea pigs showed that rH1N1 was not transmissible, whereas pandemic H1N1/2009 displayed efficient transmissibility. To further determine which gene segment played a key role in transmissibility, we constructed a series of reassortants derived from rH1N1 and H1N1/2009 viruses. Direct contact transmission studies demonstrated that the HA and NS genes contributed to the transmission of H1N1/2009 virus. Second, the HA gene of H1N1/2009 virus, when combined with the H1N1/2009 NA gene, conferred efficient contact transmission among guinea pigs. The present results reveal that not only gene segment reassortment but also amino acid mutation were needed for the generation of the pandemic influenza virus.", "link"=>"http://www.mendeley.com/research/characterization-artificial-swineorigin-influenza-virus-same-gene-combination-h1n12009-virus-genesis", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>3, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Denmark"=>1, "United Kingdom"=>1, "Kenya"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/378979", "https://ndownloader.figshare.com/files/379028", "https://ndownloader.figshare.com/files/379064"], "description"=>"<div><p>Pandemic H1N1/2009 influenza virus, derived from a reassortment of avian, human, and swine influenza viruses, possesses a unique gene segment combination that had not been detected previously in animal and human populations. Whether such a gene combination could result in the pathogenicity and transmission as H1N1/2009 virus remains unclear. In the present study, we used reverse genetics to construct a reassortant virus (rH1N1) with the same gene combination as H1N1/2009 virus (NA and M genes from a Eurasian avian-like H1N1 swine virus and another six genes from a North American triple-reassortant H1N2 swine virus). Characterization of rH1N1 in mice showed that this virus had higher replicability and pathogenicity than those of the seasonal human H1N1 and Eurasian avian-like swine H1N1 viruses, but was similar to the H1N1/2009 and triple-reassortant H1N2 viruses. Experiments performed on guinea pigs showed that rH1N1 was not transmissible, whereas pandemic H1N1/2009 displayed efficient transmissibility. To further determine which gene segment played a key role in transmissibility, we constructed a series of reassortants derived from rH1N1 and H1N1/2009 viruses. Direct contact transmission studies demonstrated that the HA and NS genes contributed to the transmission of H1N1/2009 virus. Second, the HA gene of H1N1/2009 virus, when combined with the H1N1/2009 NA gene, conferred efficient contact transmission among guinea pigs. The present results reveal that not only gene segment reassortment but also amino acid mutation were needed for the generation of the pandemic influenza virus.</p> </div>", "links"=>[], "tags"=>["characterization", "swine-origin", "influenza", "genesis", "pandemic"], "article_id"=>134891, "categories"=>["Cancer", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.s001", "https://dx.doi.org/10.1371/journal.pone.0022091.s002", "https://dx.doi.org/10.1371/journal.pone.0022091.s003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Characterization_of_an_Artificial_Swine_Origin_Influenza_Virus_with_the_Same_Gene_Combination_as_H1N1_2009_Virus_A_Genesis_Clue_of_Pandemic_Strain/134891", "title"=>"Characterization of an Artificial Swine-Origin Influenza Virus with the Same Gene Combination as H1N1/2009 Virus: A Genesis Clue of Pandemic Strain", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-07-25 01:21:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/752044"], "description"=>"<p>MDCK cells were infected with virus at a MOI of 0.05, supernatants were harvested every 12 h, and samples were titrated by plaque assay in MDCK cells. Results represent the average of three independent experiments.</p>", "links"=>[], "tags"=>["kinetics", "mdck"], "article_id"=>422408, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Viral_growth_kinetics_in_MDCK_cells_/422408", "title"=>"Viral growth kinetics in MDCK cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-25 00:40:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/752171"], "description"=>"<p>Groups of four BALB/c mice were intranasally inoculated with 10<sup>4.0</sup> PFU of each virus. Body weight and survival status were checked daily. Mice were euthanized upon the loss of 30% of their initial body weight.</p>", "links"=>[], "tags"=>["Virology", "microbiology"], "article_id"=>422536, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Weight_change_A_and_survival_B_of_mice_/422536", "title"=>"Weight change (<i>A</i>) and survival (<i>B</i>) of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-25 00:42:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/752275"], "description"=>"<p>Groups of three BALB/c mice were intranasally inoculated with 10<sup>4.0</sup> PFU of each virus. Titers of virus recovered from the supernatant of homogenized nasal turbinates, trachea and lung on days 3, 5 and 7 p.i. are shown. Results represent the average titers from the tissues of three infected mice per group. The limit of virus detection was 100 PFU/g. ** in Fig. 3<i>A</i> indicates the significant difference between rH1N1 and pBJ09 viruses (<i>P</i><0.01; ANOVA). * and ** in Fig. 3<i>B</i> and <i>C</i> indicates the replication titers of Eurasian-204 or hTJ15 are significantly different from those of rH1N1, pBJ09 and Triple-1222 viruses (* is with <i>P</i><0.05, ** is with <i>P</i><0.01; ANOVA).</p>", "links"=>[], "tags"=>["replication", "nasal", "turbinates", "trachea"], "article_id"=>422633, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Viral_replication_in_nasal_turbinates_A_trachea_B_and_lung_C_of_mice_/422633", "title"=>"Viral replication in nasal turbinates (<i>A</i>), trachea (<i>B</i>) and lung (<i>C</i>) of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-25 00:43:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/752443"], "description"=>"<p>Photomicrographs of H&E stained sections from nasal turbinates, trachea and lungs of mice on day 7 p.i. are shown. <b>(</b><b><i>A)</i></b><b> rH1N1 virus-infected lung.</b> Observation of extensive dropout and necrosis of mucous epithelium cells (open arrows), inflammatory cell infiltration and thickening of alveolar walls (solid arrows). <b>(</b><b><i>B</i></b><b>) pBJ09 virus-infected lung.</b> Dropout of mucous epithelium (open arrows), interstitial edema near the small blood vessels (solid arrows). <b>(</b><b><i>C</i></b><b>) Triple-1222 virus-infected lung.</b> Inflammatory cells infiltrate near the blood vessels (solid arrows) and dropout of mucous epithelium cells (open arrows). <b>(</b><b><i>D</i></b><b>) Eurasian-204 virus-infected lung.</b> Few inflammatory cells infiltrated near the bronchiole and blood vessels (solid arrows). <b>(</b><b><i>E</i></b><b>) hTJ15 virus-infected lung.</b> Few inflammatory cell infiltrated near the bronchiole and blood vessels (solid arrows). <b>(F) rH1N1 virus-infected trachea.</b> Dropout of mucous epithelium and inflammatory cell infiltration (solid arrows). <b>(</b><b><i>G</i></b><b>) pBJ09 virus-infected trachea.</b> Severe dropout of mucous epithelium cells in trachea, lamina propria bareness (solid arrows). <b>(</b><b><i>H</i></b><b>) Triple-1222 virus-infected trachea.</b> Dropout of mucous epithelium cells and many erythrocytes (solid arrows). <b>Eurasian-204 virus-infected trachea (</b><b><i>I</i></b><b>) and hTJ15 virus-infected trachea (J).</b> Rare histopathologic lesion. <b>(</b><b><i>K</i></b><b>) rH1N1 virus-infected nasal turbinate.</b> Dropout of mucous epithelium cells (solid arrows). <b>(</b><b><i>L</i></b><b>) pBJ09 virus-infected nasal turbinate.</b> Extensive dropout of mucous epithelium cells in nasal turbinates (solid arrows). <b>(</b><b><i>M</i></b><b>) Triple-1222 virus-infected nasal turbinate.</b> Lesional tunica mucosa nasi (solid arrows). <b>Eurasian-204 virus infected nasal turbinates (</b><b><i>N</i></b><b>) and hTJ15 virus-infected nasal turbinates (</b><b><i>O</i></b><b>).</b> No apparent histopathologic lesion. Bar = 50 µm.</p>", "links"=>[], "tags"=>["changes", "h1", "virus-infected"], "article_id"=>422807, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histopathological_changes_in_H1_virus_infected_mice_/422807", "title"=>"Histopathological changes in H1 virus-infected mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-25 00:46:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/752684"], "description"=>"<p>Four guinea pigs were intranasally inoculated with 10<sup>4.0</sup> PFU of virus and each animal was housed in a separate cage. At 24 h p.i., a naïve guinea pig was placed in the same cage with each inoculated guinea pig. Virus titers in nasal washes were plotted as a function of time post-inoculation. Titers of intranasally inoculated animals are represented by dashed lines and solid squares; virus titers of exposed guinea pigs are shown with solid lines and solid triangles. The limit of virus detection was 10 PFU/mL.</p>", "links"=>[], "tags"=>["rh1n1", "pbj09", "triple-1222", "eurasian-204", "htj15", "viruses", "guinea"], "article_id"=>423029, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Contact_transmission_of_rH1N1_A_pBJ09_B_Triple_1222_C_Eurasian_204_D_and_hTJ15_E_viruses_in_guinea_pigs_/423029", "title"=>"Contact transmission of rH1N1 (<i>A</i>), pBJ09 (<i>B</i>), Triple-1222 (<i>C</i>), Eurasian-204 (<i>D</i>) and hTJ15 (<i>E</i>) viruses in guinea pigs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-25 00:50:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/752757"], "description"=>"a<p>Number of the infected guinea pigs/total number of the guinea pigs (mean peak titer log<sub>10</sub>PFU/mL ± standard deviation).</p>b<p>Serum was collected on day 18 p.i. and seroconversion was confirmed by hemagglutination inhibition (HI) assay.</p>", "links"=>[], "tags"=>["wild-type", "rh1n1-pbj09", "reassortant", "viruses", "guinea"], "article_id"=>423119, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Direct_contact_transmission_of_wild_type_and_rH1N1_pBJ09_reassortant_viruses_in_guinea_pigs_/423119", "title"=>"Direct contact transmission of wild-type and rH1N1-pBJ09 reassortant viruses in guinea pigs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-25 00:51:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/752805"], "description"=>"a<p>Amino acids in the HA receptor binding site are bold.</p>b<p>H3 numbering.</p>", "links"=>[], "tags"=>["differences", "proteins", "rh1n1", "pbj09"], "article_id"=>423164, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amino_acid_differences_of_the_HA_proteins_between_rH1N1_and_pBJ09_viruses_a_/423164", "title"=>"Amino acid differences of the HA proteins between rH1N1 and pBJ09 viruses<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-25 00:52:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/752841"], "description"=>"a<p>Comparison of the full-length gene sequences.</p>", "links"=>[], "tags"=>["homology", "rh1n1", "influenza"], "article_id"=>423202, "categories"=>["Virology", "Microbiology"], "users"=>["Xueli Zhao", "Yipeng Sun", "Juan Pu", "Lihong Fan", "Weimin Shi", "Yanxin Hu", "Jun Yang", "Qi Xu", "Jingjing Wang", "Dongjun Hou", "Guangpeng Ma", "Jinhua Liu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022091.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Gene_homology_of_the_rH1N1_vs_H1N1_2009_influenza_virusesa_a_/423202", "title"=>"Gene homology of the rH1N1 vs. H1N1/2009 influenza virusesa<sup>a</sup>.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-25 00:53:22"}

PMC Usage Stats | Further Information

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