Gene Expression Profiling of Dendritic Cells Reveals Important Mechanisms Associated with Predisposition to Staphylococcus Infections
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{"title"=>"Gene Expression Profiling of Dendritic Cells Reveals Important Mechanisms Associated with Predisposition to Staphylococcus Infections", "type"=>"journal", "authors"=>[{"first_name"=>"Mehdi", "last_name"=>"Toufeer"}, {"first_name"=>"Cécile M. D.", "last_name"=>"Bonnefont"}, {"first_name"=>"Eliane", "last_name"=>"Foulon"}, {"first_name"=>"Cécile", "last_name"=>"Caubet"}, {"first_name"=>"Christian", "last_name"=>"Tasca"}, {"first_name"=>"Marie-Rose", "last_name"=>"Aurel"}, {"first_name"=>"Christèle", "last_name"=>"Robert-Granié"}, {"first_name"=>"Rachel", "last_name"=>"Rupp"}, {"first_name"=>"Gilles", "last_name"=>"Foucras"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0022147", "isbn"=>"1932-6203", "pmid"=>"21857913"}, "id"=>"4ddfbebe-6f50-3235-ac2a-1106296e9103", "abstract"=>"Staphylococcus aureus is a major pathogen of humans and animals and emerging antibiotic-resistant strains have further increased the concern of this health issue. Host genetics influence susceptibility to S. aureus infections, and the genes determining the outcome of infections should be identified to find alternative therapies to treatment with antibiotics. Here, we used outbred animals from a divergent selection based on susceptibility towards Staphylococcus infection to explore host immunogenetics.", "link"=>"http://www.mendeley.com/research/gene-expression-profiling-dendritic-cells-reveals-important-mechanisms-associated-predisposition-sta", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Ph. D. Student"=>2, "Other"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Ph. D. Student"=>2, "Other"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}}, "reader_count_by_country"=>{"India"=>2}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/377090", "https://ndownloader.figshare.com/files/377097", "https://ndownloader.figshare.com/files/377109", "https://ndownloader.figshare.com/files/377116"], "description"=>"<div><h3>Background</h3><p><em>Staphylococcus aureus</em> is a major pathogen of humans and animals and emerging antibiotic-resistant strains have further increased the concern of this health issue. Host genetics influence susceptibility to <em>S</em>. <em>aureus</em> infections, and the genes determining the outcome of infections should be identified to find alternative therapies to treatment with antibiotics. Here, we used outbred animals from a divergent selection based on susceptibility towards <em>Staphylococcus</em> infection to explore host immunogenetics.</p> <h3>Methodology/Principal Findings</h3><p>We investigated how dendritic cells respond to heat-inactivated <em>S. aureus</em> and whether dendritic cells from animals showing different degrees of susceptibility had distinct gene expression profiles. We measured gene expression levels of <em>in vitro S. aureus</em>-stimulated bone marrow-derived dendritic cells at three different time points (0, 3 and 8 hrs) by using 15 k ovine Agilent microarrays. Furthermore, differential expression of a selected number of genes was confirmed by RT-qPCR. Gene signatures of stimulated DCs were obtained and showed that genes involved in the inflammatory process and T helper cell polarization were highly up-regulated upon stimulation. Moreover, a set of 204 genes were statistically differentially expressed between susceptible and resistant animals, and grouped them according to their predisposition to staphylococcal infection. Interestingly, over-expression of the <em>C1q</em> and <em>Ido1</em> genes was observed in the resistant line and suggested a role of classical pathway of complement and early regulation of inflammation pathways, respectively. On the contrary, over expression of genes involved in the IL1R pathway was observed in susceptible animals. Furthermore, the leucocyte extravasation pathway was also found to be dominant in the susceptible line.</p> <h3>Conclusion/Significance</h3><p>We successfully obtained <em>Staphylococcus aureus</em> associated gene expression of ovine BM-DC in an 8-hour kinetics experiment. The distinct transcriptional profiles of dendritic cells obtained from resistant and susceptible animals may explain susceptibility towards <em>S. aureus</em> infections in a broader context.</p> </div>", "links"=>[], "tags"=>["profiling", "dendritic", "cells", "reveals", "mechanisms", "predisposition", "infections"], "article_id"=>134492, "categories"=>["Biological Sciences", "Cancer", "Genetics", "Microbiology", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.s001", "https://dx.doi.org/10.1371/journal.pone.0022147.s002", "https://dx.doi.org/10.1371/journal.pone.0022147.s003", "https://dx.doi.org/10.1371/journal.pone.0022147.s004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Gene_Expression_Profiling_of_Dendritic_Cells_Reveals_Important_Mechanisms_Associated_with_Predisposition_to_Staphylococcus_Infections/134492", "title"=>"Gene Expression Profiling of Dendritic Cells Reveals Important Mechanisms Associated with Predisposition to <em>Staphylococcus</em> Infections", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-08-12 01:14:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/746303"], "description"=>"<p>Relative expression of mRNAs of different cytokines at three time points (0, 3 and 8 hrs post-stimulation) normalized by common reference genes (<i>rp19</i>, <i>hprt</i>, <i>tyr</i> and <i>gapdh</i>) by using 2<sup>−ΔΔ</sup>method. Data was combined from both resistant and susceptible animals in this experiment (A) Pro inflammatory cytokines (<i>Il1a</i>, −<i>1b</i>, −<i>6</i> and <i>tnfa</i>). (B) il8 (C) <i>il15</i> (D) T helper polarizing cytokines (<i>il10</i>, −<i>12</i> and −<i>23p19</i>) (E) Toll like receptors (<i>tlr2</i>, −<i>4</i> and −<i>6</i>).</p>", "links"=>[], "tags"=>["validation", "dc", "activation"], "article_id"=>416663, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pre_microarray_validation_of_DC_activation_by_RT_qPCR_/416663", "title"=>"Pre-microarray validation of DC activation by RT-qPCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-12 01:51:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/746396"], "description"=>"<p>(A) Clustering analysis of differentially expressed genes (BH1%, FC>2, n = 419) at 0, 3 and 8 hrs post stimulation. (B) Rapidly exhausted genes subset (n = 176) (C) Post-stimulation up-regulated genes subset (n = 120) (D) Down-regulated genes at 3 hrs but up-regulated at 8 hrs post-stimulation (n = 63) (E) Post stimulation down-regulated genes (n = 60).</p>", "links"=>[], "tags"=>["points"], "article_id"=>416767, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DC_gene_signature_upon_Staphylococcus_aureus_interaction_at_three_different_time_points_0_3_and_8_hrs_/416767", "title"=>"DC gene signature upon <i>Staphylococcus aureus</i> interaction at three different time points (0, 3 and 8 hrs).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-12 01:52:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/746483"], "description"=>"<p>(A) Venn diagram presenting number of differentially-expressed genes between the two lines at three different time points (Volcano plot analysis, FC>1.5). (B) Distinct transcriptional profiles of dendritic cells belonging to resistant and susceptible lines. Clustering analysis of differentially-expressed genes (ANOVA analysis, BH1%, FC>1.5, n = 204).</p>", "links"=>[], "tags"=>["profiling", "dcs", "resistant", "susceptible"], "article_id"=>416849, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Transcriptional_profiling_of_DCs_in_resistant_and_susceptible_lines_/416849", "title"=>"Transcriptional profiling of DCs in resistant and susceptible lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-12 01:54:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/746566"], "description"=>"<p>Data represent the expression ratio of resistant animals over susceptible animals at three different time points (0, 3 and 8 hrs). Relative data were normalized with common reference genes (<i>rp19</i>,<i>hprt</i>,<i>tyr</i> and <i>gapdh</i>) by using 2<sup>−ΔΔ</sup>method.</p>", "links"=>[], "tags"=>["differentially-expressed", "genes", "resistant", "susceptible"], "article_id"=>416925, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_RT_qPCR_analysis_Biomark_system_Fluidigm_of_differentially_expressed_genes_between_resistant_and_susceptible_lines_/416925", "title"=>"RT-qPCR analysis (Biomark system, Fluidigm) of differentially-expressed genes between resistant and susceptible lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-12 01:55:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/746657"], "description"=>"<p>Top canonical pathways obtained by IPA analysis of differentially-expressed genes (n = 419, FC>2, BH 2%) between three time points (0, 3 and 8 hrs).</p>", "links"=>[], "tags"=>["canonical", "pathways", "ipa", "differentially-expressed", "genes", "bh", "points"], "article_id"=>417017, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Top_canonical_pathways_obtained_by_IPA_analysis_of_differentially_expressed_genes_n_8202_8202_419_FC_gt_2_BH_2_between_three_time_points_0_3_and_8_hrs_/417017", "title"=>"Top canonical pathways obtained by IPA analysis of differentially-expressed genes (n = 419, FC>2, BH 2%) between three time points (0, 3 and 8 hrs).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-12 01:56:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/746800"], "description"=>"<p>(A) GO BP terms obtained at T0 (B) GO BP terms obtained at T3 (C) GO BP terms obtained at T8.</p>", "links"=>[], "tags"=>["bp", "over-expressed", "genes", "points"], "article_id"=>417162, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.g006"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Enriched_BP_GO_terms_for_over_expressed_genes_in_each_line_at_three_independent_time_points_by_DAVID_/417162", "title"=>"Enriched BP GO terms for over-expressed genes in each line at three independent time points by DAVID.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-12 01:59:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/746901"], "description"=>"<p>RT-qPCR data are normalized according to multiple housekeeping genes (<i>rp19</i>,<i>hprt</i>, <i>tyr</i> and <i>gapdh</i>) by using 2<sup>−ΔΔ</sup>method and present expression ratio of resistant over susceptible animals.</p>", "links"=>[], "tags"=>["stimulation", "differential", "kinetics", "microarrays"], "article_id"=>417266, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Post_stimulation_3_and_8_hrs_differential_kinetics_of_gene_expression_in_BM_DCs_a_comparison_of_fold_change_measured_by_microarrays_and_RT_qPCR_/417266", "title"=>"Post stimulation (3 and 8 hrs) differential kinetics of gene expression in BM-DCs, a comparison of fold change measured by microarrays and RT-qPCR.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-12 02:01:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/746941"], "description"=>"a<p>mode of expression of the gene.</p>b<p>up-regulation at three time points (0, 3 and 8 hrs).</p>c<p>down-regulation at three time points (0, 3 and 8 hrs).</p>", "links"=>[], "tags"=>["differentially", "genes", "hrs", "post-stimulation", "resistant", "susceptible"], "article_id"=>417301, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_the_top_differentially_expressed_genes_BH1_and_FC_gt_1_5_at_8_hrs_post_stimulation_between_the_resistant_and_susceptible_lines_/417301", "title"=>"List of the top differentially expressed genes (BH1% and FC>1.5) at 8 hrs post-stimulation between the resistant and susceptible lines.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-12 02:01:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/746972"], "description"=>"a<p>mode of expression of gene.</p>b<p>up-regulation at three time point (0, 3, and 8 h).</p>c<p>down-regulation at three time points (0, 3, and 8 h).</p>", "links"=>[], "tags"=>["differentially", "genes", "hrs"], "article_id"=>417339, "categories"=>["Microbiology", "Biological Sciences", "Genetics", "Infectious Diseases", "Immunology"], "users"=>["Mehdi Toufeer", "Cécile M. D. Bonnefont", "Eliane Foulon", "Cécile Caubet", "Christian Tasca", "Marie-Rose Aurel", "Christèle Robert-Granié", "Rachel Rupp", "Gilles Foucras"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022147.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_List_of_the_top_differentially_expressed_genes_BH1_and_FC_gt_2_at_8_hrs_post_stimulation_/417339", "title"=>"List of the top differentially expressed genes (BH1% and FC>2) at 8 hrs post stimulation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-12 02:02:19"}

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