Pre & Postsynaptic Tuning of Action Potential Timing by Spontaneous GABAergic Activity
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Mendeley | Further Information

{"title"=>"Pre and postsynaptic tuning of action potential timing by spontaneous gabaergic activity", "type"=>"journal", "authors"=>[{"first_name"=>"Olivier", "last_name"=>"Caillard", "scopus_author_id"=>"6602163523"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"362136976", "pmid"=>"21789249", "doi"=>"10.1371/journal.pone.0022322", "scopus"=>"2-s2.0-79960320554", "issn"=>"19326203", "sgr"=>"79960320554"}, "id"=>"99ae0374-3993-33b0-b196-f94c5b89f73f", "abstract"=>"Frequency and timing of action potential discharge are key elements for coding and transfer of information between neurons. The nature and location of the synaptic contacts, the biophysical parameters of the receptor-operated channels and their kinetics of activation are major determinants of the firing behaviour of each individual neuron. Ultimately the intrinsic excitability of each neuron determines the input-output function. Here we evaluate the influence of spontaneous GABAergic synaptic activity on the timing of action potentials in Layer 2/3 pyramidal neurones in acute brain slices from the somatosensory cortex of young rats. Somatic dynamic current injection to mimic synaptic input events was employed, together with a simple computational model that reproduce subthreshold membrane properties. Besides the well-documented control of neuronal excitability, spontaneous background GABAergic activity has a major detrimental effect on spike timing. In fact, GABA(A) receptors tune the relationship between the excitability and fidelity of pyramidal neurons via a postsynaptic (the reversal potential for GABA(A) activity) and a presynaptic (the frequency of spontaneous activity) mechanism. GABAergic activity can decrease or increase the excitability of pyramidal neurones, depending on the difference between the reversal potential for GABA(A) receptors and the threshold for action potential. In contrast, spike time jitter can only be increased proportionally to the difference between these two membrane potentials. Changes in excitability by background GABAergic activity can therefore only be associated with deterioration of the reliability of spike timing.", "link"=>"http://www.mendeley.com/research/pre-postsynaptic-tuning-action-potential-timing-spontaneous-gabaergic-activity", "reader_count"=>28, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Ph. D. Student"=>8, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Ph. D. Student"=>8, "Other"=>2, "Student > Bachelor"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>3, "Neuroscience"=>4, "Psychology"=>1, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Neuroscience"=>{"Neuroscience"=>4}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"United States"=>2, "Chile"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/755802"], "description"=>"<p>a, From upper to lower, an example of a GABA<sub>A</sub> conductance (G<sub>GABA-A</sub>) pattern of 33 events/s, GABA<sub>A</sub> current (I<sub>GABA-A</sub>), Vm and the DC protocol in a dynamic clamp recording of a L2/3 pyramidal cell. b, Superimposed (5) Vm fluctuations in response to a DC step (1 s, 170 pA) in control (green), in the presence of 33 (blue) or 100 (red) randomly occurring GABA<sub>A</sub> events/s dynamically injected with E<sub>GABA</sub> set at −70 mV. Same cell and colour code for c,d and e. c, Waterfall view of Vm when the 5<sup>th</sup> spike was set as the time reference. d, Mean Firing rate <i>vs</i> DC step. e, CV<sub>ISI </sub><i>vs</i> mean spike firing rate. f, Normalised changes in excitability observed when neurons receive different levels of randomly occurring GABA<sub>A</sub> events/s. g, Normalised changes in spike jitter for an interpolated firing rate of 10 spikes/s.</p>", "links"=>[], "tags"=>["tuning", "pyramidal", "excitability", "spike"], "article_id"=>426176, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g002", "stats"=>{"downloads"=>4, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_dependent_tuning_of_pyramidal_cell_excitability_and_spike_timing_/426176", "title"=>"Frequency-dependent tuning of pyramidal cell excitability and spike timing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:42:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/756166"], "description"=>"<p>a, Superimposed (10) Vm fluctuations of the LIF model in response to a DC step (2 s) that allows a firing rate of 5 spikes/s, in control conditions (green, 95 pA), when the LIF model received 33 randomly occurring GABA<sub>A</sub> events/s (blue, 111 pA), an invariable pattern of 33 GABA<sub>A</sub> events/s (red, 110 pA), or when the neuron model received a constant G<sub>GABA-A</sub> equivalent to the average conductance for a rate of 33 events/s (orange, 110 pA). b up, Raster plot of spike times collected from 50 consecutive trials in the various conditions depicted in a; down, Spike probability over time for these 50 consecutive trials.</p>", "links"=>[], "tags"=>["occurring", "conductance", "transients", "underlie", "frequency-dependent", "tuning", "pyramidal", "discharge"], "article_id"=>426536, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Randomly_occurring_GABA_A_conductance_transients_underlie_the_frequency_dependent_tuning_of_pyramidal_cell_discharge_fidelity_/426536", "title"=>"Randomly occurring GABA<sub>A</sub> conductance transients underlie the frequency-dependent tuning of pyramidal cell discharge fidelity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:48:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/755676"], "description"=>"<p>a, Superimposed (5) membrane potential (Vm) fluctuations of a gramicidin-perforated current-clamped L2/3 pyramidal cell in response to a DC step (1 s, 170 pA) before (control, blue) and after extracellular application of picrotoxin (100 µM, PTX, green). The cell was held at around −80 mV in both conditions. Same cell and colour code for b, c and d. b, Waterfall view of Vm when the 5<sup>th</sup> spike was set as the time reference. c, Mean firing rate <i>vs</i> DC step. d, Coefficient of Variation of the Inter Spike Interval (CV<sub>ISI</sub>) <i>vs</i> firing rate. e, Normalised changes in excitability observed when adding PTX (n = 7). f, Changes in spike jitter for an interpolated firing rate of 10 spikes/s.</p>", "links"=>[], "tags"=>["gabaergic", "affects", "excitability", "spike", "pyramidal"], "article_id"=>426054, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spontaneous_GABAergic_activity_affects_excitability_and_spike_timing_of_pyramidal_cells_/426054", "title"=>"Spontaneous GABAergic activity affects excitability and spike timing of pyramidal cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:40:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/756298"], "description"=>"<p>a, Superimposed (5) Vm fluctuations of a whole-cell L2/3 pyramidal neurone in response to a DC step (1 s, 170 pA) in control conditions (green), when 33 randomly occurring GABA<sub>A</sub> events/s were dynamically injected at E<sub>GABA</sub> = −70 mV (blue) or −30 mV (red). Same cell and colour code for b, c and d. b, Waterfall view of Vm when the 5<sup>th</sup> spike was set as the time reference. c, Mean firing rate <i>vs</i> DC step. d, CV<sub>ISI </sub><i>vs</i> firing rate. e, Normalised changes in excitability observed when neurons received 33 randomly occurring GABA<sub>A</sub> dynamic currents/s at various differences between E<sub>GABA</sub> and the calculated threshold for AP in each individual cell (n = 9). f, Normalised changes in spike jitter observed for a firing rate of 10 spikes/s. Same conditions as in e.</p>", "links"=>[], "tags"=>["potential-dependent", "tuning", "pyramidal", "excitability", "discharge"], "article_id"=>426673, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reversal_potential_dependent_tuning_of_pyramidal_cell_excitability_and_discharge_fidelity_/426673", "title"=>"Reversal potential-dependent tuning of pyramidal cell excitability and discharge fidelity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:51:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/380468", "https://ndownloader.figshare.com/files/380479", "https://ndownloader.figshare.com/files/380491", "https://ndownloader.figshare.com/files/380503", "https://ndownloader.figshare.com/files/380517"], "description"=>"<div><p>Frequency and timing of action potential discharge are key elements for coding and transfer of information between neurons. The nature and location of the synaptic contacts, the biophysical parameters of the receptor-operated channels and their kinetics of activation are major determinants of the firing behaviour of each individual neuron. Ultimately the intrinsic excitability of each neuron determines the input-output function. Here we evaluate the influence of spontaneous GABAergic synaptic activity on the timing of action potentials in Layer 2/3 pyramidal neurones in acute brain slices from the somatosensory cortex of young rats. Somatic dynamic current injection to mimic synaptic input events was employed, together with a simple computational model that reproduce subthreshold membrane properties. Besides the well-documented control of neuronal excitability, spontaneous background GABAergic activity has a major detrimental effect on spike timing. In fact, GABA<sub>A</sub> receptors tune the relationship between the excitability and fidelity of pyramidal neurons via a postsynaptic (the reversal potential for GABA<sub>A</sub> activity) and a presynaptic (the frequency of spontaneous activity) mechanism. GABAergic activity can decrease or increase the excitability of pyramidal neurones, depending on the difference between the reversal potential for GABA<sub>A</sub> receptors and the threshold for action potential. In contrast, spike time jitter can only be increased proportionally to the difference between these two membrane potentials. Changes in excitability by background GABAergic activity can therefore only be associated with deterioration of the reliability of spike timing.</p> </div>", "links"=>[], "tags"=>["pre", "postsynaptic", "tuning", "spontaneous", "gabaergic"], "article_id"=>135165, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022322.s001", "https://dx.doi.org/10.1371/journal.pone.0022322.s002", "https://dx.doi.org/10.1371/journal.pone.0022322.s003", "https://dx.doi.org/10.1371/journal.pone.0022322.s004", "https://dx.doi.org/10.1371/journal.pone.0022322.s005"], "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Pre_Postsynaptic_Tuning_of_Action_Potential_Timing_by_Spontaneous_GABAergic_Activity/135165", "title"=>"Pre & Postsynaptic Tuning of Action Potential Timing by Spontaneous GABAergic Activity", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-07-15 01:26:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/756476"], "description"=>"<p>a, Superimposed (5) Vm fluctuations of the LIF model in response to a DC step (1 s, 160 pA) in control conditions (green), when the LIF model received 33 randomly occurring GABA<sub>A</sub> events/s at E<sub>GABA</sub> = −70 mV (blue) or −35 mV (red). Same colour code for b, c and d. b, Waterfall view of Vm when the 5<sup>th</sup> spike was set as the time reference. c, Mean firing rate <i>vs</i> DC step. d, CV<sub>ISI </sub><i>vs</i> firing rate. e, Normalised changes in excitability observed when LIF model received 33 randomly occurring GABA<sub>A</sub> events/s at various E<sub>GABA</sub> in control conditions (black), when GABA activity induced only transient changes in I<sub>GABA-A</sub> (gray) or when GABA activity induced only transient changes in R<sub>in</sub> (light gray). f, Normalised changes in spike jitter observed for a rate of 10 spikes/s. Same conditions as in e. g, From left to right firing rate displayed on a pseudocolor scale <i>vs</i> DC step and E<sub>GABA</sub> when the LIF model received 33 randomly occurring GABA<sub>A</sub> events/s in control conditions (left), when GABA<sub>A</sub> activity induced only transient changes in I<sub>GABA-A</sub> (middle) or when GABA activity induced only transient changes in R<sub>in</sub> (right). h, CV<sub>ISI</sub> displayed on a pseudocolor scale <i>vs</i> firing rate and E<sub>GABA</sub>. Same conditions as in g.</p>", "links"=>[], "tags"=>["reversal", "potential-dependent", "tuning", "pyramidal", "excitability", "discharge"], "article_id"=>426853, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g007", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_and_reversal_potential_dependent_tuning_of_pyramidal_cell_excitability_and_discharge_fidelity_/426853", "title"=>"Frequency and reversal potential-dependent tuning of pyramidal cell excitability and discharge fidelity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:54:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/756032"], "description"=>"<p>a, Waterfall view of conductance fluctuations injected into the LIF model in control conditions (no conductance, green), when the LIF model received 33 randomly occurring GABA<sub>A</sub> events/s (blue), an invariable pattern of 33 GABA<sub>A</sub> events/s (red), or when the neuron model received a constant G<sub>GABA-A</sub> equivalent to the average conductance for a rate of 33 events/s (orange). Same cell and colour code for b,c,d and e. b, Superimposed (5) Vm fluctuations of the LIF model in response to a DC step (1 s, 160 pA) in the various conditions depicted in a. c, Waterfall view of Vm when the 5<sup>th</sup> spike was set as the time reference. d, Mean firing rate <i>vs</i> DC step. e CV<sub>ISI </sub><i>vs</i> firing rate. f, Mean firing rate displayed on a pseudocolor scale <i>vs</i> DC step and rate of GABA<sub>A</sub> activity when LIF model received random (left), invariable (middle) or constant conductance (right). g, CV<sub>ISI</sub> displayed on a pseudocolor scale <i>vs</i> firing and GABA<sub>A</sub> activity rate. Same conditions as in f.</p>", "links"=>[], "tags"=>["occurring", "conductance", "transients", "underlie", "frequency-dependent", "tuning", "pyramidal", "discharge"], "article_id"=>426406, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Randomly_occurring_GABA_A_conductance_transients_underlie_the_frequency_dependent_tuning_of_pyramidal_cell_discharge_fidelity_/426406", "title"=>"Randomly occurring GABA<sub>A</sub> conductance transients underlie the frequency-dependent tuning of pyramidal cell discharge fidelity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:46:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/755894"], "description"=>"<p>a, From upper to lower, an example of G<sub>GABA-A</sub> pattern of 33 events/s, I<sub>GABA-A</sub>, R<sub>in</sub>, Vm and a DC step (1 s, 120 pA) when running the LIF model. b, Superimposed (5) Vm fluctuations in response to a DC step (1 s, 160 pA) in control (green), in the presence of 33 (blue) or 100 (red) randomly occurring GABA<sub>A</sub> events/s with E<sub>GABA</sub> set at −70 mV. Same cell and colour code for c,d and e. c, Waterfall view of Vm when the 5<sup>th</sup> spike was set as time reference. d, Mean Firing rate <i>vs</i> DC step. e, CV<sub>ISI </sub><i>vs</i> firing rate. f, Normalised changes in excitability observed when LIF received 1 to 100 randomly occurring GABA<sub>A</sub> events/s. g, Normalised changes in spike jitter for a firing rate of 10 spikes/s.</p>", "links"=>[], "tags"=>["frequency-dependent", "tuning", "neuronal", "excitability", "spike"], "article_id"=>426271, "categories"=>["Neuroscience"], "users"=>["Olivier Caillard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022322.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Modelling_frequency_dependent_tuning_of_neuronal_excitability_and_spike_timing_/426271", "title"=>"Modelling frequency-dependent tuning of neuronal excitability and spike timing.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-15 01:44:31"}

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