Force Measurements of TCR/pMHC Recognition at T Cell Surface
Publication Date
July 22, 2011
Journal
PLOS ONE
Authors
Pierre Henri Puech, Damien Nevoltris, Philippe Robert, Laurent Limozin, et al
Volume
6
Issue
7
Pages
e22344
DOI
https://dx.plos.org/10.1371/journal.pone.0022344
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0022344
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21799834
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142151
Europe PMC
http://europepmc.org/abstract/MED/21799834
Web of Science
000293097300038
Scopus
79960683380
Mendeley
http://www.mendeley.com/research/force-measurements-tcrpmhc-recognition-t-cell-surface
Events
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/753655"], "description"=>"<p>A : Schematic representation of the cantilever decorating structure employed to favor a correct presentation of the pMHC. B : Schematic of the recognition force measurements on polylysine adhered T hybridomas using a pMHC decorated AFM lever (not to scale). C : Typical force curve (<i>F</i> vs. piezo position – pushing, black and pulling, grey) for a contact force of 50 pN, a contact time of 0 sec and at a speed of <i>v<sub>press</sub> = v<sub>pull</sub></i> = 1 µm/sec showing <i>no</i> adhesion. D : Typical force curve, taken in the same conditions as C, showing a single adhesion event. The white line is a 45 points running average of the noisy force curve used to automatically detect and measure the force jump using JPK-IP software (vertical grey line).</p>", "links"=>[], "tags"=>["immunology", "biophysics", "physics"], "article_id"=>424024, "categories"=>["Physics", "Biophysics", "Immunology"], "users"=>["Pierre-Henri Puech", "Damien Nevoltris", "Philippe Robert", "Laurent Limozin", "Claude Boyer", "Pierre Bongrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022344.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AFM_force_mode_experiments_/424024", "title"=>"AFM force mode experiments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-22 01:07:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/753935"], "description"=>"<p>Adhesion/recognition data: number of curves (number of cells ; days) as a function of cell type and peptide.</p>", "links"=>[], "tags"=>["curves", "cells"], "article_id"=>424306, "categories"=>["Physics", "Biophysics", "Immunology"], "users"=>["Pierre-Henri Puech", "Damien Nevoltris", "Philippe Robert", "Laurent Limozin", "Claude Boyer", "Pierre Bongrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022344.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adhesion_recognition_data_number_of_curves_number_of_cells_days_as_a_function_of_cell_type_and_peptide_/424306", "title"=>"Adhesion/recognition data: number of curves (number of cells ; days) as a function of cell type and peptide.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-07-22 01:11:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/379392", "https://ndownloader.figshare.com/files/379429", "https://ndownloader.figshare.com/files/379466", "https://ndownloader.figshare.com/files/379517", "https://ndownloader.figshare.com/files/379565"], "description"=>"<div><p>The rupture forces and adhesion frequencies of single recognition complexes between an affinity selected peptide/MHC complex and a TCR at a murine hybridoma surface were measured using Atomic Force Microscopy. When the CD8 coreceptor is absent, the adhesion frequency depends on the nature of the peptide but the rupture force does not. When CD8 is present, no effect of the nature of the peptide is observed. CD8 is proposed to act as a time and distance lock, enabling the shorter TCR molecule to bridge the pMHC and have time to finely read the peptide. Ultimately, such experiments could help the dissection of the sequential steps by which the TCR reads the peptide/MHC complex in order to control T cell activation.</p> </div>", "links"=>[], "tags"=>["measurements"], "article_id"=>134979, "categories"=>["Physics", "Biophysics", "Immunology"], "users"=>["Pierre-Henri Puech", "Damien Nevoltris", "Philippe Robert", "Laurent Limozin", "Claude Boyer", "Pierre Bongrand"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0022344.s001", "https://dx.doi.org/10.1371/journal.pone.0022344.s002", "https://dx.doi.org/10.1371/journal.pone.0022344.s003", "https://dx.doi.org/10.1371/journal.pone.0022344.s004", "https://dx.doi.org/10.1371/journal.pone.0022344.s005"], "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Force_Measurements_of_TCR_pMHC_Recognition_at_T_Cell_Surface/134979", "title"=>"Force Measurements of TCR/pMHC Recognition at T Cell Surface", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-07-22 01:22:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/753878"], "description"=>"<p>A : Schematics of the optimal configuration of TCR / pMHC recognition, following strutural data. This geometry is complex and may limit the formation of the recognition bridges. B : The cellular case, where the surface molecules are free to move and rotate due to their inclusion in a membrane or to their grafting spacer. This situation is rendered even complex by the presence of surrounding molecules, that can be larger that the TCR as exemplified by the case of CD8. C : The proposed energetical profile of the recognition <i>E<sub>rec</sub></i>, without any force applied to the system, along a suitable reaction coordinate <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022344#pone.0022344-Robert2\" target=\"_blank\">[44]</a>. Several wells may exist, and their access is limited by the exact ”contact time” between the molecules eg. before entering the deeper well of TCR / pMHC close fitting. D. Proposed mechanism of CD8 enhancement of TCR/pMHC recognition. CD8 could help maintain the TCR and pMHC in close proximity to achieve (i) TCR / MHC binding, then (ii) TCR / p fitting, providing a time and distance guidance / locking mechanism, resulting in an addition intermediate well in the energetical pathway (panel C).</p>", "links"=>[], "tags"=>["immunology", "biophysics", "physics"], "article_id"=>424245, "categories"=>["Physics", "Biophysics", "Immunology"], "users"=>["Pierre-Henri Puech", "Damien Nevoltris", "Philippe Robert", "Laurent Limozin", "Claude Boyer", "Pierre Bongrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022344.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proposed_mechanism_/424245", "title"=>"Proposed mechanism.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-22 01:10:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/753767"], "description"=>"<p>A. Schematics of the experiments leading to the data presented in B–D. B : Adhesion frequency, <i>AF</i> (+/− SEM), per cell and C : index of multiplicity, <i>MI,</i> vs. peptide, as a function of cell type for an apparent contact time of 0 sec and a contact force of 50 pN. Stars depict significantly different values (t-test, <i>p</i><0.05). D : Average rupture force of single complex ruptures, extracted from the histograms (+/− SD), as a function of cell type and peptide. The values are <i>not</i> significantly different (ANOVA + post-test, <i>p</i>>0.05). For the number of cells and force curves that have been analysed, see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022344#pone-0022344-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["immunology", "biophysics", "physics"], "article_id"=>424136, "categories"=>["Physics", "Biophysics", "Immunology"], "users"=>["Pierre-Henri Puech", "Damien Nevoltris", "Philippe Robert", "Laurent Limozin", "Claude Boyer", "Pierre Bongrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022344.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_AFM_force_mode_experiments_/424136", "title"=>"AFM force mode experiments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-22 01:08:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/753563"], "description"=>"<p>On the first six panels (left to right), numbers represent the mean fluorescence for TCR or CD3/ CD8 using relevant antibodies (see Material and methods). On the last two panels (right), dilutions of the H-2Kb DimerX loaded with OVA or pBM1 peptide are expressed in µg/mL.</p>", "links"=>[], "tags"=>["cytometry"], "article_id"=>423935, "categories"=>["Physics", "Biophysics", "Immunology"], "users"=>["Pierre-Henri Puech", "Damien Nevoltris", "Philippe Robert", "Laurent Limozin", "Claude Boyer", "Pierre Bongrand"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022344.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_cytometry_experiments_/423935", "title"=>"Flow cytometry experiments.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-07-22 01:05:35"}

PMC Usage Stats | Further Information

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Relative Metric

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