Spermidine Promotes Human Hair Growth and Is a Novel Modulator of Human Epithelial Stem Cell Functions
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{"title"=>"Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions", "type"=>"journal", "authors"=>[{"first_name"=>"Yuval", "last_name"=>"Ramot", "scopus_author_id"=>"24485320200"}, {"first_name"=>"Stephan", "last_name"=>"Tiede", "scopus_author_id"=>"14626827300"}, {"first_name"=>"Tamás", "last_name"=>"Bíró", "scopus_author_id"=>"35174247800"}, {"first_name"=>"Mohd Hilmi Abu", "last_name"=>"Bakar", "scopus_author_id"=>"55617099200"}, {"first_name"=>"Koji", "last_name"=>"Sugawara", "scopus_author_id"=>"35243993200"}, {"first_name"=>"Michael P.", "last_name"=>"Philpott", "scopus_author_id"=>"7005271493"}, {"first_name"=>"Wesley", "last_name"=>"Harrison", "scopus_author_id"=>"16309679700"}, {"first_name"=>"Marko", "last_name"=>"Pietilä", "scopus_author_id"=>"6601973308"}, {"first_name"=>"Ralf", "last_name"=>"Paus", "scopus_author_id"=>"34572423200"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-79960822716", "pui"=>"362224312", "doi"=>"10.1371/journal.pone.0022564", "isbn"=>"1932-6203", "sgr"=>"79960822716", "pmid"=>"21818338"}, "id"=>"e68f8894-2404-3273-9009-7e6aa61fed71", "abstract"=>"Rapidly regenerating tissues need sufficient polyamine synthesis. Since the hair follicle (HF) is a highly proliferative mini-organ, polyamines may also be important for normal hair growth. However, the role of polyamines in human HF biology and their effect on HF epithelial stem cells in situ remains largely unknown.", "link"=>"http://www.mendeley.com/research/spermidine-promotes-human-hair-growth-novel-modulator-human-epithelial-stem-cell-functions-5", "reader_count"=>21, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>5, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Other"=>3, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Environmental Science"=>1, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>11, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>11}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Poland"=>1, "Italy"=>1, "Portugal"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/752134"], "description"=>"<p>Selected genes up-regulated in HFs by spermidine (0.5 µM).</p>", "links"=>[], "tags"=>["genes", "up-regulated", "hfs", "spermidine"], "article_id"=>422497, "categories"=>["Developmental Biology"], "users"=>["Yuval Ramot", "Stephan Tiede", "Tamás Bíró", "Mohd Hilmi Abu Bakar", "Koji Sugawara", "Michael P. Philpott", "Wesley Harrison", "Marko Pietilä", "Ralf Paus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022564.t001", "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Selected_genes_up_regulated_in_HFs_by_spermidine_0_5_181_M_/422497", "title"=>"Selected genes up-regulated in HFs by spermidine (0.5 µM).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 16:20:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/751568"], "description"=>"<p><b>A.</b> Spermidine treatment for 6d increased hair shaft elongation of microdissected organ cultured HFs, maximal and significant in the 0.5 µM dose. In this clinically highly relevant <i>in vitro</i>-assay, amputated HFs in the growth phase of the hair cycle (anagen) continue for several days to produce a pigmented hair shaft at almost the normal speed of normal anagen HFs <i>in vivo</i>, and display cyclic growth activity <i>in vitro</i> by spontaneously entering into the regression phase of the hair cycle (catagen). <b>B.</b> Total increase in hair shaft elongation relative to control after 6d in culture (cumulative results of two different experiments)<b>. C.</b> Spermidine treatment prolonged anagen in all three doses after 6d in culture. *<i>P</i><0.05. Columns represent means±SEM; n = 30–36 HFs/group; cumulative results of two different experiments.</p>", "links"=>[], "tags"=>["increases", "shaft", "elongation", "prolongs"], "article_id"=>421923, "categories"=>["Developmental Biology"], "users"=>["Yuval Ramot", "Stephan Tiede", "Tamás Bíró", "Mohd Hilmi Abu Bakar", "Koji Sugawara", "Michael P. Philpott", "Wesley Harrison", "Marko Pietilä", "Ralf Paus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022564.g001", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spermidine_treatment_increases_hair_shaft_elongation_and_prolongs_anagen_/421923", "title"=>"Spermidine treatment increases hair shaft elongation and prolongs anagen.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:17:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/751774"], "description"=>"<p><b>A.</b> By quantitative Ki67/TUNEL immunohistomorphometry, spermidine tended to slightly stimulate hair matrix keratinocyte proliferation <i>in situ</i>; however, this did not reach statistical significance. No effect was seen on hair matrix keratinocyte apoptosis <i>in situ</i>. Columns represent means±SEM; n = 30–36 HFs/group; cumulative results of two different experiments. <b>B.</b> Spermidine significantly stimulated proliferation of primary human keratinocytes after 48 h, as assessed by fluorimetric proliferation assay. The values shown are means±SEM of triplicate experiments. Scale bars, 50 µm. Columns represent means±SEM; ***<i>P</i><0.001. DP, dermal papilla; MK, matrix keratinocytes.</p>", "links"=>[], "tags"=>["stimulated", "proliferation", "keratinocytes", "tended", "matrix"], "article_id"=>422134, "categories"=>["Developmental Biology"], "users"=>["Yuval Ramot", "Stephan Tiede", "Tamás Bíró", "Mohd Hilmi Abu Bakar", "Koji Sugawara", "Michael P. Philpott", "Wesley Harrison", "Marko Pietilä", "Ralf Paus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022564.g003", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spermidine_stimulated_proliferation_of_primary_human_keratinocytes_and_tended_to_stimulate_hair_matrix_keratinocytes_/422134", "title"=>"Spermidine stimulated proliferation of primary human keratinocytes and tended to stimulate hair matrix keratinocytes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:18:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/752027"], "description"=>"<p><b>A.</b> Spermidine regulates expression of <i>K15</i> promoter-driven GFP expression in hair follicles <i>in situ</i> in a dose-dependent manner; scale bars, 100 µm. <b>B.</b> Colony formation assay of isolated and cultured K15-GFP+ under different spermidine concentrations revealed that 0.5 µM spermidine significantly upregulated colony forming efficiency, whereas 0.1 and 1 µM reduced it. <b>C.</b> Quantitative RT-PCR of <i>K15</i> in isolated and cultured K15-GFP+ cells under the presence of spermidine<b>. </b><i>K15</i> expression is presented in comparison to the housekeeping gene <i>rS26</i>. <b>D.</b> Evaluation of proliferative and apoptotic events in isolated and cultured K15-GFP+ cells under the influence of spermidine for 6 days. At three time points (d1, d3, and d6) cells were labeled with K15, Ki-67 and DAPI. K15- and Ki-67-positive cells were counted and expressed as percentage of all DAPI-positive cells (nuclei). Error bars represent means±SEM; data were analysed by unpaired Student's t-test (vehicle group vs. test group; A, C) and two-way ANOVA test (within corresponding groups; B, D);*<i>P</i><0.05; **<i>P</i><0.01;***<i>P</i><0.001.</p>", "links"=>[], "tags"=>["modulates", "forming", "k15", "cells"], "article_id"=>422392, "categories"=>["Developmental Biology"], "users"=>["Yuval Ramot", "Stephan Tiede", "Tamás Bíró", "Mohd Hilmi Abu Bakar", "Koji Sugawara", "Michael P. Philpott", "Wesley Harrison", "Marko Pietilä", "Ralf Paus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022564.g005", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spermidine_modulates_colony_forming_efficiency_and_K15_expression_of_isolated_K15_GFP_cells_in_vitro_/422392", "title"=>"Spermidine modulates colony forming efficiency and K15 expression of isolated K15-GFP+ cells <i>in vitro</i>.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:20:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/751656"], "description"=>"<p><b>A.</b> Immunoreactivity of ODC in the proximal HF demonstrates moderate ODC expression in the matrix keratinocytes, and strong expression in the proximal companion layer. <b>B.</b> Spermidine treatment for 6d decreased ODC immunoreactivity in the lower doses (0.1 and 0.5 µM). Columns represent means±SEM; n = 9–13 HFs/group <b>C.</b> By Q-PCR, spermidine treatment for 24 h slightly decreased the <i>ODC</i> transcript steady-state levels in human anagen HF mRNA extracts, compared to <i>PPIA,</i> although this did not reach significances. <b>D.</b> However, spermidine significantly down regulated <i>ODC</i> transcription in cultured human ORS keratinocytes after 48 h. *<i>P</i><0.05. Columns represent means±SEM. Results represent triplicate determinations of samples. Total RNA was pooled from 20 HFs. DP, dermal papilla; MK, matrix keratinocytes; ORS, outer root sheath.</p>", "links"=>[], "tags"=>["down-regulates", "odc"], "article_id"=>422025, "categories"=>["Developmental Biology"], "users"=>["Yuval Ramot", "Stephan Tiede", "Tamás Bíró", "Mohd Hilmi Abu Bakar", "Koji Sugawara", "Michael P. Philpott", "Wesley Harrison", "Marko Pietilä", "Ralf Paus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022564.g002", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spermidine_treatment_down_regulates_ODC_expression_in_the_HF_/422025", "title"=>"Spermidine treatment down-regulates ODC expression in the HF.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:18:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/751906"], "description"=>"<p><b>A</b>. Spermidine treatment for 6d increased K15-like immunoreactivity in the 0.5 µM and 1 µM doses, as assessed by quantitative immunoreactivity. n = 10–15 HFs/group; cumulative results of two different experiments. <b>B.</b> Spermidine significantly upregulated <i>K15</i> mRNA expression in cultured ORS keratinocytes after 48 h of treatment. Results represent triplicate determinations of samples. Total RNA was pooled from 20 HFs. <b>C.</b> DFMO (400 mg/l) significantly decreased K15-like immunoreactivity after 6d. n = 6–8 HFs/group<b>. D.</b> Spermidine treatment for 6d increased K19-like immunoreactivity in the 0.1 µM and 0.5 µM doses, as assessed by quantitative immunoreactivity. n =  30–36 HFs/group; cumulative results of two different experiments. <b>E.</b> By Q-PCR, spermidine treatment for 48 h significantly increased the <i>K19</i> transcript steady-state levels in human anagen HF mRNA extracts. <b>F.</b> Treatment of ORS keratinocytes for 48 h showed a tendency of <i>K19</i> mRNA upregulation, but these results were not statistically significant. Results represent triplicate determinations of samples. Total RNA was pooled from 20 HFs. Scale bars, 50 µm. Columns represent means±SEM; *<i>P</i><0.05; **<i>P</i><0.01. ORS, outer root sheath.</p>", "links"=>[], "tags"=>["up-regulates", "epithelial", "cell-associated", "keratins", "k15"], "article_id"=>422267, "categories"=>["Developmental Biology"], "users"=>["Yuval Ramot", "Stephan Tiede", "Tamás Bíró", "Mohd Hilmi Abu Bakar", "Koji Sugawara", "Michael P. Philpott", "Wesley Harrison", "Marko Pietilä", "Ralf Paus"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022564.g004", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spermidine_up_regulates_expression_of_the_epithelial_stem_cell_associated_keratins_K15_and_K19_/422267", "title"=>"Spermidine up-regulates expression of the epithelial stem cell-associated keratins K15 and K19.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:19:21"}

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Relative Metric

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