Liver-Derived IGF-I Regulates Mean Life Span in Mice
Publication Date
July 25, 2011
Journal
PLOS ONE
Authors
Johan Svensson, Klara Sjögren, Jenny Fäldt, Niklas Andersson, et al
Volume
6
Issue
7
Pages
e22640
DOI
https://dx.plos.org/10.1371/journal.pone.0022640
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0022640
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21799924
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143189
Europe PMC
http://europepmc.org/abstract/MED/21799924
Web of Science
000293172900060
Scopus
79960731115
Mendeley
http://www.mendeley.com/research/liverderived-igfi-regulates-mean-life-span-mice
Events
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/753349"], "description"=>"<p>At 13 months of age, before there was any difference in body weight, food intake, feces output, activity level, and oxygen consumption at rest were determined in female control (n = 8) and LI-IGF-I<sup>-/-</sup> (n = 8) mice. Values are given as means (SEM).</p>", "links"=>[], "tags"=>["igf-i", "inactivated", "12", "months"], "article_id"=>423715, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Liver_derived_IGF_I_were_inactivated_at_12_months_of_age_/423715", "title"=>"Liver-derived IGF-I were inactivated at 12 months of age.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 16:27:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/752966"], "description"=>"<p>A) The percentage of pregnant female mice in relation to the total number of female mice in each group. B) Litter size when female LI-IGF-I<sup>-/-</sup> mice were mated with age-matched male control mice at 5 and 8 months of age (n = 12-14 in each group). The experiments showed normal fertility in female LI-IGF-I<sup>-/-</sup> mice. In Figure 3B, the error bars indicate the standard error for the mean values shown.</p>", "links"=>[], "tags"=>["fertility"], "article_id"=>423334, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Normal_fertility_in_female_LI_IGF_I_mice_/423334", "title"=>"Normal fertility in female LI-IGF-I<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:25:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/753098"], "description"=>"<p>A) The volume of O<sub>2</sub> consumed (VO<sub>2</sub>) and B) respiratory exchange ratio (RER) during submaximal exercise (30 min) and post-exercise (20 min) in 18-month-old female control (n = 7) and LI-IGF-I<sup>-/-</sup> (n = 7) mice. The vertical bars indicate the SE for the mean values shown. ** p<0.01 vs. control mice</p>", "links"=>[], "tags"=>["submaximal", "post-exercise"], "article_id"=>423465, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_oxygen_consumption_during_submaximal_exercise_and_post_exercise_in_LI_IGF_I_mice_/423465", "title"=>"Increased oxygen consumption during submaximal exercise and post-exercise in LI-IGF-I<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:25:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/753394"], "description"=>"<p>The regulation of mRNA levels of different genes is indicated by the average-fold change (FC) according to the rules given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022640#s4\" target=\"_blank\">Materials and Methods</a>.</p><p>Exp  =  Expression; *, 0–500; ** 501–2000; *** 2001–8000 (Arbitrary units by Affymetrix).</p><p>NC indicates no change (according to the rules given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022640#s4\" target=\"_blank\">Materials and Methods</a>) and ND indicates not detectable.</p>", "links"=>[], "tags"=>["regulated", "skeletal", "7-month-old", "mice", "dna", "microarray"], "article_id"=>423757, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Genes_regulated_in_liver_skeletal_muscle_heart_fat_retroperitoneal_fat_and_bone_vertebrae_in_7_month_old_female_control_n_6_and_LI_IGF_I_n_8202_8202_7_mice_as_determined_by_DNA_microarray_analyses_/423757", "title"=>"Genes regulated in liver, skeletal muscle, heart, fat (retroperitoneal fat), and bone (vertebrae) in 7-month-old female control (n = 6) and LI-IGF-I<sup>-/-</sup> (n = 7) mice as determined by DNA microarray analyses.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 16:27:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/753438"], "description"=>"<p>In control (n = 6) and LI-IGF-I<sup>-/-</sup> (n = 8) mice, at 18 months of age, measurements using DEXA and dissections of fat pads were performed. The DEXA scans were from the lower level of the head to the inferior level of the first tail vertebra (the maximal scan area of the DEXA). Values are given as means (SEM).</p><p>BW  =  body weight.</p>", "links"=>[], "tags"=>["igf-i", "inactivated", "12", "months"], "article_id"=>423802, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Liver_derived_IGF_I_were_inactivated_at_12_months_of_age_/423802", "title"=>"Liver-derived IGF-I were inactivated at 12 months of age.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 16:27:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/752858"], "description"=>"<p>A) Female LI-IGF-I<sup>-/-</sup> mice live 16% longer than female control mice (26.7 ± 1.1 vs. 23.0 ± 0.7 months, p<0.01 using unpaired <i>t</i>-test; Kaplan-Meyer analysis p<0.001, Cox's test). B) Although not statistically significant, male LI-IGF-I<sup>-/-</sup> mice live 6% longer than male control mice (23.5 ± 0.8 vs. 22.1 ± 0.7 months, p = 0.17 using unpaired t-test; Kaplan-Meyer analysis: p = 0.10, Cox's test).</p>", "links"=>[], "tags"=>["span"], "article_id"=>423227, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_mean_life_span_of_female_LI_IGF_I_mice_/423227", "title"=>"Increased mean life span of female LI-IGF-I<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:24:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/752744"], "description"=>"<p>Body weight in A) female and B) male mice. Body weight was determined every third month during 3-30 months of age. Between 3 and 27 months of age, body weight was significantly lower in LI-IGF-I<sup>-/-</sup> compared with control mice in the total number of mice and also in the male and female subgroups (all analyses p<0.001). The vertical bars indicate the SE for the mean values shown.</p>", "links"=>[], "tags"=>["diabetes and endocrinology", "molecular biology", "physiology", "developmental biology", "Biochemistry"], "article_id"=>423100, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_body_weight_in_LI_IGF_I_mice_/423100", "title"=>"Reduced body weight in LI-IGF-I<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:23:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/753217"], "description"=>"<p>To confirm the microarray findings, RT-PCR analyses were performed on skeletal muscle (triceps) samples from individual mice. The RT-PCR analyses showed reduced mRNA levels of A) heat shock protein 1A (Hspa1a), B) heat shock protein 1B (Hspa1b), and C) connective tissue growth factor (Ctgf). D) IGF-I receptor mRNA level was unchanged. The mRNA levels in LI-IGF-I<sup>-/-</sup> mice (n = 7) are expressed as percent of that in control mice (n = 6). The vertical bars indicate the SE for the mean values shown.* p<0.05 ** p<0.01 vs. control mice.</p>", "links"=>[], "tags"=>["mrna", "levels", "ctgf"], "article_id"=>423582, "categories"=>["Physiology", "Molecular Biology", "Biochemistry", "Chemistry", "Developmental Biology"], "users"=>["Johan Svensson", "Klara Sjögren", "Jenny Fäldt", "Niklas Andersson", "Olle Isaksson", "John-Olov Jansson", "Claes Ohlsson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022640.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decreased_mRNA_levels_of_Hspa1a_Hspa1b_and_Ctgf_in_LI_IGF_I_mice_/423582", "title"=>"Decreased mRNA levels of Hspa1a, Hspa1b, and Ctgf in LI-IGF-I<sup>-/-</sup> mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 16:26:29"}

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Relative Metric

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