Serum Cholesterol and the Progression of Parkinson's Disease: Results from DATATOP
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{"title"=>"Serum cholesterol and the progression of parkinson's disease: Results from DATATOP", "type"=>"journal", "authors"=>[{"first_name"=>"Xuemei", "last_name"=>"Huang", "scopus_author_id"=>"55770777800"}, {"first_name"=>"Peggy", "last_name"=>"Auinger", "scopus_author_id"=>"6701507975"}, {"first_name"=>"Shirley", "last_name"=>"Eberly", "scopus_author_id"=>"57201346207"}, {"first_name"=>"David", "last_name"=>"Oakes", "scopus_author_id"=>"7005174631"}, {"first_name"=>"Michael", "last_name"=>"Schwarzschild", "scopus_author_id"=>"7003651412"}, {"first_name"=>"Alberto", "last_name"=>"Ascherio", "scopus_author_id"=>"7004443355"}, {"first_name"=>"Richard", "last_name"=>"Mailman", "scopus_author_id"=>"7004614507"}, {"first_name"=>"Honglei", "last_name"=>"Chen", "scopus_author_id"=>"35331605500"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "scopus"=>"2-s2.0-80051603129", "pui"=>"362335595", "doi"=>"10.1371/journal.pone.0022854", "issn"=>"19326203", "pmid"=>"21853051", "sgr"=>"80051603129"}, "id"=>"9bec8607-11db-34b8-8541-8c08d96a4397", "abstract"=>"BACKGROUND: Recent studies have suggested that higher serum cholesterol may be associated with lower occurrence of Parkinson's disease (PD). This study is to test the hypothesis that higher serum cholesterol correlates with slower PD progression.\\n\\nMETHODS: Baseline non-fasting serum total cholesterol was measured in 774 of the 800 subjects with early PD enrolled between 1987 and 1988 in the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) trial. Participants were followed for up to two years, with clinical disability requiring levodopa therapy as the primary endpoint. Hazard ratios (HRs) and 95% confidence intervals (CI) were determined for increasing serum cholesterol concentration (in quintiles) for clinical disability requiring levodopa therapy, after adjusting for confounders. At baseline, only nine subjects reported use of cholesterol-lowering agents (two with statins).\\n\\nRESULTS: The overall mean cholesterol level was 216 mg/dL (range 100-355). The HR of progressing to the primary endpoint decreased with increasing serum cholesterol concentrations. Compared to the lowest quintile, the HRs (95%CI), for each higher quintile (in ascending order) are 0.83 (0.59-1.16); 0.86 (0.61-1.20); 0.84 (0.60-1.18); and 0.75 (0.52-1.09). The HR for one standard deviation (SD) increase = 0.90 [(0.80-1.01), p for trend = 0.09]. This trend was found in males (HR per SD = 0.88 [(0.77-1.00), p for trend = 0.05], but not in females [HR = 1.03 (0.81-1.32)].\\n\\nCONCLUSIONS: This secondary analysis of the DATATOP trial provides preliminary evidence that higher total serum cholesterol concentrations may be associated with a modest slower clinical progression of PD, and this preliminary finding needs confirmation from larger prospective studies.", "link"=>"http://www.mendeley.com/research/serum-cholesterol-progression-parkinsons-disease-results-datatop", "reader_count"=>27, "reader_count_by_academic_status"=>{"Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>4, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>9, "Neuroscience"=>6, "Sports and Recreations"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>6}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "United Kingdom"=>1, "Spain"=>2, "India"=>1}, "group_count"=>0}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/745995"], "description"=>"<p>HR = hazard ratio; CI = confidence interval. Models are adjusted for gender, treatment group, baseline age, uric acid concentration, PD subtype, and BMI.</p>a<p>A 1-standard deviation (SD) increase indicates an increase of 39.2 mg/dL in all subjects, 37.6 mg/dL in males, and, 41.0 mg/dL in females.</p>", "links"=>[], "tags"=>["ratios", "quintiles", "baseline", "serum", "corresponding", "1-sd"], "article_id"=>416360, "categories"=>["Neuroscience"], "users"=>["Xuemei Huang", "Peggy Auinger", "Shirley Eberly", "David Oakes", "Michael Schwarzschild", "Alberto Ascherio", "Richard Mailman", "Honglei Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022854.t002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hazard_ratios_for_reaching_the_primary_end_point_according_to_quintiles_of_baseline_serum_cholesterol_concentration_or_corresponding_to_a_1_SD_increase_in_serum_cholesterol_concentration_/416360", "title"=>"Hazard ratios for reaching the primary end point according to quintiles of baseline serum cholesterol concentration or corresponding to a 1-SD increase in serum cholesterol concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-11 01:46:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/746047"], "description"=>"<p>HR = hazard ratio; CI = confidence interval. Models are adjusted for gender (for total cohort), treatment group, baseline age, uric acid concentration, PD subtype, and BMI.</p>a<p>A 1-standard deviation (SD) increase indicates an increase of 39.2 mg/dL in all subjects, 37.6 mg/dL in males, and, 41.0 mg/dL in females.</p>", "links"=>[], "tags"=>["ratios", "points", "quintiles", "baseline", "serum", "corresponding", "1-sd"], "article_id"=>416405, "categories"=>["Neuroscience"], "users"=>["Xuemei Huang", "Peggy Auinger", "Shirley Eberly", "David Oakes", "Michael Schwarzschild", "Alberto Ascherio", "Richard Mailman", "Honglei Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022854.t004", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Hazard_ratios_for_reaching_secondary_end_points_according_to_quintiles_of_baseline_serum_cholesterol_concentration_and_the_corresponding_to_a_1_SD_increase_in_serum_cholesterol_concentration_/416405", "title"=>"Hazard ratios for reaching secondary end points according to quintiles of baseline serum cholesterol concentration and the corresponding to a 1-SD increase in serum cholesterol concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-11 01:46:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/745952"], "description"=>"<p>CI = confidence interval. Models are adjusted for gender, treatment group, baseline UPDRS score, age, uric acid concentration, PD subtype, and BMI.</p>a<p>A 1-standard deviation (SD) increase indicates an increase of 39.2 mg/dL in all subjects, 37.6 mg/dL in males, and, 41.0 mg/dL in females.</p>", "links"=>[], "tags"=>["means", "annualized", "updrs", "scores", "quintiles", "baseline", "serum", "corresponding", "1-sd"], "article_id"=>416311, "categories"=>["Neuroscience"], "users"=>["Xuemei Huang", "Peggy Auinger", "Shirley Eberly", "David Oakes", "Michael Schwarzschild", "Alberto Ascherio", "Richard Mailman", "Honglei Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022854.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adjusted_means_for_annualized_rate_of_change_in_UPDRS_scores_according_to_quintiles_of_baseline_serum_cholesterol_concentration_or_corresponding_to_a_1_SD_increase_in_serum_cholesterol_concentration_/416311", "title"=>"Adjusted means for annualized rate of change in UPDRS scores according to quintiles of baseline serum cholesterol concentration or corresponding to a 1-SD increase in serum cholesterol concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-11 01:45:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/376269"], "description"=>"<div><h3>Background</h3><p>Recent studies have suggested that higher serum cholesterol may be associated with lower occurrence of Parkinson's disease (PD). This study is to test the hypothesis that higher serum cholesterol correlates with slower PD progression.</p> <h3>Methods</h3><p>Baseline non-fasting serum total cholesterol was measured in 774 of the 800 subjects with early PD enrolled between 1987 and 1988 in the Deprenyl and Tocopherol Antioxidative Therapy of Parkinsonism (DATATOP) trial. Participants were followed for up to two years, with clinical disability requiring levodopa therapy as the primary endpoint. Hazard ratios (HRs) and 95% confidence intervals (CI) were determined for increasing serum cholesterol concentration (in quintiles) for clinical disability requiring levodopa therapy, after adjusting for confounders. At baseline, only nine subjects reported use of cholesterol-lowering agents (two with statins).</p> <h3>Results</h3><p>The overall mean cholesterol level was 216 mg/dL (range 100–355). The HR of progressing to the primary endpoint decreased with increasing serum cholesterol concentrations. Compared to the lowest quintile, the HRs (<em>95%CI</em>), for each higher quintile (in ascending order) are 0.83 <em>(0.59–1.16)</em>; 0.86 <em>(0.61–1.20)</em>; 0.84 <em>(0.60–1.18)</em>; and 0.75 <em>(0.52–1.09)</em>. The HR for one standard deviation (SD) increase = 0.90 [(0.80–1.01), p for trend = 0.09]. This trend was found in males (HR per SD = 0.88 [(0.77–1.00), p for trend = 0.05], but not in females [HR = 1.03 (0.81–1.32)].</p> <h3>Conclusions</h3><p>This secondary analysis of the DATATOP trial provides preliminary evidence that higher total serum cholesterol concentrations may be associated with a modest slower clinical progression of PD, and this preliminary finding needs confirmation from larger prospective studies.</p> </div>", "links"=>[], "tags"=>["serum", "progression", "results", "datatop"], "article_id"=>134327, "categories"=>["Neuroscience"], "users"=>["Xuemei Huang", "Peggy Auinger", "Shirley Eberly", "David Oakes", "Michael Schwarzschild", "Alberto Ascherio", "Richard Mailman", "Honglei Chen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0022854", "stats"=>{"downloads"=>2, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Serum_Cholesterol_and_the_Progression_of_Parkinson_s_Disease_Results_from_DATATOP/134327", "title"=>"Serum Cholesterol and the Progression of Parkinson's Disease: Results from DATATOP", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-11 01:12:07"}

PMC Usage Stats | Further Information

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Relative Metric

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