Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology
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{"title"=>"Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology", "type"=>"journal", "authors"=>[{"first_name"=>"Veerle", "last_name"=>"van Hoeck", "scopus_author_id"=>"35735452000"}, {"first_name"=>"Roger G.", "last_name"=>"Sturmey", "scopus_author_id"=>"8840478600"}, {"first_name"=>"Pablo", "last_name"=>"Bermejo-Alvarez", "scopus_author_id"=>"23989957400"}, {"first_name"=>"Dimitrios", "last_name"=>"Rizos", "scopus_author_id"=>"55946184900"}, {"first_name"=>"Alfonso", "last_name"=>"Gutierrez-Adan", "scopus_author_id"=>"7003720587"}, {"first_name"=>"Henry J.", "last_name"=>"Leese", "scopus_author_id"=>"7006373192"}, {"first_name"=>"Peter E J", "last_name"=>"Bols", "scopus_author_id"=>"6701793761"}, {"first_name"=>"Jo L M R", "last_name"=>"Leroy", "scopus_author_id"=>"35607670400"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-80051763728", "pui"=>"362361071", "doi"=>"10.1371/journal.pone.0023183", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "sgr"=>"80051763728", "pmid"=>"21858021"}, "id"=>"47ad7ccc-03e3-3779-b5a7-4319c019afc6", "abstract"=>"Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and physiology of zygotes formed from such oocytes, using the cow as a model. The zygotes were grown to blastocysts, which were evaluated for their quality in terms of cell number, apoptosis, expression of key genes, amino acid turnover and oxidative metabolism. Oocyte maturation under elevated NEFA concentrations resulted in blastocysts with significantly lower cell number, increased apoptotic cell ratio and altered mRNA abundance of DNMT3A, IGF2R and SLC2A1. In addition, the blastocysts displayed reduced oxygen, pyruvate and glucose consumption, up-regulated lactate consumption and higher amino acid metabolism. These data indicate that exposure of maturing oocytes to elevated NEFA concentrations has a negative impact on fertility not only through a reduction in oocyte developmental capacity but through compromised early embryo quality, viability and metabolism.", "link"=>"http://www.mendeley.com/research/elevated-nonesterified-fatty-acid-concentrations-during-bovine-oocyte-maturation-compromise-early-em-2", "reader_count"=>59, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>3, "Student > Master"=>8, "Student > Bachelor"=>10, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>3, "Student > Master"=>8, "Student > Bachelor"=>10, "Lecturer"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>7, "Agricultural and Biological Sciences"=>32, "Medicine and Dentistry"=>13, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>32}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>7}, "Unspecified"=>{"Unspecified"=>4}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "Sudan"=>1, "Brazil"=>1, "Spain"=>1}, "group_count"=>5}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/745123"], "description"=>"<p>Oocytes (n = 1024; three replicates) were matured in maturation medium supplemented with 1) physiological NEFA  =  control (150 µM of total NEFA, i.e. OA, SA and PA); 2) elevated Stearic Acid  =  HIGH SA (75 µM SA); 3) elevated Palmitic Acid  =  HIGH PA (150 µM PA) and 4) elevated Oleic Acid  =  HIGH OA (200 µM OA). Data marked with different superscripts per row are significantly different between treatments (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["bovine", "oocytes", "reduced", "oocyte", "competence", "resultant"], "article_id"=>415488, "categories"=>["Chemistry", "Biochemistry", "Mathematics", "Developmental Biology", "Physiology", "Genetics"], "users"=>["Veerle Van Hoeck", "Roger G. Sturmey", "Pablo Bermejo-Alvarez", "Dimitrios Rizos", "Alfonso Gutierrez-Adan", "Henry J. Leese", "Peter E. J. Bols", "Jo L. M. R. Leroy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023183.t001", "stats"=>{"downloads"=>6, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_NEFA_exposure_of_bovine_oocytes_significantly_reduced_the_oocyte_developmental_competence_and_the_quality_of_the_resultant_blastocysts_/415488", "title"=>"NEFA exposure of bovine oocytes significantly reduced the oocyte developmental competence and the quality of the resultant blastocysts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-17 01:31:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/375480", "https://ndownloader.figshare.com/files/375550", "https://ndownloader.figshare.com/files/375608", "https://ndownloader.figshare.com/files/375640"], "description"=>"<div><p>Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and physiology of zygotes formed from such oocytes, using the cow as a model. The zygotes were grown to blastocysts, which were evaluated for their quality in terms of cell number, apoptosis, expression of key genes, amino acid turnover and oxidative metabolism. Oocyte maturation under elevated NEFA concentrations resulted in blastocysts with significantly lower cell number, increased apoptotic cell ratio and altered mRNA abundance of <em>DNMT3A</em>, <em>IGF2R</em> and <em>SLC2A1</em>. In addition, the blastocysts displayed reduced oxygen, pyruvate and glucose consumption, up-regulated lactate consumption and higher amino acid metabolism. These data indicate that exposure of maturing oocytes to elevated NEFA concentrations has a negative impact on fertility not only through a reduction in oocyte developmental capacity but through compromised early embryo quality, viability and metabolism.</p> </div>", "links"=>[], "tags"=>["elevated", "non-esterified", "fatty", "concentrations", "bovine", "oocyte", "maturation", "embryo", "physiology"], "article_id"=>134153, "categories"=>["Chemistry", "Biochemistry", "Mathematics", "Developmental Biology", "Physiology", "Genetics"], "users"=>["Veerle Van Hoeck", "Roger G. Sturmey", "Pablo Bermejo-Alvarez", "Dimitrios Rizos", "Alfonso Gutierrez-Adan", "Henry J. Leese", "Peter E. J. Bols", "Jo L. M. R. Leroy"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023183.s001", "https://dx.doi.org/10.1371/journal.pone.0023183.s002", "https://dx.doi.org/10.1371/journal.pone.0023183.s003", "https://dx.doi.org/10.1371/journal.pone.0023183.s004"], "stats"=>{"downloads"=>5, "page_views"=>42, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Elevated_Non_Esterified_Fatty_Acid_Concentrations_during_Bovine_Oocyte_Maturation_Compromise_Early_Embryo_Physiology/134153", "title"=>"Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-08-17 01:09:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/744848"], "description"=>"<p>A. Amino acid ‘turnover’ of day 7 blastocysts as calculated by summing all amino acids produced and consumed on a per-embryo basis. Comparison was done between blastocysts (n = 135; three replicates) derived from oocytes matured under control, HIGH SA and HIGH COMBI conditions. B. Overall mean profiles of individual amino acids by blastocyst in the three treatments. Bars with different superscripts are significantly different between treatments (P<0.05).</p>", "links"=>[], "tags"=>["metabolism", "blastocysts", "originating", "nefa-exposed", "oocytes"], "article_id"=>415216, "categories"=>["Chemistry", "Biochemistry", "Mathematics", "Developmental Biology", "Physiology", "Genetics"], "users"=>["Veerle Van Hoeck", "Roger G. Sturmey", "Pablo Bermejo-Alvarez", "Dimitrios Rizos", "Alfonso Gutierrez-Adan", "Henry J. Leese", "Peter E. J. Bols", "Jo L. M. R. Leroy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023183.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amino_acid_metabolism_of_blastocysts_originating_from_NEFA_exposed_oocytes_is_compromised_/415216", "title"=>"Amino acid metabolism of blastocysts originating from NEFA-exposed oocytes is compromised.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-17 01:26:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/744974"], "description"=>"<p>A. Mean oxygen consumption of day 7 blastocysts. Blastocysts (n = 66; three replicates) were derived from control-, HIGH SA- and HIGH COMBI-exposed oocytes. Different superscripts indicate significant differences between treatments (P<0.05). B. Mean pyruvate, glucose and lactate consumption of blastocysts. Blastocysts (n = 84; five replicates) originated from oocytes matured in control, HIGH SA and HIGH COMBI maturation medium. Different superscripts indicate significant differences between treatments (P<0.05).</p>", "links"=>[], "tags"=>["processes", "atp", "altered", "blastocysts", "arising", "oocytes", "exposed"], "article_id"=>415342, "categories"=>["Chemistry", "Biochemistry", "Mathematics", "Developmental Biology", "Physiology", "Genetics"], "users"=>["Veerle Van Hoeck", "Roger G. Sturmey", "Pablo Bermejo-Alvarez", "Dimitrios Rizos", "Alfonso Gutierrez-Adan", "Henry J. Leese", "Peter E. J. Bols", "Jo L. M. R. Leroy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023183.g003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Key_processes_of_ATP_production_are_significantly_altered_in_blastocysts_arising_from_oocytes_exposed_to_NEFA_/415342", "title"=>"Key processes of ATP production are significantly altered in blastocysts arising from oocytes exposed to NEFA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-17 01:29:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/745075"], "description"=>"<p>Cleavage rate at day 2 p.i., number of formed blastocysts at day 7 p.i. relative to the number of matured oocytes or to the number of cleaved zygotes. Oocytes (n = 595; three replicates) were matured in standard serum-free maturation medium devoid of all fatty acids <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023183#pone.0023183-Leroy2\" target=\"_blank\">[59]</a> and in physiologically relevant, NEFA containing maturation medium with physiological, non toxic NEFA concentrations ( =  control medium used in this study: 150 µM of total NEFA, i.e. OA, SA and PA). Data marked with different superscripts per row are significantly different between treatments (<i>P</i><0.05).</p>", "links"=>[], "tags"=>["physiological"], "article_id"=>415448, "categories"=>["Chemistry", "Biochemistry", "Mathematics", "Developmental Biology", "Physiology", "Genetics"], "users"=>["Veerle Van Hoeck", "Roger G. Sturmey", "Pablo Bermejo-Alvarez", "Dimitrios Rizos", "Alfonso Gutierrez-Adan", "Henry J. Leese", "Peter E. J. Bols", "Jo L. M. R. Leroy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023183.t002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_a_physiological_relevant_control_medium_/415448", "title"=>"Validation of a physiological relevant control medium.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-17 01:30:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/744727"], "description"=>"<p>Blastocysts were derived from oocytes matured under control, HIGH SA and HIGH COMBI conditions (n = 192; five replicates). Bars with different superscripts are significantly different between treatments with P<0.05.</p>", "links"=>[], "tags"=>["patterns", "genes", "altered", "bovine", "blastocysts", "arising", "oocytes", "matured", "elevated"], "article_id"=>415090, "categories"=>["Chemistry", "Biochemistry", "Mathematics", "Developmental Biology", "Physiology", "Genetics"], "users"=>["Veerle Van Hoeck", "Roger G. Sturmey", "Pablo Bermejo-Alvarez", "Dimitrios Rizos", "Alfonso Gutierrez-Adan", "Henry J. Leese", "Peter E. J. Bols", "Jo L. M. R. Leroy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0023183.g001", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_patterns_of_key_genes_are_altered_in_bovine_blastocysts_arising_from_oocytes_matured_in_the_presence_of_elevated_NEFA_/415090", "title"=>"Expression patterns of key genes are altered in bovine blastocysts arising from oocytes matured in the presence of elevated NEFA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-17 01:24:50"}

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Relative Metric

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