Association of Organophosphate Pesticide Exposure and Paraoxonase with Birth Outcome in Mexican-American Women
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{"title"=>"Association of organophosphate pesticide exposure and paraoxonase with birth outcome in mexican-american women", "type"=>"journal", "authors"=>[{"first_name"=>"Kim G.", "last_name"=>"Harley", "scopus_author_id"=>"7003344120"}, {"first_name"=>"Karen", "last_name"=>"Huen", "scopus_author_id"=>"12785910500"}, {"first_name"=>"Raul Aguilar", "last_name"=>"Schall", "scopus_author_id"=>"50661799200"}, {"first_name"=>"Nina T.", "last_name"=>"Holland", "scopus_author_id"=>"7102605602"}, {"first_name"=>"Asa", "last_name"=>"Bradman", "scopus_author_id"=>"6602211513"}, {"first_name"=>"Dana Boyd", "last_name"=>"Barr", "scopus_author_id"=>"7202363221"}, {"first_name"=>"Brenda", "last_name"=>"Eskenazi", "scopus_author_id"=>"7005313147"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"21904599", "doi"=>"10.1371/journal.pone.0023923", "sgr"=>"80052334311", "isbn"=>"10.1371/journal.pone.0023923", "scopus"=>"2-s2.0-80052334311", "issn"=>"19326203", "pui"=>"362471892"}, "id"=>"0155bf2a-bb89-3814-900c-bb2a3f948197", "abstract"=>"BACKGROUND: Epidemiologic studies suggest that maternal organophosphorus (OP) pesticide exposure is associated with poorer fetal growth, but findings are inconsistent. We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association.\\n\\nMETHODS: The study population included 470 pregnant women enrolled in the CHAMACOS Study, a longitudinal cohort study of mothers and children living in an agricultural region of California. We analyzed urine samples collected from mothers twice during pregnancy for dialkyl phosphate (DAP) metabolites of OP pesticides. We analyzed maternal and fetal (cord) blood samples for PON1 genotype (PON1(192) and PON1(-108)) and enzyme activity (paraoxonase and arylesterase). Infant birth weight, head circumference, and gestational age were obtained from medical records.\\n\\nRESULTS: Infants' PON1 genotype and activity were associated with birth outcome, but mothers' were not. Infants with the susceptible PON1(-108TT) genotype had shorter gestational age (β = -0.5 weeks, 95% Confidence Interval (CI): -0.9, 0.0) and smaller head circumference (β = -0.4 cm, 95% CI: -0.7, 0.0) than those with the PON1(-108CC) genotype. Infants' arylesterase and paraoxonase activity were positively associated with gestational age. There was some evidence of effect modification with DAPs: maternal DAP concentrations were associated with shorter gestational age only among infants of the susceptible PON1(-108TT) genotype (p-value(interaction) = 0.09). However, maternal DAP concentrations were associated with larger birth weight (p-value(interaction) = 0.06) and head circumference (p-value(interaction)<0.01) in infants with non-susceptible genotypes.\\n\\nCONCLUSIONS: Infants whose PON1 genotype and enzyme activity levels suggested that they might be more susceptible to the effects of OP pesticide exposure had decreased fetal growth and length of gestation. PON1 may be another factor contributing to preterm or low birth weight birth.", "link"=>"http://www.mendeley.com/research/association-organophosphate-pesticide-exposure-paraoxonase-birth-outcome-mexicanamerican-women", "reader_count"=>58, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>8, "Researcher"=>12, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>13, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Student > Doctoral Student"=>8, "Researcher"=>12, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>1, "Student > Master"=>13, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>2, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>10, "Chemistry"=>3, "Computer Science"=>1, "Engineering"=>1, "Environmental Science"=>8, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>3, "Materials Science"=>1, "Mathematics"=>1, "Medicine and Dentistry"=>14, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>4, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>4}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>8}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Engineering"=>{"Engineering"=>1}, "Chemistry"=>{"Chemistry"=>3}, "Neuroscience"=>{"Neuroscience"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}}, "reader_count_by_country"=>{"Denmark"=>1, "Jordan"=>1, "Spain"=>1}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/373442"], "description"=>"<div><h3>Background</h3><p>Epidemiologic studies suggest that maternal organophosphorus (OP) pesticide exposure is associated with poorer fetal growth, but findings are inconsistent. We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier in this association.</p> <h3>Methods</h3><p>The study population included 470 pregnant women enrolled in the CHAMACOS Study, a longitudinal cohort study of mothers and children living in an agricultural region of California. We analyzed urine samples collected from mothers twice during pregnancy for dialkyl phosphate (DAP) metabolites of OP pesticides. We analyzed maternal and fetal (cord) blood samples for PON1 genotype (<em>PON1<sub>192</sub></em> and <em>PON1<sub>−108</sub></em>) and enzyme activity (paraoxonase and arylesterase). Infant birth weight, head circumference, and gestational age were obtained from medical records.</p> <h3>Results</h3><p>Infants' PON1 genotype and activity were associated with birth outcome, but mothers' were not. Infants with the susceptible <em>PON1<sub>−108TT</sub></em> genotype had shorter gestational age (β = −0.5 weeks, 95% Confidence Interval (CI): −0.9, 0.0) and smaller head circumference (β = −0.4 cm, 95% CI: −0.7, 0.0) than those with the <em>PON1<sub>−108CC</sub></em> genotype. Infants' arylesterase and paraoxonase activity were positively associated with gestational age. There was some evidence of effect modification with DAPs: maternal DAP concentrations were associated with shorter gestational age only among infants of the susceptible <em>PON1<sub>−108TT</sub></em> genotype (p-value<sub>interaction</sub> = 0.09). However, maternal DAP concentrations were associated with larger birth weight (p-value<sub>interaction</sub> = 0.06) and head circumference (p-value<sub>interaction</sub><0.01) in infants with non-susceptible genotypes.</p> <h3>Conclusions</h3><p>Infants whose PON1 genotype and enzyme activity levels suggested that they might be more susceptible to the effects of OP pesticide exposure had decreased fetal growth and length of gestation. PON1 may be another factor contributing to preterm or low birth weight birth.</p> </div>", "links"=>[], "tags"=>["organophosphate", "pesticide", "paraoxonase", "mexican-american", "women"], "article_id"=>133752, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Association_of_Organophosphate_Pesticide_Exposure_and_Paraoxonase_with_Birth_Outcome_in_Mexican_American_Women/133752", "title"=>"Association of Organophosphate Pesticide Exposure and Paraoxonase with Birth Outcome in Mexican-American Women", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-31 01:02:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/740402"], "description"=>"<p>Models of gestational age controlling for timing of urine collection, timing of entry into prenatal care, maternal age, parity, country of birth, and poverty level. Models of birth weight and head circumference control for timing of urine collection, timing of entry into prenatal care, maternal age, parity, infant sex, country of birth, weight gain, BMI, poverty level, gestational age, and (gestational age)<sup>2</sup>.</p>", "links"=>[], "tags"=>["maternal", "urinary", "daps", "stratified", "pon1"], "article_id"=>410771, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_maternal_urinary_DAPs_with_birth_outcome_stratified_by_infant_PON1_genotype_/410771", "title"=>"Association of maternal urinary DAPs with birth outcome, stratified by infant PON1 genotype.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-08-31 00:12:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/740584"], "description"=>"<p>Demographic characteristics of CHAMACOS study population, Salinas Valley, California, 2000–2001 (N = 467).</p>", "links"=>[], "tags"=>["characteristics", "chamacos", "salinas"], "article_id"=>410954, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_characteristics_of_CHAMACOS_study_population_Salinas_Valley_California_2000_8211_2001_N_8202_8202_467_/410954", "title"=>"Demographic characteristics of CHAMACOS study population, Salinas Valley, California, 2000–2001 (N = 467).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-31 00:15:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/740632"], "description"=>"<p>*p-value<0.05.</p>a<p>Models adjusted for maternal BMI, maternal weight gain, gestational age, and (gestational age)<sup>2</sup>.</p>b<p>Models additionally adjusted for <i>PON1<sub>192</sub></i> genotype, maternal age, country of birth, and assay temperature. Change per 1 standard deviation increase in activity.</p>", "links"=>[], "tags"=>["pon1", "genotype", "chamacos", "salinas"], "article_id"=>410996, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_infant_PON1_genotype_N_8202_8202_436_and_activity_N_8202_8202_324_with_birth_outcome_CHAMACOS_Study_Salinas_Valley_CA_/410996", "title"=>"Association of infant PON1 genotype (N = 436) and activity (N = 324) with birth outcome, CHAMACOS Study, Salinas Valley, CA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-31 00:16:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/740668"], "description"=>"a,b,c,…<p>Values with the same superscript are significantly different (p<0.05) in pairwise Bonferroni's multiple comparison tests (<i>PON1<sub>−108</sub></i> and <i>PON1<sub>192</sub></i> analyses).</p><p>*Values significantly different (p<0.05) from CC/RR individuals in pairwise Bonferroni's multiple comparison tests (<i>PON1<sub>−108</sub></i>×<i>PON1<sub>192</sub></i> analyses).</p>", "links"=>[], "tags"=>["pon1", "genotype", "enzyme", "mothers", "chamacos", "salinas"], "article_id"=>411039, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distribution_of_PON1_genotype_and_enzyme_activity_in_mothers_and_neonates_CHAMACOS_Study_Salinas_Valley_CA_/411039", "title"=>"Distribution of PON1 genotype and enzyme activity in mothers and neonates, CHAMACOS Study, Salinas Valley, CA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-31 00:17:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/740707"], "description"=>"<p>Abbreviations: BW = birth weight, LBW = low birth weight, GA = gestational age, Head = head circumference, – not examined.</p>1<p>↓GA indicates that genotype is associated with decreased GA; ↑GA indicates association with increased GA.</p>2<p>+GA indicates that enzyme activity is positively associated with GA; −GA indicates negative association with GA.</p>", "links"=>[], "tags"=>["studies", "pon1"], "article_id"=>411075, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_studies_of_PON1_and_birth_outcome_/411075", "title"=>"Comparison of studies of PON1 and birth outcome.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-31 00:17:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/740756"], "description"=>"a<p>Gestational age models adjusted for timing of urine collection, timing of entry into prenatal care, maternal age, parity, country of birth, and household income.</p>b<p>Models of birth weight and head circumference adjusted for timing of urine collection, timing of entry into prenatal care, maternal age, parity, country of birth, household income, prepregnancy BMI, maternal weight gain, infant sex, gestational age, and (gestational age)<sup>2</sup>.</p><p>*p-value on stratified association <0.05.</p>†<p>p-value for interaction <0.1.</p>", "links"=>[], "tags"=>["log10", "daps", "stratified", "pon1", "genotype", "tertiles", "arylesterase", "chamacos", "salinas"], "article_id"=>411113, "categories"=>["Cell Biology", "Medicine", "Biotechnology", "Chemistry", "Genetics"], "users"=>["Kim G. Harley", "Karen Huen", "Raul Aguilar Schall", "Nina T. Holland", "Asa Bradman", "Dana Boyd Barr", "Brenda Eskenazi"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0023923.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Adjusted_association_of_log10_increase_in_DAPs_and_birth_outcome_stratified_by_child_PON1_genotype_or_tertiles_of_arylesterase_activity_CHAMACOS_Study_Salinas_Valley_CA_/411113", "title"=>"Adjusted association of log10 increase in DAPs and birth outcome, stratified by child PON1 genotype or tertiles of arylesterase activity, CHAMACOS Study, Salinas Valley, CA.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-08-31 00:18:33"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
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Relative Metric

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