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{"title"=>"Chondrogenic and gliogenic subpopulations of neural crest play distinct roles during the assembly of epibranchial ganglia", "type"=>"journal", "authors"=>[{"first_name"=>"Maya D.", "last_name"=>"Culbertson", "scopus_author_id"=>"55648772500"}, {"first_name"=>"Zachary R.", "last_name"=>"Lewis", "scopus_author_id"=>"24728977900"}, {"first_name"=>"Alexei V.", "last_name"=>"Nechiporuk", "scopus_author_id"=>"6603958565"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"362523782", "pmid"=>"21931719", "doi"=>"10.1371/journal.pone.0024443", "scopus"=>"2-s2.0-80052595406", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "sgr"=>"80052595406"}, "id"=>"1b26c526-1be9-338e-af6e-f49b920dc2bd", "abstract"=>"In vertebrates, the sensory neurons of the epibranchial (EB) ganglia transmit somatosensory signals from the periphery to the CNS. These ganglia are formed during embryogenesis by the convergence and condensation of two distinct populations of precursors: placode-derived neuroblasts and neural crest- (NC) derived glial precursors. In addition to the gliogenic crest, chondrogenic NC migrates into the pharyngeal arches, which lie in close proximity to the EB placodes and ganglia. Here, we examine the respective roles of these two distinct NC-derived populations during development of the EB ganglia using zebrafish morphant and mutants that lack one or both of these NC populations. Our analyses of mutant and morphant zebrafish that exhibit deficiencies in chondrogenic NC at early stages reveal a distinct requirement for this NC subpopulation during early EB ganglion assembly and segmentation. Furthermore, restoration of wildtype chondrogenic NC in one of these mutants, prdm1a, is sufficient to restore ganglion formation, indicating a specific requirement of the chondrogenic NC for EB ganglia assembly. By contrast, analysis of the sox10 mutant, which lacks gliogenic NC, reveals that the initial assembly of ganglia is not affected. However, during later stages of development, EB ganglia are dispersed in the sox10 mutant, suggesting that glia are required to maintain normal EB ganglion morphology. These results highlight novel roles for two subpopulations of NC cells in the formation and maintenance of EB ganglia: chondrogenic NC promotes the early-stage formation of the developing EB ganglia while glial NC is required for the late-stage maintenance of ganglion morphology.", "link"=>"http://www.mendeley.com/research/chondrogenic-gliogenic-subpopulations-neural-crest-play-distinct-roles-during-assembly-epibranchial", "reader_count"=>18, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>17, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>17}}, "reader_count_by_country"=>{"Argentina"=>1, "United States"=>1, "Japan"=>1, "France"=>1}, "group_count"=>1}

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• http://doi.org/10.21769/BioProtoc.2725
• http://doi.org/10.1002/dvg.22850
• http://doi.org/10.1002/wdev.226
• http://doi.org/10.1002/dvg.23107
• http://doi.org/10.1371/journal.pone.0047394
• http://doi.org/10.1051/medsci/20132911011
• http://doi.org/10.1371/journal.pone.0085087
• http://doi.org/10.1016/j.ydbio.2013.11.009
• http://doi.org/10.3389/fphys.2020.586432
• http://doi.org/10.1038/ncb2772
• http://doi.org/10.1016/j.ydbio.2014.01.021
• http://doi.org/10.1098/rstb.2019.0559

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{"UNIPROT"=>14}

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• 4439187
• 4556368
• 3498280
• 3866233
• 3742142

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• {"files"=>["https://ndownloader.figshare.com/files/372620", "https://ndownloader.figshare.com/files/372662", "https://ndownloader.figshare.com/files/372726", "https://ndownloader.figshare.com/files/372770", "https://ndownloader.figshare.com/files/372805", "https://ndownloader.figshare.com/files/372885", "https://ndownloader.figshare.com/files/372930", "https://ndownloader.figshare.com/files/372969", "https://ndownloader.figshare.com/files/373007", "https://ndownloader.figshare.com/files/373058"], "description"=>"<div><p>In vertebrates, the sensory neurons of the epibranchial (EB) ganglia transmit somatosensory signals from the periphery to the CNS. These ganglia are formed during embryogenesis by the convergence and condensation of two distinct populations of precursors: placode-derived neuroblasts and neural crest- (NC) derived glial precursors. In addition to the gliogenic crest, chondrogenic NC migrates into the pharyngeal arches, which lie in close proximity to the EB placodes and ganglia. Here, we examine the respective roles of these two distinct NC-derived populations during development of the EB ganglia using zebrafish morphant and mutants that lack one or both of these NC populations. Our analyses of mutant and morphant zebrafish that exhibit deficiencies in chondrogenic NC at early stages reveal a distinct requirement for this NC subpopulation during early EB ganglion assembly and segmentation. Furthermore, restoration of wildtype chondrogenic NC in one of these mutants, <em>prdm1a</em>, is sufficient to restore ganglion formation, indicating a specific requirement of the chondrogenic NC for EB ganglia assembly. By contrast, analysis of the <em>sox10</em> mutant, which lacks gliogenic NC, reveals that the initial assembly of ganglia is not affected. However, during later stages of development, EB ganglia are dispersed in the <em>sox10</em> mutant, suggesting that glia are required to maintain normal EB ganglion morphology. These results highlight novel roles for two subpopulations of NC cells in the formation and maintenance of EB ganglia: chondrogenic NC promotes the early-stage formation of the developing EB ganglia while glial NC is required for the late-stage maintenance of ganglion morphology.</p> </div>", "links"=>[], "tags"=>["chondrogenic", "gliogenic", "subpopulations", "neural", "crest", "roles", "epibranchial", "ganglia"], "article_id"=>133600, "categories"=>["Physiology", "Biological Sciences", "Neuroscience", "Cell Biology", "Developmental Biology"], "users"=>["Maya D. Culbertson", "Zachary R. Lewis", "Alexei V. Nechiporuk"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0024443.s001", "https://dx.doi.org/10.1371/journal.pone.0024443.s002", "https://dx.doi.org/10.1371/journal.pone.0024443.s003", "https://dx.doi.org/10.1371/journal.pone.0024443.s004", "https://dx.doi.org/10.1371/journal.pone.0024443.s005", "https://dx.doi.org/10.1371/journal.pone.0024443.s006", "https://dx.doi.org/10.1371/journal.pone.0024443.s007", "https://dx.doi.org/10.1371/journal.pone.0024443.s008", "https://dx.doi.org/10.1371/journal.pone.0024443.s009", "https://dx.doi.org/10.1371/journal.pone.0024443.s010"], "stats"=>{"downloads"=>2, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Chondrogenic_and_Gliogenic_Subpopulations_of_Neural_Crest_Play_Distinct_Roles_during_the_Assembly_of_Epibranchial_Ganglia/133600", "title"=>"Chondrogenic and Gliogenic Subpopulations of Neural Crest Play Distinct Roles during the Assembly of Epibranchial Ganglia", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-09-09 01:00:00"}
• {"files"=>["https://ndownloader.figshare.com/files/736557"], "description"=>"<p>(<b>A</b>) Lateral view of <i>Tg(pax2a:EGFP)^w37/+</i> embryo at the six somite stage showing fluorescein uncaged in rhombomere 5 (outlined region). Placode precursor field expressing EGFP is visible below the uncaged region (arrowheads). (<b>B</b>) Lateral view of the same embryo at 24 hpf. Fluorescein-labeled NC cells derived from rhombomere 5 (green) are visible in two regions (brackets) ventral to the otic vesicle (asterisk). (<b>C</b> and <b>D</b>) Transverse section through embryo at level indicated by dotted line in B. Placode is visible as thickened ectoderm under transmitted light and by α-Pax2 staining in red (C and D, thick arrows). In D, fluorescein-labeled cells are just medial to, but excluded from, the placode. (<b>E</b> and <b>F</b>) <i>In situ</i> hybridization at the level of the vagal placode shows neural crest-derived glial precursors adjacent to the neural tube expressing <i>foxd3</i>; in F, a group of cells corresponding to the fluorescein-labeled region in D expressing the chondrogenic crest marker <i>dlx2a</i>. Placodes in E and F indicated by black arrows. Scale bar = 50 µm.</p>", "links"=>[], "tags"=>["crest", "cells", "migrate", "abut", "epibranchial"], "article_id"=>406910, "categories"=>["Physiology", "Biological Sciences", "Neuroscience", "Cell Biology", "Developmental Biology"], "users"=>["Maya D. Culbertson", "Zachary R. Lewis", "Alexei V. Nechiporuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024443.g001", "stats"=>{"downloads"=>2, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neural_crest_cells_migrate_to_abut_epibranchial_placodes_/406910", "title"=>"Neural crest cells migrate to abut epibranchial placodes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-09 01:55:10"}
• {"files"=>["https://ndownloader.figshare.com/files/736682"], "description"=>"<p>(<b>A–E</b>) Ventral view of head skeleton visualized with anti-Collagen2a antibody at 4 dpf. (A) The following structures are visible in wildtype: Meckel's cartilage, palatoquadrate, ceratohyal and ceratobranchial arches. <i>Sox10</i> mutant (B) exhibits normal morphology. Radical disruption of structure is apparent in <i>foxd3</i> mutants (C) and <i>disc1</i> morphants (E). <i>prdm1a</i> mutant (D) displays grossly normal anterior jaw structures and deficits in the posterior arches; in this example, an unpaired ceratobranchial vestige can be seen (arrowhead). (<b>F–J</b>) Anti-Pax2 immunofluorescence at 24 hpf. Wildtype (F) shows facial placode and unsegmented glossopharyngeal/vagal placode field (<b>K–O</b>) <i>phox2b</i> expression at 48 hpf. Wildtype (K) displays normal segregation of facial,glossopharyngeal, and vagal ganglia. Defects are apparent in <i>foxd3</i> (M) and <i>prdm1a</i> (N) mutants and <i>disc1</i> morphant (O). <i>sox10</i> mutant (K) display morphology and segmentation comparable to wildtype siblings (F). <b>P–T:</b> Ganglion morphology visualized by anti-Elavl3/4 antibody staining at 4 dpf. (K) Wildtype control shows glossopharyngeal and vagal ganglia. Posterior lateral line, statoacoustic and the fused trigeminal, anterior lateral line and facial ganglia can also be seen. Defects are apparent in <i>sox10</i> (Q), <i>foxd3</i> (R), <i>prdm1a</i> (S) mutants and <i>disc1</i> morphant (T). Arrow in (S) shows an example of fusion often seen in <i>prdm1a</i> mutants. Abbreviations: mk = Meckel's cartilage; pq = palatoquadrate; ch = ceratohyal; cb = ceratobranchial arches; OV = otic vesicle; F = facial ganglion; Tg/aLL/F = trigeminal/anterior lateral line/facial ganglion complex; SA = statoacoustic ganglion; pLLg = posterior lateral line ganglion; G = glossopharyngeal ganglion; V = vagal ganglia. Scale bar in (A) = 100 µm. Scale bars in (F), (K) and (P) = 50 µm.</p>", "links"=>[], "tags"=>["neural", "crest", "defects", "epibranchial", "ganglion", "morphology", "affecting", "placode"], "article_id"=>407034, "categories"=>["Physiology", "Biological Sciences", "Neuroscience", "Cell Biology", "Developmental Biology"], "users"=>["Maya D. Culbertson", "Zachary R. Lewis", "Alexei V. Nechiporuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024443.g002", "stats"=>{"downloads"=>3, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disruptions_in_neural_crest_cause_late_defects_in_epibranchial_ganglion_morphology_without_affecting_placode_specification_/407034", "title"=>"Disruptions in neural crest cause late defects in epibranchial ganglion morphology without affecting placode specification.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-09 01:57:14"}
• {"files"=>["https://ndownloader.figshare.com/files/736822"], "description"=>"<p>(<b>A–F</b>) EB ganglion rescue mediated by transplantation of wildtype NC into <i>prdm1a^nl3</i> mutant embryos expressing T<i>g(NeuroD:EGFP)</i>. (<b>A, B</b>) Left (control) and right (transplanted) lateral views of <i>prdm1a^nl3</i> mutant head with rhodamine-positive wildtype NC donor cells at 3 dpf. <i>Tg(neuroD:EGFP)^nl1</i> expression reveals an absence of identifiable cranial ganglion structures on the non-transplanted side (A) while transplanted side shows restoration of these structures, including identifiable glossopharyngeal and vagal ganglia. (<b>C, D</b>) Distribution of rhodamine-positive donor NC cells shows an absence of fluorescent label in the cranial ganglion field of the non-transplanted side (C). In the transplant side (D), rhodamine-positive donor cells are present in parallel columns extending ventrally from the ganglion field (arrows) and in a single line perpendicular and immediately dorsal to columns (star), likely corresponding to the ceratobranchials and the rostral basicranial commisure, respectively. (<b>E and F</b>) Merged channel high-magnification views of control (E) and rescue (F) sides with DAPI counterstain (blue). Note DAPI-labeled branchial arches containing rhodamine-positive donor cells (brackets). (<b>G–L</b>) Partial EB ganglion rescue following transplantation of <i>sox10^−/−</i> NC cells into <i>prdm1a^nl3</i> host embryos. (<b>G,H</b>) <i>Tg(NeuroD:EGFP)</i> expression in <i>prdm1a^nl3</i> embryo showing absence of small EB ganglia in control side (G) and a partial rescue of ganglion formation in ventral vagal region of transplanted side (arrowhead). (<b>I,J</b>) Distribution of rhodamine-labeled donor cells in control side (I) and rescue side (J). (<b>K,L</b>) Merged channel high-magnification views of control (K) and rescue (L) sides with DAPI counterstain. Rescued side shows juxtaposition of rescued ganglion with the rhodamine-positive arches (brackets). Margins of statoacoustic ganglia are indicated by dashed white lines. Abbreviations: Tg/aLL/F = trigeminal/anterior lateral line/facial ganglion complex; SA = statoacoustic ganglion; pLLg = posterior lateral line ganglion; G = glossopharyngeal ganglion; V = vagal ganglia. Scale bar in (A) = 50 µm.</p>", "links"=>[], "tags"=>["nc", "rescuing", "cranial", "ganglion", "mutant"], "article_id"=>407175, "categories"=>["Physiology", "Biological Sciences", "Neuroscience", "Cell Biology", "Developmental Biology"], "users"=>["Maya D. Culbertson", "Zachary R. Lewis", "Alexei V. Nechiporuk"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0024443.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Wildtype_and_sox10_8722_8722_NC_is_capable_of_rescuing_cranial_ganglion_formation_in_prdm1a_nl3_mutant_embryos_/407175", "title"=>"Wildtype and <i>sox10^−/−</i> NC is capable of rescuing cranial ganglion formation in <i>prdm1a^nl3</i> mutant embryos.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-09 01:59:35"}

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Relative Metric

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F1000Prime