Changes in Cytokine Levels and NK Cell Activation Associated with Influenza
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{"title"=>"Changes in cytokine levels and NK cell activation associated with influenza", "type"=>"journal", "authors"=>[{"first_name"=>"Stephanie", "last_name"=>"Jost", "scopus_author_id"=>"7006334860"}, {"first_name"=>"Heloise", "last_name"=>"Quillay", "scopus_author_id"=>"51161955100"}, {"first_name"=>"Jeff", "last_name"=>"Reardon", "scopus_author_id"=>"40561581200"}, {"first_name"=>"Eric", "last_name"=>"Peterson", "scopus_author_id"=>"55574229653"}, {"first_name"=>"Rachel P.", "last_name"=>"Simmons", "scopus_author_id"=>"7402335369"}, {"first_name"=>"Blair A.", "last_name"=>"Parry", "scopus_author_id"=>"9277511100"}, {"first_name"=>"Nancy N P", "last_name"=>"Bryant", "scopus_author_id"=>"54382952900"}, {"first_name"=>"William D.", "last_name"=>"Binder", "scopus_author_id"=>"7005259838"}, {"first_name"=>"Marcus", "last_name"=>"Altfeld", "scopus_author_id"=>"7003649192"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-80053103401", "pmid"=>"21966414", "sgr"=>"80053103401", "doi"=>"10.1371/journal.pone.0025060", "issn"=>"19326203", "pui"=>"362619306"}, "id"=>"c4ec087b-fdd7-3fb2-a36f-1f59bf588be7", "abstract"=>"Several studies have highlighted the important role played by murine natural killer (NK) cells in the control of influenza infection. However, human NK cell responses in acute influenza infection, including infection with the 2009 pandemic H1N1 influenza virus, are poorly documented. Here, we examined changes in NK cell phenotype and function and plasma cytokine levels associated with influenza infection and vaccination. We show that absolute numbers of peripheral blood NK cells, and particularly those of CD56(bright) NK cells, decreased upon acute influenza infection while this NK cell subset expanded following intramuscular influenza vaccination. NK cells exposed to influenza antigens were activated, with higher proportions of NK cells expressing CD69 in study subjects infected with seasonal influenza strains. Vaccination led to increased levels of CD25+ NK cells, and notably CD56(bright) CD25+ NK cells, whereas decreased amounts of this subset were present in the peripheral blood of influenza infected individuals, and predominantly in study subjects infected with the 2009 pandemic H1N1 influenza virus. Finally, acute influenza infection was associated with low plasma concentrations of inflammatory cytokines, including IFN-γ, MIP-1β, IL-2 and IL-15, and high levels of the anti-inflammatory cytokines IL-10 and IL-1ra. Altogether, these data suggest a role for the CD56(bright) NK cell subset in the response to influenza, potentially involving their recruitment to infected tissues and a local production and/or uptake of inflammatory cytokines.", "link"=>"http://www.mendeley.com/research/changes-cytokine-levels-nk-cell-activation-associated-influenza", "reader_count"=>7, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>2, "Chemistry"=>1, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Germany"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/731667"], "description"=>"<p>Dot plots represent (A), absolute numbers of NK cells (B), percentages of total NK cells and (C), absolute numbers of CD56<sup>bright</sup> (CD3-CD56+CD16−), CD56<sup>dim</sup> (CD3-CD56+CD16+) and CD56<sup>neg</sup> (CD3-CD56−CD16+) NK cells from 17 subjects prior to influenza vaccination, and at day 1 and 4 post-vaccination, 9 patients with acute seasonal influenza and 21 with acute 2009 pandemic H1N1 influenza virus infection. Complete blood counts at baseline were only available for 13 of the vaccinated subjects. Horizontal lines indicate the median percentages. Differences where p<0.05 are indicated. (•, healthy subjects prior vaccination; ▪, healthy subjects post-vaccination; dark grey ▴, acutely infected with 2009 seasonal influenza strains; light grey ▴, acutely infected with 2009 pandemic H1N1 influenza virus). D: day post-vaccination.</p>", "links"=>[], "tags"=>["nk", "numbers", "subset", "acute", "influenza"], "article_id"=>402001, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Stephanie Jost", "Heloise Quillay", "Jeff Reardon", "Eric Peterson", "Rachel P. Simmons", "Blair A. Parry", "Nancy N. P. Bryant", "William D. Binder", "Marcus Altfeld"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025060.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_NK_cell_numbers_and_subset_distribution_in_acute_influenza_infection_and_influenza_vaccination_/402001", "title"=>"Changes in NK cell numbers and subset distribution in acute influenza infection and influenza vaccination.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:25:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/731752"], "description"=>"<p>Dot plots represent (A), percentages and (B), absolute numbers of CD69+ NK cells from 17 subjects prior to influenza vaccination, and at day 1, 4 and 7 post-vaccination, 9 patients with acute seasonal influenza and 21 with acute 2009 pandemic H1N1 influenza virus infection. Complete blood counts at baseline were only available for 13 of the vaccinated subjects. (•, healthy subjects prior vaccination; ▪, healthy subjects post-vaccination; dark grey ▴, acutely infected with 2009 seasonal influenza strains; light grey ▴, acutely infected with 2009 pandemic H1N1 influenza virus). (C) Representative primary flow panels show percentages of CD69+ CD56<sup>bright</sup>, CD56<sup>dim</sup> and CD56<sup>neg</sup> NK cells prior to and 7 days post-vaccination and in seasonal and pandemic influenza infection. Percentages of CD69+ total NK cells are indicated.</p>", "links"=>[], "tags"=>["cd69", "nk", "cells", "influenza"], "article_id"=>402096, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Stephanie Jost", "Heloise Quillay", "Jeff Reardon", "Eric Peterson", "Rachel P. Simmons", "Blair A. Parry", "Nancy N. P. Bryant", "William D. Binder", "Marcus Altfeld"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025060.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_CD69_expression_on_NK_cells_in_response_to_influenza_infection_and_vaccination_/402096", "title"=>"Changes in CD69 expression on NK cells in response to influenza infection and vaccination.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:26:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/731878"], "description"=>"<p>(A) Dot plots represent percentages of CD25+ CD56<sup>bright</sup> NK cells from 17 subjects prior to influenza vaccination, and at day 1 and 4 post-vaccination, 9 patients with acute seasonal influenza and 21 with acute 2009 H1N1 pandemic influenza. (B) Representative primary flow panels show percentages of CD25+ CD56<sup>bright</sup>, CD56<sup>dim</sup> and CD56<sup>neg</sup> NK cells prior to and at day 1 and 4 post-vaccination as well as in seasonal and pandemic influenza infection. Percentages of CD25+ total and CD25+ CD56<sup>bright</sup> NK cells are indicated in the upper right corner of the total NK cell gate and CD56<sup>bright</sup> NK cell gate, respectively. (C) Dot plots represent absolute numbers of CD25+ CD56<sup>bright</sup> NK cells from 17 subjects prior to influenza vaccination, and at day 1 and 4 post-vaccination, 9 patients with acute seasonal influenza and 21 with acute 2009 pandemic H1N1 influenza virus infection. Complete blood counts at baseline were only available for 13 of the vaccinated subjects. (•, healthy subjects prior vaccination; ▪, healthy subjects post-vaccination; dark grey ▴, acutely infected with 2009 seasonal influenza strains; light grey ▴, acutely infected with 2009 pandemic H1N1 influenza virus). Horizontal lines indicate the median percentages. Differences where p<0.05 are indicated. D: day post-vaccination.</p>", "links"=>[], "tags"=>["cd25", "nk", "cells", "influenza"], "article_id"=>402222, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Stephanie Jost", "Heloise Quillay", "Jeff Reardon", "Eric Peterson", "Rachel P. Simmons", "Blair A. Parry", "Nancy N. P. Bryant", "William D. Binder", "Marcus Altfeld"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025060.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_CD25_expression_on_NK_cells_in_response_to_influenza_infection_and_vaccination_/402222", "title"=>"Changes in CD25 expression on NK cells in response to influenza infection and vaccination.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:26:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/731978"], "description"=>"<p>Dot plots represent percentages of CD107a+ NK cells from 17 healthy subjects prior to influenza vaccination (C) and 7 subjects with acute seasonal influenza infection (Flu) following incubation with medium alone, H1N1 PR8 influenza virus for 16 h, or 221 and K562 target cells for 4 h at an effector∶ target ratio of 10∶1. Influenza-stimulation of NK cells was only performed on 10 subjects prior to vaccination (C).</p>", "links"=>[], "tags"=>["nk", "cells", "influenza-infected"], "article_id"=>402325, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Stephanie Jost", "Heloise Quillay", "Jeff Reardon", "Eric Peterson", "Rachel P. Simmons", "Blair A. Parry", "Nancy N. P. Bryant", "William D. Binder", "Marcus Altfeld"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025060.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Functional_response_of_NK_cells_from_influenza_infected_subjects_/402325", "title"=>"Functional response of NK cells from influenza-infected subjects.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:27:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/732068"], "description"=>"<p>Columns represent mean concentrations of indicated cytokines in 7 controls (black), 9 patients with acute seasonal influenza (dark grey) and 21 with acute 2009 pandemic H1N1 influenza (light grey). For each column, N represents the number of values included in the analysis based on a coefficient of variation <30. Low out of range values were set to half of the lowest standard value (1.6 pg/mL). Bars indicate standard error of the mean. <b>*</b> represents <i>p</i><0.05; <b>**</b> represents <i>p</i><0.001 and <b>***</b> represents <i>p</i><0.0001.</p>", "links"=>[], "tags"=>["plasma", "cytokine", "concentrations", "acute", "influenza"], "article_id"=>402404, "categories"=>["Microbiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Stephanie Jost", "Heloise Quillay", "Jeff Reardon", "Eric Peterson", "Rachel P. Simmons", "Blair A. Parry", "Nancy N. P. Bryant", "William D. Binder", "Marcus Altfeld"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025060.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_plasma_cytokine_concentrations_associated_with_acute_influenza_infection_/402404", "title"=>"Changes in plasma cytokine concentrations associated with acute influenza infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:27:47"}

PMC Usage Stats | Further Information

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  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"56", "year"=>"2012", "pdf"=>"36", "unique-ip"=>"48", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
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  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"22", "year"=>"2012", "pdf"=>"12", "unique-ip"=>"27", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
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  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2012", "month"=>"12"}
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  • {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
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  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"25", "full-text"=>"29", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"3", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
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Relative Metric

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