Dopamine Regulates Angiogenesis in Normal Dermal Wound Tissues
Publication Date
September 20, 2011
Journal
PLOS ONE
Authors
Saurav Shome, Tapasi Rana, Subhalakshmi Ganguly, Biswarup Basu, et al
Volume
6
Issue
9
Pages
e25215
DOI
https://dx.plos.org/10.1371/journal.pone.0025215
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0025215
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21949884
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176820
Europe PMC
http://europepmc.org/abstract/MED/21949884
Web of Science
000295260400053
Scopus
80052960442
Mendeley
http://www.mendeley.com/research/dopamine-regulates-angiogenesis-normal-dermal-wound-tissues
Events
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Mendeley | Further Information

{"title"=>"Dopamine regulates angiogenesis in normal dermal wound tissues", "type"=>"journal", "authors"=>[{"first_name"=>"Saurav", "last_name"=>"Shome", "scopus_author_id"=>"36457048200"}, {"first_name"=>"Tapasi", "last_name"=>"Rana", "scopus_author_id"=>"22235303200"}, {"first_name"=>"Subhalakshmi", "last_name"=>"Ganguly", "scopus_author_id"=>"7102863068"}, {"first_name"=>"Biswarup", "last_name"=>"Basu", "scopus_author_id"=>"15130932200"}, {"first_name"=>"Sandipan", "last_name"=>"Chaki Choudhury", "scopus_author_id"=>"50660970400"}, {"first_name"=>"Chandrani", "last_name"=>"Sarkar", "scopus_author_id"=>"7103284142"}, {"first_name"=>"Debanjan", "last_name"=>"Chakroborty", "scopus_author_id"=>"6506442043"}, {"first_name"=>"Partha Sarathi", "last_name"=>"Dasgupta", "scopus_author_id"=>"24295725400"}, {"first_name"=>"Sujit", "last_name"=>"Basu", "scopus_author_id"=>"35566638300"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"21949884", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0025215", "issn"=>"19326203", "scopus"=>"2-s2.0-80052960442", "pui"=>"362585432", "sgr"=>"80052960442"}, "id"=>"5e11a98e-03cb-31ae-a579-2b1e49aa0379", "abstract"=>"Cutaneous wound healing is a normal physiological process and comprises different phases. Among these phases, angiogenesis or new blood vessel formation in wound tissue plays an important role. Skin is richly supplied by sympathetic nerves and evidences indicate the significant role of the sympathetic nervous system in cutaneous wound healing. Dopamine (DA) is an important catecholamine neurotransmitter released by the sympathetic nerve endings and recent studies have demonstrated the potent anti-angiogenic action of DA, which is mediated through its D(2) DA receptors. We therefore postulate that this endogenous catecholamine neurotransmitter may have a role in the neovascularization of dermal wound tissues and subsequently in the process of wound healing. In the present study, the therapeutic efficacy of D(2) DA receptor antagonist has been investigated for faster wound healing in a murine model of full thickness dermal wound. Our results indicate that treatment with specific D(2) DA receptor antagonist significantly expedites the process of full thickness normal dermal wound healing in mice by inducing angiogenesis in wound tissues. The underlined mechanisms have been attributed to the up-regulation of homeobox transcription factor HoxD3 and its target α5β1 integrin, which play a pivotal role in wound angiogenesis. Since D(2) DA receptor antagonists are already in clinical use for other disorders, these results have significant translational value from the bench to the bedside for efficient wound management along with other conventional treatment modalities.", "link"=>"http://www.mendeley.com/research/dopamine-regulates-angiogenesis-normal-dermal-wound-tissues", "reader_count"=>25, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>4, "Researcher"=>4, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>7, "Neuroscience"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>2, "Chemistry"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>3}, "Psychology"=>{"Psychology"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Switzerland"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/733729"], "description"=>"<p>(<b>A</b>) The treatment with eticlopride, a specific D<sub>2</sub> dopamine receptor antagonist; 10 mg/kg/4 days/i.p. significantly accelerated the rate of wound healing with resurfacing occurring by 9 days whereas complete wound closure in controls occurred on day 14. The control group received similar volume of normal saline only. (<b>B</b>) Wound closure analysis. In treatment group of mice eticlopride significantly accelerated wound closure compared to vehicle treated control (each group, n = 6; *, P<0.05). Time to wound closure was defined as the time until the re-epithelialization process was complete and the wound bed was filled with new tissues. The percentage of wound closure was calculated as: (area of original wound − area of actual wound) x100/area of original wound and were measured by analyzing images using an image analysis program (ImageJ, NIH). (<b>C</b>) Immunohistochemical staining of CD31, a specific endothelial cell surface marker to enumerate the number of microvessels. The figure shows significantly greater number of microvessels (reddish brown in color) in wound tissue sections of eticlopride treated mice in comparison to vehicle treated controls. Original magnifications, × 100. (<b>D</b>) Graphical representation shows significantly higher number of microvessels in eticlopride treated groups when compared to vehicle treated controls at day 5, 24 hours after completion of treatment schedule. Microvessel density was measured by counting the number of microvessels in 10 randomly chosen high power microscopic fields within the sections,*, P<0.05). Results are representative of six separate experiments each yielding similar results.</p>", "links"=>[], "tags"=>["eticlopride", "macroscopic", "closure", "vessels"], "article_id"=>404072, "categories"=>["Physiology", "Biochemistry", "Neuroscience", "Cancer"], "users"=>["Saurav Shome", "Tapasi Rana", "Subhalakshmi Ganguly", "Biswarup Basu", "Sandipan Chaki Choudhury", "Chandrani Sarkar", "Debanjan Chakroborty", "Partha Sarathi Dasgupta", "Sujit Basu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025215.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_eticlopride_treatment_on_macroscopic_aspect_of_wound_closure_and_formation_of_new_blood_vessels_in_wound_bed_/404072", "title"=>"Effect of eticlopride treatment on macroscopic aspect of wound closure and formation of new blood vessels in wound bed.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:36:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/733863"], "description"=>"<p>(<b>A</b>) Immunoprecipitation followed by immunoblot analysis of HoxD3 expression in wound tissues of both eticlopride and saline treated wound bearing mice at day 5 post wounding. The immunoblot analysis shows significantly higher expression of HoxD3 protein in wound tissues of eticlopride treated mice than vehicle treated controls at 5<sup>th</sup> day after creation of wounds. (<b>B</b>) The bar graphs represent the density of each HoxD3 protein band relative to the IgG expression as quantified by ImageJ (NIH), *, P<0.05. (<b>C</b>) Immunohistochemical analysis of the expression of α5β1 integrin in cutaneous wound tissues of both control and eticlopride treated mice at day 5 post wounding. Frozen sections were immunostained with anti-α5β1 integrin antibodies followed by biotin conjugated secondary antibodies. The sections were stained using ABC staining kit and Nova-Red substrate solution to develop color. Significantly more areas of wound bed show positive staining (reddish brown color) for α5β1 integrin following eticlopride treatment. Original magnifications, x 100. Results are representative of six separate experiments each yielding similar results.</p>", "links"=>[], "tags"=>["eticlopride", "hoxd3", "integrin", "cutaneous"], "article_id"=>404211, "categories"=>["Physiology", "Biochemistry", "Neuroscience", "Cancer"], "users"=>["Saurav Shome", "Tapasi Rana", "Subhalakshmi Ganguly", "Biswarup Basu", "Sandipan Chaki Choudhury", "Chandrani Sarkar", "Debanjan Chakroborty", "Partha Sarathi Dasgupta", "Sujit Basu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025215.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_eticlopride_treatment_on_expression_of_HoxD3_and_its_target_945_5_946_1_integrin_in_cutaneous_wound_tissue_of_mice_/404211", "title"=>"Effect of eticlopride treatment on expression of HoxD3 and its target α5β1 integrin in cutaneous wound tissue of mice.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:37:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/734004"], "description"=>"<p>(<b>A</b>) Immunoblot shows presence of D<sub>2</sub> dopamine receptors in HUVEC. (<b>B</b>) Flow cytometric analysis of D<sub>2</sub> dopamine Receptors in HUVEC. Over 81% cells of the total HUVEC population express D<sub>2</sub> dopamine receptors on their surfaces as evident from the lower right quadrant.</p>", "links"=>[], "tags"=>["dopamine", "receptors", "umbilical", "vein", "endothelial"], "article_id"=>404354, "categories"=>["Physiology", "Biochemistry", "Neuroscience", "Cancer"], "users"=>["Saurav Shome", "Tapasi Rana", "Subhalakshmi Ganguly", "Biswarup Basu", "Sandipan Chaki Choudhury", "Chandrani Sarkar", "Debanjan Chakroborty", "Partha Sarathi Dasgupta", "Sujit Basu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025215.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_D_2_Dopamine_receptors_are_present_on_the_surface_of_human_umbilical_vein_endothelial_cells_/404354", "title"=>"D<sub>2</sub> Dopamine receptors are present on the surface of human umbilical vein endothelial cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:37:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/734090"], "description"=>"<p>(<b>A, B and C</b>) Western blot analysis of the effect of dopamine on VEGF induced expressions of HoxD3 and its target genes α5 and β1 integrins in HUVEC. Lane 1: Serum starved Human Umbilical Vein Endothelial Cells show no expression of HoxD3. However expression of both α5 and β1 integrins was observed. Lane 2: Cells stimulated with VEGF (10 ng/ml) show significant expression of HoxD3 and both the integrins after 8 hours of stimulation. Lane 3: Cells pretreated with 1 µM dopamine (concentration of DA found in synaptic clefts) 5 minutes before being exposed to VEGF (10 ng/ml) show significantly down-regulated VEGF induced expression of HoxD3 and both α5 and β1 integrins compared with VEGF treated controls. Lane 4: Cells treated with 100 µM eticlopride followed by dopamine and VEGF. Pre-treatment with eticlopride abrogated dopamine-induced down-regulation of HoxD3 and its target α5 and β1 integrin expression in HUVEC. β-actin was used as loading controls. Results are representative of six separate experiments each yielding similar results. (<b>D, E and F</b>) The bar graphs represent the density of each protein band relative to the β-actin expression. These have been quantified by ImageJ (NIH), *, P<0.05.</p>", "links"=>[], "tags"=>["receptors", "downregulate", "vegf", "induced", "expressions", "hoxd3", "genes", "integrins"], "article_id"=>404430, "categories"=>["Physiology", "Biochemistry", "Neuroscience", "Cancer"], "users"=>["Saurav Shome", "Tapasi Rana", "Subhalakshmi Ganguly", "Biswarup Basu", "Sandipan Chaki Choudhury", "Chandrani Sarkar", "Debanjan Chakroborty", "Partha Sarathi Dasgupta", "Sujit Basu"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025215.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dopamine_through_its_D_2_receptors_can_significantly_downregulate_VEGF_induced_expressions_of_HoxD3_and_its_target_genes_945_5_and_946_1_integrins_in_HUVEC_/404430", "title"=>"Dopamine through its D<sub>2</sub> receptors can significantly downregulate VEGF induced expressions of HoxD3 and its target genes α5 and β1 integrins in HUVEC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 14:38:24"}

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