Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats
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{"title"=>"Increased cardiovascular reactivity to acute stress and salt-loading in adult male offspring of fat fed non-obese rats", "type"=>"journal", "authors"=>[{"first_name"=>"Olena", "last_name"=>"Rudyk", "scopus_author_id"=>"6506453209"}, {"first_name"=>"Péter", "last_name"=>"Makra", "scopus_author_id"=>"6507409655"}, {"first_name"=>"Eugene", "last_name"=>"Jansen", "scopus_author_id"=>"7202577720"}, {"first_name"=>"Michael J.", "last_name"=>"Shattock", "scopus_author_id"=>"7007067275"}, {"first_name"=>"Lucilla", "last_name"=>"Poston", "scopus_author_id"=>"55791911200"}, {"first_name"=>"Paul D.", "last_name"=>"Taylor", "scopus_author_id"=>"55233536600"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22043281", "doi"=>"10.1371/journal.pone.0025250", "pui"=>"362771734", "issn"=>"19326203", "sgr"=>"80054725365", "scopus"=>"2-s2.0-80054725365"}, "id"=>"d3243621-c014-31b4-8d6f-d8c2195e1de6", "abstract"=>"Diet-induced obesity in rat pregnancy has been shown previously to be associated with consistently raised blood pressure in the offspring, attributed to sympathetic over-activation, but the relative contributions to this phenotype of maternal obesity versus raised dietary fat is unknown. Sprague-Dawley female rats were fed either a control (4.3% fat, n = 11) or lard-enriched (23.6% fat, n = 16) chow 10 days prior to mating, throughout pregnancy and lactation. In conscious adult (9-month-old) offspring cardiovascular parameters were measured (radiotelemetry). The short period of fat-feeding did not increase maternal weight versus controls and the baseline blood pressure was similar in offspring of fat fed dams (OF) and controls (OC). However, adult male OF showed heightened cardiovascular reactivity to acute restraint stress (p<0.01; Δ systolic blood pressure (SBP) and Δheart rate (HR)) with a prolonged recovery time compared to male OC. α1/β-adrenergic receptor blockade normalised the response. Also, after dietary salt-loading (8%-NaCl ad libitum for 1 week) male OF demonstrated higher SBP (p<0.05) in the awake phase (night-time) and increased low/high frequency ratio of power spectral density of HR variability versus OC. Baroreflex gain and basal power spectral density components of the heart rate or blood pressure were similar in male OF and OC. Minor abnormalities were evident in female OF. Fat feeding in the absence of maternal obesity in pregnant rats leads to altered sympathetic control of cardiovascular function in adult male offspring, and hypertension in response to stressor stimuli.", "link"=>"http://www.mendeley.com/research/increased-cardiovascular-reactivity-acute-stress-saltloading-adult-male-offspring-fat-fed-nonobese-r", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>3, "Student > Master"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>6, "Neuroscience"=>2, "Psychology"=>4, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Neuroscience"=>{"Neuroscience"=>2}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/723900"], "description"=>"<p>(A, B) SBP and (D, E) HR responses during 30 min of acute stress and 120 min of recovery, before (A, D) and after adrenergic receptor blockade (B, E) in female offspring born to dams fed a control (open circles) or a fat diet (closed circles), n = 5–15 per group. (C) Area under the curve for SBP and (F) HR during stress before and after blockade in female offspring born to dams fed a control (unfilled bars) or a fat diet (filled bars). n = 15 per group before blockade; n = 6 per group after blockade. ††P≤0.01, †††P≤0.001 versus before blockade. Error bars represent mean±SEM.</p>", "links"=>[], "tags"=>["offspring", "fat-fed", "dams", "had", "stress-response", "compared"], "article_id"=>394248, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Female_offspring_of_fat_fed_dams_had_a_similar_stress_response_compared_with_controls_/394248", "title"=>"Female offspring of fat-fed dams had a similar stress-response compared with controls.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-17 01:10:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/723749"], "description"=>"<p>(A, B) SBP and (D, E) HR responses during 30 min of acute stress and 120 min of recovery, before (A, D) and after adrenergic receptor blockade (B, E) in male offspring born to dams fed a control (open circles) or a fat diet (closed circles), n = 11 per group before blockade; n = 5 per group after blockade. *P≤0.05, **P≤0.01 versus control. (C) Area under the curve (AUC) for SBP and (F) HR during stress before and after blockade in male offspring born to dams fed a control (unfilled bars) or a fat diet (filled bars), n = 11 per group before blockade; n = 5 per group after blockade. *P≤0.05, **P≤0.01 versus control. †††P≤0.001 versus before blockade. Error bars represent mean±SEM.</p>", "links"=>[], "tags"=>["offspring", "fat-fed", "dams", "had", "pressor", "chronotropic", "acute"], "article_id"=>394097, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Male_offspring_of_fat_fed_dams_had_an_increased_pressor_and_chronotropic_response_during_acute_stress_/394097", "title"=>"Male offspring of fat-fed dams had an increased pressor and chronotropic response during acute stress.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-17 01:08:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/724165"], "description"=>"<p>(A, C) SBP response and delta SBP (B, D) in response to combined adrenergic blockade before (A, B) and after (C, D) salt-loading in adult male offspring from dams fed a control (OC, open circles) or a fat diet (OF, closed circles). (E) Area under the curve of delta SBP in response to combined adrenergic blockade before and after salt-loading in adult male offspring from dams fed a control (unfilled bars) or a fat diet (filled bars). n = 5 per group, * P≤0.05 versus before salt-loading). Error bars represent mean±SEM.</p>", "links"=>[], "tags"=>["offspring", "fat-fed", "dams", "had", "greater", "depressor", "adrenergic", "blockade", "salt-loading"], "article_id"=>394512, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.g005", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Male_offspring_of_fat_fed_dams_had_a_greater_depressor_response_following_adrenergic_blockade_after_salt_loading_than_before_/394512", "title"=>"Male offspring of fat-fed dams had a greater depressor response following adrenergic blockade after salt-loading than before.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-17 01:15:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/724348"], "description"=>"<p>(A, C) HR response and delta HR (B, D) in response to combined adrenergic blockade before (A, B) and after (C, D) salt-loading in adult male offspring from dams fed a control (OC, open circles) or a fat diet (OF, closed circles). (E) Area under the curve of delta HR in response to combined adrenergic blockade before and after salt-loading in adult male offspring from dams fed a control (unfilled bars) or a fat diet (filled bars). n = 5 per group, * P≤0.05 versus before salt-loading. Error bars represent mean±SEM.</p>", "links"=>[], "tags"=>["offspring", "fat-fed", "dams", "had", "greater", "bradycardiac", "adrenergic", "blockade", "salt-loading"], "article_id"=>394685, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.g006", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Male_offspring_of_fat_fed_dams_had_a_greater_bradycardiac_response_following_adrenergic_blockade_after_salt_loading_than_before_/394685", "title"=>"Male offspring of fat-fed dams had a greater bradycardiac response following adrenergic blockade after salt-loading than before.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-17 01:18:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/365921", "https://ndownloader.figshare.com/files/365971", "https://ndownloader.figshare.com/files/366015", "https://ndownloader.figshare.com/files/366058", "https://ndownloader.figshare.com/files/366102", "https://ndownloader.figshare.com/files/366163", "https://ndownloader.figshare.com/files/366194"], "description"=>"<div><p>Diet-induced obesity in rat pregnancy has been shown previously to be associated with consistently raised blood pressure in the offspring, attributed to sympathetic over-activation, but the relative contributions to this phenotype of maternal obesity <em>versus</em> raised dietary fat is unknown. Sprague-Dawley female rats were fed either a control (4.3% fat, n = 11) or lard-enriched (23.6% fat, n = 16) chow 10 days prior to mating, throughout pregnancy and lactation. In conscious adult (9-month-old) offspring cardiovascular parameters were measured (radiotelemetry). The short period of fat-feeding did not increase maternal weight <em>versus</em> controls and the baseline blood pressure was similar in offspring of fat fed dams (OF) and controls (OC). However, adult male OF showed heightened cardiovascular reactivity to acute restraint stress (p<0.01; Δ systolic blood pressure (SBP) and Δheart rate (HR)) with a prolonged recovery time compared to male OC. α1/β-adrenergic receptor blockade normalised the response. Also, after dietary salt-loading (8%-NaCl <em>ad libitum</em> for 1 week) male OF demonstrated higher SBP (p<0.05) in the awake phase (night-time) and increased low/high frequency ratio of power spectral density of HR variability <em>versus</em> OC. Baroreflex gain and basal power spectral density components of the heart rate or blood pressure were similar in male OF and OC. Minor abnormalities were evident in female OF. Fat feeding in the absence of maternal obesity in pregnant rats leads to altered sympathetic control of cardiovascular function in adult male offspring, and hypertension in response to stressor stimuli.</p> </div>", "links"=>[], "tags"=>["cardiovascular", "reactivity", "acute", "salt-loading", "offspring", "fed", "non-obese", "rats"], "article_id"=>132331, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025250.s001", "https://dx.doi.org/10.1371/journal.pone.0025250.s002", "https://dx.doi.org/10.1371/journal.pone.0025250.s003", "https://dx.doi.org/10.1371/journal.pone.0025250.s004", "https://dx.doi.org/10.1371/journal.pone.0025250.s005", "https://dx.doi.org/10.1371/journal.pone.0025250.s006", "https://dx.doi.org/10.1371/journal.pone.0025250.s007"], "stats"=>{"downloads"=>18, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Increased_Cardiovascular_Reactivity_to_Acute_Stress_and_Salt_Loading_in_Adult_Male_Offspring_of_Fat_Fed_Non_Obese_Rats/132331", "title"=>"Increased Cardiovascular Reactivity to Acute Stress and Salt-Loading in Adult Male Offspring of Fat Fed Non-Obese Rats", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-10-17 00:38:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/724583"], "description"=>"<p>IBI, inter-beat interval; SD IBI, standard deviation of inter-beat interval; RMSSD, root mean square of successive differences. Data given as mean±SEM (SD).</p>†<p>P≤0.05,</p>†††<p>P≤0.001 <i>versus</i> offspring of the same dietary group.</p>", "links"=>[], "tags"=>["variability", "parameters", "offspring", "dams", "fed"], "article_id"=>394935, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Heart_rate_and_blood_pressure_variability_parameters_in_adult_offspring_born_to_dams_fed_a_control_OC_or_a_fat_diet_OF_/394935", "title"=>"Heart rate and blood pressure variability parameters in adult offspring born to dams fed a control (OC) or a fat diet (OF).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-17 01:22:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/723675"], "description"=>"<p>(A) Body weight, g, and (B) calorific intake, MJ rat<sup>−1</sup> day<sup>−1</sup>, in dams fed a control (open circles) or a fat diet (closed circles), n = 11 for control, n = 16 for fat-fed dams. Error bars represent mean±SEM.</p>", "links"=>[], "tags"=>["fat-fed", "dams", "had", "calorific"], "article_id"=>394021, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.g001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Control_and_fat_fed_dams_had_a_similar_body_weight_gain_and_calorific_intake_/394021", "title"=>"Control and fat-fed dams had a similar body weight gain and calorific intake.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-17 01:07:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/724042"], "description"=>"<p>SBP and DBP, mmHg, before, during and after salt-loading in (A) male and (B) female offspring of control (open circles) or fat fed dams (closed circles), n = 6 per group. *P<0.05 <i>versus</i> control (night-time; active phase). Error bars represent mean±SEM.</p>", "links"=>[], "tags"=>["offspring", "fat-fed", "dams", "had", "pressor"], "article_id"=>394390, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Male_offspring_of_fat_fed_dams_had_an_increased_pressor_response_to_salt_loading_but_not_females_/394390", "title"=>"Male offspring of fat-fed dams had an increased pressor response to salt-loading, but not females.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-17 01:13:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/724502"], "description"=>"<p>Content of fatty acids in experimental diets.</p>", "links"=>[], "tags"=>["fatty", "acids"], "article_id"=>394852, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.t001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Content_of_fatty_acids_in_experimental_diets_/394852", "title"=>"Content of fatty acids in experimental diets.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-17 01:20:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/724547"], "description"=>"<p>Data given as mean±SEM (SD).</p>†<p>P≤0.05,</p>††<p>P≤0.01 <i>versus</i> offspring of the same dietary group.</p>", "links"=>[], "tags"=>["cardiovascular", "parameters", "offspring", "dams", "fed"], "article_id"=>394898, "categories"=>["Physiology", "Cell Biology"], "users"=>["Olena Rudyk", "Péter Makra", "Eugène Jansen", "Michael J. Shattock", "Lucilla Poston", "Paul D. Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025250.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Basal_cardiovascular_parameters_and_activity_in_adult_offspring_born_to_dams_fed_a_control_OC_or_a_fat_diet_OF_/394898", "title"=>"Basal cardiovascular parameters and activity in adult offspring born to dams fed a control (OC) or a fat diet (OF).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-17 01:21:38"}

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