Dysregulation of Gene Expression in the Artificial Human Trisomy Cells of Chromosome 8 Associated with Transformed Cell Phenotypes
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{"title"=>"Dysregulation of gene expression in the artificial human trisomy cells of chromosome 8 associated with transformed cell phenotypes", "type"=>"journal", "authors"=>[{"first_name"=>"Hisakatsu", "last_name"=>"Nawata", "scopus_author_id"=>"53868359400"}, {"first_name"=>"Genro", "last_name"=>"Kashino", "scopus_author_id"=>"6508118431"}, {"first_name"=>"Keizo", "last_name"=>"Tano", "scopus_author_id"=>"7005439861"}, {"first_name"=>"Kazuhiro", "last_name"=>"Daino", "scopus_author_id"=>"6507556237"}, {"first_name"=>"Yoshiya", "last_name"=>"Shimada", "scopus_author_id"=>"55747087300"}, {"first_name"=>"Hiroyuki", "last_name"=>"Kugoh", "scopus_author_id"=>"6603747100"}, {"first_name"=>"Mitsuo", "last_name"=>"Oshimura", "scopus_author_id"=>"7102847689"}, {"first_name"=>"Masami", "last_name"=>"Watanabe", "scopus_author_id"=>"55516229500"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-80053300903", "pmid"=>"21980425", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0025319", "pui"=>"362661114", "sgr"=>"80053300903"}, "id"=>"729cccbd-0de8-3a23-867c-375d97845e1b", "abstract"=>"A change in chromosome number, known as aneuploidy, is a common characteristic of cancer. Aneuploidy disrupts gene expression in human cancer cells and immortalized human epithelial cells, but not in normal human cells. However, the relationship between aneuploidy and cancer remains unclear. To study the effects of aneuploidy in normal human cells, we generated artificial cells of human primary fibroblast having three chromosome 8 (trisomy 8 cells) by using microcell-mediated chromosome transfer technique. In addition to decreased proliferation, the trisomy 8 cells lost contact inhibition and reproliferated after exhibiting senescence-like characteristics that are typical of transformed cells. Furthermore, the trisomy 8 cells exhibited chromosome instability, and the overall gene expression profile based on microarray analyses was significantly different from that of diploid human primary fibroblasts. Our data suggest that aneuploidy, even a single chromosome gain, can be introduced into normal human cells and causes, in some cases, a partial cancer phenotype due to a disruption in overall gene expression.", "link"=>"http://www.mendeley.com/research/dysregulation-gene-expression-artificial-human-trisomy-cells-chromosome-8-associated-transformed-cel", "reader_count"=>24, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/730607"], "description"=>"<p>(A) Clustering analysis of 127 genes that exhibited statistically significant changes in the trisomy 8 cells (HE35tri8-1, -2, and -3) versus the diploid HE35 cells (HE35-1, -2, and -4). Three independent experiments were performed for each clone. (B) Average gene expression pattern by chromosome. The average chromosome expression ratios relative to the same reference RNA pool for each trisomy 8 cells was then normalized to the average of the ratio value for the diploid HE35 cells. (C) CADM1 (11q23.2) and WT1 (11p13) gene expression in the trisomy 8 cells (HE35tri8-1, -2, and -3) and the diploid HE35 cells (HE35-1, -2, and -4).</p>", "links"=>[], "tags"=>["patterns", "trisomy"], "article_id"=>400962, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025319.g004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disruption_of_the_global_gene_expression_patterns_in_the_trisomy_8_cells_/400962", "title"=>"Disruption of the global gene expression patterns in the trisomy 8 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-29 00:16:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/730086"], "description"=>"<p>(A) Example of a Multicolor FISH analysis of a metaphase spread prepared from HE35tri8-1 at TPDL 30. The arrow indicates the transferred chromosome 8 (the yellow arrow is the neomycin-resistant gene in the transferred chromosome). (B) Chromosome distribution in the trisomy 8 cells.</p>", "links"=>[], "tags"=>["trisomic", "cells", "chromosome"], "article_id"=>400435, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025319.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Generation_of_trisomic_human_cells_of_chromosome_8_trisomy_8_cells_/400435", "title"=>"Generation of trisomic human cells of chromosome 8 (trisomy 8 cells).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-29 00:07:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/730763"], "description"=>"<p>*Sister Union.</p>", "links"=>[], "tags"=>["chromosome", "aberrations", "trisomy"], "article_id"=>401118, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025319.t002", "stats"=>{"downloads"=>8, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_of_chromosome_aberrations_in_the_trisomy_8_cells_/401118", "title"=>"Frequency of chromosome aberrations in the trisomy 8 cells.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-29 00:18:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/369374", "https://ndownloader.figshare.com/files/369418", "https://ndownloader.figshare.com/files/369477", "https://ndownloader.figshare.com/files/369530", "https://ndownloader.figshare.com/files/369656", "https://ndownloader.figshare.com/files/369778", "https://ndownloader.figshare.com/files/369880"], "description"=>"<div><p>A change in chromosome number, known as aneuploidy, is a common characteristic of cancer. Aneuploidy disrupts gene expression in human cancer cells and immortalized human epithelial cells, but not in normal human cells. However, the relationship between aneuploidy and cancer remains unclear. To study the effects of aneuploidy in normal human cells, we generated artificial cells of human primary fibroblast having three chromosome 8 (trisomy 8 cells) by using microcell-mediated chromosome transfer technique. In addition to decreased proliferation, the trisomy 8 cells lost contact inhibition and reproliferated after exhibiting senescence-like characteristics that are typical of transformed cells. Furthermore, the trisomy 8 cells exhibited chromosome instability, and the overall gene expression profile based on microarray analyses was significantly different from that of diploid human primary fibroblasts. Our data suggest that aneuploidy, even a single chromosome gain, can be introduced into normal human cells and causes, in some cases, a partial cancer phenotype due to a disruption in overall gene expression.</p> </div>", "links"=>[], "tags"=>["dysregulation", "trisomy", "cells", "chromosome", "transformed", "phenotypes"], "article_id"=>132979, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025319.s001", "https://dx.doi.org/10.1371/journal.pone.0025319.s002", "https://dx.doi.org/10.1371/journal.pone.0025319.s003", "https://dx.doi.org/10.1371/journal.pone.0025319.s004", "https://dx.doi.org/10.1371/journal.pone.0025319.s005", "https://dx.doi.org/10.1371/journal.pone.0025319.s006", "https://dx.doi.org/10.1371/journal.pone.0025319.s007"], "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Dysregulation_of_Gene_Expression_in_the_Artificial_Human_Trisomy_Cells_of_Chromosome_8_Associated_with_Transformed_Cell_Phenotypes/132979", "title"=>"Dysregulation of Gene Expression in the Artificial Human Trisomy Cells of Chromosome 8 Associated with Transformed Cell Phenotypes", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-09-29 00:49:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/730336"], "description"=>"<p>(A) Proliferation defects in the artificial trisomy 8 cells. The diploid HE35 cells (open squares, open triangles, and open circles) and the trisomy 8 cells (solid squares, solid triangles, and solid circles) were plated and counted daily to detect changes in the cell numbers. (B) Loss of contact inhibition in the trisomy 8 cells (HE35tri8-1 at TPDL 30, HE35-1 at TPDL 30). (C) Cell growth of the cultured diploid HE35 cells and the trisomy 8 cells. (D) A small portion of the trisomy 8 cells regrew and formed colonies after 4–6 weeks of exhibiting a senescence-like state. (D-a) HE35tri8-1 colony, (D-b) HE35tri8-2 colony, (D-c) HE35tri8-3 colony.</p>", "links"=>[], "tags"=>["regrowth", "trisomy"], "article_id"=>400685, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025319.g002", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Proliferation_defects_loss_of_contact_inhibition_and_regrowth_in_the_trisomy_8_cells_/400685", "title"=>"Proliferation defects, loss of contact inhibition, and regrowth in the trisomy 8 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-29 00:11:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/730730"], "description"=>"a<p>Total population doubling levels (TPDL) show the number of cell division that cells divided until reaching to senescence.</p>b<p>Frequency of colony formation by regrowth cells in three P100 dishes after senescence. Briefly, 1.5×10<sup>6</sup> cells were inoculated into three P100 dishes. Then, cells were incubated in a 100% humidified CO<sub>2</sub> incubator at 37°C for 6 weeks with medium change every 3 days. Regrowth colonies were counted. Data show the mean ± S.D. of six independent experiments.</p>", "links"=>[], "tags"=>["regrowth", "cells"], "article_id"=>401086, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025319.t001", "stats"=>{"downloads"=>5, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Frequency_of_colony_formation_by_regrowth_cells_after_senescence_/401086", "title"=>"Frequency of colony formation by regrowth cells after senescence.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-09-29 00:18:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/730465"], "description"=>"<p>(A) Number of γ-H2AX and 53BP1 <i>foci</i> in the diploid HE35 cells (HE35-1, -2, and -4) and the trisomy 8 cells (HE35tri8-1, -2, and -3). (B) Micronucleus frequency in the diploid HE35 cells and the trisomy 8 cells.</p>", "links"=>[], "tags"=>["chromosome"], "article_id"=>400818, "categories"=>["Genetics"], "users"=>["Hisakatsu Nawata", "Genro Kashino", "Keizo Tano", "Kazuhiro Daino", "Yoshiya Shimada", "Hiroyuki Kugoh", "Mitsuo Oshimura", "Masami Watanabe"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025319.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DNA_damage_and_chromosome_aberrations_/400818", "title"=>"DNA damage and chromosome aberrations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-09-29 00:13:38"}

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Relative Metric

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