LRRN4 and UPK3B Are Markers of Primary Mesothelial Cells
Publication Date
October 03, 2011
Journal
PLOS ONE
Authors
Mutsumi Kanamori Katayama, Ai Kaiho, Yuri Ishizu, Yuko Okamura Oho, et al
Volume
6
Issue
10
Pages
e25391
DOI
https://dx.plos.org/10.1371/journal.pone.0025391
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0025391
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/21984916
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184985
Europe PMC
http://europepmc.org/abstract/MED/21984916
Web of Science
000295943000028
Scopus
80053460099
Mendeley
http://www.mendeley.com/research/lrrn4-upk3b-markers-primary-mesothelial-cells
Events
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Mendeley | Further Information

{"title"=>"LRRN4 and UPK3B are markers of primary mesothelial cells", "type"=>"journal", "authors"=>[{"first_name"=>"Mutsumi", "last_name"=>"Kanamori-Katayama", "scopus_author_id"=>"13407202100"}, {"first_name"=>"Ai", "last_name"=>"Kaiho", "scopus_author_id"=>"24076585000"}, {"first_name"=>"Yuri", "last_name"=>"Ishizu", "scopus_author_id"=>"14040633400"}, {"first_name"=>"Yuko", "last_name"=>"Okamura-Oho", "scopus_author_id"=>"6602507841"}, {"first_name"=>"Okio", "last_name"=>"Hino", "scopus_author_id"=>"7103104523"}, {"first_name"=>"Masaaki", "last_name"=>"Abe", "scopus_author_id"=>"55624476566"}, {"first_name"=>"Takumi", "last_name"=>"Kishimoto", "scopus_author_id"=>"7401589818"}, {"first_name"=>"Hisahiko", "last_name"=>"Sekihara", "scopus_author_id"=>"7005565670"}, {"first_name"=>"Yukio", "last_name"=>"Nakamura", "scopus_author_id"=>"55503284800"}, {"first_name"=>"Harukazu", "last_name"=>"Suzuki", "scopus_author_id"=>"7406835659"}, {"first_name"=>"Alistair R R", "last_name"=>"Forrest", "scopus_author_id"=>"7202936901"}, {"first_name"=>"Yoshihide", "last_name"=>"Hayashizaki", "scopus_author_id"=>"35355246400"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-80053460099", "pmid"=>"21984916", "sgr"=>"80053460099", "doi"=>"10.1371/journal.pone.0025391", "issn"=>"19326203", "pui"=>"362681570"}, "id"=>"96553e8f-b7d2-34b3-b803-c881fbc695c7", "abstract"=>"BACKGROUND: Mesothelioma is a highly malignant tumor that is primarily caused by occupational or environmental exposure to asbestos fibers. Despite worldwide restrictions on asbestos usage, further cases are expected as diagnosis is typically 20-40 years after exposure. Once diagnosed there is a very poor prognosis with a median survival rate of 9 months. Considering this the development of early pre clinical diagnostic markers may help improve clinical outcomes.\\n\\nMETHODOLOGY: Microarray expression arrays on mesothelium and other tissues dissected from mice were used to identify candidate mesothelial lineage markers. Candidates were further tested by qRTPCR and in-situ hybridization across a mouse tissue panel. Two candidate biomarkers with the potential for secretion, uroplakin 3B (UPK3B), and leucine rich repeat neuronal 4 (LRRN4) and one commercialized mesothelioma marker, mesothelin (MSLN) were then chosen for validation across a panel of normal human primary cells, 16 established mesothelioma cell lines, 10 lung cancer lines, and a further set of 8 unrelated cancer cell lines.\\n\\nCONCLUSIONS: Within the primary cell panel, LRRN4 was only detected in primary mesothelial cells, but MSLN and UPK3B were also detected in other cell types. MSLN was detected in bronchial epithelial cells and alveolar epithelial cells and UPK3B was detected in retinal pigment epithelial cells and urothelial cells. Testing the cell line panel, MSLN was detected in 15 of the 16 mesothelioma cells lines, whereas LRRN4 was only detected in 8 and UPK3B in 6. Interestingly MSLN levels appear to be upregulated in the mesothelioma lines compared to the primary mesothelial cells, while LRRN4 and UPK3B, are either lost or down-regulated. Despite the higher fraction of mesothelioma lines positive for MSLN, it was also detected at high levels in 2 lung cancer lines and 3 other unrelated cancer lines derived from papillotubular adenocarcinoma, signet ring carcinoma and transitional cell carcinoma.", "link"=>"http://www.mendeley.com/research/lrrn4-upk3b-markers-primary-mesothelial-cells", "reader_count"=>29, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>7, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>4, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>13, "Medicine and Dentistry"=>6, "Neuroscience"=>2, "Chemistry"=>1, "Psychology"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Italy"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/729103"], "description"=>"<p>Note the mesothelial staining in blue.</p>", "links"=>[], "tags"=>["hybridization", "images", "pleural", "mesothelium", "stained", "uroplakin", "leucine", "neuronal", "transporting", "atpase", "interacting"], "article_id"=>399432, "categories"=>["Molecular Biology", "Genetics", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Mutsumi Kanamori-Katayama", "Ai Kaiho", "Yuri Ishizu", "Yuko Okamura-Oho", "Okio Hino", "Masaaki Abe", "Takumi Kishimoto", "Hisahiko Sekihara", "Yukio Nakamura", "Harukazu Suzuki", "Alistair R. R. Forrest", "Yoshihide Hayashizaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025391.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_situ_hybridization_images_of_mouse_lung_tissue_with_pleural_mesothelium_intact_stained_for_A_mesothelin_B_uroplakin_3b_C_leucine_rich_repeat_neuronal_4_and_D_Na_K_transporting_ATPase_interacting_4_/399432", "title"=>"In-situ hybridization images of mouse lung tissue with pleural mesothelium intact stained for A) mesothelin, B) uroplakin 3b, C) leucine rich repeat neuronal 4 and D) Na+/K+ transporting ATPase interacting 4.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-03 02:37:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/729457"], "description"=>"<p>Note: Gene names in bold have been previously associated with mesothelioma or the mesothelial lineage.</p>", "links"=>[], "tags"=>["enriched", "genes", "microarray"], "article_id"=>399801, "categories"=>["Molecular Biology", "Genetics", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Mutsumi Kanamori-Katayama", "Ai Kaiho", "Yuri Ishizu", "Yuko Okamura-Oho", "Okio Hino", "Masaaki Abe", "Takumi Kishimoto", "Hisahiko Sekihara", "Yukio Nakamura", "Harukazu Suzuki", "Alistair R. R. Forrest", "Yoshihide Hayashizaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025391.t001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mesothelium_enriched_genes_identified_by_microarray_analysis_/399801", "title"=>"Mesothelium enriched genes identified by microarray analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-03 02:43:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/729217"], "description"=>"<p>Expression of A) MSLN, B) LRRN4, C) UPK3B, D) NKAIN4 across a panel of primary human cell types and cancer cell lines measured by qRTPCR.</p>", "links"=>[], "tags"=>["nkain4", "types", "cancer", "lines"], "article_id"=>399558, "categories"=>["Molecular Biology", "Genetics", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Mutsumi Kanamori-Katayama", "Ai Kaiho", "Yuri Ishizu", "Yuko Okamura-Oho", "Okio Hino", "Masaaki Abe", "Takumi Kishimoto", "Hisahiko Sekihara", "Yukio Nakamura", "Harukazu Suzuki", "Alistair R. R. Forrest", "Yoshihide Hayashizaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025391.g002", "stats"=>{"downloads"=>4, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_A_MSLN_B_LRRN4_C_UPK3B_D_NKAIN4_across_a_panel_of_primary_human_cell_types_and_cancer_cell_lines_measured_by_qRTPCR_/399558", "title"=>"Expression of A) MSLN, B) LRRN4, C) UPK3B, D) NKAIN4 across a panel of primary human cell types and cancer cell lines measured by qRTPCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-03 02:39:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/729353"], "description"=>"<p>Immunohistochemisty of a human epithelial mesothelioma stained with antibodies against MSLN, LRRN4, UPK3B.</p>", "links"=>[], "tags"=>["epithelial", "mesothelioma", "stained", "antibodies"], "article_id"=>399697, "categories"=>["Molecular Biology", "Genetics", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Mutsumi Kanamori-Katayama", "Ai Kaiho", "Yuri Ishizu", "Yuko Okamura-Oho", "Okio Hino", "Masaaki Abe", "Takumi Kishimoto", "Hisahiko Sekihara", "Yukio Nakamura", "Harukazu Suzuki", "Alistair R. R. Forrest", "Yoshihide Hayashizaki"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025391.g003", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunohistochemisty_of_a_human_epithelial_mesothelioma_stained_with_antibodies_against_MSLN_LRRN4_UPK3B_/399697", "title"=>"Immunohistochemisty of a human epithelial mesothelioma stained with antibodies against MSLN, LRRN4, UPK3B.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-03 02:41:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/368263", "https://ndownloader.figshare.com/files/368372", "https://ndownloader.figshare.com/files/368417", "https://ndownloader.figshare.com/files/368432", "https://ndownloader.figshare.com/files/368454", "https://ndownloader.figshare.com/files/368466"], "description"=>"<div><h3>Background</h3><p>Mesothelioma is a highly malignant tumor that is primarily caused by occupational or environmental exposure to asbestos fibers. Despite worldwide restrictions on asbestos usage, further cases are expected as diagnosis is typically 20–40 years after exposure. Once diagnosed there is a very poor prognosis with a median survival rate of 9 months. Considering this the development of early pre clinical diagnostic markers may help improve clinical outcomes.</p> <h3>Methodology</h3><p>Microarray expression arrays on mesothelium and other tissues dissected from mice were used to identify candidate mesothelial lineage markers. Candidates were further tested by qRTPCR and in-situ hybridization across a mouse tissue panel. Two candidate biomarkers with the potential for secretion, uroplakin 3B (UPK3B), and leucine rich repeat neuronal 4 (LRRN4) and one commercialized mesothelioma marker, mesothelin (MSLN) were then chosen for validation across a panel of normal human primary cells, 16 established mesothelioma cell lines, 10 lung cancer lines, and a further set of 8 unrelated cancer cell lines.</p> <h3>Conclusions</h3><p>Within the primary cell panel, LRRN4 was only detected in primary mesothelial cells, but MSLN and UPK3B were also detected in other cell types. MSLN was detected in bronchial epithelial cells and alveolar epithelial cells and UPK3B was detected in retinal pigment epithelial cells and urothelial cells. Testing the cell line panel, MSLN was detected in 15 of the 16 mesothelioma cells lines, whereas LRRN4 was only detected in 8 and UPK3B in 6. Interestingly MSLN levels appear to be upregulated in the mesothelioma lines compared to the primary mesothelial cells, while LRRN4 and UPK3B, are either lost or down-regulated. Despite the higher fraction of mesothelioma lines positive for MSLN, it was also detected at high levels in 2 lung cancer lines and 3 other unrelated cancer lines derived from papillotubular adenocarcinoma, signet ring carcinoma and transitional cell carcinoma.</p> </div>", "links"=>[], "tags"=>["lrrn4", "upk3b", "are", "markers", "mesothelial", "cells"], "article_id"=>132767, "categories"=>["Molecular Biology", "Genetics", "Biological Sciences", "Cancer", "Cell Biology"], "users"=>["Mutsumi Kanamori-Katayama", "Ai Kaiho", "Yuri Ishizu", "Yuko Okamura-Oho", "Okio Hino", "Masaaki Abe", "Takumi Kishimoto", "Hisahiko Sekihara", "Yukio Nakamura", "Harukazu Suzuki", "Alistair R. R. Forrest", "Yoshihide Hayashizaki"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025391.s001", "https://dx.doi.org/10.1371/journal.pone.0025391.s002", "https://dx.doi.org/10.1371/journal.pone.0025391.s003", "https://dx.doi.org/10.1371/journal.pone.0025391.s004", "https://dx.doi.org/10.1371/journal.pone.0025391.s005", "https://dx.doi.org/10.1371/journal.pone.0025391.s006"], "stats"=>{"downloads"=>19, "page_views"=>16, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/LRRN4_and_UPK3B_Are_Markers_of_Primary_Mesothelial_Cells/132767", "title"=>"LRRN4 and UPK3B Are Markers of Primary Mesothelial Cells", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-10-03 00:46:07"}

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Relative Metric

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