T-helper Cell-Mediated Proliferation and Cytokine Responses against Recombinant Merkel Cell Polyomavirus-Like Particles
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{"title"=>"T-helper cell-mediated proliferation and cytokine responses against recombinant merkel cell polyomavirus-like particles", "type"=>"journal", "authors"=>[{"first_name"=>"Arun", "last_name"=>"Kumar", "scopus_author_id"=>"9274549600"}, {"first_name"=>"Tingting", "last_name"=>"Chen", "scopus_author_id"=>"55687630400"}, {"first_name"=>"Sari", "last_name"=>"Pakkanen", "scopus_author_id"=>"36821703900"}, {"first_name"=>"Anu", "last_name"=>"Kantele", "scopus_author_id"=>"7004712967"}, {"first_name"=>"Maria", "last_name"=>"Söderlund-Venermo", "scopus_author_id"=>"6603440454"}, {"first_name"=>"Klaus", "last_name"=>"Hedman", "scopus_author_id"=>"7006799529"}, {"first_name"=>"Rauli", "last_name"=>"Franssila", "scopus_author_id"=>"6507182696"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-80053448904", "sgr"=>"80053448904", "pui"=>"362681668", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"21991346", "doi"=>"10.1371/journal.pone.0025751"}, "id"=>"b79aa02c-0cea-36c0-a9c0-dd9c2e124317", "abstract"=>"The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral antigen in MCC cells. The mutated MCPyV has recently been found in highly purified leukemic cells from patients with chronic lymphocytic leukemia (CLL), suggesting a pathogenic role also in CLL. About 50-80% of adults display MCPyV-specific antibodies. The humoral immunity does not protect against the development of MCC, as neutralizing MCPyV antibodies occur in higher levels among MCC patients than healthy controls. Impaired T-cell immunity has been linked with aggressive MCC behavior. Therefore, cellular immunity appears to be important in MCPyV infection surveillance. In order to elucidate the role of MCPyV-specific Th-cell immunity, peripheral blood mononuclear cells (PBMC) of healthy adults were stimulated with MCPyV VP1 virus-like particles (VLPs), using human bocavirus (HBoV) VLPs and Candida albicans antigen as positive controls. Proliferation, IFN-γ, IL-13 and IL-10 responses were examined in 15 MCPyV-seropositive and 15 seronegative volunteers. With the MCPyV antigen, significantly stronger Th-cell responses were found in MCPyV-seropositive than MCPyV-seronegative subjects, whereas with the control antigens, the responses were statistically similar. The most readily detectable cytokine was IFN-γ. The MCPyV antigen tended to induce stronger IFN-γ responses than HBoV VLP antigen. Taken together, MCPyV-specific Th-cells elicit vigorous IFN-γ responses. IFN-γ being a cytokine with major antiviral and tumor suppressing functions, Th-cells are suggested to be important mediators of MCPyV-specific immune surveillance.", "link"=>"http://www.mendeley.com/research/thelper-cellmediated-proliferation-cytokine-responses-against-recombinant-merkel-cell-polyomavirusli", "reader_count"=>18, "reader_count_by_academic_status"=>{"Researcher"=>8, "Student > Ph. D. Student"=>5, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>8, "Student > Ph. D. Student"=>5, "Other"=>1, "Student > Bachelor"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>4, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Mexico"=>1, "Germany"=>1}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/728599"], "description"=>"a<p>Δ CPM: antigen-specific CPM- background.</p>", "links"=>[], "tags"=>["mcpyv-specific", "proliferation", "cytokine", "responses", "mcpyv", "seropositive", "subjects", "antigen"], "article_id"=>398944, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.t002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_MCPyV_specific_proliferation_and_cytokine_responses_among_MCPyV_seropositive_and_8211_seronegative_subjects_at_2_5_181_g_ml_antigen_concentration_/398944", "title"=>"Comparison of MCPyV-specific proliferation and cytokine responses among MCPyV seropositive and –seronegative subjects at 2.5 µg/ml antigen concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-03 02:29:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/368209", "https://ndownloader.figshare.com/files/368274", "https://ndownloader.figshare.com/files/368305"], "description"=>"<div><p>The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral antigen in MCC cells. The mutated MCPyV has recently been found in highly purified leukemic cells from patients with chronic lymphocytic leukemia (CLL), suggesting a pathogenic role also in CLL. About 50–80% of adults display MCPyV-specific antibodies. The humoral immunity does not protect against the development of MCC, as neutralizing MCPyV antibodies occur in higher levels among MCC patients than healthy controls. Impaired T-cell immunity has been linked with aggressive MCC behavior. Therefore, cellular immunity appears to be important in MCPyV infection surveillance. In order to elucidate the role of MCPyV-specific Th-cell immunity, peripheral blood mononuclear cells (PBMC) of healthy adults were stimulated with MCPyV VP1 virus-like particles (VLPs), using human bocavirus (HBoV) VLPs and <em>Candida albicans</em> antigen as positive controls. Proliferation, IFN-γ, IL-13 and IL-10 responses were examined in 15 MCPyV-seropositive and 15 seronegative volunteers. With the MCPyV antigen, significantly stronger Th-cell responses were found in MCPyV-seropositive than MCPyV-seronegative subjects, whereas with the control antigens, the responses were statistically similar. The most readily detectable cytokine was IFN-γ. The MCPyV antigen tended to induce stronger IFN-γ responses than HBoV VLP antigen. Taken together, MCPyV-specific Th-cells elicit vigorous IFN-γ responses. IFN-γ being a cytokine with major antiviral and tumor suppressing functions, Th-cells are suggested to be important mediators of MCPyV-specific immune surveillance.</p> </div>", "links"=>[], "tags"=>["t-helper", "cell-mediated", "proliferation", "cytokine", "responses", "recombinant", "merkel", "polyomavirus-like", "particles"], "article_id"=>132749, "categories"=>["Physiology", "Cancer", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0025751.s001", "https://dx.doi.org/10.1371/journal.pone.0025751.s002", "https://dx.doi.org/10.1371/journal.pone.0025751.s003"], "stats"=>{"downloads"=>9, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/T_helper_Cell_Mediated_Proliferation_and_Cytokine_Responses_against_Recombinant_Merkel_Cell_Polyomavirus_Like_Particles/132749", "title"=>"T-helper Cell-Mediated Proliferation and Cytokine Responses against Recombinant Merkel Cell Polyomavirus-Like Particles", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-10-03 00:45:49"}
  • {"files"=>["https://ndownloader.figshare.com/files/728550"], "description"=>"a<p>Δ CPM: antigen-specific CPM- background.</p>", "links"=>[], "tags"=>["mcpyv-specific", "proliferation", "cytokine", "responses", "15", "mcpyv", "seropositive", "seronegative", "subjects", "antigen"], "article_id"=>398887, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_MCPyV_specific_proliferation_and_cytokine_responses_among_15_MCPyV_seropositive_and_8722_15_seronegative_subjects_at_0_25_181_g_ml_antigen_concentration_/398887", "title"=>"Comparison of MCPyV-specific proliferation and cytokine responses among 15 MCPyV seropositive and −15 seronegative subjects at 0.25 µg/ml antigen concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-03 02:28:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/728647"], "description"=>"a<p>Δ CPM: antigen-specific CPM- background.</p>", "links"=>[], "tags"=>["hbov-specific", "proliferation", "cytokine", "responses", "mcpyv", "seropositive", "subjects", "antigen"], "article_id"=>398984, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_HBoV_specific_proliferation_and_cytokine_responses_among_MCPyV_seropositive_and_8211_seronegative_subjects_at_2_5_181_g_ml_antigen_concentration_/398984", "title"=>"Comparison of HBoV-specific proliferation and cytokine responses among MCPyV seropositive and –seronegative subjects at 2.5 µg/ml antigen concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-03 02:29:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/728491"], "description"=>"a<p>Δ CPM: antigen-specific CPM- background.</p>", "links"=>[], "tags"=>["proliferation", "cytokine", "responses", "mcpyv", "seropositive", "subjects", "antigen"], "article_id"=>398837, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.t004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_Candida_albicans_specific_proliferation_and_cytokine_responses_among_MCPyV_seropositive_and_seronegative_subjects_at_2_5_g_ml_antigen_concentration_/398837", "title"=>"Comparison of <i>Candida albicans</i>-specific proliferation and cytokine responses among MCPyV seropositive and –seronegative subjects at 2.5 µg/ml antigen concentration.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-03 02:27:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/728118"], "description"=>"<p>PBMC of four MCPyV seropositive (P1 to P4) and one seronegative subject with strong MCPyV-specific CMI (N1) were depleted of either CD4+ or CD8+ T cells and stimulated with MCPyV VP1-VLPs (2.5 µg/ml). Proliferation (panel A) and cytokine (IFN-γ, IL-13 and IL-10) responses (panel B, C, D) were studied by thymidine incorporation and ELISA, respectively.</p>", "links"=>[], "tags"=>["responses", "mcpyv", "seropositive", "individuals", "subset"], "article_id"=>398461, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_MCPyV_VP1_8211_specific_T_cell_responses_of_MCPyV_seropositive_individuals_after_T_cell_subset_depletion_/398461", "title"=>"MCPyV VP1–specific T cell responses of MCPyV seropositive individuals after T cell subset depletion.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-03 02:21:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/728267"], "description"=>"<p>PBMC from four MCPyV seropositive subjects (P1 to P3 and P5) and from a seronegative subject (N1) were incubated either with a HLA class II-specific blocking MAb or with an isotype-matched control MAb. The effect of these MAbs on MCPyV-specific (2.5 µg/ml) proliferation (panel A) and cytokine (panels B, C and D) responses are shown. Subjects P1 to P3 and N1 are same than in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025751#pone-0025751-g001\" target=\"_blank\">Figure 1</a>.</p>", "links"=>[], "tags"=>["hla", "ii-specific", "monoclonal", "antibodies", "mcpyv-vp1", "proliferation", "cytokine"], "article_id"=>398606, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effect_of_HLA_class_II_specific_monoclonal_antibodies_MAbs_on_MCPyV_VP1_specific_proliferation_and_cytokine_responses_/398606", "title"=>"Effect of HLA class II-specific monoclonal antibodies (MAbs) on MCPyV-VP1 specific proliferation and cytokine responses.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-03 02:23:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/728419"], "description"=>"<p>Silver staining of capsid protein (panel A) in 10% SDS PAGE. Lane 1: molecular weight markers, lane 2: MCPyV VP1 capsid antigen. Dot blotting (panel B) for MCPyV antigen, studied with MCPyV-IgG positive (I) and negative (II) sera. Electron microscopy of sterile MCPyV particles (panel C) purified by caesium chloride density gradient ultracentrifugation, with 200 nm scale bar shown.</p>", "links"=>[], "tags"=>["mcpyv", "vp1"], "article_id"=>398774, "categories"=>["Physiology", "Cancer", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Arun Kumar", "Tingting Chen", "Sari Pakkanen", "Anu Kantele", "Maria Söderlund-Venermo", "Klaus Hedman", "Rauli Franssila"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0025751.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_MCPyV_VP1_antigens_/398774", "title"=>"Characterization of MCPyV VP1 antigens.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-03 02:26:14"}

PMC Usage Stats | Further Information

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