Treatment of Rat Spinal Cord Injury with the Neurotrophic Factor Albumin-Oleic Acid: Translational Application for Paralysis, Spasticity and Pain
Publication Date
October 26, 2011
Journal
PLOS ONE
Authors
Gerardo Avila Martin, Iriana Galan Arriero, Julio Gómez Soriano & Julian Taylor
Volume
6
Issue
10
Pages
e26107
DOI
https://dx.plos.org/10.1371/journal.pone.0026107
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0026107
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22046257
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202524
Europe PMC
http://europepmc.org/abstract/MED/22046257
Web of Science
000296519600009
Scopus
80055064642
Mendeley
http://www.mendeley.com/research/treatment-rat-spinal-cord-injury-neurotrophic-factor-albuminoleic-acid-translational-application-par
Events
Loading … Spinner
Mendeley 3328 Apr 07:24 UTC

Mendeley | Further Information

{"title"=>"Treatment of rat spinal cord injury with the neurotrophic factor Albumin-Oleic acid: Translational application for paralysis, spasticity and pain", "type"=>"journal", "authors"=>[{"first_name"=>"Gerardo", "last_name"=>"Avila-Martin", "scopus_author_id"=>"53979401200"}, {"first_name"=>"Iriana", "last_name"=>"Galan-Arriero", "scopus_author_id"=>"53979590200"}, {"first_name"=>"Julio", "last_name"=>"Gómez-Soriano", "scopus_author_id"=>"35221422400"}, {"first_name"=>"Julian", "last_name"=>"Taylor", "scopus_author_id"=>"7405407626"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"0100020100", "scopus"=>"2-s2.0-80055064642", "pui"=>"362825581", "doi"=>"10.1371/journal.pone.0026107", "issn"=>"19326203", "pmid"=>"22046257", "sgr"=>"80055064642"}, "id"=>"b8464cfc-2ddc-3f9e-8d36-40b3f6f8d42a", "abstract"=>"Sensorimotor dysfunction following incomplete spinal cord injury (iSCI) is often characterized by the debilitating symptoms of paralysis, spasticity and pain, which require treatment with novel pleiotropic pharmacological agents. Previous in vitro studies suggest that Albumin (Alb) and Oleic Acid (OA) may play a role together as an endogenous neurotrophic factor. Although Alb can promote basic recovery of motor function after iSCI, the therapeutic effect of OA or Alb-OA on a known translational measure of SCI associated with symptoms of spasticity and change in nociception has not been studied. Following T9 spinal contusion injury in Wistar rats, intrathecal treatment with: i) Saline, ii) Alb (0.4 nanomoles), iii) OA (80 nanomoles), iv) Alb-Elaidic acid (0.4/80 nanomoles), or v) Alb-OA (0.4/80 nanomoles) were evaluated on basic motor function, temporal summation of noxious reflex activity, and with a new test of descending modulation of spinal activity below the SCI up to one month after injury. Albumin, OA and Alb-OA treatment inhibited nociceptive Tibialis Anterior (TA) reflex activity. Moreover Alb-OA synergistically promoted early recovery of locomotor activity to 50 ± 10% of control and promoted de novo phasic descending inhibition of TA noxious reflex activity to 47 ± 5% following non-invasive electrical conditioning stimulation applied above the iSCI. Spinal L4-L5 immunohistochemistry demonstrated a unique increase in serotonin fibre innervation up to 4.2 ± 1.1 and 2.3 ± 0.3 fold within the dorsal and ventral horn respectively with Alb-OA treatment when compared to uninjured tissue, in addition to a reduction in NR1 NMDA receptor phosphorylation and microglia reactivity. Early recovery of voluntary motor function accompanied with tonic and de novo phasic descending inhibition of nociceptive TA flexor reflex activity following Alb-OA treatment, mediated via known endogenous spinal mechanisms of action, suggests a clinical application of this novel neurotrophic factor for the treatment of paralysis, spasticity and pain.", "link"=>"http://www.mendeley.com/research/treatment-rat-spinal-cord-injury-neurotrophic-factor-albuminoleic-acid-translational-application-par", "reader_count"=>33, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>6, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>2, "Professor"=>7}, "reader_count_by_subject_area"=>{"Engineering"=>3, "Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>7, "Neuroscience"=>5, "Sports and Recreations"=>1, "Psychology"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Neuroscience"=>{"Neuroscience"=>5}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Psychology"=>{"Psychology"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>0}
Scopus 3523 Feb 14:08 UTC

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80055064642"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80055064642?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80055064642&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80055064642&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/80055064642", "dc:identifier"=>"SCOPUS_ID:80055064642", "eid"=>"2-s2.0-80055064642", "dc:title"=>"Treatment of rat spinal cord injury with the neurotrophic factor Albumin-Oleic acid: Translational application for paralysis, spasticity and pain", "dc:creator"=>"Avila-Martin G.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"10", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-11-02", "prism:coverDisplayDate"=>"2011", "prism:doi"=>"10.1371/journal.pone.0026107", "citedby-count"=>"35", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Hospital Nacional de Paraplejicos", "affiliation-city"=>"Toledo", "affiliation-country"=>"Spain"}], "pubmed-id"=>"22046257", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e26107", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true, "freetoread"=>{"value"=>[{"$"=>"all"}, {"$"=>"publisherfullgold"}, {"$"=>"repository"}, {"$"=>"repositoryvor"}, {"$"=>"repositoryam"}]}, "freetoreadLabel"=>{"value"=>[{"$"=>"All Open Access"}, {"$"=>"Gold"}, {"$"=>"Green"}]}}
Facebook29 Jul 13:02 UTC

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0026107", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}
Counter 517525 Feb 00:38 UTC

Counter

  • {"month"=>"10", "year"=>"2011", "pdf_views"=>"15", "xml_views"=>"4", "html_views"=>"269"}
  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"57", "xml_views"=>"2", "html_views"=>"150"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"31", "xml_views"=>"16", "html_views"=>"54"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"56", "xml_views"=>"40", "html_views"=>"55"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"40", "xml_views"=>"16", "html_views"=>"93"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"8", "html_views"=>"91"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"9", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"64"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"5", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"46"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"95"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"90"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"65"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"3", "html_views"=>"62"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"100"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"32"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"28", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"65", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"54", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"63"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"17", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"31"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"47"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"4", "html_views"=>"9"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"10"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"13"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"11", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"3", "year"=>"2020", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"4", "year"=>"2020", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"6", "year"=>"2020", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2020", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2020", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"9", "year"=>"2020", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"10", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"11", "year"=>"2020", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"12", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"1", "year"=>"2021", "pdf_views"=>"3", "xml_views"=>"6", "html_views"=>"22"}
  • {"month"=>"2", "year"=>"2021", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"11"}
Figshare 6229 Apr 04:38 UTC

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/719904"], "description"=>"<p>Analysis of the first and second phase of Tibialis Anterior (TA) reflex temporal summation in naïve animals (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g004\" target=\"_blank\">Fig. 4A</a>) and those with SCI 28 days after T9 spinal contusion (Cont) revealed that the synergistic phasic inhibitory effect of Albumin-Oleic acid produced with the high-frequency electrical conditioning stimulation when normalized to the first phase of the pre-conditioned response was present during both the early and late phases of temporal summation (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g004\" target=\"_blank\">Fig. 4C</a>), but not in the group treated with Saline (Sal, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g004\" target=\"_blank\">Fig. 4B</a>) or in naïve animals (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g004\" target=\"_blank\">Fig. 4A</a>). Furthermore activation of phasic inhibition of absolute integrated TA reflex activity measured during both phases of temporal summation revealed that Alb-OA treatment significantly inhibited nociceptive activity to below the normal value observed in naïve animals during the early phase (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g004\" target=\"_blank\">Fig. 4D</a>). Statistical analysis was performed with a one-way ANOVA supported by a post-hoc Bonferroni test (* - p<0.05; ** - p<0.01, ***-p<0.001).</p>", "links"=>[], "tags"=>["phasic", "inhibition", "tibialis", "anterior", "reflex"], "article_id"=>390259, "categories"=>["Physiology", "Neuroscience"], "users"=>["Gerardo Avila-Martin", "Iriana Galan-Arriero", "Julio Gómez-Soriano", "Julian Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026107.g004", "stats"=>{"downloads"=>2, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Albumin_Oleic_Acid_Promotes_Phasic_Inhibition_of_Early_and_Late_Tibialis_Anterior_Reflex_Activity_following_SCI_/390259", "title"=>"Albumin-Oleic Acid Promotes Phasic Inhibition of Early and Late Tibialis Anterior Reflex Activity following SCI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:19:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/720059"], "description"=>"<p>Immunohistochemical images revealed that 5-HT innervation density was increased within both the dorsal and ventral horn following Albumin-Oleic acid treatment (0.4/80 nanomoles, 5C and 5I, 10x) compared to either naïve animals (A and G, 10x) or those with SCI contusion (Cont) treated with saline alone (Sal, B and H, 10x). Detailed photographs of laminae I-II (D-F, note faint medial signal in D), lamina VII (J–L) and lamina IX (M–O) revealed the normal presence of 5-HT fibres with varicosities (D, J, M), following SCI (E, K, N) and in animals with spinal T9 contusion with albumin-oleic acid treatment (F, L, O). Quantification of the increase in lumbar 5-HT innervation levels below the SCI within the dorsal (P, p<0.001) or ventral horn (Q, p<0.001) following Albumin-OA treatment (Alb-OA, 0.4/80 nanomoles) was observed, but not after saline (Sal), albumin (Alb), oleic acid (OA) or albumin-elaidic acid (Alb-EA) administration. Statistical analysis was performed with a one-way ANOVA for each experimental group (P and Q, *** - p<0.001). Detailed original examples of fluorescent images of 5-HT fibres within laminae I–II (R) and laminae VII (S) are included with Alb-OA treatment 28 days after T9 SCI.</p>", "links"=>[], "tags"=>["increases", "serotonin", "innervation", "levels"], "article_id"=>390419, "categories"=>["Physiology", "Neuroscience"], "users"=>["Gerardo Avila-Martin", "Iriana Galan-Arriero", "Julio Gómez-Soriano", "Julian Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026107.g005", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Albumin_Oleic_Acid_Increases_Serotonin_5_HT_Innervation_to_Above_Normal_Levels_after_SCI_/390419", "title"=>"Albumin-Oleic Acid Increases Serotonin (5-HT) Innervation to Above Normal Levels after SCI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:20:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/719605"], "description"=>"<p>Longitudinal analysis of the mean time spent on the rotarod following contusion (Cont) SCI from 4 to 28 days revealed that intrathecal administration of both Alb (0.4 nanomoles, p<0.05) and Alb-OA (80 nanomoles, p<0.01) promoted better motor recovery, compared to the spinal contusion group treated with saline (Sal) alone (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g001\" target=\"_blank\">Fig. 1A</a>). Treatment with OA (80 nanomoles) alone or Alb-Elaidic acid (Alb-EA, 0.4/80 nanomoles) failed to potentiate locomotor recovery (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g001\" target=\"_blank\">Fig. 1A</a>). Analysis of voluntary motor function during the early (4–14 day) and subacute (21–28 day) period of contusion SCI demonstrated that Alb-OA (0.4/80 nanomoles) synergistically promoted functional recovery soon after contusion injury when compared to animals treated with saline (Sal) alone, while Alb treatment enhanced the time spent on the rotarod specifically during the late phase (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g001\" target=\"_blank\">Fig. 1B</a>). Statistical analysis was performed with a two-way (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g001\" target=\"_blank\">Fig. 1A</a>) and one-way ANOVA (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g001\" target=\"_blank\">Fig. 1B</a>), supported by a post-hoc Bonferronni test for each experimental group compared with animals with SCI treated with Sal alone (* - p<0.05; ** - p<0.01).</p>", "links"=>[], "tags"=>["synergistically", "t9", "spinal"], "article_id"=>389961, "categories"=>["Physiology", "Neuroscience"], "users"=>["Gerardo Avila-Martin", "Iriana Galan-Arriero", "Julio Gómez-Soriano", "Julian Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026107.g001", "stats"=>{"downloads"=>1, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Albumin_Oleic_Acid_Alb_OA_Synergistically_Promotes_Early_Recovery_of_Motor_Function_following_T9_Spinal_Cord_Injury_/389961", "title"=>"Albumin-Oleic Acid (Alb-OA) Synergistically Promotes Early Recovery of Motor Function following T9 Spinal Cord Injury.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:18:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/719688"], "description"=>"<p>Qualitative analysis of rectified nociceptive Tibialis Anterior (TA) noxious reflex temporal summation at 28 days following spinal contusion (Cont, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2A–2F</a>, scale bar 20 µV/2.5 s) supported the quantification of reflex inhibition (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2H</a>) with either albumin (Alb, 0.4 nanomoles, p<0.001), oleic acid (OA, 80 nanomoles, p<0.001) or the complex Alb-OA (0.4/80 nanomoles, p<0.001) when compared to animals with SCI treated with saline alone (Sal). Importantly noxious TA reflex activity following moderate T9 contusion injury was not different for either the averaged response calculated from the second to seventh stimulus (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2G</a>) or the first reflex response (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2G</a> inset, same format) amongst the experimental treatment groups when compared to the responses observed in naïve animals or with SCI treated with saline alone. Although no increase in temporal summation for the first to the sixteenth reflex response was identified following contusion SCI (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2H</a>), significant inhibition of noxious TA temporal summation in animals with contusion SCI was observed with albumin (p<0.001), oleic acid (OA, p<0.001) and albumin-oleic acid (Alb-OA, p<.001) when compared to the group treated with saline alone (Sal, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2H</a>). The stereoisomer complex albumin-elaidic acid (Alb-EA, 0.4/80 nanomoles) failed to inhibit flexor reflex activity following contusion SCI (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g002\" target=\"_blank\">Fig. 2H</a>). Statistical analysis was performed with a two-way ANOVA supported by the post-hoc Bonferronni test compared to the SCI group treated with saline alone (*** - p<0.001).</p>", "links"=>[], "tags"=>["tibialis", "anterior", "reflex", "oleic", "albumin-oleic"], "article_id"=>390042, "categories"=>["Physiology", "Neuroscience"], "users"=>["Gerardo Avila-Martin", "Iriana Galan-Arriero", "Julio Gómez-Soriano", "Julian Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026107.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Inhibition_of_Tibialis_Anterior_Reflex_Activity_with_Albumin_Oleic_Acid_and_Albumin_Oleic_Acid_after_SCI_/390042", "title"=>"Inhibition of Tibialis Anterior Reflex Activity with Albumin, Oleic Acid and Albumin-Oleic Acid after SCI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:18:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/719782"], "description"=>"<p>Examination of rectified Tibialis Anterior (TA) electromyograhic reflex activity (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3A–3C</a>) revealed strong inhibition of temporal summation in animals with T9 spinal contusion (Cont) treated with albumin-oleic acid (Alb-OA, 0.4/80 nanomoles) following high-frequency conditioning stimulation (Post-Cond) above the SCI when compared to the pre-conditioning (Pre-Cond) response (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3C</a>, scale bar 10 µV/2.5 s). No inhibition was observed either in naïve (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3A</a>, scale bar 20 µV/2.5 s) or in animals with contusion SCI treated with saline alone (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3B</a>, scale bar 20 µV/2.5 s). Quantitative analysis of TA reflex temporal summation (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3D–3I</a>) demonstrated a phasic facilitation in naïve animals following high-frequency electrical conditioning (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3D</a>), which was absent in the experimental SCI groups (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3E–3I</a>). Indeed <i>de novo</i> synergistic phasic inhibition of TA reflex activity mediated across the SCI was only promoted by treatment with albumin-oleic acid (Alb-OA, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3I</a>, p<0.001), but not with albumin (Alb, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3F</a>), oleic acid (OA, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3G</a>) or albumin-elaidic acid (Alb-EA, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3H</a>). Statistical analysis was performed with a one-way ANOVA for each experimental group (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0026107#pone-0026107-g003\" target=\"_blank\">Fig. 3D–3I</a>, * - p<0.05; *** - p<0.001).</p>", "links"=>[], "tags"=>["synergistic", "descending", "inhibition", "tibialis", "anterior", "reflex"], "article_id"=>390141, "categories"=>["Physiology", "Neuroscience"], "users"=>["Gerardo Avila-Martin", "Iriana Galan-Arriero", "Julio Gómez-Soriano", "Julian Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026107.g003", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Albumin_Oleic_Acid_Promotes_De_Novo_Synergistic_Descending_Inhibition_of_Tibialis_Anterior_Reflex_Activity_after_SCI_/390141", "title"=>"Albumin-Oleic Acid Promotes <i>De Novo</i> Synergistic Descending Inhibition of Tibialis Anterior Reflex Activity after SCI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:19:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/720217"], "description"=>"<p>Alb-OA treatment (C and F, 20x) reduced microglia reactivity (OX-42, B and E, 20x) observed after SCI within both dorsal laminae I–II (C) and lamina V (F) when compared to naïve animals (A and D). Quantification of OX-42 area within laminae I–II (G) and lamina V (H) supported the qualitative inhibitory effect of Alb-OA treatment on increased microglia reactivity area following T9 contusion SCI when compared to naïve animals. Alb-OA treatment (K, 10x) reduced the accentuated number of cells with NR1 NMDA receptor phosphorylation (pNR-1) within the dorsal horn observed after SCI (J, 10x) when compared to normal tissue (I). Quantification of pNR1-positive cell number within the dorsal laminae I–II (L) and lamina V (M) supported the inhibition of NMDA receptor phosphorylation with Alb-OA. Statistical analysis was performed with an unpaired t-test (* - p<0.05; ** - p<0.01, *** - p<0.001).</p>", "links"=>[], "tags"=>["decreases", "microglia", "activation", "nmda", "nr1", "phosphorylation"], "article_id"=>390574, "categories"=>["Physiology", "Neuroscience"], "users"=>["Gerardo Avila-Martin", "Iriana Galan-Arriero", "Julio Gómez-Soriano", "Julian Taylor"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026107.g006", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Albumin_Oleic_Acid_Decreases_Microglia_Activation_and_Reduces_NMDA_NR1_Phosphorylation_after_SCI_/390574", "title"=>"Albumin-Oleic Acid Decreases Microglia Activation and Reduces NMDA NR1 Phosphorylation after SCI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:21:40"}
PMC Usage Stats 156017 Feb 16:48 UTC

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"90", "unique-ip"=>"76", "pdf"=>"60", "year"=>"2011", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"45", "year"=>"2011", "pdf"=>"42", "unique-ip"=>"43", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"41", "unique-ip"=>"41", "pdf"=>"33", "year"=>"2012", "figure"=>"2", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"31", "year"=>"2012", "pdf"=>"35", "unique-ip"=>"29", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"43", "unique-ip"=>"37", "pdf"=>"23", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"3", "full-text"=>"31", "year"=>"2012", "pdf"=>"17", "unique-ip"=>"28", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"23", "unique-ip"=>"21", "pdf"=>"13", "year"=>"2012", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"17", "year"=>"2012", "pdf"=>"9", "unique-ip"=>"13", "figure"=>"0", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"10", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"7", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"11", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"20", "full-text"=>"19", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"6", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"15", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"15", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"12", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"35", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"17", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"4", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"4", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2021", "month"=>"1"}
Relative Metric 29508610 May 16:31 UTC

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Behavior", "average_usage"=>[321, 534, 647, 753, 850, 938, 1018, 1091, 1168, 1231, 1299, 1357, 1420, 1473, 1538, 1604, 1670, 1737, 1800, 1864, 1928, 1985, 2051, 2102, 2169, 2240, 2298, 2361, 2435, 2484, 2550, 2606, 2651, 2718, 2792, 2830, 2875]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 571, 709, 823, 937, 1038, 1133, 1216, 1298, 1370, 1447, 1518, 1588, 1656, 1725, 1790, 1856, 1926, 1992, 2054, 2118, 2182, 2242, 2301, 2363, 2425, 2484, 2544, 2602, 2662, 2716, 2776, 2841, 2901, 2960, 3016, 3071]}, {"subject_area"=>"/Medicine and health sciences/Critical care and emergency medicine", "average_usage"=>[297, 609, 729, 868, 987, 1098, 1218, 1329, 1406, 1487, 1584, 1650, 1697, 1740, 1834, 1929, 1998, 2060, 2125, 2176, 2242, 2320, 2396, 2446, 2497, 2544, 2592, 2656, 2770, 2847, 2916, 2980, 3040, 3099, 3181, 3245, 3283, 3310]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[306, 594, 747, 886, 1029, 1141, 1243, 1346, 1446, 1520, 1606, 1689, 1766, 1845, 1921, 1996, 2076, 2136, 2224, 2295, 2367, 2436, 2519, 2589, 2662, 2731, 2806, 2865, 2924, 2980, 3064, 3112, 3167, 3225, 3298, 3364, 3438]}]}
F1000Prime 124 Feb 12:14 UTC

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts