Autonomic Modulation and Health-Related Quality of Life among Schizophrenic Patients Treated with Non-Intensive Case Management
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{"title"=>"Autonomic Modulation and Health-Related Quality of Life among Schizophrenic Patients Treated with Non-Intensive Case Management", "type"=>"journal", "authors"=>[{"first_name"=>"Li-Ren", "last_name"=>"Chang"}, {"first_name"=>"Yu-Hsuan", "last_name"=>"Lin"}, {"first_name"=>"Terry B. J.", "last_name"=>"Kuo"}, {"first_name"=>"Hung-Chieh", "last_name"=>"Wu Chang"}, {"first_name"=>"Chih-Min", "last_name"=>"Liu"}, {"first_name"=>"Chen-Chung", "last_name"=>"Liu"}, {"first_name"=>"Hai-Gwo", "last_name"=>"Hwu"}, {"first_name"=>"Cheryl C. H.", "last_name"=>"Yang"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0026378", "isbn"=>"1932-6203", "pmid"=>"22073161"}, "id"=>"501c9c94-f8ac-3604-b1ac-38da67559e8f", "abstract"=>"BACKGROUND: Schizophrenia is associated with autonomic dysfunction and this may increase cardiovascular mortality. Past studies on autonomic modulation of schizophrenic patients focused on inpatients rather than individuals in a community setting, especially those receiving non-intensive case management (non-ICM). Besides, autonomic modulation and its association with health-related quality of life (HRQoL) in this population remain unexplored.\\n\\nMETHODS: A total of 25 schizophrenic patients treated by non-ICM and 40 healthy volunteers were matched by age, gender and body mass index; smokers were excluded. Between the two groups, we compared the individuals' 5 min resting assessments of heart rate variability and their HRQoL, which was measured using EuroQoL-5D (EQ-5D). Patients with schizophrenia were assessed for psychopathology using the Positive and Negative Syndrome Scale for Schizophrenia (PANSS). We examined the relationship between heart rate variability measurements, HRQoL scores, PANSS scores, and other clinical variables among the schizophrenic patients treated by non-ICM.\\n\\nRESULTS: Compared to the controls, patients with schizophrenia showed a significant impairment of autonomic modulation and a worse HRQoL. Cardiovagal dysfunction among the schizophrenic patients could be predicted independently based on lower educational level and more negative symptoms. Sympathetic predominance was directly associated with anticholinergics use and EQ-5D using a visual analogue scale (EQ-VAS).\\n\\nCONCLUSION: Patients with schizophrenia treated by non-ICM show a significant impairment of their autonomic function and HRQoL compared to the controls. Since the sympathovagal dysfunction is associated with more negative symptoms or higher VAS score, the treatment of the negative symptoms as well as the monitoring of HRQoL might help to manage cardiovascular risk among these individuals. In addition, EQ-VAS scores must be interpreted more cautiously in such a population.", "link"=>"http://www.mendeley.com/research/autonomic-modulation-healthrelated-quality-life-among-schizophrenic-patients-treated-nonintensive-ca-3", "reader_count"=>28, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>5, "Other"=>3, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>6, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>5, "Other"=>3, "Student > Master"=>3, "Student > Bachelor"=>2, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>2, "Psychology"=>10, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>10}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Korea (South)"=>2, "Poland"=>1, "United Kingdom"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/715913"], "description"=>"<p>Note: RR, mean of all RR intervals; TP, total power; HF, high-frequency spectral component; LF, low-frequency spectral component of HRV.</p><p>*<i>p</i><0.05.</p><p>**<i>p</i><0.01.</p><p>***<i>p</i><0.001.</p><p>PANSS, Positive and Negative Syndrome Scale; BMI, body mass index; GAF, global assessment of functioning; CGI, clinical global impression; EQ-TTO, EuroQoL-5D time-trade-off score; EQ-VAS, EuroQoL-5D score on visual analogue scale.</p>", "links"=>[], "tags"=>["variability", "measures", "schizophrenia"], "article_id"=>386264, "categories"=>["Mental Health"], "users"=>["Li-Ren Chang", "Yu-Hsuan Lin", "Terry B. J. Kuo", "Hung-Chieh Wu Chang", "Chih-Min Liu", "Chen-Chung Liu", "Hai-Gwo Hwu", "Cheryl C. H. Yang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026378.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Univariate_correlation_of_heart_rate_variability_measures_in_schizophrenia_group_N_8202_8202_25_/386264", "title"=>"Univariate correlation of heart rate variability measures in schizophrenia group (N = 25).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 11:59:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/715951"], "description"=>"<p>Note: N refers to the number of cases. Values are means (±Standard Deviation).</p><p>PANSS, Positive and Negative Syndrome Scale; BMI, body mass index; GAF, global assessment of functioning; CGI, clinical global impression; EQ-TTO, EuroQoL-5D time-trade-off score; EQ-VAS, EuroQoL-5D score on visual analogue scale.</p>", "links"=>[], "tags"=>["Mental health"], "article_id"=>386312, "categories"=>["Mental Health"], "users"=>["Li-Ren Chang", "Yu-Hsuan Lin", "Terry B. J. Kuo", "Hung-Chieh Wu Chang", "Chih-Min Liu", "Chen-Chung Liu", "Hai-Gwo Hwu", "Cheryl C. H. Yang"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026378.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sample_Description_/386312", "title"=>"Sample Description.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 11:59:16"}

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  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 571, 709, 823, 937, 1038, 1133, 1216, 1298, 1370, 1447, 1518, 1588, 1656, 1725, 1790, 1856, 1926, 1992, 2054, 2118, 2182, 2242, 2301, 2363, 2425, 2484, 2544, 2602, 2662, 2716, 2776, 2841, 2901, 2960, 3016, 3071]}, {"subject_area"=>"/Medicine and health sciences/Health care", "average_usage"=>[337, 676, 827, 964, 1066, 1171, 1267, 1396, 1503, 1580, 1663, 1758, 1822, 1887, 1968, 2037, 2107, 2173, 2246, 2357, 2419, 2488, 2576, 2637, 2724, 2815, 2887, 2956, 3034, 3111, 3174, 3245, 3294, 3357, 3404, 3464, 3529]}, {"subject_area"=>"/Medicine and health sciences/Pharmacology", "average_usage"=>[337, 604, 750, 875, 1001, 1107, 1205, 1299, 1391, 1468, 1552, 1629, 1709, 1785, 1862, 1935, 2013, 2081, 2140, 2212, 2281, 2352, 2422, 2489, 2564, 2629, 2698, 2752, 2833, 2880, 2925, 2983, 3042, 3111, 3183, 3250, 3311]}, {"subject_area"=>"/Social sciences", "average_usage"=>[340, 584, 708, 809, 915, 1005, 1089, 1174, 1254, 1334, 1408, 1478, 1563, 1648, 1716, 1791, 1847, 1915, 1979, 2044, 2105, 2163, 2218, 2297, 2382, 2436, 2493, 2553, 2618, 2682, 2741, 2786, 2847, 2937, 2989, 3039, 3102]}, {"subject_area"=>"/Social sciences/Sociology", "average_usage"=>[426, 807, 983, 1078, 1202, 1297, 1394, 1505, 1611, 1713, 1819, 1918, 2007, 2092, 2190, 2261, 2341, 2445, 2522, 2612, 2692, 2754, 2830, 2908, 2987, 3076, 3157, 3246, 3319, 3431, 3527, 3602, 3670, 3725, 3772, 3821, 3879]}]}
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