Contribution of ARLTS1 Cys148Arg (T442C) Variant with Prostate Cancer Risk and ARLTS1 Function in Prostate Cancer Cells
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{"title"=>"Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells", "type"=>"journal", "authors"=>[{"first_name"=>"Sanna", "last_name"=>"Siltanen", "scopus_author_id"=>"24482427100"}, {"first_name"=>"Tiina", "last_name"=>"Wahlfors", "scopus_author_id"=>"8728446000"}, {"first_name"=>"Martin", "last_name"=>"Schindler", "scopus_author_id"=>"57196653945"}, {"first_name"=>"Outi R.", "last_name"=>"Saramäki", "scopus_author_id"=>"7801581235"}, {"first_name"=>"John Patrick", "last_name"=>"Mpindi", "scopus_author_id"=>"25621987600"}, {"first_name"=>"Leena", "last_name"=>"Latonen", "scopus_author_id"=>"7801518847"}, {"first_name"=>"Robert L.", "last_name"=>"Vessella", "scopus_author_id"=>"7007065462"}, {"first_name"=>"Teuvo L.J.", "last_name"=>"Tammela", "scopus_author_id"=>"7102917803"}, {"first_name"=>"Olli", "last_name"=>"Kallioniemi", "scopus_author_id"=>"7005031465"}, {"first_name"=>"Tapio", "last_name"=>"Visakorpi", "scopus_author_id"=>"7006392459"}, {"first_name"=>"Johanna", "last_name"=>"Schleutker", "scopus_author_id"=>"6603885868"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"362778312", "doi"=>"10.1371/journal.pone.0026595", "sgr"=>"80054786082", "scopus"=>"2-s2.0-80054786082", "pmid"=>"22028916"}, "id"=>"fb7d6e6a-a4a4-3f7d-b4fc-079b36d450b3", "abstract"=>"ARLTS1 is a recently characterized tumor suppressor gene at 13q14.3, a region frequently deleted in both sporadic and hereditary prostate cancer (PCa). ARLTS1 variants, especially Cys148Arg (T442C), increase susceptibility to different cancers, including PCa. In this study the role of Cys148Arg substitution was investigated as a risk factor for PCa using both genetic and functional analysis. Cys148Arg genotypes and expression of the ARLTS1 were explored in a large set of familial and unselected PCa cases, clinical tumor samples, xenografts, prostate cancer cell lines and benign prostatic hyperplasia (BPH) samples. The frequency of the variant genotype CC was significantly higher in familial (OR = 1.67, 95% CI = 1.08-2.56, P = 0.019) and unselected patients (OR = 1.52, 95% CI = 1.18-1.97, P = 0.001) and the overall risk was increased (OR = 1.54, 95% CI = 1.20-1.98, P = 0.0007). Additional analysis with clinicopathological data revealed an association with an aggressive disease (OR = 1.28, 95% CI = 1.05-∞, P = 0.02). The CC genotype of the Cys148Arg variant was also contributing to the lowered ARLTS1 expression status in lymphoblastoid cells from familial patients. In addition significantly lowered ARLTS1 expression was observed in clinical tumor samples compared to BPH samples (P = 0.01). The ARLTS1 co-expression signature based on previously published microarray data was generated from 1587 cancer samples confirming the low expression of ARLTS1 in PCa and showed that ARLTS1 expression was strongly associated with immune processes. This study provides strong confirmation of the important role of ARLTS1 Cys148Arg variant as a contributor in PCa predisposition and a potential marker for aggressive disease outcome.", "link"=>"http://www.mendeley.com/research/contribution-arlts1-cys148arg-t442c-variant-prostate-cancer-risk-arlts1-function-prostate-cancer-cel", "reader_count"=>21, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>4, "Researcher"=>5, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Other"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>4, "Researcher"=>5, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>2, "Other"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>1, "Chemistry"=>12, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>12}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Sweden"=>1, "United States"=>1, "United Kingdom"=>1, "Lithuania"=>1, "Switzerland"=>1, "Spain"=>1}, "group_count"=>1}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/722139"], "description"=>"<p>The Cys148Arg (T442C) genotype as well as the choromosomal aberration is shown. <b>C</b>, Cys148Arg (T442C) variant in two clinical cancer tissue samples and in two normal blood DNA (sequences are in reverse orientation). * determined as in Saramäki OR et al., 2006.</p>", "links"=>[], "tags"=>["lucap", "prostate", "cancer", "epithelial", "cells", "bph"], "article_id"=>392481, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.g003", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Relative_expression_of_ARLTS1_in_A_LuCaP_xenografts_prostate_cancer_cell_lines_prostate_epithelial_cells_and_in_normal_prostate_and_B_in_BPH_and_clinical_tumor_samples_as_determined_by_Q_RT_PCR_/392481", "title"=>"Relative expression of <i>ARLTS1</i> in A, LuCaP xenografts, prostate cancer cell lines, prostate epithelial cells and in normal prostate and B, in BPH and clinical tumor samples, as determined by Q-RT-PCR.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-20 00:41:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/365809", "https://ndownloader.figshare.com/files/365845", "https://ndownloader.figshare.com/files/365877"], "description"=>"<div><p><em>ARLTS1</em> is a recently characterized tumor suppressor gene at 13q14.3, a region frequently deleted in both sporadic and hereditary prostate cancer (PCa). <em>ARLTS1</em> variants, especially Cys148Arg (T442C), increase susceptibility to different cancers, including PCa. In this study the role of Cys148Arg substitution was investigated as a risk factor for PCa using both genetic and functional analysis. Cys148Arg genotypes and expression of the <em>ARLTS1</em> were explored in a large set of familial and unselected PCa cases, clinical tumor samples, xenografts, prostate cancer cell lines and benign prostatic hyperplasia (BPH) samples. The frequency of the variant genotype CC was significantly higher in familial (OR = 1.67, 95% CI = 1.08–2.56, <em>P</em> = 0.019) and unselected patients (OR = 1.52, 95% CI = 1.18–1.97, <em>P</em> = 0.001) and the overall risk was increased (OR = 1.54, 95% CI = 1.20–1.98, <em>P</em> = 0.0007). Additional analysis with clinicopathological data revealed an association with an aggressive disease (OR = 1.28, 95% CI = 1.05-∞, <em>P</em> = 0.02). The CC genotype of the Cys148Arg variant was also contributing to the lowered <em>ARLTS1</em> expression status in lymphoblastoid cells from familial patients. In addition significantly lowered <em>ARLTS1</em> expression was observed in clinical tumor samples compared to BPH samples (<em>P</em> = 0.01). The <em>ARLTS1</em> co-expression signature based on previously published microarray data was generated from 1587 cancer samples confirming the low expression of ARLTS1 in PCa and showed that <em>ARLTS1</em> expression was strongly associated with immune processes. This study provides strong confirmation of the important role of <em>ARLTS1</em> Cys148Arg variant as a contributor in PCa predisposition and a potential marker for aggressive disease outcome.</p> </div>", "links"=>[], "tags"=>["cys148arg", "variant", "prostate", "cancer", "arlts1", "cells"], "article_id"=>132304, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0026595.s001", "https://dx.doi.org/10.1371/journal.pone.0026595.s002", "https://dx.doi.org/10.1371/journal.pone.0026595.s003"], "stats"=>{"downloads"=>2, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Contribution_of_ARLTS1_Cys148Arg_T442C_Variant_with_Prostate_Cancer_Risk_and_ARLTS1_Function_in_Prostate_Cancer_Cells/132304", "title"=>"Contribution of <em>ARLTS1</em> Cys148Arg (T442C) Variant with Prostate Cancer Risk and ARLTS1 Function in Prostate Cancer Cells", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-10-20 00:38:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/722486"], "description"=>"<p>Observed <i>ARLTS1</i> variants and their frequencies in clinical prostate tumors and LuCap xenografts.</p>", "links"=>[], "tags"=>["variants", "frequencies", "prostate", "tumors", "lucap"], "article_id"=>392833, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Observed_ARLTS1_variants_and_their_frequencies_in_clinical_prostate_tumors_and_LuCap_xenografts_/392833", "title"=>"Observed <i>ARLTS1</i> variants and their frequencies in clinical prostate tumors and LuCap xenografts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-20 00:47:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/722443"], "description"=>"<p>Association of the Cys148Arg (T442C) variant with clinicopathologic variables of prostate cancer patients.</p>", "links"=>[], "tags"=>["cys148arg", "variant", "clinicopathologic", "variables", "prostate", "cancer"], "article_id"=>392790, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.t003", "stats"=>{"downloads"=>2, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_the_Cys148Arg_T442C_variant_with_clinicopathologic_variables_of_prostate_cancer_patients_/392790", "title"=>"Association of the Cys148Arg (T442C) variant with clinicopathologic variables of prostate cancer patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-20 00:46:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/722307"], "description"=>"<p>Protein expression status in six prostate cancer cell lines and in one normal prostate epithelial cell line. Actin is shown as a loading control. ARL11 expected/observed Mw 21.4 kDa. A non-specific band is marked with an asterisk (*).</p>", "links"=>[], "tags"=>["levels", "arlts1"], "article_id"=>392659, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.g004", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_levels_of_ARLTS1_protein_by_Western_blotting_/392659", "title"=>"The levels of ARLTS1 protein by Western blotting.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-20 00:44:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/722391"], "description"=>"<p>*<i>compared to TT homozygotes</i>.</p>", "links"=>[], "tags"=>["cys148arg", "variant", "prostate", "cancer", "benign", "prostatic"], "article_id"=>392740, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.t001", "stats"=>{"downloads"=>1, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_the_ARLTS1_Cys148Arg_variant_with_prostate_cancer_and_benign_prostatic_hyperplasia_/392740", "title"=>"Association of the <i>ARLTS1</i> Cys148Arg variant with prostate cancer and benign prostatic hyperplasia.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-10-20 00:45:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/721877"], "description"=>"<p>Squares represent males; circles represent females. Open symbols indicate no neoplasm, and filled symbols denote prostate cancer cases. +indicates the presence of the T442C variant in the DNA sample of the family members, followed by the actual genotype. An arrow indicates the individual initially screened for <i>ARLTS1</i> sequence variants. Age at diagnosis for prostate cancer patients (in years) is indicated below the symbol for each family member. An asterisk (*) denotes the persons with no sample available.</p>", "links"=>[], "tags"=>["segregation", "cys148arg", "variant-positive", "prostate"], "article_id"=>392225, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_segregation_analysis_in_three_ARLTS1_Cys148Arg_T442C_variant_positive_families_with_prostate_cancer_/392225", "title"=>"Examples of segregation analysis in three <i>ARLTS1</i> Cys148Arg (T442C) variant-positive families with prostate cancer.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-20 00:37:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/722020"], "description"=>"<p>Determined by Q-RT-PCR. *, <i>P</i><0.05. Columns, mean of eight individuals; bars, SD.</p>", "links"=>[], "tags"=>["cys148arg", "genotyped", "lymphoblastoid"], "article_id"=>392370, "categories"=>["Cancer", "Genetics"], "users"=>["Sanna Siltanen", "Tiina Wahlfors", "Martin Schindler", "Outi R. Saramäki", "John Patrick Mpindi", "Leena Latonen", "Robert L. Vessella", "Teuvo L. J. Tammela", "Olli Kallioniemi", "Tapio Visakorpi", "Johanna Schleutker"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0026595.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_relative_expression_of_ARLTS1_in_Cys148Arg_T442C_genotyped_lymphoblastoid_cell_lines_/392370", "title"=>"The relative expression of <i>ARLTS1</i> in Cys148Arg (T442C) genotyped lymphoblastoid cell lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-10-20 00:39:30"}

PMC Usage Stats | Further Information

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Relative Metric

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