Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Alzheimer's disease and non-demented high pathology control nonagenarians: Comparing and contrasting the biochemistry of cognitively successful aging", "type"=>"journal", "authors"=>[{"first_name"=>"Chera L.", "last_name"=>"Maarouf", "scopus_author_id"=>"25925155200"}, {"first_name"=>"Ian D.", "last_name"=>"Daugs", "scopus_author_id"=>"24491791100"}, {"first_name"=>"Tyler A.", "last_name"=>"Kokjohn", "scopus_author_id"=>"7004916975"}, {"first_name"=>"Douglas G.", "last_name"=>"Walker", "scopus_author_id"=>"7404440176"}, {"first_name"=>"Jesse M.", "last_name"=>"Hunter", "scopus_author_id"=>"55581759200"}, {"first_name"=>"Jane C.", "last_name"=>"Kruchowsky", "scopus_author_id"=>"54380373700"}, {"first_name"=>"Randy", "last_name"=>"Woltjer", "scopus_author_id"=>"6701554969"}, {"first_name"=>"Jeffrey", "last_name"=>"Kaye", "scopus_author_id"=>"35351332100"}, {"first_name"=>"Eduardo M.", "last_name"=>"Castaño", "scopus_author_id"=>"7007163976"}, {"first_name"=>"Marwan N.", "last_name"=>"Sabbagh", "scopus_author_id"=>"35380609700"}, {"first_name"=>"Thomas G.", "last_name"=>"Beach", "scopus_author_id"=>"7005917418"}, {"first_name"=>"Alex E.", "last_name"=>"Roher", "scopus_author_id"=>"7005377759"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-80555148798", "sgr"=>"80555148798", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0027291", "pmid"=>"22087282", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"362876621"}, "id"=>"7335caa1-d94d-3d16-a5c1-25325f882e1c", "abstract"=>"The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while enduring high amyloid plaque loads for decades. If amyloid accumulation is the prime instigator of neurotoxicity and dementia, specific protective mechanisms must enable these HPC to evade cognitive decline. We evaluated the neuropathological and biochemical differences existing between non-demented (ND)-HPC and an age-matched cohort with AD dementia. The ND-HPC selected for our study were clinically assessed as ND and possessed high amyloid plaque burdens. ELISA and Western blot analyses were used to quantify a group of proteins related to APP/Aβ/tau metabolism and other neurotrophic and inflammation-related molecules that have been found to be altered in neurodegenerative disorders and are pivotal to brain homeostasis and mental health. The molecules assumed to be critical in AD dementia, such as soluble or insoluble Aβ40, Aβ42 and tau were quantified by ELISA. Interestingly, only Aβ42 demonstrated a significant increase in ND-HPC when compared to the AD group. The vascular amyloid load which was not used in the selection of cases, was on the average almost 2-fold greater in AD than the ND-HPC, suggesting that a higher degree of microvascular dysfunction and perfusion compromise was present in the demented cohort. Neurofibrillary tangles were less frequent in the frontal cortices of ND-HPC. Biochemical findings included elevated vascular endothelial growth factor, apolipoprotein E and the neuroprotective factor S100B in ND-HPC, while anti-angiogenic pigment epithelium derived factor levels were lower. The lack of clear Aβ-related pathological/biochemical demarcation between AD and ND-HPC suggests that in addition to amyloid plaques other factors, such as neurofibrillary tangle density and vascular integrity, must play important roles in cognitive failure.", "link"=>"http://www.mendeley.com/research/alzheimers-disease-nondemented-high-pathology-control-nonagenarians-comparing-contrasting-biochemist", "reader_count"=>65, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>13, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>5, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>13, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>5, "Student > Master"=>6, "Other"=>3, "Student > Bachelor"=>4, "Lecturer"=>1, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>6, "Engineering"=>2, "Biochemistry, Genetics and Molecular Biology"=>4, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>18, "Medicine and Dentistry"=>12, "Neuroscience"=>13, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Psychology"=>4, "Computer Science"=>1, "Decision Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Neuroscience"=>{"Neuroscience"=>13}, "Decision Sciences"=>{"Decision Sciences"=>1}, "Psychology"=>{"Psychology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>18}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>6}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}}, "reader_count_by_country"=>{"Netherlands"=>1, "Mexico"=>1}, "group_count"=>4}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80555148798"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/80555148798?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80555148798&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=80555148798&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/80555148798", "dc:identifier"=>"SCOPUS_ID:80555148798", "eid"=>"2-s2.0-80555148798", "dc:title"=>"Alzheimer's disease and non-demented high pathology control nonagenarians: Comparing and contrasting the biochemistry of cognitively successful aging", "dc:creator"=>"Maarouf C.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"6", "prism:issueIdentifier"=>"11", "prism:pageRange"=>nil, "prism:coverDate"=>"2011-11-07", "prism:coverDisplayDate"=>"7 November 2011", "prism:doi"=>"10.1371/journal.pone.0027291", "citedby-count"=>"40", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Banner Sun Health Research Institute", "affiliation-city"=>"Sun City", "affiliation-country"=>"United States"}], "pubmed-id"=>"22087282", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e27291", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0027291", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"11", "year"=>"2011", "pdf_views"=>"131", "xml_views"=>"11", "html_views"=>"394"}
  • {"month"=>"12", "year"=>"2011", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"74"}
  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"79"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"22", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"26"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"4", "html_views"=>"19"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"38"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"86"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"80"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"85"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"44"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"66"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"38"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"75"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"76"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"3", "html_views"=>"69"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"45"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"32"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"49"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"57"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"85"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"14", "xml_views"=>"2", "html_views"=>"41"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"21"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"3", "xml_views"=>"5", "html_views"=>"8"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"9"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"1"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/715932"], "description"=>"<p>A-D and G-J gray matter included 8 ND-HPC and 6 AD cases. The white matter analysis in E and F also contained 8 ND-HPC and 6 AD cases. All values are adjusted for total protein. The statistical analysis used was an unpaired, 2-tailed t-test. Aβ  = amyloid-beta; GM  =  gray matter; WM  =  white matter; GDFA  = 90% glass distilled formic acid; GHCl  =  5M guanidine hydrochloride; HPC  =  non-demented high pathology controls; AD  =  Alzheimer's disease.</p>", "links"=>[], "tags"=>["plots", "tau", "levels", "observed", "frontal", "lobes", "oldest-old", "HPC"], "article_id"=>386272, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ELISA_scatter_plots_of_A_946_40_A_946_42_tau_and_945_synuclein_levels_observed_in_the_frontal_lobes_of_oldest_old_HPC_and_AD_cases_/386272", "title"=>"ELISA scatter plots of Aβ40, Aβ42, tau and α-synuclein levels observed in the frontal lobes of oldest-old HPC and AD cases.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:59:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/716309"], "description"=>"<p>A total of 20 µg of total protein was loaded into each lane for the ApoE blot, while all other blots contained 40 µg of total protein. Unpaired, 2-tailed t-tests were used for statistical analysis. The primary and secondary antibody descriptions and sources are given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027291#pone-0027291-t002\" target=\"_blank\"><b>Table 2</b></a>. The relative abundance of the proteins were densitometrically estimated. Each blot was reprobed with actin as a loading control, as shown at the bottom of each primary antibody Western blot. The numbers to the left of the Western blots are the molecular weight in kDa. HPC  =  non-demented high pathology controls; AD  =  Alzheimer's disease; exp  =  exposure.</p>", "links"=>[], "tags"=>["blots"], "article_id"=>386659, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g006", "stats"=>{"downloads"=>1, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blots_of_tau_ApoE_945_synuclein_and_ApoJ_/386659", "title"=>"Western blots of tau, ApoE, α-synuclein and ApoJ.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:01:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/716537"], "description"=>"<p>APP, amyloid-β precursor protein; aa, amino acid; BACE, β-site APP cleaving enzyme; IDE, insulin degrading enzyme; NICD, Notch-1 intracellular domain; PHF, paired helical filament; ptau, phosphorylated tau; VEGF, vascular endothelial growth factor; PEDF, pigment epithelium derived factor; BDNF, brain derived neurotrophic factor; TDP-43, TAR DNA-binding protein 43; ApoE, apolipoprotein E; ApoJ, apolipoprotein J; M, HRP conjugated AffiniPure goat-anti mouse IgG (catalog # 111-035-144, Jackson Laboratory); R, HRP conjugated AffiniPure goat-anti rabbit IgG, (catalog # 111-035-146 Jackson Laboratory); G, HRP conjugated AffiniPure bovine-anti goat IgG (catalog #805-035-180).</p>", "links"=>[], "tags"=>["antibodies"], "article_id"=>386888, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.t002", "stats"=>{"downloads"=>27, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primary_and_Secondary_Antibodies_Used_in_Western_Blots_/386888", "title"=>"Primary and Secondary Antibodies Used in Western Blots.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 12:02:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/715745"], "description"=>"<p>The histological fields are representative of the neurofibrillary tangle abundance shown in 40 µm coronal sections of the frontal lobe and hippocampus. The numbers on the top right corners correspond to the case identification numbers given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027291#pone-0027291-t001\" target=\"_blank\"><b>Table 1</b></a> and the letters F and H represent frontal cortex and hippocampus, respectively. Scale bars  = 100 µm.</p>", "links"=>[], "tags"=>["tangles", "stained", "gallyas"], "article_id"=>386089, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Neurofibrillary_tangles_stained_by_the_Gallyas_technique_/386089", "title"=>"Neurofibrillary tangles stained by the Gallyas technique.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:58:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/715466"], "description"=>"<p>The histological fields are representative of the amyloid plaque burden shown in 40 µm coronal sections of the frontal lobe. The numbers on the top right corners correspond to the case identification numbers given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027291#pone-0027291-t001\" target=\"_blank\"><b>Table 1</b></a>. Scale bars  = 100 µm.</p>", "links"=>[], "tags"=>["plaques", "stained", "campbell-switzer"], "article_id"=>385803, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g001", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Amyloid_plaques_stained_by_the_Campbell_Switzer_technique_/385803", "title"=>"Amyloid plaques stained by the Campbell-Switzer technique.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:56:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/716202"], "description"=>"<p>Five % SDS was used to homogenize the brain tissue for the CT9APP, 4G8 and 6E10 antibody blots, while the remaining blots used RIPA buffer as homogenizing medium. A total of 40 µg of total protein was loaded into each lane. Unpaired, 2-tailed t-tests were used for statistical analysis. The primary and secondary antibody descriptions and sources a given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027291#pone-0027291-t002\" target=\"_blank\"><b>Table 2</b></a>. The relative abundance of the proteins were densitometrically estimated. Each blot was reprobed with actin as a loading control, as shown at the bottom of each primary antibody Western blot. The numbers to the left of the Western blots are the molecular weight in kDa. HPC  =  non-demented high pathology controls; AD  =  Alzheimer's disease; exp  = exposure.</p>", "links"=>[], "tags"=>["blots", "metabolism-related"], "article_id"=>386544, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g005", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blots_of_APP_A_946_metabolism_related_molecules_/386544", "title"=>"Western blots of APP/Aβ metabolism-related molecules.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:00:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/716405"], "description"=>"<p>Forty µg of total protein was loaded onto VEFG, BDNF and TDP-43 acrylamide gels. The PEDF and synpaptophysin blots contained 20 µg and 10 µg of total protein, respectively. Unpaired, 2-tailed t-tests were used for statistical analysis. The primary and secondary antibody descriptions and sources are given in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027291#pone-0027291-t002\" target=\"_blank\"><b>Table 2</b></a>. The relative abundance of the proteins were densitometrically estimated. Each blot was reprobed with actin as a loading control, as shown at the bottom of each primary antibody Western blot. The numbers to the left of the Western blots are the molecular weight in kDa. HPC  =  non-demented high pathology controls; AD  =  Alzheimer's disease; exp  =  exposure.</p>", "links"=>[], "tags"=>["blots", "synaptophysin"], "article_id"=>386747, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g007", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blots_of_VEGF_PEDF_BDNF_TDP_43_synaptophysin_and_S100B_/386747", "title"=>"Western blots of VEGF, PEDF, BDNF, TDP-43, synaptophysin and S100B.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 12:01:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/716498"], "description"=>"<p>ND-HPC  =  non-demented high pathology controls; AD  =  Alzheimer's disease; y  =  years; M  =  male; F  =  female; PMI  =  postmortem interval; h  =  hours; g  =  grams; MMSE  =  mini-mental state examination; ApoE  =  apolipoprotein E; GT  =  genotype; WMR  =  white matter rarefaction; CAA  =  cerebral amyloid angiopathy.</p>", "links"=>[], "tags"=>["bshri"], "article_id"=>386844, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.t001", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Oldest_old_BSHRI_Study_Subject_Data_/386844", "title"=>"Oldest-old BSHRI Study Subject Data.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 12:02:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/716083"], "description"=>"<p><b>A</b>) TNF-α homogenized in HEPES buffer; <b>B</b>) CD200 homogenized in RIPA buffer; <b>C</b>) Synaptophysin homogenized in RIPA buffer; <b>D</b>) GFAP homogenized in RIPA buffer; <b>F</b>) ApoE homogenized in Tris buffer; <b>G</b>) ApoE homogenized in RIPA buffer; <b>H</b>) ApoE homogenized in 5% SDS buffer; <b>I</b>) ApoE homogenized in GDFA/GHCl. All values were adjusted for total protein. The statistical analysis used was an unpaired, 2-tailed t-test. TNF-α  =  tumor necrosis factor-alpha; GFAP  =  glial fibrillary acid protein; ApoE  =  apolipoprotein E; GDFA  =  glass distilled formic acid; GHCl  =  guanidine hydrochloride; HPC  =  non-demented high pathology controls; AD  =  Alzheimer's disease.</p>", "links"=>[], "tags"=>["plots", "frontal", "lobe"], "article_id"=>386429, "categories"=>["Physiology", "Biochemistry", "Neuroscience"], "users"=>["Chera L. Maarouf", "Ian D. Daugs", "Tyler A. Kokjohn", "Douglas G. Walker", "Jesse M. Hunter", "Jane C. Kruchowsky", "Randy Woltjer", "Jeffrey Kaye", "Eduardo M. Castaño", "Marwan N. Sabbagh", "Thomas G. Beach", "Alex E. Roher"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027291.g004", "stats"=>{"downloads"=>1, "page_views"=>43, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_ELISA_scatter_plots_of_frontal_lobe_gray_matter_proteins_/386429", "title"=>"ELISA scatter plots of frontal lobe gray matter proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:59:52"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"11", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"62", "unique-ip"=>"64", "pdf"=>"65", "year"=>"2011", "figure"=>"16", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"12", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"72", "year"=>"2011", "pdf"=>"58", "unique-ip"=>"72", "figure"=>"12", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"1", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"55", "unique-ip"=>"49", "pdf"=>"36", "year"=>"2012", "figure"=>"6", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"49", "year"=>"2012", "pdf"=>"39", "unique-ip"=>"48", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"35", "unique-ip"=>"39", "pdf"=>"35", "year"=>"2012", "figure"=>"1", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"30", "year"=>"2012", "pdf"=>"13", "unique-ip"=>"31", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"20", "unique-ip"=>"22", "pdf"=>"17", "year"=>"2012", "figure"=>"9", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"28", "year"=>"2012", "pdf"=>"23", "unique-ip"=>"23", "figure"=>"3", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"32", "full-text"=>"28", "pdf"=>"22", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"27", "full-text"=>"30", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"21", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"25", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"26", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"19", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"18", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"19", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"8", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"23", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"18", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"12", "full-text"=>"30", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"21", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"31", "full-text"=>"44", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"37", "full-text"=>"66", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"16", "full-text"=>"7", "pdf"=>"12", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"35", "full-text"=>"59", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"14", "full-text"=>"20", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"29", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"7", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"1", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"31", "full-text"=>"4", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"2", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"20", "full-text"=>"17", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"13", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"26", "full-text"=>"10", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"22", "full-text"=>"14", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"40", "full-text"=>"15", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"29", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[304, 568, 702, 818, 927, 1027, 1118, 1206, 1285, 1357, 1427, 1500, 1564, 1636, 1705, 1773, 1840, 1909, 1974, 2039, 2106, 2170, 2234, 2296, 2358, 2423, 2484, 2546, 2606, 2673, 2734, 2795, 2857, 2921, 2984, 3046, 3100]}, {"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[301, 558, 690, 806, 916, 1018, 1112, 1197, 1275, 1349, 1421, 1495, 1561, 1631, 1697, 1762, 1835, 1895, 1954, 2020, 2078, 2142, 2197, 2258, 2313, 2376, 2437, 2494, 2557, 2618, 2682, 2744, 2818, 2880, 2940, 3000, 3056]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[298, 559, 690, 805, 916, 1018, 1115, 1201, 1283, 1356, 1425, 1498, 1565, 1635, 1703, 1767, 1835, 1902, 1962, 2027, 2089, 2150, 2210, 2265]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[303, 571, 709, 823, 937, 1038, 1133, 1216, 1298, 1370, 1447, 1518, 1588, 1656, 1725, 1790, 1856, 1926, 1992, 2054, 2118, 2182, 2242, 2301, 2363, 2425, 2484, 2544, 2602, 2662, 2716, 2776, 2841, 2901, 2960, 3016, 3071]}, {"subject_area"=>"/Medicine and health sciences/Mental health and psychiatry", "average_usage"=>[317, 582, 735, 863, 982, 1104, 1210, 1309, 1395, 1475, 1549, 1610, 1687, 1755, 1811, 1879, 1944, 2018, 2086, 2138, 2234, 2279, 2331, 2401, 2482, 2561, 2612, 2685, 2765, 2841, 2901, 2978, 3053, 3107, 3158, 3235, 3294]}, {"subject_area"=>"/Medicine and health sciences/Neurology", "average_usage"=>[306, 594, 747, 886, 1029, 1141, 1243, 1346, 1446, 1520, 1606, 1689, 1766, 1845, 1921, 1996, 2076, 2136, 2224, 2295, 2367, 2436, 2519, 2589, 2662, 2731, 2806, 2865, 2924, 2980, 3064, 3112, 3167, 3225, 3298, 3364, 3438]}]}
Loading … Spinner
There are currently no alerts