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Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese

Publication Date: November 16, 2011
Journal: PLOS ONE
Authors: Liang Sun, An Pan, Zhijie Yu, Huaixing Li, et al
Volume: 6
Issue: 11
Pages: e27515
DOI: https://dx.plos.org/10.1371/journal.pone.0027515
Publisher URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0027515
PubMed: http://www.ncbi.nlm.nih.gov/pubmed/22110665
PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217970
Europe PMC: http://europepmc.org/abstract/MED/22110665
Web of Science: 000297555400052
Scopus: 81155137458
Mendeley: http://www.mendeley.com/research/snoring-inflammatory-markers-adipokines-metabolic-syndrome-apparently-healthy-chinese

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{"title"=>"Snoring, inflammatory markers, adipokines and metabolic syndrome in apparently healthy Chinese", "type"=>"journal", "authors"=>[{"first_name"=>"Liang", "last_name"=>"Sun", "scopus_author_id"=>"56176664500"}, {"first_name"=>"An", "last_name"=>"Pan", "scopus_author_id"=>"56108327800"}, {"first_name"=>"Zhijie", "last_name"=>"Yu", "scopus_author_id"=>"23026213500"}, {"first_name"=>"Huaixing", "last_name"=>"Li", "scopus_author_id"=>"35277217100"}, {"first_name"=>"Aizhen", "last_name"=>"Shi", "scopus_author_id"=>"54586014300"}, {"first_name"=>"Danxia", "last_name"=>"Yu", "scopus_author_id"=>"29967552400"}, {"first_name"=>"Geng", "last_name"=>"Zhang", "scopus_author_id"=>"37056508300"}, {"first_name"=>"Geng", "last_name"=>"Zong", "scopus_author_id"=>"36638868700"}, {"first_name"=>"Yong", "last_name"=>"Liu", "scopus_author_id"=>"36063498400"}, {"first_name"=>"Xu", "last_name"=>"Lin", "scopus_author_id"=>"24385545200"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-81155137458", "pmid"=>"22110665", "sgr"=>"81155137458", "doi"=>"10.1371/journal.pone.0027515", "isbn"=>"2011049075", "issn"=>"19326203", "pui"=>"362925645"}, "id"=>"46b2e776-3b69-33de-9006-397ed556650b", "abstract"=>"OBJECTIVE: Chronic low-grade inflammation and adipokines dysregulation are linked to mechanisms underscoring the pathogenesis of obesity-related metabolic disorders. Little is known about roles of these cytokines on the association between snoring and metabolic syndrome (MetS). We aimed to investigate whether a cluster of cytokines are related to snoring frequency and its association with MetS in apparently healthy Chinese.\\n\\nMETHODS: Current analyses used a population-based sample including 1059 Shanghai residents aged 35-54 years. Self-reported snoring frequency was classified as never, occasionally and regularly. Fasting plasma glucose, lipid profile, insulin, C-reactive protein, interleukin-6, interleukin-18, lipopolysaccharide binding protein, high-molecular-weight adiponectin and leptin were measured. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.\\n\\nRESULTS: Overweight/obese subjects had significantly higher prevalence of regular snorers than their normal-weight counterparts (34.8% vs. 11.5%, P<0.001). Regular snoring was associated with unfavorable profile of inflammatory markers and adipokines. However, those associations were abolished after adjustment for body mass index (BMI) or waist circumference. The MetS risk (multivariate-adjusted odds ratio 5.41, 95% confidence interval 3.72-7.88) was substantially higher in regular snorers compared with non-snorers. Controlling for BMI remarkably attenuated the association (2.03, 1.26-3.26), while adjusting for inflammatory markers and adipokines showed little effects.\\n\\nCONCLUSION: Frequent snoring was associated with an elevated MetS risk independent of lifestyle factors, adiposity, inflammatory markers and adipokines in apparently healthy Chinese. Whether snoring pattern is an economic and no-invasive indicator for screening high-risk persons needs to be addressed prospectively.", "link"=>"http://www.mendeley.com/research/snoring-inflammatory-markers-adipokines-metabolic-syndrome-apparently-healthy-chinese", "reader_count"=>22, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>4, "Student > Bachelor"=>2, "Professor"=>2, "Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Other"=>4, "Student > Bachelor"=>2, "Professor"=>2, "Unspecified"=>2, "Professor > Associate Professor"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Earth and Planetary Sciences"=>1, "Physics and Astronomy"=>1, "Nursing and Health Professions"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Chemistry"=>{"Chemistry"=>1}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

ORCID 101 Apr 15:39 UTC

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Figshare 1302 Apr 20:29 UTC

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{"files"=>["https://ndownloader.figshare.com/files/360743"], "description"=>"<div><h3>Objective</h3><p>Chronic low-grade inflammation and adipokines dysregulation are linked to mechanisms underscoring the pathogenesis of obesity-related metabolic disorders. Little is known about roles of these cytokines on the association between snoring and metabolic syndrome (MetS). We aimed to investigate whether a cluster of cytokines are related to snoring frequency and its association with MetS in apparently healthy Chinese.</p> <h3>Methods</h3><p>Current analyses used a population-based sample including 1059 Shanghai residents aged 35–54 years. Self-reported snoring frequency was classified as never, occasionally and regularly. Fasting plasma glucose, lipid profile, insulin, C-reactive protein, interleukin-6, interleukin-18, lipopolysaccharide binding protein, high-molecular-weight adiponectin and leptin were measured. MetS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans.</p> <h3>Results</h3><p>Overweight/obese subjects had significantly higher prevalence of regular snorers than their normal-weight counterparts (34.8% vs. 11.5%, <em>P</em><0.001). Regular snoring was associated with unfavorable profile of inflammatory markers and adipokines. However, those associations were abolished after adjustment for body mass index (BMI) or waist circumference. The MetS risk (multivariate-adjusted odds ratio 5.41, 95% confidence interval 3.72–7.88) was substantially higher in regular snorers compared with non-snorers. Controlling for BMI remarkably attenuated the association (2.03, 1.26–3.26), while adjusting for inflammatory markers and adipokines showed little effects.</p> <h3>Conclusion</h3><p>Frequent snoring was associated with an elevated MetS risk independent of lifestyle factors, adiposity, inflammatory markers and adipokines in apparently healthy Chinese. Whether snoring pattern is an economic and no-invasive indicator for screening high-risk persons needs to be addressed prospectively.</p> </div>", "links"=>[], "tags"=>["inflammatory", "adipokines", "metabolic", "chinese"], "article_id"=>131312, "categories"=>["Physiology", "Neuroscience", "Biotechnology", "Immunology"], "users"=>["Liang Sun", "An Pan", "Zhijie Yu", "Huaixing Li", "Aizhen Shi", "Danxia Yu", "Geng Zhang", "Geng Zong", "Yong Liu", "Xu Lin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027515", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Snoring_Inflammatory_Markers_Adipokines_and_Metabolic_Syndrome_in_Apparently_Healthy_Chinese/131312", "title"=>"Snoring, Inflammatory Markers, Adipokines and Metabolic Syndrome in Apparently Healthy Chinese", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-11-16 00:21:52"}
{"files"=>["https://ndownloader.figshare.com/files/711765"], "description"=>"a<p>Excluding 140 participants who met the criteria for type 2 diabetes during the physical examinations;</p><p>Model 1: adjusted for age, sex, smoking, alcohol drinking, physical activity, education, family history of chronic diseases, marital status, annual income, self-rated health status, depressive symptoms, sleep quality and duration;</p><p>Model 2: model 1 plus BMI;</p><p>Model 3: model 2 plus inflammatory markers (CRP, LBP, IL-6 and IL-18) and adipokines (HMW-adiponectin and leptin).</p><p>Abbreviations: BMI = body mass index; CRP = C-reactive protein; HDL = high-density lipoprotein; HMW-adiponectin = high-molecular-weight adiponectin; IL = Interleukin; LBP = Lipopolysaccharide-binding protein.</p>", "links"=>[], "tags"=>["ratios", "metabolic", "snoring"], "article_id"=>382117, "categories"=>["Physiology", "Neuroscience", "Biotechnology", "Immunology"], "users"=>["Liang Sun", "An Pan", "Zhijie Yu", "Huaixing Li", "Aizhen Shi", "Danxia Yu", "Geng Zhang", "Geng Zong", "Yong Liu", "Xu Lin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027515.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Odds_ratios_and_95_confidence_interval_for_metabolic_syndrome_according_to_snoring_frequency_n_8202_8202_1003_/382117", "title"=>"Odds ratios and 95% confidence interval for metabolic syndrome according to snoring frequency (n = 1003).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-11-16 00:35:17"}
{"files"=>["https://ndownloader.figshare.com/files/711570"], "description"=>"<p>Modified metabolic syndrome was defined as having 2 or more components of metabolic syndrome without central obesity. <b>A to B</b>: Adjusted for age (<b>A</b>), sex (<b>B</b>), smoking, alcohol drinking, physical activity, education, family history of chronic diseases, marriage status, annual income, self-rated health status, depressive symptoms, sleep quality and duration, and BMI. <b>C</b>: Adjusted for age, sex, smoking, alcohol drinking, physical activity, education, family history of chronic diseases, marriage status, annual income, self-rated health status, depressive symptoms, sleep quality and duration. <b>D to E</b>: Adjusted for covariates in C and BMI. Abbreviations: BMI = body mass index.</p>", "links"=>[], "tags"=>["metabolic", "classification", "snoring", "obesity", "inflammatory", "adipokine"], "article_id"=>381918, "categories"=>["Physiology", "Neuroscience", "Biotechnology", "Immunology"], "users"=>["Liang Sun", "An Pan", "Zhijie Yu", "Huaixing Li", "Aizhen Shi", "Danxia Yu", "Geng Zhang", "Geng Zong", "Yong Liu", "Xu Lin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027515.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Odds_ratio_for_metabolic_syndrome_according_to_joint_classification_of_snoring_status_and_sex_A_age_B_obesity_status_C_inflammatory_index_D_and_adipokine_index_E_/381918", "title"=>"Odds ratio for metabolic syndrome according to joint classification of snoring status and sex (A), age (B), obesity status (C), inflammatory index (D) and adipokine index (E).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-11-16 00:31:58"}
{"files"=>["https://ndownloader.figshare.com/files/711722"], "description"=>"<p><i>P</i> value was calculated after adjustment for age and sex. Data are arithmetic mean (SD).</p>a<p>Data not adjusted for itself.</p><p>Percentages may not sum to 100 because of rounding.</p><p>Abbreviations: BMI = body mass index.</p>", "links"=>[], "tags"=>["snoring"], "article_id"=>382075, "categories"=>["Physiology", "Neuroscience", "Biotechnology", "Immunology"], "users"=>["Liang Sun", "An Pan", "Zhijie Yu", "Huaixing Li", "Aizhen Shi", "Danxia Yu", "Geng Zhang", "Geng Zong", "Yong Liu", "Xu Lin"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0027515.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_participants_across_snoring_frequency_n_8202_8202_1003_/382075", "title"=>"Characteristics of participants across snoring frequency (n = 1003).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-11-16 00:34:35"}

PMC Usage Stats 137517 Feb 16:51 UTC

PMC Usage Stats | Further Information

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Relative Metric 28270905 Apr 18:58 UTC

Relative Metric

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F1000Prime24 Feb 12:18 UTC

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