Higher Frequency of T-Cell Response to M. tuberculosis Latency Antigen Rv2628 at the Site of Active Tuberculosis Disease than in Peripheral Blood
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{"title"=>"Higher frequency of T-cell response to M. tuberculosis latency antigen RV2628 at the site of active tuberculosis disease than in peripheral blood", "type"=>"journal", "authors"=>[{"first_name"=>"Teresa", "last_name"=>"Chiacchio", "scopus_author_id"=>"35193532700"}, {"first_name"=>"Elisa", "last_name"=>"Petruccioli", "scopus_author_id"=>"36449703800"}, {"first_name"=>"Valentina", "last_name"=>"Vanini", "scopus_author_id"=>"35194987100"}, {"first_name"=>"Ornella", "last_name"=>"Butera", "scopus_author_id"=>"9241715500"}, {"first_name"=>"Gilda", "last_name"=>"Cuzzi", "scopus_author_id"=>"23488644800"}, {"first_name"=>"Linda", "last_name"=>"Petrone", "scopus_author_id"=>"21934731800"}, {"first_name"=>"Giuseppe", "last_name"=>"Matteucci", "scopus_author_id"=>"50761245800"}, {"first_name"=>"Francesco Nicola", "last_name"=>"Lauria", "scopus_author_id"=>"55111815200"}, {"first_name"=>"Kees L M C", "last_name"=>"Franken", "scopus_author_id"=>"6701784579"}, {"first_name"=>"Enrico", "last_name"=>"Girardi", "scopus_author_id"=>"7007115968"}, {"first_name"=>"Tom H M", "last_name"=>"Ottenhoff", "scopus_author_id"=>"7005159872"}, {"first_name"=>"Delia", "last_name"=>"Goletti", "scopus_author_id"=>"7004262091"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-80755159593", "pui"=>"362897830", "doi"=>"10.1371/journal.pone.0027539", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"80755159593", "pmid"=>"22102905"}, "id"=>"38a7276f-12bd-3faf-ac58-b20a23a77948", "abstract"=>"RATIONALE: Due to the invasive nature of the procedures involved, most studies of Mycobacterium tuberculosis (Mtb)-specific immunity in humans have focused on the periphery rather than the site of active infection, the lung. Recently, antigens associated with Mtb-latency and -dormancy have been described using peripheral blood (PB) cells; however their response in the lung is unknown. The objective of this report was to evaluate, in patients prospectively enrolled with suspected active tuberculosis (TB), whether the latency antigen Rv2628 induces local-specific immune response in bronchoalveolar lavage (BAL) cells compared to PB cells.\\n\\nMATERIAL/METHODS: Among the 41 subjects enrolled, 20 resulted with active TB. Among the 21 without active disease, 9 were defined as subjects with latent TB-infection (LTBI) [Quantiferon TB Gold In-tube positive]. Cytokine responses to Rv2628 were evaluated by enzyme linked immunospot (ELISPOT) assay and flow cytometric (FACS) analysis. RD1-secreted antigen stimulation was used as control.\\n\\nRESULTS: There was a significantly higher frequency of Rv2628- and RD1-specific CD4+ T-cells in the BAL of active TB patients than in PB. However the trend of the response to Rv2628 in subjects with LTBI was higher than in active TB in both PB and BAL, although this difference was not significant. In active TB, Rv2628 and RD1 induced a cytokine-response profile mainly consisting of interferon (IFN)-γ-single-positive over double-IFN-γ/interleukin (IL)-2 T-cells in both PB and BAL. Finally, BAL-specific CD4+ T-cells were mostly effector memory (EM), while peripheral T-cell phenotypes were distributed among naïve, central memory and terminally differentiated effector memory T-cells.\\n\\nCONCLUSIONS: In this observational study, we show that there is a high frequency of specific T-cells for Mtb-latency and RD1-secreted antigens (mostly IFN-γ-single-positive specific T-cells with an EM phenotype) in the BAL of active TB patients. These data may be important for better understanding the pathogenesis of TB in the lung.", "link"=>"http://www.mendeley.com/research/higher-frequency-tcell-response-m-tuberculosis-latency-antigen-rv2628-site-active-tuberculosis-disea", "reader_count"=>36, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>11, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>11, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>3, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>17, "Agricultural and Biological Sciences"=>10, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>17}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}}, "reader_count_by_country"=>{"United Kingdom"=>1, "South Africa"=>1, "Ethiopia"=>1}, "group_count"=>1}

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  • {"files"=>["https://ndownloader.figshare.com/files/713665"], "description"=>"<p>ELISPOT evaluation of IFN-γ-producing CD4<sup>+</sup> T-cells in circulating and BAL lymphocytes in response to Rv2628- and RD1-antigens in active TB and LTBI subjects. Response to Rv2628- (A) and RD1-antigens (B) in active TB patients; response to Rv2628- (C) and RD1-antigens (D) in LTBI subjects. <b>Footnote:</b> PBMC: peripheral blood mononuclear cells; BALC: bronchoalveolar lavage cells; SFC: spot-forming cells; IFN: interferon; TB: tuberculosis; LTBI: latent TB infection. Dotted lines link the results obtained for circulating and local lymphocytes for the same patient.</p>", "links"=>[], "tags"=>["rv2628-", "rd1-response", "balc", "pbmc", "evaluated"], "article_id"=>384003, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_frequency_of_Rv2628_and_RD1_response_in_BALC_than_PBMC_in_active_TB_evaluated_by_ELISPOT_/384003", "title"=>"Increased frequency of Rv2628- and RD1-response in BALC than PBMC in active TB, evaluated by ELISPOT.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:46:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/713781"], "description"=>"<p>ELISPOT evaluation of IFN-γ-producing CD4<sup>+</sup> T-cells in PBMC and BALC in response to Rv2628- and RD1-antigens in LTBI and active TB subjects. Response to Rv2628- and RD1-antigens in PBMC of active TB and LTBI subjects (A), response to Rv2628- and RD1-antigens in BALC of LTBI and active TB subjects (B) <b>Footnote:</b> PBMC: peripheral blood mononuclear cells; BALC: bronchoalveolar lavage cells; SFC: spot-forming cells; IFN: interferon; TB: tuberculosis; LTBI: latent TB infection.</p>", "links"=>[], "tags"=>["rd1-response", "higher", "rv2628-response", "pbmc", "evaluated"], "article_id"=>384128, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Magnitude_of_RD1_response_is_significantly_higher_than_Rv2628_response_in_PBMC_and_BALC_evaluated_by_ELISPOT_/384128", "title"=>"Magnitude of RD1-response is significantly higher than Rv2628-response in PBMC and BALC, evaluated by ELISPOT.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:47:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/713915"], "description"=>"<p>FACS analysis of the multiple cytokine producing CD4<sup>+</sup> T-cells (IFN-γ and/or IL-2) in PB and BALC in response to Rv2628- (A) and RD1-antigens (B) stimulation in active TB patients. <b>Footnote:</b> PB: whole blood; BALC: bronchoalveolar lavage cells. Dotted lines link the results obtained for circulating and local lymphocytes for the same patient.</p>", "links"=>[], "tags"=>["rv2628-", "rd1-response", "balc", "pb", "evaluated"], "article_id"=>384262, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Increased_frequency_of_Rv2628_and_RD1_response_in_BALC_than_PB_in_active_TB_evaluated_by_FACS_/384262", "title"=>"Increased frequency of Rv2628- and RD1-response in BALC than PB in active TB, evaluated by FACS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:47:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/714066"], "description"=>"<p>Polyfunctional cytokine production analysis of Mtb-specific CD4<sup>+</sup> T-cells by FACS. PB and BALC from active TB patients were stimulated overnight with Rv2628- and RD1-antigens. T- cells were classified as single IFN-γ-producing, single IL-2-producing or double IFN-γ/IL-2–producing cells in response to Rv2628- (A) and RD1-antigens (B). The results are reported as relative median in PB compared to BALC samples (A–B). Black triangles: PB; open triangles: BALC. <b>Footnote:</b> PB: peripheral blood; BALC: bronchoalveolar lavage cells; IFN: interferon; IL: interleukin.</p>", "links"=>[], "tags"=>["antigens"], "article_id"=>384423, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.g004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Cytokine_profile_in_response_to_Mtb_specific_antigens_in_active_TB_/384423", "title"=>"Cytokine profile in response to <i>Mtb</i>-specific antigens in active TB.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:48:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/714170"], "description"=>"<p>Phenotypical T-cell subset distribution of the total cytokine-producing T-cells in response to Rv2628- (A) or RD1-antigens (B) are reported in PB and BALC samples. <b>Footnote:</b> PB: peripheral blood; BALC: bronchoalveolar lavage cells; N: naïve; CM: central memory; EM: effector memory; EF: terminally<sup>-</sup>differentiated effector memory.</p>", "links"=>[], "tags"=>["antigens"], "article_id"=>384525, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.g005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotype_profile_in_response_to_Mtb_specific_antigens_in_active_TB_/384525", "title"=>"Phenotype profile in response to <i>Mtb</i>-specific antigens in active TB.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 11:49:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/714241"], "description"=>"<p><b>Footnote:</b> ELISPOT: enzyme-linked immunosorbent spot; FACS: flow cytometric analysis; TB: tuberculosis; LTBI: latent tuberculosis infection; cell constraint: mononuclear cells from BAL < 6×10<sup>6</sup>; cell anergy: by ELISPOT, if the results are less than 20 SFC/well in the positive control; cell anergy: by FACS, if the results are less than 0.06% in the positive control; indeterminate: by ELISPOT, if the results are more than 10 SFC/well in the negative control.</p>", "links"=>[], "tags"=>["samples", "enrolled"], "article_id"=>384592, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_BAL_samples_obtained_and_analyzed_in_the_enrolled_patients_/384592", "title"=>"BAL samples obtained and analyzed in the enrolled patients.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 11:49:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/714285"], "description"=>"<p><b>Footnotes:</b> TB: Tuberculosis; IQR: Interquartile range; BCG: Bacillus Calmette et Guérin; QTF-IT: QuantiFERON TB Gold in Tube; NA: not available.</p>", "links"=>[], "tags"=>["characteristics", "subjects", "enrolled"], "article_id"=>384636, "categories"=>["Physiology", "Cell Biology", "Infectious Diseases", "Immunology"], "users"=>["Teresa Chiacchio", "Elisa Petruccioli", "Valentina Vanini", "Ornella Butera", "Gilda Cuzzi", "Linda Petrone", "Giuseppe Matteucci", "Francesco Nicola Lauria", "Kees L. M. C. Franken", "Enrico Girardi", "Tom H. M. Ottenhoff", "Delia Goletti"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0027539.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_and_clinical_characteristics_of_the_subjects_enrolled_in_the_study_/384636", "title"=>"Demographic and clinical characteristics of the subjects enrolled in the study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 11:49:58"}

PMC Usage Stats | Further Information

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Relative Metric

{"start_date"=>"2011-01-01T00:00:00Z", "end_date"=>"2011-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy", "average_usage"=>[301, 558, 690, 806, 916, 1018, 1112, 1197, 1275, 1349, 1421, 1495, 1561, 1631, 1697, 1762, 1835, 1895, 1954, 2020, 2078, 2142, 2197, 2258, 2313, 2376, 2437, 2494, 2557, 2618, 2682, 2744, 2818, 2880, 2940, 3000, 3056]}, {"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[298, 559, 690, 805, 916, 1018, 1115, 1201, 1283, 1356, 1425, 1498, 1565, 1635, 1703, 1767, 1835, 1902, 1962, 2027, 2089, 2150, 2210, 2265]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[296, 551, 687, 800, 903, 1001, 1095, 1184, 1259, 1327, 1406, 1473, 1535, 1600, 1669, 1736, 1794, 1857, 1922, 1983, 2046, 2109, 2169, 2223, 2278, 2344, 2402, 2457, 2517, 2574, 2621, 2688, 2756, 2811, 2872, 2936, 2985]}, {"subject_area"=>"/Medicine and health sciences/Hematology", "average_usage"=>[318, 581, 714, 833, 954, 1053, 1145, 1241, 1327, 1405, 1490, 1556, 1632, 1699, 1767, 1834, 1898, 1978, 2041, 2103, 2165, 2225, 2282, 2345, 2403, 2460, 2530, 2582, 2659, 2711, 2768, 2819, 2879, 2939, 2997, 3052, 3100]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[299, 582, 725, 844, 971, 1076, 1167, 1253, 1328, 1403, 1480, 1551, 1620, 1691, 1756, 1821, 1893, 1962, 2032, 2110, 2178, 2236, 2300, 2358, 2419, 2465, 2529, 2587, 2643, 2700, 2756, 2817, 2869, 2932, 2986, 3046, 3101]}, {"subject_area"=>"/Medicine and health sciences/Infectious diseases", "average_usage"=>[335, 648, 777, 906, 1018, 1131, 1224, 1307, 1396, 1462, 1541, 1619, 1695, 1764, 1821, 1892, 1959, 2029, 2095, 2155, 2218, 2270, 2329, 2395, 2457, 2528, 2590, 2638, 2708, 2759, 2823, 2882, 2930, 2990, 3041, 3099, 3150]}]}
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Net::HTTPTooManyRequests

Source
Scopus
Time
2019-08-27 18:06:27 UTC
Target URL
https://api.elsevier.com/content/search/index:SCOPUS?query=DOI(10.1371%2Fjournal.pone.0027539)
Trace

/app/models/concerns/networkable.rb:21:in `get_result'
/app/models/source.rb:165:in `get_data'
/app/models/retrieval_status.rb:47:in `perform_get_data'
/app/jobs/source_job.rb:52:in `block (2 levels) in perform'
/app/jobs/source_job.rb:51:in `block in perform'
/app/jobs/source_job.rb:35:in `each'
/app/jobs/source_job.rb:35:in `perform'