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{"title"=>"Small protein-mediated quorum sensing in a Gram-negative bacterium", "type"=>"journal", "authors"=>[{"first_name"=>"Sang Wook", "last_name"=>"Han", "scopus_author_id"=>"55487827100"}, {"first_name"=>"Malinee", "last_name"=>"Sriariyanun", "scopus_author_id"=>"24473777500"}, {"first_name"=>"Sang Won", "last_name"=>"Lee", "scopus_author_id"=>"57200928745"}, {"first_name"=>"Manoj", "last_name"=>"Sharma", "scopus_author_id"=>"16231070900"}, {"first_name"=>"Ofir", "last_name"=>"Bahar", "scopus_author_id"=>"24472914700"}, {"first_name"=>"Zachary", "last_name"=>"Bower", "scopus_author_id"=>"54583161900"}, {"first_name"=>"Pamela C.", "last_name"=>"Ronald", "scopus_author_id"=>"7005957829"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-83155167625", "pui"=>"363066848", "doi"=>"10.1371/journal.pone.0029192", "isbn"=>"1944-7930 (Electronic)\\r1539-6509 (Linking)", "sgr"=>"83155167625", "pmid"=>"22174954"}, "id"=>"14426b82-404d-3e12-afb2-42b06008d312", "abstract"=>"The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axY(S)22, derived from the Ax21 (activator of XA21-mediated immunity) protein. The conservation of Ax21 in all sequenced Xanthomonas spp. and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in Xanthomonas oryzae pv. oryzae. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the Xoo RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium.", "link"=>"http://www.mendeley.com/research/small-proteinmediated-quorum-sensing-gramnegative-bacterium", "reader_count"=>78, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Librarian"=>1, "Student > Doctoral Student"=>6, "Researcher"=>21, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>4, "Librarian"=>1, "Student > Doctoral Student"=>6, "Researcher"=>21, "Student > Ph. D. Student"=>19, "Student > Postgraduate"=>2, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>9, "Lecturer"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>4, "Biochemistry, Genetics and Molecular Biology"=>2, "Materials Science"=>1, "Mathematics"=>1, "Agricultural and Biological Sciences"=>58, "Design"=>1, "Sports and Recreations"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Design"=>{"Design"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>58}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>4}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>3, "Japan"=>2, "Italy"=>1, "Israel"=>1, "Chile"=>1, "France"=>1, "Germany"=>1}, "group_count"=>2}

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• http://doi.org/10.7717/peerj.242
• http://doi.org/10.1016/j.ymeth.2017.08.019
• http://doi.org/10.1073/pnas.1208003109
• http://doi.org/10.1038/nj7492-389a
• http://doi.org/10.1146/annurev-phyto-082712-102334
• http://doi.org/10.1080/14787210.2019.1685875
• http://doi.org/10.1021/pr4001543
• http://doi.org/10.3389/fcimb.2018.00122
• http://doi.org/10.1111/j.1364-3703.2012.00804.x
• http://doi.org/10.3389/fmicb.2019.01100
• http://doi.org/10.1016/j.micinf.2012.04.001
• http://doi.org/10.7717/peerj.1734
• http://doi.org/10.1111/1574-6968.12123
• http://doi.org/10.1146/annurev-arplant-042811-105518
• http://doi.org/10.1038/nature.2015.18055
• http://doi.org/10.1111/mpp.12005
• http://doi.org/10.1016/j.pbi.2012.05.006
• http://doi.org/10.1038/ncomms2157
• http://doi.org/10.5423/PPJ.OA.06.2013.0057
• http://doi.org/10.1016/j.coph.2013.07.003
• http://doi.org/10.1371/journal.pone.0059428
• http://doi.org/10.1371/journal.pone.0103730

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• {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0029192", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Journal Comments | Further Information

• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/ef1c679b-6867-44a0-9568-92b4b8f51ba4", "title"=>"Lets talk: A story of interspecies communication", "body"=>"It was Sept 4, 1939, the day after the UK declared war on Germany, when mathematician Alan Turing reported to work at the Government Code and Cypher School at Bletchley Park. Within weeks of his arrival, Turing and his colleagues were able to intercept high-level encrypted enemy communication signals and decode a vast number of these messages. The intelligence gleaned from this effort was passed on to field commanders, a process that was decisive to Allied victory.\n\nLike the German military strategists, single-celled bacteria communicate with each other using coded messages to coordinate attacks on their targets. For bacteria these targets are plants and animals that provide the nutrients needed for growth. Until now, the diversity of codes employed by invading bacteria was thought to be extremely limited. However, our new research shows that bacteria communicate with a previously unknown signal. The research is described in two articles published today in the Public Library of Science and Discovery Medicine.\n\nIn a feat worthy of the Turing cryptographers, some plants have evolved a cypher-breaking detection system, called the XA21 receptor, that intercept the bacterial code and use this information to trigger a robust immune response, preventing disease. \n\nFor more, please read the full story here:\nhttp://scienceblogs.com/tomorrowstable/2011/12/lets_talk_a_story_of_interspec.php", "isRemoved"=>false, "created"=>"2011-12-13T17:30:41Z", "lastModified"=>"2011-12-13T17:30:41Z", "creator"=>{"userId"=>"31129"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0029192", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2011-12-13T17:30:41Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/167fb0b9-a72d-404d-bb9d-3109618842fe", "title"=>"Media Coverage of This Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: R&D Magazine \nTitle: “New communication code discovered in disease-causing bacteria | R&D Mag”\nhttp://www.rdmag.com/News/2011/12/Life-Science-Bacteria-Disease-New-communication-code-discovered-in-disease-causing-bacteria\n\nPublication: Science Blogs Tomorrow's Table \nTitle: “Lets Talk: A Story of Interspecies Communication : Tomorrow's Table”\nhttp://scienceblogs.com/tomorrowstable/2011/12/lets_talk_a_story_of_interspec.php#more\n\nPublication: Western Farm Press \nTitle: “Bacteria 'talk' and trigger defensive response in crops | Management content from Western Farm Press”\nhttp://westernfarmpress.com/management/bacteria-talk-and-trigger-defensive-response-crops\n\nPublication: Eureka Alert \nTitle: “Tiny protein helps bacteria 'talk' and triggers defensive response in plants”\nhttp://www.eurekalert.org/pub_releases/2011-12/uoc--tph121011.php\n\nPublication: Scientific American Blogs \nTitle: “Lets Talk: A story of interspecies communication | Guest Blog, Scientific American Blog Network”\nhttp://blogs.scientificamerican.com/guest-blog/2011/12/12/lets-talk-a-story-of-interspecies-communication\n\nPublication: Eureka Alert \nTitle: “New communication code discovered in disease-causing bacteria”\nhttp://www.eurekalert.org/pub_releases/2011-12/plos-ncc120911.php\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. ", "isRemoved"=>false, "created"=>"2011-12-16T21:37:38Z", "lastModified"=>"2011-12-16T21:37:38Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLoS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0029192", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>1, "mostRecentActivity"=>"2012-01-13T19:34:06Z", "replies"=>[{"type"=>"REPLY", "parentID"=>1947, "annotationUri"=>"info:doi/10.1371/reply/bebd2f85-35f6-4613-8949-140cb58a813d", "title"=>"RE: Media Coverage of This Article", "body"=>"The following article represents some of the media coverage that has occurred for this paper:\n\nPublication: Tree Of Life blog \nTitle: “The Tree of Life: Cracking the microbial code: Pam Ronald @pcronald and her story behind recent papers”\nhttp://phylogenomics.blogspot.com/2012/01/cracking-microbial-code-pam-ronald.html\n\nIf you see any additional coverage of this paper in the press or blogosphere, please reply to this thread and add the link to the article. ", "isRemoved"=>false, "created"=>"2012-01-13T19:34:06Z", "lastModified"=>"2012-01-13T19:34:06Z", "creator"=>{"userId"=>"80539"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>true, "body"=>"PLoS ONE Staff"}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0029192", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-01-13T19:34:06Z", "replies"=>[]}]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/86828aca-cbbf-485a-9a7f-da94d373229b", "title"=>"Blog post relating to this article", "body"=>"The senior author on this paper, Pamela Ronald, has written a post for my blog on the \"Story behind the paper\" for this paper. The post covers many details on the history behind the work. See http://phylogenomics.blogspot.com/2012/01/cracking-microbial-code-pam-ronald.html ", "isRemoved"=>false, "created"=>"2012-01-14T03:55:13Z", "lastModified"=>"2012-01-14T03:55:13Z", "creator"=>{"userId"=>"162783"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0029192", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2012-01-14T03:55:13Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/0a21d6f6-f9b9-4cef-9e01-10f86838679a", "title"=>"Correction", "body"=>"As a result of recent experiments in my laboratory, I wish to comment on the report of Han et al., 2011. Specifically, members of my laboratory have recently discovered critical errors in strain PXO99Δax21 used in the reported work. Because key parts of the work depend on the integrity of strain PXO99Δax21, we are now repeating all of the experiments using newly generated and validated strains. We will report the outcome of each of these experiments on this page. We note that much of the work has been independently validated in other laboratories (see McCarthy et al., 2011, J Bacteriology 193:6375-6378). \n\n\nSang-Wook Han, Malinee Sriariyanun, Sang-Won Lee, Manoj Sharma, Ofir Bahar, Zachary Bower and Pamela C. Ronald\n\n", "isRemoved"=>false, "created"=>"2013-01-29T02:33:12Z", "lastModified"=>"2013-01-29T02:33:12Z", "creator"=>{"userId"=>"31129"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0029192", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2013-01-29T02:33:12Z", "replies"=>[]}
• {"type"=>"COMMENT", "annotationUri"=>"info:doi/10.1371/annotation/9a2586d9-c8fe-4f7a-8bda-f2bdfdfdff0c", "title"=>"Lablife: Anatomy of a Retraction", "body"=>"Read the details on Scientific American. \n\nhttp://blogs.scientificamerican.com/food-matters/2013/10/10/lab-life-the-anatomy-of-a-retraction/", "isRemoved"=>false, "created"=>"2013-10-10T20:02:22Z", "lastModified"=>"2013-10-10T20:02:22Z", "creator"=>{"userId"=>"31129"}, "highlightedText"=>"", "competingInterestStatement"=>{"creatorWasPrompted"=>true, "hasCompetingInterests"=>false}, "parentArticle"=>{"doi"=>"info:doi/10.1371/journal.pone.0029192", "state"=>"published", "journals"=>{"PLoSONE"=>{"journalKey"=>"PLoSONE", "eIssn"=>"1932-6203", "title"=>"PLOS ONE"}}}, "replyTreeSize"=>0, "mostRecentActivity"=>"2013-10-10T20:02:22Z", "replies"=>[]}

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• {"id"=>"316662161751543809", "text"=>"@surt_lab Quorum sensing role for Ax21 from @pcronald lab http://t.co/sJr5jTeafs", "created_at"=>"2013-03-26T21:25:17Z", "user"=>"plantTF", "user_name"=>"Transcription Factor", "user_profile_image"=>"http://a0.twimg.com/profile_images/3393335554/2d94490686833af7c779487b4250db03_normal.png"}
• {"id"=>"597550761258586114", "text"=>"@arjunrajlab @leonidkruglyak @BioMickWatson @joe_pickrell eg. http://t.co/udFBC2OdCF", "created_at"=>"2015-05-10T23:56:18Z", "user"=>"lizatucsf", "user_name"=>"Liz Silva", "user_profile_image"=>"http://pbs.twimg.com/profile_images/574715820279926784/BkNs0-7M_normal.jpeg"}

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• {"title"=>"Pamela Ronald", "url"=>"http://en.wikipedia.org/wiki/Pamela_Ronald", "timestamp"=>"2019-02-18T00:13:28Z"}

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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/704092"], "description"=>"<p>Expression of the <i>raxST, raxB,</i> and <i>raxR</i> genes in PXO99 (10⁶ and 10⁸ CFU/ml, grey), PXO99<i>Δax21</i> (10⁸ CFU/ml, black), and PXO99<i>Δax21</i> (10⁸ CFU/ml) supplemented with exogenous addition of the flow-through (FT), 150 mM (150), or 250 mM (250) imidazole buffer-eluted fractions (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029192#pone.0029192.s002\" target=\"_blank\">figure S2</a>) was assessed. Levels of gene expression were calculated relative to 16sRNA expression. Primers specific to each gene are as listed in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029192#pone.0029192.s021\" target=\"_blank\">table S8</a>. Data are mean of four replicates ± standard deviation (SD.).</p>", "links"=>[], "tags"=>["recombinant", "ax21", "complements", "density-dependent"], "article_id"=>374437, "categories"=>["Microbiology", "Immunology", "Plant Biology"], "users"=>["Sang-Wook Han", "Malinee Sriariyanun", "Sang-Won Lee", "Manoj Sharma", "Ofir Bahar", "Zachary Bower", "Pamela C. Ronald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029192.g001", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Purified_recombinant_Ax21_complements_density_dependent_expression_of_raxST_raxB_and_raxR_in_PXO99_916_ax21_/374437", "title"=>"Purified recombinant Ax21 complements density-dependent expression of <i>raxST, raxB</i>, and <i>raxR</i> in PXO99<i>Δax21.</i>", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-12 01:13:57"}
• {"files"=>["https://ndownloader.figshare.com/files/704180"], "description"=>"<p>A heat map represents the ratio of gene expression levels in a log₂-based pseudocolor scale (red, positive; green, negative). (A) Expression pattern of genes encoding proteins predicted to regulate c-di-GMP turnover in PXO99 (Left) and PXO99<i>Δax21</i> (Right). (B) Ax21 up-regulated genes that are highly expressed in early log phase including bacterial motility genes and xanthan gum biosynthesis. The functions of the genes marked by a star were assessed for phenotypes in <i>Xoo</i> knockout strains (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029192#pone.0029192.s013\" target=\"_blank\">Figure S13</a>).</p>", "links"=>[], "tags"=>["genome", "transcriptomics", "pxo99", "densities", "identifies", "ax21-regulated"], "article_id"=>374526, "categories"=>["Microbiology", "Immunology", "Plant Biology"], "users"=>["Sang-Wook Han", "Malinee Sriariyanun", "Sang-Won Lee", "Manoj Sharma", "Ofir Bahar", "Zachary Bower", "Pamela C. Ronald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029192.g002", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Whole_genome_transcriptomics_of_PXO99_vs_PXO99_916_ax21_at_different_population_densities_identifies_Ax21_regulated_genes_/374526", "title"=>"Whole genome transcriptomics of PXO99 vs. PXO99<i>Δax21</i> at different population densities identifies Ax21-regulated genes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-12 01:15:26"}
• {"files"=>["https://ndownloader.figshare.com/files/358515", "https://ndownloader.figshare.com/files/358548", "https://ndownloader.figshare.com/files/358627", "https://ndownloader.figshare.com/files/358685", "https://ndownloader.figshare.com/files/358725", "https://ndownloader.figshare.com/files/358773", "https://ndownloader.figshare.com/files/358834", "https://ndownloader.figshare.com/files/358874", "https://ndownloader.figshare.com/files/358934", "https://ndownloader.figshare.com/files/359004", "https://ndownloader.figshare.com/files/359079", "https://ndownloader.figshare.com/files/359154", "https://ndownloader.figshare.com/files/359197", "https://ndownloader.figshare.com/files/359330", "https://ndownloader.figshare.com/files/359385", "https://ndownloader.figshare.com/files/359433", "https://ndownloader.figshare.com/files/359498", "https://ndownloader.figshare.com/files/359601", "https://ndownloader.figshare.com/files/359651", "https://ndownloader.figshare.com/files/359755", "https://ndownloader.figshare.com/files/359835", "https://ndownloader.figshare.com/files/359882", "https://ndownloader.figshare.com/files/359930", "https://ndownloader.figshare.com/files/359965"], "description"=>"<div><p>The rice XA21 pattern recognition receptor binds a type I secreted sulfated peptide, called axY^S22, derived from the Ax21 (<u>a</u>ctivator of <u>X</u>A<u>21</u>-mediated immunity) protein. The conservation of Ax21 in all sequenced <em>Xanthomonas spp.</em> and closely related genera suggests that Ax21 serves a key biological function. Here we show that the predicted N-terminal sequence of Ax21 is cleaved prior to secretion outside the cell and that mature Ax21 serves as a quorum sensing (QS) factor in <em>Xanthomonas oryzae</em> pv. <em>oryzae</em>. Ax21-mediated QS controls motility, biofilm formation and virulence. We provide genetic evidence that the <em>Xoo</em> RaxH histidine kinase serves as the bacterial receptor for Ax21. This work establishes a critical role for small protein-mediated QS in a Gram-negative bacterium.</p> </div>", "links"=>[], "tags"=>["protein-mediated", "quorum", "sensing", "gram-negative", "bacterium"], "article_id"=>130875, "categories"=>["Microbiology", "Immunology", "Cell Biology"], "users"=>["Sang-Wook Han", "Malinee Sriariyanun", "Sang-Won Lee", "Manoj Sharma", "Ofir Bahar", "Zachary Bower", "Pamela C. Ronald"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029192.s001", "https://dx.doi.org/10.1371/journal.pone.0029192.s002", "https://dx.doi.org/10.1371/journal.pone.0029192.s003", "https://dx.doi.org/10.1371/journal.pone.0029192.s004", "https://dx.doi.org/10.1371/journal.pone.0029192.s005", "https://dx.doi.org/10.1371/journal.pone.0029192.s006", "https://dx.doi.org/10.1371/journal.pone.0029192.s007", "https://dx.doi.org/10.1371/journal.pone.0029192.s008", "https://dx.doi.org/10.1371/journal.pone.0029192.s009", "https://dx.doi.org/10.1371/journal.pone.0029192.s010", "https://dx.doi.org/10.1371/journal.pone.0029192.s011", "https://dx.doi.org/10.1371/journal.pone.0029192.s012", "https://dx.doi.org/10.1371/journal.pone.0029192.s013", "https://dx.doi.org/10.1371/journal.pone.0029192.s014", "https://dx.doi.org/10.1371/journal.pone.0029192.s015", "https://dx.doi.org/10.1371/journal.pone.0029192.s016", "https://dx.doi.org/10.1371/journal.pone.0029192.s017", "https://dx.doi.org/10.1371/journal.pone.0029192.s018", "https://dx.doi.org/10.1371/journal.pone.0029192.s019", "https://dx.doi.org/10.1371/journal.pone.0029192.s020", "https://dx.doi.org/10.1371/journal.pone.0029192.s021", "https://dx.doi.org/10.1371/journal.pone.0029192.s022", "https://dx.doi.org/10.1371/journal.pone.0029192.s023", "https://dx.doi.org/10.1371/journal.pone.0029192.s024"], "stats"=>{"downloads"=>7, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Small_Protein_Mediated_Quorum_Sensing_in_a_Gram_Negative_Bacterium/130875", "title"=>"Small Protein-Mediated Quorum Sensing in a Gram-Negative Bacterium", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-12-12 00:14:35"}
• {"files"=>["https://ndownloader.figshare.com/files/704273"], "description"=>"<p>(A) Biofilm formation of PXO99, PXO99<i>Δax21</i>, PXO99<i>Δax21</i> supplemented with exogenous addition of the flow-through (FT), 150 mM (150), or 250 mM (250) imidazole buffer-eluted fractions (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029192#pone.0029192.s002\" target=\"_blank\">figure S2</a>) were measured according to absorbance at A₅₉₀ using the polyvinyl chloride plate assay and normalized with the value of PXO99. Bars represent the mean of ten biological replicates ± SD. (B) Aggregation assays were performed using PXO99 and PXO99Δ<i>ax21</i> strains carrying a green fluorescent protein. <i>Xoo</i> strains were observed with a microscope equipped with a fluorescein isothiocyanate filter (excitation filter, 450 to 490 nm; emission filter, 520 nm; dichroic mirror, 510 nm). The bars indicate 10 µm. (C) Swimming motility of PXO99 and PXO99<i>Δax21</i> strains were quantified by measuring the diameter of colony expansion in swimming motility assays. Bars represent the mean of four biological replicates ± SD. (D) Virulence of PXO99 and PXO99<i>Δax21</i> was monitored at low population densities. Rice leaves (TP309 cultivar) were inoculated with PXO99, PXO99Δ<i>raxST</i>, and PXO99Δ<i>ax21</i> strains using the soaking method (10³ CFU/ml) for two days. Bacterial populations were determined two days after inoculation. Bars represent the mean from at least seven leaves ± SD. The experiment was repeated four times with similar results.</p>", "links"=>[], "tags"=>["regulates", "biofilm"], "article_id"=>374630, "categories"=>["Microbiology", "Immunology", "Plant Biology"], "users"=>["Sang-Wook Han", "Malinee Sriariyanun", "Sang-Won Lee", "Manoj Sharma", "Ofir Bahar", "Zachary Bower", "Pamela C. Ronald"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029192.g003", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ax21_regulates_Xoo_biofilm_formation_cell_aggregation_motility_and_virulence_/374630", "title"=>"Ax21 regulates <i>Xoo</i> biofilm formation, cell aggregation, motility, and virulence.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-12 01:17:10"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime | Further Information

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