Blue News Update: BODIPY-GTP Binds to the Blue-Light Receptor YtvA While GTP Does Not
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{"title"=>"Blue news update: BODIPY-GTP binds to the blue-light receptor YtvA while GTP does not", "type"=>"journal", "authors"=>[{"first_name"=>"Matthias", "last_name"=>"Dorn", "scopus_author_id"=>"36672777600"}, {"first_name"=>"Marcel", "last_name"=>"Jurk", "scopus_author_id"=>"35094052900"}, {"first_name"=>"Peter", "last_name"=>"Schmieder", "scopus_author_id"=>"7003292403"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84855705834", "doi"=>"10.1371/journal.pone.0029201", "scopus"=>"2-s2.0-84855705834", "pui"=>"364073987", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22247770"}, "id"=>"14339303-5b93-3276-833e-943e8586a79b", "abstract"=>"Light is an important environmental factor for almost all organisms. It is mainly used as an energy source but it is also a key factor for the regulation of multiple cellular functions. Light as the extracellular stimulus is thereby converted into an intracellular signal by photoreceptors that act as signal transducers. The blue-light receptor YtvA, a bacterial counterpart of plant phototropins, is involved in the stress response of Bacillus subtilis. The mechanism behind its activation, however, remains unknown. It was suggested based on fluorescence spectroscopic studies that YtvA function involves GTP binding and that this interaction is altered by absorption of light. We have investigated this interaction by several biophysical methods and show here using fluorescence spectroscopy, ITC titrations, and three NMR spectroscopic assays that while YtvA interacts with BODIPY-GTP as a fluorescent GTP analogue originally used for the detection of GTP binding, it does not bind GTP.", "link"=>"http://www.mendeley.com/research/blue-news-update-bodipygtp-binds-bluelight-receptor-ytva-while-gtp-not", "reader_count"=>19, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Bachelor"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>8, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Bachelor"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>1, "Physics and Astronomy"=>2, "Chemistry"=>4, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Chemistry"=>{"Chemistry"=>4}, "Physics and Astronomy"=>{"Physics and Astronomy"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/694012"], "description"=>"<p>WaterLOGSY (A) and STD-Watergate (B) of 20 µM dark state YtvA mixed with 200 µM GTP. WaterLOGSY (C) and STD-Watergate (D) of 20 µM lit state YtvA mixed with 200 µM GTP. Watergate of (E) 20 µM dark state YtvA and (F) 200 µM GTP. Signals belonging to GTP are connected by dotted lines. Exchangeable ligand protons are marked by arrows.</p>", "links"=>[], "tags"=>["ligand", "1d", "spectra", "molecular", "interactions", "ytva"], "article_id"=>364449, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.g006", "stats"=>{"downloads"=>2, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sections_of_ligand_detected_1D_1_H_NMR_spectra_from_the_analysis_of_weak_molecular_interactions_between_YtvA_and_GTP_/364449", "title"=>"Sections of ligand detected 1D <sup>1</sup>H-NMR spectra from the analysis of weak molecular interactions between YtvA and GTP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-11 01:14:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/693587"], "description"=>"<p>Fluorescence spectra obtained from experiments using BODIPY-GTP (A) or BODIPY (B) as the fluorophore. The spectra are shown in a ‘bottom to the top’ order for 2.2 µM sole fluorophore, 3 µM sole fluorophore, 2.2 µM fluorophore with 12 µM YtvA and 3 µM fluorophore with 12 µM YtvA-STAS.</p>", "links"=>[], "tags"=>["fluorescence"], "article_id"=>364035, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.g002", "stats"=>{"downloads"=>3, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_fluorescence_spectra_/364035", "title"=>"Comparison of fluorescence spectra.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-11 01:07:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/693438"], "description"=>"<p>Structural formula of BODIPY-GTP (top) and BODIPY methyl ester (bottom).</p>", "links"=>[], "tags"=>["immunology", "microbiology", "cell biology", "biophysics", "Biochemistry"], "article_id"=>363877, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fluorescent_dyes_/363877", "title"=>"Fluorescent dyes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-11 01:04:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/693813"], "description"=>"<p>Plots of the <sup>1</sup>H-<sup>15</sup>N-TROSY cross peak intensity ratios of (A) 50 µM uniformly <sup>2</sup>H-<sup>15</sup>N-labeled YtvA with and without 500 µM GTP and (B) 50 µM uniformly <sup>2</sup>H-<sup>15</sup>N-labeled YtvA with and without 500 µM BODIPY-GTP against the YtvA sequence. Corresponding 2D <sup>1</sup>H-<sup>15</sup>N-TROSY spectra were recorded with YtvA kept in the dark state. Residues are represented by asterisks for the LOV domain, triangles for the Jα-helix and circles for STAS domain. An intensity ratio of 1 (dashed line) means that the addition of the appropriate ligand has shown no effect on corresponding residues.</p>", "links"=>[], "tags"=>["ratios"], "article_id"=>364264, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.g004", "stats"=>{"downloads"=>2, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Plots_of_1_H_15_N_TROSY_cross_peak_intensity_ratios_of_YtvA_/364264", "title"=>"Plots of <sup>1</sup>H-<sup>15</sup>N-TROSY cross peak intensity ratios of YtvA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-11 01:11:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/694119"], "description"=>"<p>n.b.d.: no binding detected.</p>", "links"=>[], "tags"=>["itc", "experiments", "ytva"], "article_id"=>364554, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_the_ITC_experiments_with_YtvA_and_YtvA_STAS_/364554", "title"=>"Results of the ITC experiments with YtvA and YtvA-STAS.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-01-11 01:15:54"}
  • {"files"=>["https://ndownloader.figshare.com/files/353508", "https://ndownloader.figshare.com/files/353568", "https://ndownloader.figshare.com/files/353599", "https://ndownloader.figshare.com/files/353628", "https://ndownloader.figshare.com/files/353662", "https://ndownloader.figshare.com/files/353705", "https://ndownloader.figshare.com/files/353745"], "description"=>"<div><p>Light is an important environmental factor for almost all organisms. It is mainly used as an energy source but it is also a key factor for the regulation of multiple cellular functions. Light as the extracellular stimulus is thereby converted into an intracellular signal by photoreceptors that act as signal transducers. The blue-light receptor YtvA, a bacterial counterpart of plant phototropins, is involved in the stress response of <em>Bacillus subtilis</em>. The mechanism behind its activation, however, remains unknown. It was suggested based on fluorescence spectroscopic studies that YtvA function involves GTP binding and that this interaction is altered by absorption of light. We have investigated this interaction by several biophysical methods and show here using fluorescence spectroscopy, ITC titrations, and three NMR spectroscopic assays that while YtvA interacts with BODIPY-GTP as a fluorescent GTP analogue originally used for the detection of GTP binding, it does not bind GTP.</p> </div>", "links"=>[], "tags"=>["bodipy-gtp", "binds", "blue-light", "receptor", "ytva", "gtp"], "article_id"=>129871, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029201.s001", "https://dx.doi.org/10.1371/journal.pone.0029201.s002", "https://dx.doi.org/10.1371/journal.pone.0029201.s003", "https://dx.doi.org/10.1371/journal.pone.0029201.s004", "https://dx.doi.org/10.1371/journal.pone.0029201.s005", "https://dx.doi.org/10.1371/journal.pone.0029201.s006", "https://dx.doi.org/10.1371/journal.pone.0029201.s007"], "stats"=>{"downloads"=>23, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Blue_News_Update_BODIPY_GTP_Binds_to_the_Blue_Light_Receptor_YtvA_While_GTP_Does_Not/129871", "title"=>"Blue News Update: BODIPY-GTP Binds to the Blue-Light Receptor YtvA While GTP Does Not", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-01-11 02:44:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/693711"], "description"=>"<p><sup>1</sup>H-<sup>15</sup>N-HSQC spectra of (A) 30 µM uniformly <sup>15</sup>N-labeled YtvA-STAS without (black) and with 180 µM GTP (red) and (B) 30 µM uniformly <sup>15</sup>N-labeled YtvA-STAS without (black) and with 180 µM BODIPY-GTP (red).</p>", "links"=>[], "tags"=>["spectra", "ytva-stas"], "article_id"=>364155, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Superposition_of_1_H_15_N_HSQC_spectra_of_YtvA_STAS_without_and_with_added_ligands_/364155", "title"=>"Superposition of <sup>1</sup>H-<sup>15</sup>N-HSQC spectra of YtvA-STAS without and with added ligands.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-11 01:09:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/693923"], "description"=>"<p>WaterLOGSY (A) and STD-Watergate (B) of 20 µM YtvA mixed with 200 µM BODIPY-GTP. Watergate of (C) 20 µM dark state YtvA and (D) 200 µM BODIPY-GTP. Signals of protons from the aromatic BODIPY part are marked by asterisks. Exchangeable ligand protons are marked by arrows.</p>", "links"=>[], "tags"=>["ligand", "1d", "spectra", "molecular", "interactions", "ytva"], "article_id"=>364357, "categories"=>["Microbiology", "Biochemistry", "Cell Biology", "Immunology", "Biophysics"], "users"=>["Matthias Dorn", "Marcel Jurk", "Peter Schmieder"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029201.g005", "stats"=>{"downloads"=>2, "page_views"=>25, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Sections_of_ligand_detected_1D_1_H_NMR_spectra_from_the_analysis_of_weak_molecular_interactions_between_dark_state_YtvA_and_BODIPY_GTP_/364357", "title"=>"Sections of ligand detected 1D <sup>1</sup>H-NMR spectra from the analysis of weak molecular interactions between dark state YtvA and BODIPY-GTP.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-11 01:12:37"}

PMC Usage Stats | Further Information

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Relative Metric

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