Safety and Immunogenicity of an HIV-1 Gag DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults
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{"title"=>"Safety and immunogenicity of an HIV-1 gag DNA vaccine with or without IL-12 and/or IL-15 plasmid cytokine adjuvant in healthy, HIV-1 uninfected adults", "type"=>"journal", "authors"=>[{"first_name"=>"Spyros A.", "last_name"=>"Kalams", "scopus_author_id"=>"7004215696"}, {"first_name"=>"Scott", "last_name"=>"Parker", "scopus_author_id"=>"35782373300"}, {"first_name"=>"Xia", "last_name"=>"Jin", "scopus_author_id"=>"26642974700"}, {"first_name"=>"Marnie", "last_name"=>"Elizaga", "scopus_author_id"=>"6506202106"}, {"first_name"=>"Barbara", "last_name"=>"Metch", "scopus_author_id"=>"35473322600"}, {"first_name"=>"Maggie", "last_name"=>"Wang", "scopus_author_id"=>"35199126000"}, {"first_name"=>"John", "last_name"=>"Hural", "scopus_author_id"=>"6508306131"}, {"first_name"=>"Michael", "last_name"=>"Lubeck", "scopus_author_id"=>"57198330003"}, {"first_name"=>"John", "last_name"=>"Eldridge", "scopus_author_id"=>"7102066998"}, {"first_name"=>"Massimo", "last_name"=>"Cardinali", "scopus_author_id"=>"56209629500"}, {"first_name"=>"William A.", "last_name"=>"Blattner", "scopus_author_id"=>"7102371375"}, {"first_name"=>"Magda", "last_name"=>"Sobieszczyk", "scopus_author_id"=>"6506322561"}, {"first_name"=>"Vinai", "last_name"=>"Suriyanon", "scopus_author_id"=>"6603605706"}, {"first_name"=>"Artur", "last_name"=>"Kalichman", "scopus_author_id"=>"6506117028"}, {"first_name"=>"David B.", "last_name"=>"Weiner", "scopus_author_id"=>"7202357355"}, {"first_name"=>"Lindsey R.", "last_name"=>"Baden", "scopus_author_id"=>"7004226511"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"364038014", "doi"=>"10.1371/journal.pone.0029231", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22242162", "issn"=>"19326203", "scopus"=>"2-s2.0-84855361060", "sgr"=>"84855361060"}, "id"=>"2e0a515b-0883-3812-8419-7521cc02b9b3", "abstract"=>"BACKGROUND: DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: We performed two first in human HIV vaccine trials in the US, Brazil and Thailand of an RNA-optimized truncated HIV-1 gag gene (p37) DNA derived from strain HXB2 administered either alone or in combination with dose-escalation of IL-12 or IL-15 plasmid cytokine adjuvants. Vaccinations with both the HIV immunogen and cytokine adjuvant were generally well-tolerated and no significant vaccine-related adverse events were identified. A small number of subjects developed asymptomatic low titer antibodies to IL-12 or IL-15. Cellular immunogenicity following 3 and 4 vaccinations was poor, with response rates to gag of 4.9%/8.7% among vaccinees receiving gag DNA alone, 0%/11.5% among those receiving gag DNA+IL-15, and no responders among those receiving DNA+high dose (1500 ug) IL-12 DNA. However, after three doses, 44.4% (4/9) of vaccinees receiving gag DNA and intermediate dose (500 ug) of IL-12 DNA demonstrated a detectable cellular immune response.\\n\\nCONCLUSIONS/SIGNIFICANCE: This combination of HIV gag DNA with plasmid cytokine adjuvants was well tolerated. There were minimal responses to HIV gag DNA alone, and no apparent augmentation with either IL-12 or IL-15 plasmid cytokine adjuvants. Despite the promise of DNA vaccines, newer formulations or methods of delivery will be required to increase their immunogenicity.\\n\\nTRIAL REGISTRATION: Clinicaltrials.gov NCT00115960 NCT00111605.", "link"=>"http://www.mendeley.com/research/safety-immunogenicity-hiv1-gag-dna-vaccine-without-il12-andor-il15-plasmid-cytokine-adjuvant-healthy", "reader_count"=>36, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>9, "Other"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>7, "Student > Master"=>9, "Other"=>2, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>21, "Medicine and Dentistry"=>9, "Neuroscience"=>1, "Business, Management and Accounting"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>9}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>21}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Brazil"=>1}, "group_count"=>3}

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  • {"files"=>["https://ndownloader.figshare.com/files/695087"], "description"=>"<p>Allocation, follow-up, and analysis cohorts for HVTN 060 and HVTN 063.</p>", "links"=>[], "tags"=>["cohorts", "hvtn", "060"], "article_id"=>365485, "categories"=>["Biotechnology", "Physiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029231.g001", "stats"=>{"downloads"=>0, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Allocation_follow_up_and_analysis_cohorts_for_HVTN_060_and_HVTN_063_/365485", "title"=>"Allocation, follow-up, and analysis cohorts for HVTN 060 and HVTN 063.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-05 01:31:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/695289"], "description"=>"<p>Panel A shows the maximum severity of pain or tenderness at the injection site and Panel B the maximum severity of systemic reactogenicity symptoms. Systemic symptoms include malaise and/or fatigue, myalgia, headache, nausea, vomiting, chills and arthralgia. Data for vaccinations 1–3 and for vaccinations 4–5 are combined. Data for adjuvants at a dose of 100 or 500 ug are also combined (labeled as low). Abbreviation PL = placebo.</p>", "links"=>[], "tags"=>["immunology", "Virology", "Infectious diseases", "public health and epidemiology", "physiology"], "article_id"=>365690, "categories"=>["Biotechnology", "Physiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029231.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Severity_of_vaccine_reactions_/365690", "title"=>"Severity of vaccine reactions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-05 01:34:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/695443"], "description"=>"<p>Abbreviations: CI-confidence interval; SFC-spot forming cells; NA-not applicable for those randomized to 3 vaccinations; ND-assay not performed.</p>", "links"=>[], "tags"=>["elispot"], "article_id"=>365845, "categories"=>["Biotechnology", "Physiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029231.t003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IFN_947_ELISpot_response_/365845", "title"=>"IFN-γ ELISpot response.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-01-05 01:37:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/695204"], "description"=>"<p>N3-5 – Number of participants randomized to either 3 dose or 5 dose regimen; N5 – Number of participants randomized to a 5 dose regimen.</p>", "links"=>[], "tags"=>["schema", "hvtn"], "article_id"=>365603, "categories"=>["Biotechnology", "Physiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029231.g002", "stats"=>{"downloads"=>2, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_schema_for_HVTN_060_063_/365603", "title"=>"Study schema for HVTN 060/063.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-01-05 01:33:23"}
  • {"files"=>["https://ndownloader.figshare.com/files/354238", "https://ndownloader.figshare.com/files/354313", "https://ndownloader.figshare.com/files/354500"], "description"=>"<div><h3>Background</h3><p>DNA vaccines are a promising approach to vaccination since they circumvent the problem of vector-induced immunity. DNA plasmid cytokine adjuvants have been shown to augment immune responses in small animals and in macaques.</p> <h3>Methodology/Principal Findings</h3><p>We performed two first in human HIV vaccine trials in the US, Brazil and Thailand of an RNA-optimized truncated HIV-1 <em>gag</em> gene (p37) DNA derived from strain HXB2 administered either alone or in combination with dose-escalation of IL-12 or IL-15 plasmid cytokine adjuvants. Vaccinations with both the HIV immunogen and cytokine adjuvant were generally well-tolerated and no significant vaccine-related adverse events were identified. A small number of subjects developed asymptomatic low titer antibodies to IL-12 or IL-15. Cellular immunogenicity following 3 and 4 vaccinations was poor, with response rates to <em>gag</em> of 4.9%/8.7% among vaccinees receiving <em>gag</em> DNA alone, 0%/11.5% among those receiving <em>gag</em> DNA+IL-15, and no responders among those receiving DNA+high dose (1500 ug) <em>IL-12</em> DNA. However, after three doses, 44.4% (4/9) of vaccinees receiving <em>gag</em> DNA and intermediate dose (500 ug) of <em>IL-12</em> DNA demonstrated a detectable cellular immune response.</p> <h3>Conclusions/Significance</h3><p>This combination of HIV <em>gag</em> DNA with plasmid cytokine adjuvants was well tolerated. There were minimal responses to HIV <em>gag</em> DNA alone, and no apparent augmentation with either IL-12 or IL-15 plasmid cytokine adjuvants. Despite the promise of DNA vaccines, newer formulations or methods of delivery will be required to increase their immunogenicity.</p> <h3>Trial Registration</h3><p>Clinicaltrials.gov <a href=\"http://clinicaltrials.gov/ct2/results?term=NCT00115960\">NCT00115960</a><a href=\"http://clinicaltrials.gov/ct2/results?term=NCT00111605\">NCT00111605</a></p> </div>", "links"=>[], "tags"=>["immunogenicity", "hiv-1", "dna", "il-12", "il-15", "plasmid", "cytokine", "adjuvant", "uninfected", "adults"], "article_id"=>130001, "categories"=>["Physiology", "Cancer", "Biotechnology", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029231.s001", "https://dx.doi.org/10.1371/journal.pone.0029231.s002", "https://dx.doi.org/10.1371/journal.pone.0029231.s003"], "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Safety_and_Immunogenicity_of_an_HIV_1_Gag_DNA_Vaccine_with_or_without_IL_12_and_or_IL_15_Plasmid_Cytokine_Adjuvant_in_Healthy_HIV_1_Uninfected_Adults/130001", "title"=>"Safety and Immunogenicity of an HIV-1 <em>Gag</em> DNA Vaccine with or without IL-12 and/or IL-15 Plasmid Cytokine Adjuvant in Healthy, HIV-1 Uninfected Adults", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-01-05 00:00:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/695380"], "description"=>"<p>Participant characteristics.</p>", "links"=>[], "tags"=>["immunology", "Virology", "Infectious diseases", "public health and epidemiology", "physiology"], "article_id"=>365776, "categories"=>["Biotechnology", "Physiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029231.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Participant_characteristics_/365776", "title"=>"Participant characteristics.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-01-05 01:36:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/695488"], "description"=>"<p>Abbreviations: NA – not applicable.</p><p>For vaccinations 1, 2 and 3, the denominator is the number of persons randomized to receive either 3 or 5 study injections.</p><p>For vaccinations 4 and 5, the denominator is the number randomized to 5 study injections.</p><p>The numerator is the number of people who actually received the specified vaccination.</p>", "links"=>[], "tags"=>["vaccinations"], "article_id"=>365902, "categories"=>["Biotechnology", "Physiology", "Virology", "Infectious Diseases", "Immunology"], "users"=>["Spyros A. Kalams", "Scott Parker", "Xia Jin", "Marnie Elizaga", "Barbara Metch", "Maggie Wang", "John Hural", "Michael Lubeck", "John Eldridge", "Massimo Cardinali", "William A. Blattner", "Magda Sobieszczyk", "Vinai Suriyanon", "Artur Kalichman", "David B. Weiner", "Lindsey R. Baden"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029231.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_vaccinations_received_/365902", "title"=>"Number of vaccinations received.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-01-05 01:38:22"}

PMC Usage Stats | Further Information

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  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"31", "year"=>"2012", "pdf"=>"38", "unique-ip"=>"29", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"50", "unique-ip"=>"46", "pdf"=>"33", "year"=>"2012", "figure"=>"13", "scanned-summary"=>"0", "supp-data"=>"3"}
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  • {"unique-ip"=>"37", "full-text"=>"41", "pdf"=>"26", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"29", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"1", "year"=>"2012", "month"=>"10"}
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  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
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  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"22", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"12", "full-text"=>"8", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"18", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"21", "full-text"=>"27", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"28", "full-text"=>"41", "pdf"=>"2", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"20", "full-text"=>"22", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"33", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"24", "full-text"=>"35", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
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Relative Metric

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