Influenza Vaccination for Immunocompromised Patients: Systematic Review and Meta-Analysis from a Public Health Policy Perspective
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{"title"=>"Influenza vaccination for immunocompromised patients: Systematic review and meta-analysis from a public health policy perspective", "type"=>"journal", "authors"=>[{"first_name"=>"Charles R.", "last_name"=>"Beck", "scopus_author_id"=>"54787392500"}, {"first_name"=>"Bruce C.", "last_name"=>"McKenzie", "scopus_author_id"=>"54788124000"}, {"first_name"=>"Ahmed B.", "last_name"=>"Hashim", "scopus_author_id"=>"36238808300"}, {"first_name"=>"Rebecca C.", "last_name"=>"Harris", "scopus_author_id"=>"56241522000"}, {"first_name"=>"Arina", "last_name"=>"Zanuzdana", "scopus_author_id"=>"54788709500"}, {"first_name"=>"Gabriel", "last_name"=>"Agboado", "scopus_author_id"=>"35621533600"}, {"first_name"=>"Elizabeth", "last_name"=>"Orton", "scopus_author_id"=>"54788164800"}, {"first_name"=>"Laura", "last_name"=>"Béchard-Evans", "scopus_author_id"=>"12806334400"}, {"first_name"=>"Gemma", "last_name"=>"Morgan", "scopus_author_id"=>"54787982400"}, {"first_name"=>"Charlotte", "last_name"=>"Stevenson", "scopus_author_id"=>"36244471500"}, {"first_name"=>"Rachel", "last_name"=>"Weston", "scopus_author_id"=>"54788672500"}, {"first_name"=>"Mitsuru", "last_name"=>"Mukaigawara", "scopus_author_id"=>"54788078500"}, {"first_name"=>"Joanne", "last_name"=>"Enstone", "scopus_author_id"=>"16165513400"}, {"first_name"=>"Glenda", "last_name"=>"Augustine", "scopus_author_id"=>"54787418700"}, {"first_name"=>"Mobasher", "last_name"=>"Butt", "scopus_author_id"=>"54787376900"}, {"first_name"=>"Sophie", "last_name"=>"Kim", "scopus_author_id"=>"54787839600"}, {"first_name"=>"Richard", "last_name"=>"Puleston", "scopus_author_id"=>"15751395500"}, {"first_name"=>"Girija", "last_name"=>"Dabke", "scopus_author_id"=>"54406634200"}, {"first_name"=>"Robert", "last_name"=>"Howard", "scopus_author_id"=>"54787850400"}, {"first_name"=>"Julie", "last_name"=>"O'Boyle", "scopus_author_id"=>"54788029100"}, {"first_name"=>"Mary", "last_name"=>"O'Brien", "scopus_author_id"=>"57197330314"}, {"first_name"=>"Lauren", "last_name"=>"Ahyow", "scopus_author_id"=>"54787476800"}, {"first_name"=>"Helene", "last_name"=>"Denness", "scopus_author_id"=>"54787491500"}, {"first_name"=>"Siobhan", "last_name"=>"Farmer", "scopus_author_id"=>"36721145700"}, {"first_name"=>"Jose", "last_name"=>"Figureroa", "scopus_author_id"=>"54787513800"}, {"first_name"=>"Paul", "last_name"=>"Fisher", "scopus_author_id"=>"54787656800"}, {"first_name"=>"Felix", "last_name"=>"Greaves", "scopus_author_id"=>"6602298531"}, {"first_name"=>"Munib", "last_name"=>"Haroon", "scopus_author_id"=>"6602995735"}, {"first_name"=>"Sophie", "last_name"=>"Haroon", "scopus_author_id"=>"24280646000"}, {"first_name"=>"Caroline", "last_name"=>"Hird", "scopus_author_id"=>"55175934200"}, {"first_name"=>"Rachel", "last_name"=>"Isba", "scopus_author_id"=>"6504716434"}, {"first_name"=>"David A.", "last_name"=>"Ishola", "scopus_author_id"=>"8216936100"}, {"first_name"=>"Marko", "last_name"=>"Kerac", "scopus_author_id"=>"24448116200"}, {"first_name"=>"Vivienne", "last_name"=>"Parish", "scopus_author_id"=>"54787969600"}, {"first_name"=>"Jonathan", "last_name"=>"Roberts", "scopus_author_id"=>"57199185884"}, {"first_name"=>"Julia", "last_name"=>"Rosser", "scopus_author_id"=>"54788411500"}, {"first_name"=>"Sarah", "last_name"=>"Theaker", "scopus_author_id"=>"54788653700"}, {"first_name"=>"Dean", "last_name"=>"Wallace", "scopus_author_id"=>"54788427100"}, {"first_name"=>"Neil", "last_name"=>"Wigglesworth", "scopus_author_id"=>"55771132900"}, {"first_name"=>"Liz", "last_name"=>"Lingard", "scopus_author_id"=>"54788177200"}, {"first_name"=>"Yana", "last_name"=>"Vinogradova", "scopus_author_id"=>"16311003100"}, {"first_name"=>"Hiroshi", "last_name"=>"Horiuchi", "scopus_author_id"=>"54787876000"}, {"first_name"=>"Javier", "last_name"=>"Peñalver", "scopus_author_id"=>"54788254100"}, {"first_name"=>"Jonathan S.", "last_name"=>"Nguyen-Van-Tam", "scopus_author_id"=>"7003371567"}], "year"=>2011, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84055216970", "doi"=>"10.1371/journal.pone.0029249", "sgr"=>"84055216970", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "pmid"=>"22216224", "issn"=>"19326203", "pui"=>"363132816"}, "id"=>"9e143b64-6e38-3eeb-9a9d-4127fca5bbf2", "abstract"=>"BACKGROUND: Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events.\\n\\nMETHODOLOGY/PRINCIPAL FINDINGS: Electronic databases and grey literature were searched and records were screened against eligibility criteria. Data extraction and risk of bias assessments were performed in duplicate. Results were synthesised narratively and meta-analyses were conducted where feasible. Heterogeneity was assessed using I(2) and publication bias was assessed using Begg's funnel plot and Egger's regression test. Many of the 209 eligible studies included an unclear or high risk of bias. Meta-analyses showed a significant effect of preventing influenza-like illness (odds ratio [OR]=0.23; 95% confidence interval [CI]=0.16-0.34; p<0.001) and laboratory confirmed influenza infection (OR=0.15; 95% CI=0.03-0.63; p=0.01) through vaccinating immunocompromised patie nts compared to placebo or unvaccinated controls. We found no difference in the odds of influenza-like illness compared to vaccinated immunocompetent controls. The pooled odds of seroconversion were lower in vaccinated patients compared to immunocompetent controls for seasonal influenza A(H1N1), A(H3N2) and B. A similar trend was identified for seroprotection. Meta-analyses of seroconversion showed higher odds in vaccinated patients compared to placebo or unvaccinated controls, although this reached significance for influenza B only. Publication bias was not detected and narrative synthesis supported our findings. No consistent evidence of safety concerns was identified.\\n\\nCONCLUSIONS/SIGNIFICANCE: Infection prevention and control strategies should recommend vaccinating immunocompromised patients. Potential for bias and confounding and the presence of heterogeneity mean the evidence reviewed is generally weak, although the directions of effects are consistent. Areas for further research are identified.", "link"=>"http://www.mendeley.com/research/influenza-vaccination-immunocompromised-patients-systematic-review-metaanalysis-public-health-policy", "reader_count"=>48, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>11, "Student > Master"=>7, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Other"=>11, "Student > Master"=>7, "Student > Bachelor"=>5, "Lecturer > Senior Lecturer"=>1, "Professor"=>6}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Environmental Science"=>3, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>24, "Agricultural and Biological Sciences"=>6, "Philosophy"=>1, "Business, Management and Accounting"=>1, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>2, "Social Sciences"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>24}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>3}, "Philosophy"=>{"Philosophy"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "reader_count_by_country"=>{"Haiti"=>1, "Austria"=>1, "Czech Republic"=>1, "Hong Kong"=>1, "United States"=>1, "Japan"=>1, "United Kingdom"=>2, "Switzerland"=>1}, "group_count"=>3}

Scopus | Further Information

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  • {"files"=>["https://ndownloader.figshare.com/files/355571", "https://ndownloader.figshare.com/files/355619", "https://ndownloader.figshare.com/files/355836", "https://ndownloader.figshare.com/files/355900", "https://ndownloader.figshare.com/files/355943", "https://ndownloader.figshare.com/files/355987", "https://ndownloader.figshare.com/files/356155"], "description"=>"<div><h3>Background</h3><p>Immunocompromised patients are vulnerable to severe or complicated influenza infection. Vaccination is widely recommended for this group. This systematic review and meta-analysis assesses influenza vaccination for immunocompromised patients in terms of preventing influenza-like illness and laboratory confirmed influenza, serological response and adverse events.</p> <h3>Methodology/Principal Findings</h3><p>Electronic databases and grey literature were searched and records were screened against eligibility criteria. Data extraction and risk of bias assessments were performed in duplicate. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029249#s3\">Results</a> were synthesised narratively and meta-analyses were conducted where feasible. Heterogeneity was assessed using I<sup>2</sup> and publication bias was assessed using Begg's funnel plot and Egger's regression test. Many of the 209 eligible studies included an unclear or high risk of bias. Meta-analyses showed a significant effect of preventing influenza-like illness (odds ratio [OR] = 0.23; 95% confidence interval [CI] = 0.16–0.34; p<0.001) and laboratory confirmed influenza infection (OR = 0.15; 95% CI = 0.03–0.63; p = 0.01) through vaccinating immunocompromised patie nts compared to placebo or unvaccinated controls. We found no difference in the odds of influenza-like illness compared to vaccinated immunocompetent controls. The pooled odds of seroconversion were lower in vaccinated patients compared to immunocompetent controls for seasonal influenza A(H1N1), A(H3N2) and B. A similar trend was identified for seroprotection. Meta-analyses of seroconversion showed higher odds in vaccinated patients compared to placebo or unvaccinated controls, although this reached significance for influenza B only. Publication bias was not detected and narrative synthesis supported our findings. No consistent evidence of safety concerns was identified.</p> <h3>Conclusions/Significance</h3><p>Infection prevention and control strategies should recommend vaccinating immunocompromised patients. Potential for bias and confounding and the presence of heterogeneity mean the evidence reviewed is generally weak, although the directions of effects are consistent. Areas for further research are identified.</p> </div>", "links"=>[], "tags"=>["influenza", "vaccination", "immunocompromised", "systematic", "meta-analysis"], "article_id"=>130210, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029249.s001", "https://dx.doi.org/10.1371/journal.pone.0029249.s002", "https://dx.doi.org/10.1371/journal.pone.0029249.s003", "https://dx.doi.org/10.1371/journal.pone.0029249.s004", "https://dx.doi.org/10.1371/journal.pone.0029249.s005", "https://dx.doi.org/10.1371/journal.pone.0029249.s006", "https://dx.doi.org/10.1371/journal.pone.0029249.s007"], "stats"=>{"downloads"=>3, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Influenza_Vaccination_for_Immunocompromised_Patients_Systematic_Review_and_Meta_Analysis_from_a_Public_Health_Policy_Perspective/130210", "title"=>"Influenza Vaccination for Immunocompromised Patients: Systematic Review and Meta-Analysis from a Public Health Policy Perspective", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2011-12-22 00:03:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/699386"], "description"=>"<p>Summary of study selection process.</p>", "links"=>[], "tags"=>["immunology"], "article_id"=>369698, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.g001", "stats"=>{"downloads"=>1, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_study_selection_process_/369698", "title"=>"Summary of study selection process.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-22 02:41:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/700017"], "description"=>"<p>*Applied to respiratory and autoimmune conditions only; no specification of dosage or duration of therapy.</p>", "links"=>[], "tags"=>["eligibility"], "article_id"=>370350, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.t001", "stats"=>{"downloads"=>0, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Study_eligibility_criteria_/370350", "title"=>"Study eligibility criteria.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-22 00:05:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/699933"], "description"=>"<p>*Three studies recruited multiple groups of immunocompromised patients <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029249#pone.0029249-Bellei1\" target=\"_blank\">[52]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029249#pone.0029249-DelPorto1\" target=\"_blank\">[89]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029249#pone.0029249-Hodges1\" target=\"_blank\">[119]</a>.</p>", "links"=>[], "tags"=>["characteristics"], "article_id"=>370259, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.t003", "stats"=>{"downloads"=>0, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_study_characteristics_n_8202_8202_209_/370259", "title"=>"Summary of study characteristics (n = 209).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-22 00:04:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/699841"], "description"=>"<p>Information sources.</p>", "links"=>[], "tags"=>["immunology"], "article_id"=>370170, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.t002", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Information_sources_/370170", "title"=>"Information sources.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-22 00:02:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/699751"], "description"=>"<p>Values in parentheses show the reported range of adverse events and number of studies; IC = immunocompromised; VICT = vaccinated immunocompetent; PNV = placebo or no vaccination.</p>", "links"=>[], "tags"=>["adverse", "chmp"], "article_id"=>370075, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.t005", "stats"=>{"downloads"=>4, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Median_adverse_event_rate_by_CHMP_criteria_/370075", "title"=>"Median adverse event rate by CHMP criteria.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-22 00:01:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/699525"], "description"=>"<p>Legend: (A) = influenza-like illness (placebo or no vaccination comparator); (B) = influenza-like illness (vaccinated immunocompetent controls); (C) = laboratory confirmed influenza (placebo or no vaccination comparator). Note that each of the three plots shown has different scaled x-axes.</p>", "links"=>[], "tags"=>["studies", "influenza-like", "confirmed"], "article_id"=>369850, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_for_studies_on_influenza_like_illness_and_laboratory_confirmed_influenza_/369850", "title"=>"Forest plot for studies on influenza-like illness and laboratory confirmed influenza.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2011-12-22 02:44:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/699654"], "description"=>"<p>* = some studies contributed two sets of data included in this meta-analysis; (S) = seasonal; (P) = pandemic; ES = effect size; CI = confidence interval; SC1 = seroconversion (≥4 fold rise post vaccination); SC2 = seroconversion (<1∶40 to ≥1∶40 haemagglutination inhibition titre); SP = seroprotection (≥1∶40 haemagglutination inhibition titre post vaccination); VICT = vaccinated immunocompetent controls; PNV = placebo or no vaccination; NS = not statistically significant. See <i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029249#pone.0029249.s002\" target=\"_blank\">Figure S2</a></i> for citation details.</p>", "links"=>[], "tags"=>["meta-analyses"], "article_id"=>369983, "categories"=>["Immunology"], "users"=>["Charles R. Beck", "Bruce C. McKenzie", "Ahmed B. Hashim", "Rebecca C. Harris", "Arina Zanuzdana", "Gabriel Agboado", "Elizabeth Orton", "Laura Béchard-Evans", "Gemma Morgan", "Charlotte Stevenson", "Rachel Weston", "Mitsuru Mukaigawara", "Joanne Enstone", "Glenda Augustine", "Mobasher Butt", "Sophie Kim", "Richard Puleston", "Girija Dabke", "Robert Howard", "Julie O'Boyle", "Mary O'Brien", "Lauren Ahyow", "Helene Denness", "Siobhan Farmer", "Jose Figureroa", "Paul Fisher", "Felix Greaves", "Munib Haroon", "Sophie Haroon", "Caroline Hird", "Rachel Isba", "David A. Ishola", "Marko Kerac", "Vivienne Parish", "Jonathan Roberts", "Julia Rosser", "Sarah Theaker", "Dean Wallace", "Neil Wigglesworth", "Liz Lingard", "Yana Vinogradova", "Hiroshi Horiuchi", "Javier Peñalver", "Jonathan S. Nguyen-Van-Tam"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0029249.t004", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_meta_analyses_for_immune_response_to_vaccination_/369983", "title"=>"Summary of meta-analyses for immune response to vaccination.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2011-12-22 02:46:23"}

PMC Usage Stats | Further Information

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Relative Metric

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