Are Long-Term Non-Progressors Very Slow Progressors? Insights from the Chelsea and Westminster HIV Cohort, 1988–2010
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{"title"=>"Are long-term non-progressors very slow progressors? insights from the chelsea and westminster HIV cohort, 1988-2010", "type"=>"journal", "authors"=>[{"first_name"=>"Sundhiya", "last_name"=>"Mandalia", "scopus_author_id"=>"7003521085"}, {"first_name"=>"Samantha J.", "last_name"=>"Westrop", "scopus_author_id"=>"15052645900"}, {"first_name"=>"Eduard J.", "last_name"=>"Beck", "scopus_author_id"=>"7201593779"}, {"first_name"=>"Mark", "last_name"=>"Nelson", "scopus_author_id"=>"7403461374"}, {"first_name"=>"Brian G.", "last_name"=>"Gazzard", "scopus_author_id"=>"34874678500"}, {"first_name"=>"Nesrina", "last_name"=>"Imami", "scopus_author_id"=>"7003965238"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84857385883", "sgr"=>"84857385883", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0029844", "pmid"=>"22363409", "isbn"=>"1932-6203", "pui"=>"364311912"}, "id"=>"e2ea21a0-00d1-3ebd-9d12-c0c30d96f27c", "abstract"=>"Define and identify long-term non-progressors (LTNP) and HIV controllers (HIC), and estimate time until disease progression. LTNP are HIV-1(+) patients who maintain stable CD4(+) T-cell counts, with no history of opportunistic infection or antiretroviral therapy (ART). HIC are a subset of LTNP who additionally have undetectable viraemia. These individuals may provide insights for prophylactic and therapeutic development. Records of HIV-1(+) individuals attending Chelsea and Westminster Hospital (1988-2010), were analysed. LTNP were defined as: HIV-1(+) for >7 years; ART-naïve; no history of opportunistic infection and normal, stable CD4(+) T-cell counts. MIXED procedure in SAS using random intercept model identified long-term stable CD4(+) T-cell counts. Survival analysis estimated time since diagnosis until disease progression. Subjects exhibiting long-term stable CD4(+) T-cell counts with history below the normal range (<450 cells/µl blood) were compared to LTNP whose CD4(+) T-cell count always remained normal. Within these two groups subjects with HIV-1 RNA load below limit of detection (BLD) were identified. Of 14,227 patients, 1,204 were diagnosed HIV-1(+) over 7 years ago and were ART-naïve. Estimated time until disease progression for the 20% (239) whose CD4(+) T-cell counts remained within the normal range, was 6.2 years (IQR: 2.0 to 9.6); significantly longer than 4.0 years (IQR: 1.0 to 7.3) for patients with historical CD4(+) T-cell count below normal (Logrank chi-squared = 21.26; p<0.001). Within a subpopulation of 312 asymptomatic patients, 50 exhibited long-term stable CD4(+) T-cell counts. Of these, 13 were LTNP, one of whom met HIC criteria. Of the remaining 37 patients with long-term stable low CD4(+) T-cell counts, 3 controlled HIV-1 RNA load BLD. Individuals with stable, normal CD4(+) T-cell counts progressed less rapidly than those with low CD4(+) T-cell counts. Few LTNP and HIC identified in this and other studies, endorse the need for universal definitions to facilitate comparison.", "link"=>"http://www.mendeley.com/research/longterm-nonprogressors-very-slow-progressors-insights-chelsea-westminster-hiv-cohort-19882010", "reader_count"=>32, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>4, "Student > Bachelor"=>6}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>8, "Student > Postgraduate"=>1, "Student > Master"=>5, "Other"=>4, "Student > Bachelor"=>6}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>14, "Agricultural and Biological Sciences"=>10, "Business, Management and Accounting"=>1, "Computer Science"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Computer Science"=>{"Computer Science"=>2}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Belgium"=>1, "United States"=>1, "France"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/678663"], "description"=>"<p>Flow chart detailing the identification of LTNP and patients with long-term stable low CD4<sup>+</sup> T-cell counts from the Chelsea and Westminster HIV Cohort, during the study period 1988–2010.</p>", "links"=>[], "tags"=>["detailing", "ltnp", "patients", "t-cell", "counts", "chelsea", "westminster", "hiv"], "article_id"=>349130, "categories"=>["Virology", "Infectious Diseases"], "users"=>["Sundhiya Mandalia", "Samantha J. Westrop", "Eduard J. Beck", "Mark Nelson", "Brian G. Gazzard", "Nesrina Imami"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029844.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Flow_chart_detailing_the_identification_of_LTNP_and_patients_with_long_term_stable_low_CD4_T_cell_counts_from_the_Chelsea_and_Westminster_HIV_Cohort_during_the_study_period_1988_8211_2010_/349130", "title"=>"Flow chart detailing the identification of LTNP and patients with long-term stable low CD4<sup>+</sup> T-cell counts from the Chelsea and Westminster HIV Cohort, during the study period 1988–2010.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:42:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/678788"], "description"=>"<p>Dashed horizontal lines indicate the normal healthy range of CD4<sup>+</sup> T-cell count (450–1650 cells/µl blood), and a solid vertical line shows the time point 7 years post HIV-1<sup>+</sup> diagnosis. Repeated CD4 T-cell counts are plotted at the time points indicated, where different symbols represent different individual patients.</p>", "links"=>[], "tags"=>["t-cell", "counts", "13", "fulfilled", "hic", "37", "patients", "maintained", "hiv-1", "rna"], "article_id"=>349267, "categories"=>["Virology", "Infectious Diseases"], "users"=>["Sundhiya Mandalia", "Samantha J. Westrop", "Eduard J. Beck", "Mark Nelson", "Brian G. Gazzard", "Nesrina Imami"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029844.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CD4_T_cell_counts_over_the_time_since_HIV_1_diagnosis_of_A_13_LTNP_one_of_whom_fulfilled_HIC_status_with_VLBLD_as_detailed_in_the_key_and_B_37_patients_with_long_term_stable_low_CD4_T_cell_count_3_of_whom_maintained_HIV_1_RNA_load_to_BLD_/349267", "title"=>"CD4<sup>+</sup> T-cell counts over the time since HIV-1<sup>+</sup> diagnosis of (A) 13 LTNP, one of whom fulfilled HIC status, with VLBLD, as detailed in the key and (B) 37 patients with long-term stable low CD4<sup>+</sup> T-cell count, 3 of whom maintained HIV-1 RNA load to BLD.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:42:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/679002"], "description"=>"<p>No internationally recognised consensus for terminology currently exists, making comparison between studies difficult. <sup>1</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Klein1\" target=\"_blank\">[21]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Cao1\" target=\"_blank\">[22]</a>, <sup>2</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Westrop1\" target=\"_blank\">[5]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Deeks1\" target=\"_blank\">[6]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Grabar1\" target=\"_blank\">[19]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Lambotte1\" target=\"_blank\">[23]</a>, <sup>3</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Walker1\" target=\"_blank\">[24]</a>, <sup>4</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Deeks1\" target=\"_blank\">[6]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Migueles1\" target=\"_blank\">[18]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Grabar1\" target=\"_blank\">[19]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Walker1\" target=\"_blank\">[24]</a>, <sup>5</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Deeks1\" target=\"_blank\">[6]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Han1\" target=\"_blank\">[25]</a>, <sup>6</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Grabar1\" target=\"_blank\">[19]</a>, <sup>7</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Westrop1\" target=\"_blank\">[5]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Deeks1\" target=\"_blank\">[6]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Lefrre1\" target=\"_blank\">[16]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Migueles1\" target=\"_blank\">[18]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Grabar1\" target=\"_blank\">[19]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Lambotte1\" target=\"_blank\">[23]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Aiuti1\" target=\"_blank\">[26]</a>–<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Migueles3\" target=\"_blank\">[28]</a>, <sup>8</sup><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Lefrre1\" target=\"_blank\">[16]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone.0029844-Migueles2\" target=\"_blank\">[27]</a>.</p>", "links"=>[], "tags"=>["patients", "exhibiting", "atypical"], "article_id"=>349490, "categories"=>["Virology", "Infectious Diseases"], "users"=>["Sundhiya Mandalia", "Samantha J. Westrop", "Eduard J. Beck", "Mark Nelson", "Brian G. Gazzard", "Nesrina Imami"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029844.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Synonyms_used_to_describe_HIV_1_patients_exhibiting_atypical_disease_progression_/349490", "title"=>"Synonyms used to describe HIV-1<sup>+</sup> patients exhibiting atypical disease progression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:44:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/679104"], "description"=>"<p>Patients are stratified according to a history of at least one CD4<sup>+</sup> T-cell count below the normal range (<450 cells/µl blood).</p>†, ‡<p>See <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone-0029844-g001\" target=\"_blank\">Figure 1</a> for definition of patient groups.</p>#<p>median (IQR) years.</p><p>p-values using the Logrank chi-squared test.</p>", "links"=>[], "tags"=>["progression", "patients", "been", "infected", "hiv-1", "years", "symptomless"], "article_id"=>349586, "categories"=>["Virology", "Infectious Diseases"], "users"=>["Sundhiya Mandalia", "Samantha J. Westrop", "Eduard J. Beck", "Mark Nelson", "Brian G. Gazzard", "Nesrina Imami"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029844.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Time_since_HIV_1_diagnosis_until_disease_progression_in_patients_who_have_been_infected_with_HIV_1_for_more_than_7_years_and_who_remain_symptomless_in_the_absence_of_ART_/349586", "title"=>"Time since HIV-1<sup>+</sup> diagnosis until disease progression in patients who have been infected with HIV-1 for more than 7 years and who remain symptomless in the absence of ART.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 08:44:30"}
  • {"files"=>["https://ndownloader.figshare.com/files/679137"], "description"=>"<p>Where data is unavailable for all patients within a group, the number of patients for whom data available is detailed.</p>‡, †<p>\n <i>See </i><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029844#pone-0029844-g001\" target=\"_blank\"><i>Figure 1</i></a><i> for definition of patient groups.</i></p><p>\n <i>∧p-value using Mann-Whitney U test for quantitative data and chi-squared test with Yates' correction for qualitative data.</i></p>", "links"=>[], "tags"=>["immunological", "virological", "parameters", "patients", "unstable", "t-cell"], "article_id"=>349618, "categories"=>["Virology", "Infectious Diseases"], "users"=>["Sundhiya Mandalia", "Samantha J. Westrop", "Eduard J. Beck", "Mark Nelson", "Brian G. Gazzard", "Nesrina Imami"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0029844.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographic_immunological_and_virological_parameters_of_patients_with_unstable_and_stable_CD4_T_cell_counts_/349618", "title"=>"Demographic, immunological and virological parameters of patients with unstable and stable CD4<sup>+</sup> T-cell counts.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 08:44:43"}

PMC Usage Stats | Further Information

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Relative Metric

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