Immunological Evaluation of Lipopeptide Group A Streptococcus (GAS) Vaccine: Structure-Activity Relationship
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{"title"=>"Immunological evaluation of lipopeptide group A streptococcus (GAS) vaccine: Structure-activity relationship", "type"=>"journal", "authors"=>[{"first_name"=>"Mehfuz", "last_name"=>"Zaman", "scopus_author_id"=>"35768689700"}, {"first_name"=>"Abu Baker M.", "last_name"=>"Abdel-Aal", "scopus_author_id"=>"23134810500"}, {"first_name"=>"Yoshio", "last_name"=>"Fujita", "scopus_author_id"=>"7403263270"}, {"first_name"=>"Karen S.M.", "last_name"=>"Phillipps", "scopus_author_id"=>"35105781700"}, {"first_name"=>"Michael R.", "last_name"=>"Batzloff", "scopus_author_id"=>"6602552086"}, {"first_name"=>"Michael F.", "last_name"=>"Good", "scopus_author_id"=>"7202188608"}, {"first_name"=>"Istvan", "last_name"=>"Toth", "scopus_author_id"=>"7103307460"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22253911", "sgr"=>"84855765319", "doi"=>"10.1371/journal.pone.0030146", "scopus"=>"2-s2.0-84855765319", "pui"=>"364087491", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"9d1ac909-277d-3709-8df8-1ee16263737f", "abstract"=>"Streptococcus pyogenes (group A streptococcus, GAS) is a Gram-positive bacterial pathogen responsible for a wide variety of diseases. To date, GAS vaccine development has focused primarily on the M-protein. The M-protein is highly variable at the amino (N)-terminus (determining serotype) but is conserved at the carboxyl (C)-terminus. Previously a 29 amino acid peptide (named J14) from the conserved region of the M-protein was identified as a potential vaccine candidate. J14 was capable of eliciting protective antibodies that recognized many GAS serotypes when co-administered with immuno-stimulants. This minimal epitope however showed no immunogenicity when administered alone. In an attempt overcome this immunological non-responsiveness, we developed a self-adjuvanting vaccine candidate composed of three components: the B-cell epitope (J14), a universal helper T-cell epitope (P25) and a lipid moiety consisting of lipoamino acids (Laas) which target Toll-like receptor 2 (TLR2). Immunological evaluation in B10.BR (H-2k) mice demonstrated that the epitope attachment to the point of lipid moiety, and the length of the Laa alkyl chain have a profound effect on vaccine immunogenicity after intranasal administration. It was demonstrated that a vaccine featuring C-terminal lipid moiety containing alkyl chains of 16 carbons, with P25 located at the N-terminus, and J14 attached to the side chain of a central lysine residue was capable of inducing optimal antibody response. These findings have considerable relevance to the development of a broad spectrum J14-based GAS vaccine and in particular provided a rational basis for peptide vaccine design based on this self-adjuvanting lipopeptide technology.", "link"=>"http://www.mendeley.com/research/immunological-evaluation-lipopeptide-group-streptococcus-gas-vaccine-structureactivity-relationship", "reader_count"=>19, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>1, "Student > Master"=>2, "Other"=>1, "Student > Bachelor"=>3, "Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>2, "Chemical Engineering"=>1, "Chemistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>2}, "Chemical Engineering"=>{"Chemical Engineering"=>1}}, "group_count"=>1}

Scopus | Further Information

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/692652"], "description"=>"<p>Bars represent the titer for pooled sera obtained from each group. Error bars represent standard error of mean.</p>", "links"=>[], "tags"=>["j14-specific", "serum", "igg", "titers", "bleed"], "article_id"=>363094, "categories"=>["Chemistry", "Infectious Diseases", "Immunology"], "users"=>["Mehfuz Zaman", "Abu-Baker M. Abdel-Aal", "Yoshio Fujita", "Karen S. M. Phillipps", "Michael R. Batzloff", "Michael F. Good", "Istvan Toth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030146.g004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Isotypes_of_J14_specific_serum_IgG_titers_log10_present_in_the_final_bleed_day_60_after_primary_immunization_/363094", "title"=>"Isotypes of J14-specific serum IgG titers (log10) present in the final bleed (day 60) after primary immunization.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:55:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/692412"], "description"=>"<p>Lipoamino acids are described according to the total number of carbon atoms in the molecule. C12 Laa; n = 9. C14 Laa; n = 11. C16 Laa; n = 13.</p>", "links"=>[], "tags"=>["lipoamino"], "article_id"=>362852, "categories"=>["Chemistry", "Infectious Diseases", "Immunology"], "users"=>["Mehfuz Zaman", "Abu-Baker M. Abdel-Aal", "Yoshio Fujita", "Karen S. M. Phillipps", "Michael R. Batzloff", "Michael F. Good", "Istvan Toth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030146.g001", "stats"=>{"downloads"=>6, "page_views"=>124, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_structure_of_lipoamino_acid_Laa_/362852", "title"=>"The structure of lipoamino acid (Laa).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:54:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/692882"], "description"=>"<p>The several fold increase in NFκB levels in treated cells are shown relative to that of the TLR2-expressing cells treated with media, which was set to a value of 1. Bars are means ± SD of indicated number of experiments (ns, <i>p</i>>0.05; *, <i>p</i><0.05; ** <i>p</i><0.01; ***, <i>p</i><0.001).</p>", "links"=>[], "tags"=>["lipopeptides", "tlr2", "was", "tested", "hek293", "cells", "stably", "expressing", "transfected"], "article_id"=>363321, "categories"=>["Chemistry", "Infectious Diseases", "Immunology"], "users"=>["Mehfuz Zaman", "Abu-Baker M. Abdel-Aal", "Yoshio Fujita", "Karen S. M. Phillipps", "Michael R. Batzloff", "Michael F. Good", "Istvan Toth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030146.g005", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_ability_of_the_lipopeptides_to_signal_through_TLR2_was_tested_by_using_HEK293_cells_stably_expressing_TLR2_transfected_with_an_NF_954_B_luciferase_reporter_gene_/363321", "title"=>"The ability of the lipopeptides to signal through TLR2 was tested by using HEK293 cells stably expressing TLR2 transfected with an NFκB-luciferase reporter gene.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:56:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/692559"], "description"=>"<p>Mean J14-specific IgG antibody titers are represented as a bar. Statistical analysis was performed using a one-way ANOVA followed by the Tukey post hoc test (ns, <i>p</i>>0.05; *, <i>p</i><0.05; **, <i>p</i><0.01; ***, <i>p</i><0.001).</p>", "links"=>[], "tags"=>["serum", "igg", "titers", "bleed", "immunization"], "article_id"=>362999, "categories"=>["Chemistry", "Infectious Diseases", "Immunology"], "users"=>["Mehfuz Zaman", "Abu-Baker M. Abdel-Aal", "Yoshio Fujita", "Karen S. M. Phillipps", "Michael R. Batzloff", "Michael F. Good", "Istvan Toth"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030146.g003", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_J14_specific_serum_IgG_titers_log10_at_the_final_bleed_day_60_after_primary_immunization_for_each_individual_mouse_/362999", "title"=>"J14-specific serum IgG titers (log10) at the final bleed (day 60) after primary immunization for each individual mouse.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:55:16"}

PMC Usage Stats | Further Information

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Relative Metric

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