Childhood Adversity and Epigenetic Modulation of the Leukocyte Glucocorticoid Receptor: Preliminary Findings in Healthy Adults
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{"title"=>"Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: Preliminary findings in healthy adults", "type"=>"journal", "authors"=>[{"first_name"=>"Audrey R.", "last_name"=>"Tyrka", "scopus_author_id"=>"6603316932"}, {"first_name"=>"Lawrence H.", "last_name"=>"Price", "scopus_author_id"=>"7201882386"}, {"first_name"=>"Carmen", "last_name"=>"Marsit", "scopus_author_id"=>"6602980785"}, {"first_name"=>"Oakland C.", "last_name"=>"Walters", "scopus_author_id"=>"54925991900"}, {"first_name"=>"Linda L.", "last_name"=>"Carpenter", "scopus_author_id"=>"7102689168"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"364145933", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0030148", "scopus"=>"2-s2.0-84856277610", "pmid"=>"22295073", "sgr"=>"84856277610"}, "id"=>"3b6f45be-b830-378c-92f8-5cd8e2840532", "abstract"=>"BACKGROUND: A history of early adverse experiences is an important risk factor for adult psychopathology. Changes in stress sensitivity and functioning of the hypothalamic-pituitary-adrenal (HPA) axis may underlie the association between stress and risk for psychiatric disorders. Preclinical work in rodents has linked low levels of maternal care to increased methylation of the promoter region of the glucocorticoid receptor (GR) gene, as well as to exaggerated hormonal and behavioral responses to stress. Recent studies have begun to examine whether early-life stress leads to epigenetic modifications of the GR gene in humans.\\n\\nMETHODS: We examined the degree of methylation of a region of the promoter of the human GR gene (NR3C1) in leukocyte DNA from 99 healthy adults. Participants reported on their childhood experiences of parental behavior, parental death or desertion, and childhood maltreatment. On a separate day, participants completed the dexamethasone/corticotropin-releasing hormone (Dex/CRH) test, a standardized neuroendocrine challenge test.\\n\\nRESULTS: Disruption or lack of adequate nurturing, as measured by parental loss, childhood maltreatment, and parental care, was associated with increased NR3C1 promoter methylation (p<.05). In addition, NR3C1 promoter methylation was linked to attenuated cortisol responses to the Dex/CRH test (p<.05).\\n\\nCONCLUSIONS: These findings suggest that childhood maltreatment or adversity may lead to epigenetic modifications of the human GR gene. Alterations in methylation of this gene could underlie the associations between childhood adversity, alterations in stress reactivity, and risk for psychopathology.", "link"=>"http://www.mendeley.com/research/childhood-adversity-epigenetic-modulation-leukocyte-glucocorticoid-receptor-preliminary-findings-hea", "reader_count"=>248, "reader_count_by_academic_status"=>{"Unspecified"=>9, "Professor > Associate Professor"=>9, "Researcher"=>47, "Student > Doctoral Student"=>27, "Student > Ph. D. Student"=>55, "Student > Postgraduate"=>10, "Student > Master"=>36, "Other"=>14, "Student > Bachelor"=>29, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>2, "Professor"=>7}, "reader_count_by_user_role"=>{"Unspecified"=>9, "Professor > Associate Professor"=>9, "Researcher"=>47, "Student > Doctoral Student"=>27, "Student > Ph. D. Student"=>55, "Student > Postgraduate"=>10, "Student > Master"=>36, "Other"=>14, "Student > Bachelor"=>29, "Lecturer"=>3, "Lecturer > Senior Lecturer"=>2, "Professor"=>7}, "reader_count_by_subject_area"=>{"Unspecified"=>27, "Agricultural and Biological Sciences"=>44, "Philosophy"=>3, "Arts and Humanities"=>1, "Chemistry"=>2, "Computer Science"=>1, "Earth and Planetary Sciences"=>2, "Environmental Science"=>2, "Biochemistry, Genetics and Molecular Biology"=>9, "Medicine and Dentistry"=>44, "Neuroscience"=>20, "Physics and Astronomy"=>1, "Psychology"=>81, "Social Sciences"=>10, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>44}, "Social Sciences"=>{"Social Sciences"=>10}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Psychology"=>{"Psychology"=>81}, "Unspecified"=>{"Unspecified"=>27}, "Environmental Science"=>{"Environmental Science"=>2}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Neuroscience"=>{"Neuroscience"=>20}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>44}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>9}, "Philosophy"=>{"Philosophy"=>3}}, "reader_count_by_country"=>{"Colombia"=>1, "United States"=>4, "United Kingdom"=>5, "Portugal"=>1, "Switzerland"=>1, "Spain"=>1, "Turkey"=>1, "Luxembourg"=>1, "Denmark"=>1, "Mexico"=>2, "Italy"=>1, "Israel"=>1, "Germany"=>3}, "group_count"=>15}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/687304"], "description"=>"<p>The Parental Care scale of the Parental Bonding Instrument reflects parental warmth, affection, and involvement; lower scores reflect greater parental coldness, rejection, and detachment. Maltreatment reflects the total score of Childhood Trauma Questionnaire. Parental loss is defined as loss of a parent before age 18, including death (N = 12) and/or prolonged separation/desertion (N = 14).</p>", "links"=>[], "tags"=>["associations", "adversity", "variables", "percent", "methylation", "cpg", "sites"], "article_id"=>357785, "categories"=>["Chemistry", "Biochemistry", "Mental Health", "Medicine", "Biophysics", "Molecular Biology", "Neuroscience", "Genetics"], "users"=>["Audrey R. Tyrka", "Lawrence H. Price", "Carmen Marsit", "Oakland C. Walters", "Linda L. Carpenter"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0030148.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significant_Associations_of_Childhood_Adversity_Variables_and_Percent_Methylation_at_Predicted_CpG_Sites_1_8211_4_/357785", "title"=>"Significant Associations of Childhood Adversity Variables and Percent Methylation at Predicted CpG Sites (1–4).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:27:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/687420"], "description"=>"<p>AUC is defined as Area Under the Curve.</p>", "links"=>[], "tags"=>["associations", "cortisol", "auc", "percent", "methylation", "cpg"], "article_id"=>357903, "categories"=>["Chemistry", "Biochemistry", "Mental Health", "Medicine", "Biophysics", "Molecular Biology", "Neuroscience", "Genetics"], "users"=>["Audrey R. Tyrka", "Lawrence H. Price", "Carmen Marsit", "Oakland C. Walters", "Linda L. Carpenter"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0030148.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Significant_Associations_of_Cortisol_AUC_in_the_Dex_CRH_Test_and_Percent_Methylation_at_CpG_Sites_/357903", "title"=>"Significant Associations of Cortisol AUC in the Dex/CRH Test and Percent Methylation at CpG Sites.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:28:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/687533"], "description"=>"<p>Note: Statistic represents partial correlation coefficients (r) controlling for age. P values are shown underneath the coefficients. Significant and trend-level effects are highlighted in bold.</p>", "links"=>[], "tags"=>["adversity", "measures", "percent", "methylation", "hypothesized", "cpg", "sites"], "article_id"=>358015, "categories"=>["Chemistry", "Biochemistry", "Mental Health", "Medicine", "Biophysics", "Molecular Biology", "Neuroscience", "Genetics"], "users"=>["Audrey R. Tyrka", "Lawrence H. Price", "Carmen Marsit", "Oakland C. Walters", "Linda L. Carpenter"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0030148.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Associations_of_Childhood_Adversity_Measures_and_Percent_Methylation_at_Hypothesized_CpG_Sites_1_8211_4_/358015", "title"=>"Associations of Childhood Adversity Measures and Percent Methylation at Hypothesized CpG Sites (1–4).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 09:28:45"}

PMC Usage Stats | Further Information

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  • {"unique-ip"=>"20", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
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Relative Metric

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