An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation", "type"=>"journal", "authors"=>[{"first_name"=>"Masamitsu", "last_name"=>"Shimazawa", "scopus_author_id"=>"6602683783"}, {"first_name"=>"Yasushi", "last_name"=>"Ito", "scopus_author_id"=>"55698524200"}, {"first_name"=>"Yuta", "last_name"=>"Inokuchi", "scopus_author_id"=>"14031423700"}, {"first_name"=>"Hajime", "last_name"=>"Yamanaka", "scopus_author_id"=>"36524567600"}, {"first_name"=>"Tomohiro", "last_name"=>"Nakanishi", "scopus_author_id"=>"36599066900"}, {"first_name"=>"Takuya", "last_name"=>"Hayashi", "scopus_author_id"=>"55735941400"}, {"first_name"=>"Bin", "last_name"=>"Ji", "scopus_author_id"=>"7102565395"}, {"first_name"=>"Makoto", "last_name"=>"Higuchi", "scopus_author_id"=>"7402054015"}, {"first_name"=>"Tetsuya", "last_name"=>"Suhara", "scopus_author_id"=>"7102863281"}, {"first_name"=>"Kazuyuki", "last_name"=>"Imamura", "scopus_author_id"=>"7202591692"}, {"first_name"=>"Makoto", "last_name"=>"Araie", "scopus_author_id"=>"35405732300"}, {"first_name"=>"Yasuyoshi", "last_name"=>"Watanabe", "scopus_author_id"=>"35414071200"}, {"first_name"=>"Hirotaka", "last_name"=>"Onoe", "scopus_author_id"=>"7004964616"}, {"first_name"=>"Hideaki", "last_name"=>"Hara", "scopus_author_id"=>"56799750000"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22299044", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0030526", "issn"=>"19326203", "scopus"=>"2-s2.0-84856388781", "pui"=>"364167991", "sgr"=>"84856388781"}, "id"=>"c88ed772-2a4f-3193-b276-451b7ab80d41", "abstract"=>"We examined lateral geniculate nucleus (LGN) degeneration as an indicator for possible diagnosis of glaucoma in experimental glaucoma monkeys using positron emission tomography (PET). Chronic intraocular pressure (IOP) elevation was induced by laser trabeculoplasty in the left eyes of 5 cynomolgus monkeys. Glial cell activation was detected by PET imaging with [(11)C]PK11195, a PET ligand for peripheral-type benzodiazepine receptor (PBR), before and at 4 weeks after laser treatment (moderate glaucoma stage). At mild, moderate, and advanced experimental glaucoma stages (classified by histological changes based on the extent of axonal loss), brains were stained with cresyl violet, or antibodies against PBR, Iba-1 (a microglial marker), and GFAP (an activated astrocyte marker). In laser-treated eyes, IOP was persistently elevated throughout all observation periods. PET imaging showed increased [(11)C]PK11195 binding potential in the bilateral LGN at 4 weeks after laser treatment; the increase in the ipsilateral LGN was statistically significant (P<0.05, n = 4). Immunostaining showed bilateral activations of microglia and astrocytes in LGN layers receiving input from the laser-treated eye. PBR-positive cells were observed in LGN layers receiving input from laser-treated eye at all experimental glaucoma stages including the mild glaucoma stage and their localization coincided with Iba-1 positive microglia and GFAP-positive astrocytes. These data suggest that glial activation occurs in the LGN at a mild glaucoma stage, and that the LGN degeneration could be detected by a PET imaging with [(11)C]PK11195 during the moderate experimental glaucoma stage after unilateral ocular hypertension. Therefore, activated glial markers such as PBR in the LGN may be useful in noninvasive molecular imaging for diagnosis of glaucoma.", "link"=>"http://www.mendeley.com/research/alteration-lateral-geniculate-nucleus-experimental-glaucoma-monkeys-vivo-positron-emission-tomograph", "reader_count"=>31, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>8, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>8, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>3, "Student > Master"=>5, "Other"=>1, "Student > Bachelor"=>4, "Professor"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>1, "Medicine and Dentistry"=>13, "Agricultural and Biological Sciences"=>7, "Neuroscience"=>8, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>13}, "Neuroscience"=>{"Neuroscience"=>8}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Japan"=>1, "Malaysia"=>1, "Australia"=>1}, "group_count"=>0}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84856388781"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84856388781?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84856388781&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84856388781&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84856388781", "dc:identifier"=>"SCOPUS_ID:84856388781", "eid"=>"2-s2.0-84856388781", "dc:title"=>"An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation", "dc:creator"=>"Shimazawa M.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"1", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-01-27", "prism:coverDisplayDate"=>"27 January 2012", "prism:doi"=>"10.1371/journal.pone.0030526", "citedby-count"=>"23", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Gifu Pharmaceutical University", "affiliation-city"=>"Gifu", "affiliation-country"=>"Japan"}], "pubmed-id"=>"22299044", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e30526", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0030526", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"1", "year"=>"2012", "pdf_views"=>"26", "xml_views"=>"7", "html_views"=>"215"}
  • {"month"=>"2", "year"=>"2012", "pdf_views"=>"74", "xml_views"=>"23", "html_views"=>"203"}
  • {"month"=>"3", "year"=>"2012", "pdf_views"=>"23", "xml_views"=>"8", "html_views"=>"40"}
  • {"month"=>"4", "year"=>"2012", "pdf_views"=>"27", "xml_views"=>"17", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"12", "xml_views"=>"6", "html_views"=>"28"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"21"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"2", "html_views"=>"161"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"73"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"64"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"3", "html_views"=>"59"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"66"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"55"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"5", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"48"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"8", "xml_views"=>"2", "html_views"=>"61"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"50"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"52"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"33"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"16", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"12"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"7"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"10"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"26"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"28"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"16"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"0", "xml_views"=>"2", "html_views"=>"15"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"2", "html_views"=>"3"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"3", "html_views"=>"3"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"8"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"1"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"0"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/688694"], "description"=>"<p>LGN: lateral geniculate layer, ONH: optic nerve head, ON: optic nerve, GFAP: glial fibrillary acidic protein, Iba-1: ionized calcium-binding adaptermolecule-1, PBR: peripheral benzodiazepine receptor. Glaucoma stages were classified by histological changes based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced glaucoma (50–100%). Neuronal atrophy, RGC loss and immunoreactivity were classified based on the quantitative data as follows: no changes; −, mild; +, moderate; ++, robust; +++.</p>", "links"=>[], "tags"=>["changes", "cynomolgus", "monkeys"], "article_id"=>359163, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.t002", "stats"=>{"downloads"=>1, "page_views"=>37, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pathological_changes_in_cynomolgus_monkeys_after_laser_photocoagulation_/359163", "title"=>"Pathological changes in cynomolgus monkeys after laser-photocoagulation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 09:34:52"}
  • {"files"=>["https://ndownloader.figshare.com/files/688089"], "description"=>"<p>(A) Representative microphotographs of cresyl violet-stained coronal sections of LGN on the contralateral and ipsilateral sides for each experimental glaucoma stage. Each experimental glaucoma stage was classified by the glaucoma severity based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced (50–100%). Layer 1 on the contralateral side and layer 2 on the ipsilateral side receive their innervations from the glaucomatous (left) eye (shown in bold frame), whereas layer 1 on the ipsilateral side and layer 2 on the contralateral side receive their retinal inputs from the non-treated fellow (right) eye. L1 and L2: layer 1 and 2. Scale bars indicate 1000 µm in whole LGN image and 50 µm in enlarged image. Neuron number (B) and mean neuronal cell size (C) in each layer of LGN were measured and averaged as mean ± S.E.M. at each M-(layers 1 and 2) and the P-(layers 3–6) layers.</p>", "links"=>[], "tags"=>["changes", "lgn", "neurons", "cynomolgus", "monkeys"], "article_id"=>358565, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g006", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Histological_changes_in_LGN_neurons_of_cynomolgus_monkeys_after_laser_photocoagulation_/358565", "title"=>"Histological changes in LGN neurons of cynomolgus monkeys after laser photocoagulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:31:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/688735"], "description"=>"<p>C/D area ratio: cup/disc area ratio, ONH: Optic nerve head, IOP: Intraocular pressure, R: right eye, L: left eye, D: Duration, Max IOP: Maximum IOP, Integral ΔIOP: Integral IOP to right eye (Δ mmHg/day). Glaucoma stages were classified by histological changes based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced glaucoma (50–100%).</p>", "links"=>[], "tags"=>["iop", "optic", "cynomolgus", "monkeys"], "article_id"=>359207, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.t001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_IOP_and_the_optic_disc_in_cynomolgus_monkeys_after_laser_photocoagulation_/359207", "title"=>"Changes in IOP and the optic disc in cynomolgus monkeys after laser-photocoagulation.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 09:35:08"}
  • {"files"=>["https://ndownloader.figshare.com/files/687911"], "description"=>"<p>Layer 1 (L1) on the contralateral side receive their innervations from the glaucomatous (left) eye, whereas L1 on the ipsilateral side receive their retinal inputs from the non-treated fellow (right) eye. Each scale bar indicates 50 µm.</p>", "links"=>[], "tags"=>["staining", "pbr", "microglial", "reactive", "astrocyte"], "article_id"=>358378, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g005", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Double_immunofluorescence_staining_for_PBR_with_a_microglial_marker_Iba_1_or_a_reactive_astrocyte_marker_GFAP_/358378", "title"=>"Double-immunofluorescence staining for PBR with a microglial marker (Iba-1) or a reactive astrocyte marker (GFAP).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:30:43"}
  • {"files"=>["https://ndownloader.figshare.com/files/688518"], "description"=>"<p>(A) Representative photographs of Iba-1 immunoreactivity in LGN of the contralateral and ipsilateral sides are shown for each experimental glaucoma stage. Each experimental glaucoma stage was classified by the glaucoma severity based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced (50–100%). Layer 1 on the contralateral side and layer 2 on the ipsilateral side receive their innervations from the glaucomatous (left) eye (shown in bold frame), whereas layer 1 on the ipsilateral side and layer 2 on the contralateral side receive their retinal inputs from the non-treated fellow (right) eye. L1 and L2: layer 1 and 2. Scale bars indicate 1000 µm in whole LGN image and 50 µm in enlarged image. (B) The Iba-1-immunoreactive area on each section was measured, and averaged for each LGN as mean ± S.E.M. at each M-(layers 1 and 2) and the P-(layers 3–6) layers.</p>", "links"=>[], "tags"=>["activation", "lgn", "layers", "receiving", "glaucomatous"], "article_id"=>358992, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g008", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Microglial_activation_in_LGN_layers_receiving_input_from_a_glaucomatous_eye_/358992", "title"=>"Microglial activation in LGN layers receiving input from a glaucomatous eye.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:33:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/687469"], "description"=>"<p>(A) Optic nerve were cut with an ultramicrotome, mounted on glass slides, and stained for myelin using 1% toluidine blue. Each scale bar indicates 1000 µm (low magnification images) and 10 µm (high magnification images), respectively. (B) The axonal numbers in optic nerve (ON) of each experimental glaucoma stage were estimated by counting myelinated axons in each segment 145×109×1 µm (section thickness). Axon number was expressed as (healthy axon number on left side)/(healthy axon number on right side)×100% for each animal.</p>", "links"=>[], "tags"=>["degeneration", "glaucoma", "laser-treated", "eyes", "cynomolgus"], "article_id"=>357939, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Optic_nerve_degeneration_at_each_experimental_glaucoma_stage_in_laser_treated_eyes_of_cynomolgus_monkeys_/357939", "title"=>"Optic nerve degeneration at each experimental glaucoma stage in laser-treated eyes of cynomolgus monkeys.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:28:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/688306"], "description"=>"<p>(A) Representative photographs of GFAP immunoreactivity in LGN of the contralateral and ipsilateral sides are shown for each experimental glaucoma stage. Each experimental glaucoma stage was classified by the glaucoma severity based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced (50–100%). Layer 1 on the contralateral side and layer 2 on the ipsilateral side receive their innervations from the glaucomatous (left) eye (shown in bold frame), whereas layer 1 on the ipsilateral side and layer 2 on the contralateral side receive their retinal inputs from the non-treated fellow (right) eye. L1 and L2: layer 1 and 2. Scale bars indicate 1000 µm in whole LGN image and 50 µm in enlarged image. (B) The GFAP-immunoreactive area on each section was measured, and averaged for each LGN as mean ± S.E.M. at each M-(layers 1 and 2) and the P-(layers 3–6) layers.</p>", "links"=>[], "tags"=>["activation", "lgn", "layers", "receiving", "glaucomatous"], "article_id"=>358778, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g007", "stats"=>{"downloads"=>1, "page_views"=>17, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Astrocyte_activation_in_LGN_layers_receiving_input_from_a_glaucomatous_eye_/358778", "title"=>"Astrocyte activation in LGN layers receiving input from a glaucomatous eye.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:32:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/687277"], "description"=>"<p>(A) Ocular fundus photographs were taken just before the end of the experiment for each monkey Each scale bar indicates 200 µm for ONH and retina. (B) The cell numbers in ganglion cell layers (GCL) of each experimental glaucoma stage were estimated by counting GCL cells at a distance between 1750 and 2200 µm from the optic disc. Cell number was expressed as (healthy cell number on GCL of left eye)/(healthy cell number on GCL of right eye)×100% for each animal.</p>", "links"=>[], "tags"=>["fundus", "photographs", "histological", "sections", "retina", "glaucoma", "laser-treated", "eyes", "cynomolgus"], "article_id"=>357723, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g001", "stats"=>{"downloads"=>2, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Ocular_fundus_photographs_and_histological_sections_of_the_retina_at_each_experimental_glaucoma_stage_in_laser_treated_eyes_of_cynomolgus_monkeys_/357723", "title"=>"Ocular fundus photographs and histological sections of the retina at each experimental glaucoma stage in laser-treated eyes of cynomolgus monkeys.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:27:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/687637"], "description"=>"<p>(A) Accumulation of [<sup>11</sup>C]PK11195 binding potential in the LGN before and 4 weeks after laser photocoagulation. Coronal planes at the level of the LGN are shown. The PET images are shown in color, overlaid on the template MRIs is shown in gray scale. The color scale on the right represents standard uptake value (SUV). (B) Binding potential values of the right and left LGN obtained from 4 different individuals (4 monkeys; #2, #3, #4, #5, seen in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030526#pone-0030526-t001\" target=\"_blank\">tables 1</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030526#pone-0030526-t002\" target=\"_blank\">2</a>). White and black column indicate pretreatment (pre) and post treatment (post) periods, respectively, for the laser photocoagulation. Each column represents the mean ± S.E.M. (<i>n</i> = 4). *<i>p</i><0.05 versus the pretreatment.</p>", "links"=>[], "tags"=>["optic", "coronal", "slices", "cynomolgus", "monkeys"], "article_id"=>358106, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g003", "stats"=>{"downloads"=>0, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Changes_in_optic_disc_and_11_C_PK11195_PET_image_in_coronal_slices_from_cynomolgus_monkeys_at_a_moderate_stage_after_laser_photocoagulation_/358106", "title"=>"Changes in optic disc and [<sup>11</sup>C]PK11195 PET image in coronal slices from cynomolgus monkeys at a moderate stage after laser photocoagulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:29:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/687782"], "description"=>"<p>Each experimental glaucoma stage was classified by the glaucoma severity based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced (50–100%). (A) Representative photographs of PBR-positive cells in LGN layers of the contralateral (Contra) and ipsilateral (Ipsi) sides are shown for each experimental glaucoma stage. Layers 1 (L1) and 4 (L4) on the contralateral side receive their innervations from the glaucomatous (left) eye, whereas L1 and L4 on the ipsilateral side receive their retinal inputs from the non-treated fellow (right) eye. Each scale bar indicates 50 µm. (B) The numbers of PBR-positive cells on each section were measured, and averaged for each LGN as mean ± S.E.M. at each M-(layers 1 and 2) and the P-(layers 3–6) layers.</p>", "links"=>[], "tags"=>["peripheral", "benzodiazepine", "receptor", "lgn", "layers", "receiving", "glaucomatous"], "article_id"=>358245, "categories"=>["Neuroscience", "Cell Biology", "Medicine"], "users"=>["Masamitsu Shimazawa", "Yasushi Ito", "Yuta Inokuchi", "Hajime Yamanaka", "Tomohiro Nakanishi", "Takuya Hayashi", "Bin Ji", "Makoto Higuchi", "Tetsuya Suhara", "Kazuyuki Imamura", "Makoto Araie", "Yasuyoshi Watanabe", "Hirotaka Onoe", "Hideaki Hara"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030526.g004", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_expression_of_peripheral_benzodiazepine_receptor_PBR_in_LGN_layers_receiving_input_from_a_glaucomatous_eye_/358245", "title"=>"The expression of peripheral benzodiazepine receptor (PBR) in LGN layers receiving input from a glaucomatous eye.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:30:00"}

PMC Usage Stats | Further Information

  • {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"29", "year"=>"2012", "pdf"=>"20", "unique-ip"=>"29", "figure"=>"8", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"30", "unique-ip"=>"29", "pdf"=>"14", "year"=>"2012", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"17", "year"=>"2012", "pdf"=>"17", "unique-ip"=>"22", "figure"=>"7", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"1", "full-text"=>"12", "unique-ip"=>"15", "pdf"=>"6", "year"=>"2012", "figure"=>"15", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"11", "year"=>"2012", "pdf"=>"4", "unique-ip"=>"11", "figure"=>"5", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"20", "full-text"=>"24", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"18", "pdf"=>"8", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"19", "pdf"=>"9", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"18", "full-text"=>"23", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"22", "full-text"=>"23", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"20", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"12", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"20", "full-text"=>"16", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"8", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"16", "full-text"=>"19", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"4", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"17", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"3", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"11", "full-text"=>"11", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"12", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"10", "full-text"=>"9", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"6", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences/Anatomy and physiology", "average_usage"=>[307, 540, 660, 756, 847, 936, 1025, 1111, 1199, 1282, 1361, 1432]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[319, 556, 679, 785, 881, 970, 1062, 1149, 1236, 1323, 1402, 1474, 1545, 1617, 1681, 1754, 1822, 1892, 1963, 2031, 2099, 2165, 2233, 2299, 2359]}, {"subject_area"=>"/Biology and life sciences/Organisms", "average_usage"=>[331, 557, 677, 777, 868, 960, 1050, 1136, 1223, 1307, 1390, 1466, 1536, 1603, 1673, 1741, 1814, 1889, 1954, 2028, 2096, 2164, 2233, 2305, 2362]}, {"subject_area"=>"/Engineering and technology/Equipment", "average_usage"=>[287, 503, 624, 723, 827, 914, 1011, 1099, 1192, 1281, 1347, 1414, 1488, 1557, 1615, 1679, 1729, 1787, 1858, 1934, 1993, 2069, 2149, 2195, 2271]}, {"subject_area"=>"/Medicine and health sciences/Anatomy", "average_usage"=>[307, 529, 649, 751, 845, 936, 1025, 1113, 1197, 1284, 1360, 1432, 1501, 1570, 1632, 1697, 1765, 1834, 1904, 1972, 2041, 2107, 2170, 2231, 2292]}, {"subject_area"=>"/Medicine and health sciences/Diagnostic medicine", "average_usage"=>[303, 515, 631, 731, 816, 904, 995, 1087, 1171, 1251, 1334, 1405, 1474, 1539, 1615, 1679, 1745, 1806, 1874, 1943, 2006, 2070, 2141, 2199, 2263]}, {"subject_area"=>"/Medicine and health sciences/Ophthalmology", "average_usage"=>[300, 503, 606, 703, 784, 852, 936, 1043, 1127, 1188, 1280, 1352, 1392, 1481, 1531, 1589, 1661, 1731, 1824, 1851, 1917, 1962, 2040, 2103, 2170]}, {"subject_area"=>"/Medicine and health sciences/Radiology and imaging", "average_usage"=>[284, 475, 594, 690, 776, 854, 938, 1018, 1106, 1184, 1260, 1351, 1424, 1485, 1543, 1598, 1673, 1763, 1829, 1888, 1949, 2022, 2072, 2119, 2175]}]}
Loading … Spinner
There are currently no alerts