Receptors for Hyaluronic Acid and Poliovirus: A Combinatorial Role in Glioma Invasion?
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{"title"=>"Receptors for hyaluronic acid and poliovirus: A combinatorial role in glioma invasion?", "type"=>"journal", "authors"=>[{"first_name"=>"Zaynah", "last_name"=>"Maherally", "scopus_author_id"=>"55001764900"}, {"first_name"=>"James R.", "last_name"=>"Smith", "scopus_author_id"=>"35280857900"}, {"first_name"=>"Qian", "last_name"=>"An", "scopus_author_id"=>"55002103100"}, {"first_name"=>"Geoffrey J.", "last_name"=>"Pilkington", "scopus_author_id"=>"7004913006"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84857182500", "sgr"=>"84857182500", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0030691", "pmid"=>"22363471", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)", "pui"=>"364281265"}, "id"=>"f3fc3770-5815-323d-99c5-d519a2d6a3ee", "abstract"=>"BACKGROUND: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.\\n\\nMETHODS AND FINDINGS: In this study, an up-regulation of CD44 and CD155 was demonstrated in established and early-passage cultures of glioblastoma. Total internal reflected fluorescence (TIRF) microscopy revealed close proximity of CD44 and CD155. CD44 antibody blocking and gene silencing (via siRNA) resulted in greater inhibition of invasion than that for CD155. Combined interference resulted in 86% inhibition of invasion, although in these investigations no obvious evidence of synergy between CD44 and CD155 in curbing invasion was shown. Both siRNA-CD44 and siRNA-CD155 treated cells lacked processes and were rounder, while live cell imaging showed reduced motility rate compared to wild type cells. Adhesion assay demonstrated that wild type cells adhered most efficiently to laminin, whereas siRNA-treated cells (p<0.0001 for both CD44 and CD155 expression) showed decreased adhesion on several ECMs investigated. BrdU assay showed a higher proliferation of siRNA-CD44 and siRNA-CD155 cells, inversely correlated with reduced invasion. Confocal microscopy revealed overlapping of CD155 and integrins (β(1), α(v)β(1) and α(v)β(3)) on glioblastoma cell processes whereas siRNA-transfected cells showed consequent reduction in integrin expression with no specific staining patterns. Reduced expression of Rho GTPases, Cdc42, Rac1/2/3, RhoA and RhoB, was seen in siRNA-CD44 and siRNA-CD155 cells. In contrast to CD44-knockdown and 'double'-knockdown cells, no obvious decrease in RhoC expression was observed in CD155-knockdown cells.\\n\\nCONCLUSIONS: This investigation has enhanced our understanding of cell invasion and confirmed CD44 to play a more significant role in this biological process than CD155. Joint CD44/CD155 approaches may, however, merit further study in therapeutic targeting of infiltrating glioma cells.", "link"=>"http://www.mendeley.com/research/receptors-hyaluronic-acid-poliovirus-combinatorial-role-glioma-invasion", "reader_count"=>21, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>7, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>3, "Other"=>1, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>10, "Medicine and Dentistry"=>5, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>10}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Canada"=>1, "Denmark"=>1, "Brazil"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/679996"], "description"=>"<p><b>a–c</b>, Co-staining of CD44 (red) and CD155 (green) on SNB-19 and UPAB cells; scale bars: 25 µm (<b>a</b>) and 10 µm (<b>b</b>–<b>c</b>). TIRF microscopy (<b>c</b>) clearly demonstrated the juxtaposition of CD44 and CD155. CD155 is mainly expressed on the processes and invadapodia (arrows). <b>d</b>, Significantly increased expression of CD44 (<b>top panel</b>) and CD155 (<b>bottom panel</b>) in GBM cells confirmed by flow cytometry, as assessed by the percentage of antigen-expressing cells and increase in fluorescence fold. * indicates statistical significance compared to CC-2565, a normal human astrocyte cell line.</p>", "links"=>[], "tags"=>["proximity", "cd44", "cd155", "gbm"], "article_id"=>350480, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g001", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_and_close_proximity_of_CD44_and_CD155_on_GBM_cells_/350480", "title"=>"Expression and close proximity of CD44 and CD155 on GBM cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:49:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/680110"], "description"=>"<p><b>a</b>, siRNA-KD of CD44 and CD155 was confirmed by Western blotting using both wild type (<i>wt</i>) and non-targeting siRNA treated cells as controls. GAPD-siRNA was used as a positive control to validate the knockdown effect. <b>b</b>, Expression of CD44 (<b>top panels</b>) and CD155 (<b>bottom panels</b>) in non-targeting siRNA treated cells (<b>control/left panels/L</b>) and relevant siRNA-KD (<b>right panels/R</b>) cells; scale bars: 25 µm. In control cells (<b>L</b>), CD44 is uniformly distributed with intense staining at the edges of the cells (arrows) whereas CD155 is well distributed with dense staining zones at the leading edges of the cells (arrows). CD44/CD155 staining was reduced in the siRNA-KD cells with clearly altered morphology (<b>R</b>). <b>c</b>, CD44/CD155-KD was confirmed by flow cytometry. Expression levels of CD44 and CD155 were significantly reduced in siRNA-KD SNB-19 cells as indicated by percentage of positive cells and fluorescence fold. * indicates statistical significance compared to non-targeting siRNA treated cells (control).</p>", "links"=>[], "tags"=>["cd44", "cd155", "sirna-kd", "snb-19"], "article_id"=>350593, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g002", "stats"=>{"downloads"=>1, "page_views"=>24, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_expression_of_CD44_and_CD155_following_siRNA_KD_in_SNB_19_cells_/350593", "title"=>"Reduced expression of CD44 and CD155 following siRNA-KD in SNB-19 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:49:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/680430"], "description"=>"<p>Five different human ECMs including collagen I, fibronectin, laminin, tenascin C and vitronectin were employed and BSA was used as the control substrate. For each ECM substrate, the adhesive potential of manipulated SNB-19 cells (<i>via</i> either mAb-blocking or siRNA-KD) was compared with the relevant control cells. Wild type SNB-19 cells served as a control in the mAb-blocking experiments whereas non-targeting siRNA treated SNB-19 cells were used as a control in the siRNA-KD experiments. * indicates statistical significance compared to control.</p>", "links"=>[], "tags"=>["adhesive", "snb-19", "cells", "mab-blocking", "sirna-kd"], "article_id"=>350914, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g005", "stats"=>{"downloads"=>3, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Decreased_adhesive_potential_of_SNB_19_cells_following_mAb_blocking_a_and_siRNA_KD_b_of_CD44_CD155_/350914", "title"=>"Decreased adhesive potential of SNB-19 cells following mAb-blocking (a) and siRNA-KD (b) of CD44/CD155.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:51:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/680559"], "description"=>"<p><b>a</b>, Co-staining of F-actin (green/<b>left panels/L</b>) or β<sub>1</sub>-integrin (green/<b>right panels/R</b>) with CD44 (red/<b>top panels</b>) and CD155 (red/<b>bottom panels</b>) on wild type UPAB cells. <b>b</b>, Co-staining of α<sub>v</sub>β<sub>1</sub>-integrin (green/<b>L</b>) or α<sub>v</sub>β<sub>3</sub>-integrin (green/<b>R</b>) with CD44 (red/<b>top panels</b>) and CD155 (red/<b>bottom panels</b>) on wild type UPMC (CD44 staining) and non-targeting siRNA treated SNB-19 cells (CD155 staining). All images in <b>a</b> and <b>b</b> have scale bars of 25 µm. <b>c</b>, Western blotting showed reduced expression of F-actin and integrins (α<sub>v</sub>, β1 and β<sub>3</sub>) in CD44/CD155-KD SNB-19 cells when compared to non-targeting siRNA treated cells (control).</p>", "links"=>[], "tags"=>["f-actin", "integrins", "co-localisation", "gbm"], "article_id"=>351046, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g006", "stats"=>{"downloads"=>4, "page_views"=>21, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Expression_of_F_actin_and_integrins_and_their_co_localisation_with_CD44_CD155_on_GBM_cells_/351046", "title"=>"Expression of F-actin and integrins and their co-localisation with CD44/CD155 on GBM cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:51:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/680687"], "description"=>"<p>High levels of Cdc42, Rac 1/2/3, RhoA, RhoB and RhoC were detected in non-targeting siRNA treated SNB-19 cells (control) whereas those proteins of interest were downregulated in CD44/CD155-KD cells.</p>", "links"=>[], "tags"=>["blotting", "rho", "gtpases", "snb-19"], "article_id"=>351177, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g007", "stats"=>{"downloads"=>1, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blotting_of_Rho_GTPases_in_CD44_CD155_KD_SNB_19_cells_/351177", "title"=>"Western blotting of Rho GTPases in CD44/CD155-KD SNB-19 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:52:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/680339"], "description"=>"<p>Non-targeting siRNA treated SNB-19 cells were used as a control. <b>a</b>, Velocity of cell movement (<b>right panel</b>) with cell tracking (<b>left panel</b>) analysed over a period of 72 h. The speed by which CD44/CD155-KD cells moved was significantly reduced. <b>b</b>, Total distance moved by cells (<b>right panel</b>) with cell tracking (<b>left panel</b>) over a period of 72 h. The distance travelled by CD44/CD155-KD cells was markedly decreased. Start position: white arrow; end position: black arrow. * indicates statistical significance compared to control.</p>", "links"=>[], "tags"=>["motility", "snb-19"], "article_id"=>350827, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g004", "stats"=>{"downloads"=>0, "page_views"=>23, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Reduced_motility_rate_in_CD44_CD155_KD_SNB_19_cells_/350827", "title"=>"Reduced motility rate in CD44/CD155-KD SNB-19 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:50:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/680229"], "description"=>"<p>Wild type (untreated) SNB-19 cells were used as a control in the mAb-blocking experiments; non-targeting siRNA treated SNB-19 cells were used as a control in the siRNA-KD experiments. <b>a</b>, Significantly reduced invasion following mAb-blocking (<b>left panel</b>) and siRNA-KD (<b>right panel</b>) was shown compared to controls. All images have scale bars of 50 µm. <b>b</b>, Proliferation was markedly increased in mAb-blocking (<b>left panel</b>) and siRNA-KD (<b>right panel</b>) cells compared to controls. * indicates statistical significance.</p>", "links"=>[], "tags"=>["inhibited", "enhanced", "proliferation", "snb-19"], "article_id"=>350716, "categories"=>["Physiology", "Molecular Biology", "Cancer", "Cell Biology", "Genetics"], "users"=>["Zaynah Maherally", "James R. Smith", "Qian An", "Geoffrey J. Pilkington"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030691.g003", "stats"=>{"downloads"=>2, "page_views"=>28, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_CD44_CD155_depletion_inhibited_invasion_but_enhanced_proliferation_of_SNB_19_cells_/350716", "title"=>"CD44/CD155-depletion inhibited invasion but enhanced proliferation of SNB-19 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:50:14"}

PMC Usage Stats | Further Information

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Relative Metric

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