Leishmania donovani: Immunostimulatory Cellular Responses of Membrane and Soluble Protein Fractions of Splenic Amastigotes in Cured Patient and Hamsters
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{"title"=>"Leishmania donovani: Immunostimulatory cellular responses of membrane and soluble protein fractions of splenic amastigotes in cured patient and hamsters", "type"=>"journal", "authors"=>[{"first_name"=>"Shraddha", "last_name"=>"Kumari", "scopus_author_id"=>"23985364200"}, {"first_name"=>"Pragya", "last_name"=>"Misra", "scopus_author_id"=>"57194789565"}, {"first_name"=>"Rati", "last_name"=>"Tandon", "scopus_author_id"=>"54926095100"}, {"first_name"=>"Mukesh", "last_name"=>"Samant", "scopus_author_id"=>"56247690900"}, {"first_name"=>"Shyam", "last_name"=>"Sundar", "scopus_author_id"=>"56819423800"}, {"first_name"=>"Anuradha", "last_name"=>"Dube", "scopus_author_id"=>"7005041962"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0030746", "scopus"=>"2-s2.0-84856297862", "pui"=>"364154992", "issn"=>"19326203", "pmid"=>"22292030", "sgr"=>"84856297862", "isbn"=>"1932-6203 (Electronic)\\n1932-6203 (Linking)"}, "id"=>"bc9befc2-214c-3e69-93e6-5bf655db8472", "abstract"=>"Visceral leishmaniasis (VL), caused by the intracellular parasite Leishmania donovani, L. chagasi and L. infantum is characterized by defective cell-mediated immunity (CMI) and is usually fatal if not treated properly. An estimated 350 million people worldwide are at risk of acquiring infection with Leishmania parasites with approximately 500,000 cases of VL being reported each year. In the absence of an efficient and cost-effective antileishmanial drug, development of an appropriate long-lasting vaccine against VL is the need of the day. In VL, the development of a CMI, capable of mounting Th1-type of immune responses, play an important role as it correlate with recovery from and resistance to disease. Resolution of infection results in lifelong immunity against the disease which indicates towards the feasibility of a vaccine against the disease. Most of the vaccination studies in Leishmaniasis have been focused on promastigote--an infective stage of parasite with less exploration of pathogenic amastigote form, due to the cumbersome process of its purified isolation. In the present study, we have isolated and purified splenic amastigotes of L. donovani, following the traditional protocol with slight modification. These were fractionated into five membranous and soluble subfractions each i.e MAF1-5 and SAF1-5 and were subjected for evaluation of their ability to induce cellular responses. Out of five sub-fractions from each of membrane and soluble, only four viz. MAF2, MAF3, SAF2 and SAF3 were observed to stimulate remarkable lymphoproliferative, IFN-γ, IL-12 responses and Nitric Oxide production, in Leishmania-infected cured/exposed patients and hamsters. Results suggest the presence of Th-1 type immunostimulatory molecules in these sub-fractions which may further be exploited for developing a successful subunit vaccine from the less explored pathogenic stage against VL.", "link"=>"http://www.mendeley.com/research/leishmania-donovani-immunostimulatory-cellular-responses-membrane-soluble-protein-fractions-splenic", "reader_count"=>20, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>4, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>2, "Other"=>1, "Student > Master"=>4, "Student > Bachelor"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Mathematics"=>1, "Agricultural and Biological Sciences"=>6, "Medicine and Dentistry"=>5, "Immunology and Microbiology"=>3, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>6}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/687443"], "description"=>"<p>(a) DIC image (Differential interference contrast image) of purified amastigotes in confocal microscopy which is similar to that obtained by phase contrast microscopy but without the bright diffraction halo (b) Fluorescent image of purified amastigotes using anti-PPG antibody with secondary anti-rabbit FITC labeled IgG.</p>", "links"=>[], "tags"=>["ppg", "amastigotes", "derived", "splenic", "confocal", "scanning"], "article_id"=>357918, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Immunolocalization_of_PPG_in_pure_amastigotes_derived_from_splenic_tissue_by_confocal_laser_scanning_microscopy_/357918", "title"=>"Immunolocalization of PPG in pure amastigotes derived from splenic tissue by confocal laser scanning microscopy.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:28:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/687867"], "description"=>"<p>The results are presented in the graph as for individual human sample along with horizontal bar representing the median.</p>", "links"=>[], "tags"=>["cytokine", "levels", "il-12", "pbmcs", "cured", "vl", "patients", "amphotericin", "endemic", "contacts", "individuals", "membrane", "antigenic", "fractions", "10"], "article_id"=>358330, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Th1_Th2_cytokine_levels_IFN_947_IL_12_p_40_IL_10_of_PBMCs_from_cured_VL_patients_full_course_of_treatment_with_Amphotericin_B_9642_endemic_contacts_9652_and_healthy_o_individuals_against_membrane_antigenic_fractions_used_at_a_concentration_of_10_181_g_ml/358330", "title"=>"Th1/Th2 cytokine levels (IFN-γ, IL-12 p 40, IL-10) of PBMCs from cured VL patients (full course of treatment with Amphotericin B) (▪), endemic contacts (▴) and healthy (o) individuals against membrane antigenic fractions used at a concentration of 10 µg/ml (1 µg/well).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:30:25"}
  • {"files"=>["https://ndownloader.figshare.com/files/688222"], "description"=>"<p>The absorbance of the reaction product was measured at 540 nm using Griess reagent.</p>", "links"=>[], "tags"=>["oxide", "peritoneal", "macrophages", "hamsters", "j774", "lines", "ma", "sa", "10", "24"], "article_id"=>358694, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g008", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Nitric_oxide_production_181_M_by_peritoneal_macrophages_of_hamsters_n_8202_8202_9_and_J774_cell_lines_in_response_to_MA_A_and_SA_B_at_10_181_g_ml_after_24_h_stimulation_/358694", "title"=>"Nitric oxide production (µM) by peritoneal macrophages of hamsters (n = 9) and J774 cell lines in response to MA (A) and SA (B) at 10 µg/ml after 24 h stimulation.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:32:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/688134"], "description"=>"<p>Lymphoproliferative response of mononuclear cells of lymph nodes from normal, <i>L. donovani</i> infected as well as cured (with Miltefosine at 40 mg/kgx5 days) hamsters in response against MA (A) and SA (B).</p>", "links"=>[], "tags"=>["mononuclear", "cells", "lymph", "nodes", "infected", "cured", "miltefosine", "40", "hamsters", "ma", "sa"], "article_id"=>358609, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g007", "stats"=>{"downloads"=>1, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lymphoproliferative_response_of_mononuclear_cells_of_lymph_nodes_from_normal_L_donovani_infected_as_well_as_cured_with_Miltefosine_at_40_mg_kgx5_days_hamsters_in_response_against_MA_A_and_SA_B_/358609", "title"=>"Lymphoproliferative response of mononuclear cells of lymph nodes from normal, <i>L. donovani</i> infected as well as cured (with Miltefosine at 40 mg/kgx5 days) hamsters in response against MA (A) and SA (B).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:31:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/688320"], "description"=>"<p>Size and type of clinical samples taken for the study.</p>", "links"=>[], "tags"=>["samples", "taken"], "article_id"=>358812, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.t001", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Size_and_type_of_clinical_samples_taken_for_the_study_/358812", "title"=>"Size and type of clinical samples taken for the study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 09:32:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/687621"], "description"=>"<p>Lane 1: promastigote lysate; Lane 2: Amastigote lysate.</p>", "links"=>[], "tags"=>["blots", "amastigotes", "promastigotes", "monoclonal", "a2", "antibody"], "article_id"=>358105, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g003", "stats"=>{"downloads"=>1, "page_views"=>20, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Western_blots_analysis_of_amastigotes_and_promastigotes_using_mouse_monoclonal_A2_antibody_against_amastigotes_/358105", "title"=>"Western blots analysis of amastigotes and promastigotes using mouse monoclonal A2 antibody against amastigotes.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:29:14"}
  • {"files"=>["https://ndownloader.figshare.com/files/687691"], "description"=>"<p>Lymphoproliferative response of PBMCs from Cured VL patients (▪), Endemic controls (▴) and healthy (o) individuals against membrane antigenic fractions/MA and soluble antigenic fractions/SA.</p>", "links"=>[], "tags"=>["pbmcs", "cured", "vl", "patients", "endemic", "controls", "individuals", "membrane", "antigenic", "soluble"], "article_id"=>358168, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g004", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Lymphoproliferative_response_of_PBMCs_from_Cured_VL_patients_9642_Endemic_controls_9652_and_healthy_o_individuals_against_membrane_antigenic_fractions_MA_and_soluble_antigenic_fractions_SA_/358168", "title"=>"Lymphoproliferative response of PBMCs from Cured VL patients (▪), Endemic controls (▴) and healthy (o) individuals against membrane antigenic fractions/MA and soluble antigenic fractions/SA.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:29:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/687517"], "description"=>"<p>Western blot analysis of amastigotes and promastigotes using (i) GRP-78 antibody as loading control (D), (ii) mouse monoclonal LPG against promastigotes (E). Lane 1: Amastigote lysate; Lane 2: promastigote lysate.</p>", "links"=>[], "tags"=>["stained", "sds-page", "gels", "soluble", "antigenic", "membrane", "purified", "sub-fractions", "ma", "sa", "molecular"], "article_id"=>357988, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Silver_stained_12_SDS_PAGE_gels_showing_soluble_antigenic_fraction_SA_amp_membrane_antigenic_fraction_MA_A_as_well_as_purified_sub_fractions_of_MA_B_and_SA_C_according_to_their_molecular_weight_/357988", "title"=>"Silver stained 12% SDS-PAGE gels showing soluble antigenic fraction/SA & membrane antigenic fraction/MA (A) as well as purified sub-fractions of MA (B) and SA (C) according to their molecular weight.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:28:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/688009"], "description"=>"<p>The results are presented in the graph as for individual human sample along with horizontal bar representing the median.</p>", "links"=>[], "tags"=>["cytokine", "levels", "il-12", "pbmcs", "cured", "vl", "patients", "amphotericin", "endemic", "individuals", "soluble", "antigenic", "fractions", "10"], "article_id"=>358482, "categories"=>["Microbiology", "Infectious Diseases", "Immunology"], "users"=>["Shraddha Kumari", "Pragya Misra", "Rati Tandon", "Mukesh Samant", "Shyam Sundar", "Anuradha Dube"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030746.g006", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Th1_Th2_cytokine_levels_IFN_947_IL_12_p_40_IL_10_of_PBMCs_from_cured_VL_patients_full_course_of_treatment_with_Amphotericin_B_9642_endemic_9652_and_healthy_o_individuals_against_soluble_antigenic_fractions_used_at_a_concentration_of_10_181_g_ml_1_181_g_w/358482", "title"=>"Th1/Th2 cytokine levels (IFN-γ, IL-12 p 40, IL-10) of PBMCs from cured VL patients (full course of treatment with Amphotericin B) (▪), endemic (▴) and healthy (o) individuals against soluble antigenic fractions used at a concentration of 10 µg/ml (1 µg/well).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:31:12"}

PMC Usage Stats | Further Information

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Relative Metric

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