Large-Scale Cortical Dynamics of Sleep Slow Waves
Publication Date
February 17, 2012
Journal
PLOS ONE
Authors
Vicente Botella Soler, Mario Valderrama, Benoît Crépon, Vincent Navarro, et al
Volume
7
Issue
2
Pages
e30757
DOI
https://dx.plos.org/10.1371/journal.pone.0030757
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0030757
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22363484
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281874
Europe PMC
http://europepmc.org/abstract/MED/22363484
Web of Science
000302853600065
Scopus
84857181979
Mendeley
http://www.mendeley.com/research/largescale-cortical-dynamics-sleep-slow-waves
Events
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Mendeley | Further Information

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Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/679822"], "description"=>"<p><b>A. </b><i>Left</i>: 3D reconstructed implantation of one subject. The red circle marks the approximate position of the scalp reference contact. <i>Right</i>: Example of scalp slow oscillation and one of its intracranial correlates (note the polarity inversion of the intracranial signal with respect to scalp). All signals are filtered in the band 0.1–4.0 Hz. The hyperpolarization and depolarization onsets have been marked for the scalp signal. The duration of the hyperpolarization (T<sub>h</sub>) and depolarization (T<sub>d</sub>) phases of each oscillation is shown as well (black and gray horizontal lines, respectively). <b>B.</b> Segment of scalp signal presenting six detected slow waves. For the second detection, the T<sub>h</sub> and T<sub>d</sub> of the detected intracranial correlates have been plotted. The numbers stand for contacts of the same electrode. This particular implantation consisted of 55 contacts distributed in 11 electrodes, 6 electrodes (n.1–6, 30 contacts) in the left frontal lobe and 5 (n.7–11, 25 contacts) in the left temporal lobe. The contacts in the frontal lobe cover from the F1, F2 and orbital regions to interior regions like the anterior part of the cingulated gyrus, the insula and the cortex subcallosum. The electrodes in the temporal lobe cover different cortical and white matter regions as well as deeper structures like the amygdala and the hippocampus. <b>C.</b> Examples of typical Probability Density Functions of T<sub>h</sub> and T<sub>d</sub> obtained for a single subject. For the construction of the pdfs only the intracranially measured T<sub>h</sub> and T<sub>d</sub> were taken into account. mark the position of the fast/slow hyperpolarization/depolarization times of the subject.</p>", "links"=>[], "tags"=>["events", "detection"], "article_id"=>350312, "categories"=>["Physiology", "Neuroscience"], "users"=>["Vicente Botella-Soler", "Mario Valderrama", "Benoît Crépon", "Vincent Navarro", "Michel Le Van Quyen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030757.g001", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Illustration_of_the_slow_wave_events_detection_method_and_example_of_T_h_T_d_distributions_/350312", "title"=>"Illustration of the slow wave events detection method and example of T<sub>h</sub>/T<sub>d</sub> distributions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-17 00:05:12"}
  • {"files"=>["https://ndownloader.figshare.com/files/679941"], "description"=>"<p><b>A.</b> Superposition of filtered signals (0.1–4 Hz) of scalp EEG recordings (FP1) corresponding to 300 slow waves showing fast hyperpolarization (top) and 300 slow waves showing slow hyperpolarization (bottom) of a single subject (S1). The thick red line is the average profile of the shown filtered signals. A vertical dashed line marks the position of the hyperpolarization onset of the average signal. The graphs in the right panels indicate the region in the <i>mode T<sub>h</sub></i> distribution from which the events in the figures have been drawn. <b>B.</b> Superposition of filtered signals (0.1–4 Hz) of scalp EEG recordings (FP1) corresponding to 300 slow waves showing fast depolarization (top) and 300 slow waves showing slow depolarization (bottom) of subject S1. The thick red line is the average profile of the shown filtered signals. The vertical dashed line marks the end of the depolarization (as has been defined in the text). The graphs in the right panels indicate the region in the <i>mode T<sub>d</sub></i> distribution from which the events in the figure have been drawn.</p>", "links"=>[], "tags"=>["physiology", "neuroscience", "neurological disorders"], "article_id"=>350435, "categories"=>["Physiology", "Neuroscience"], "users"=>["Vicente Botella-Soler", "Mario Valderrama", "Benoît Crépon", "Vincent Navarro", "Michel Le Van Quyen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030757.g002", "stats"=>{"downloads"=>0, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_fast_slow_hyperpolarization_depolarization_slow_waves_/350435", "title"=>"Examples of fast/slow hyperpolarization/depolarization slow waves.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-17 00:07:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/348003", "https://ndownloader.figshare.com/files/348093", "https://ndownloader.figshare.com/files/348169", "https://ndownloader.figshare.com/files/348240", "https://ndownloader.figshare.com/files/348316", "https://ndownloader.figshare.com/files/348389", "https://ndownloader.figshare.com/files/348456", "https://ndownloader.figshare.com/files/348516", "https://ndownloader.figshare.com/files/348572"], "description"=>"<div><p>Slow waves constitute the main signature of sleep in the electroencephalogram (EEG). They reflect alternating periods of neuronal hyperpolarization and depolarization in cortical networks. While recent findings have demonstrated their functional role in shaping and strengthening neuronal networks, a large-scale characterization of these two processes remains elusive in the human brain. In this study, by using simultaneous scalp EEG and intracranial recordings in 10 epileptic subjects, we examined the dynamics of hyperpolarization and depolarization waves over a large extent of the human cortex. We report that both hyperpolarization and depolarization processes can occur with two different characteristic time durations which are consistent across all subjects. For both hyperpolarization and depolarization waves, their average speed over the cortex was estimated to be approximately 1 m/s. Finally, we characterized their propagation pathways by studying the preferential trajectories between most involved intracranial contacts. For both waves, although single events could begin in almost all investigated sites across the entire cortex, we found that the majority of the preferential starting locations were located in frontal regions of the brain while they had a tendency to end in posterior and temporal regions.</p> </div>", "links"=>[], "tags"=>["large-scale", "cortical", "waves"], "article_id"=>128820, "categories"=>["Physiology", "Neuroscience"], "users"=>["Vicente Botella-Soler", "Mario Valderrama", "Benoît Crépon", "Vincent Navarro", "Michel Le Van Quyen"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0030757.s001", "https://dx.doi.org/10.1371/journal.pone.0030757.s002", "https://dx.doi.org/10.1371/journal.pone.0030757.s003", "https://dx.doi.org/10.1371/journal.pone.0030757.s004", "https://dx.doi.org/10.1371/journal.pone.0030757.s005", "https://dx.doi.org/10.1371/journal.pone.0030757.s006", "https://dx.doi.org/10.1371/journal.pone.0030757.s007", "https://dx.doi.org/10.1371/journal.pone.0030757.s008", "https://dx.doi.org/10.1371/journal.pone.0030757.s009"], "stats"=>{"downloads"=>8, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Large_Scale_Cortical_Dynamics_of_Sleep_Slow_Waves/128820", "title"=>"Large-Scale Cortical Dynamics of Sleep Slow Waves", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-02-17 02:27:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/680073"], "description"=>"<p><b>A.</b> Mode T<sub>h/d</sub> Probability Density Functions of a subject and mode T<sub>h/d</sub> for each of the events detected in a whole night of sleep (5685 events were detected in that particular night of which only the first 5000 are shown). mark the position of the typical fast/slow hyperpolarization/depolarization mode times of the events of the subject. <b>B. </b><i>Left:</i> T<sub>d</sub> vs. T<sub>h</sub> for a single subject. <i>Right:</i> mode T<sub>d</sub> vs. mode T<sub>h</sub> for a single subject. (A logarithmic scale has been used in both cases for the density color coding). <b>C.</b> Probability Density Function of (T<sub>h</sub>+T<sub>d</sub>) and (mode T<sub>h</sub>+mode T<sub>d</sub>). The continuous lines correspond to the estimated PDF using KDE (See <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030757#s4\" target=\"_blank\">Materials and Methods</a>).</p>", "links"=>[], "tags"=>["hyperpolarization", "depolarization"], "article_id"=>350562, "categories"=>["Physiology", "Neuroscience"], "users"=>["Vicente Botella-Soler", "Mario Valderrama", "Benoît Crépon", "Vincent Navarro", "Michel Le Van Quyen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030757.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Distributions_of_mode_T_h_d_and_study_of_the_correlation_between_hyperpolarization_and_depolarization_times_/350562", "title"=>"Distributions of mode T<sub>h/d</sub> and study of the correlation between hyperpolarization and depolarization times.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-17 00:09:22"}
  • {"files"=>["https://ndownloader.figshare.com/files/680248"], "description"=>"<p><b>A.</b> Filtered (0.1–4 Hz) signals of intracranial EEG contacts of one global slow wave event ordered as a function of the position of the minimum (red dots). The vertical dashed line marks the position of the minimum of the first detection. <b>B.</b> Three examples of local propagation in the temporal lobe. Each example corresponds to a different slow wave event. In all cases the signals are linked to the position of the recording contacts in the brain, represented by red cubes.</p>", "links"=>[], "tags"=>["physiology", "neuroscience", "neurological disorders"], "article_id"=>350731, "categories"=>["Physiology", "Neuroscience"], "users"=>["Vicente Botella-Soler", "Mario Valderrama", "Benoît Crépon", "Vincent Navarro", "Michel Le Van Quyen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030757.g004", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Propagation_of_the_slow_waves_/350731", "title"=>"Propagation of the slow waves.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-17 00:12:11"}
  • {"files"=>["https://ndownloader.figshare.com/files/680409"], "description"=>"<p><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0030757#s2\" target=\"_blank\"><b>Results</b></a><b> of the propagation study.. </b><b>A.. </b><i>Left:</i> First and last hubs of the H-wave propagation of all studied subjects superimposed on the same reference brain (Top and left views). <i>Right:</i> First and last hubs of the D-wave propagation of all studied subjects superimposed on the same reference brain (Top and left views). The little black dots correspond to the implanted contacts not presenting a first/last hub character. These are shown to illustrate the total coverage of the sum of the individual implantations. Please note the final coverage of the sum of all the implantations is not homogeneous with 295 (71%) contacts is the left hemisphere and 122 (29%) in the right hemisphere. <b>B.</b> Number of first/last hubs found in each of the following regions: Frontal (Fro), Parietal (Par), Insula (Ins), Cingulate cortex (Cin), Temporal (Tem), Occipital (Occ) and Striatum (Str).</p>", "links"=>[], "tags"=>["physiology", "neuroscience", "neurological disorders"], "article_id"=>350898, "categories"=>["Physiology", "Neuroscience"], "users"=>["Vicente Botella-Soler", "Mario Valderrama", "Benoît Crépon", "Vincent Navarro", "Michel Le Van Quyen"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030757.g005", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Figure_5_/350898", "title"=>"Figure 5", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-02-17 00:14:58"}

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Relative Metric

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