Portable Optical Fiber Probe-Based Spectroscopic Scanner for Rapid Cancer Diagnosis: A New Tool for Intraoperative Margin Assessment
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Mendeley | Further Information

{"title"=>"Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis: A new tool for intraoperative margin assessment", "type"=>"journal", "authors"=>[{"first_name"=>"Niyom", "last_name"=>"Lue", "scopus_author_id"=>"16304481600"}, {"first_name"=>"Jeon Woong", "last_name"=>"Kang", "scopus_author_id"=>"37101739200"}, {"first_name"=>"Chung Chieh", "last_name"=>"Yu", "scopus_author_id"=>"15073542800"}, {"first_name"=>"Ishan", "last_name"=>"Barman", "scopus_author_id"=>"26640220300"}, {"first_name"=>"Narahara Chari", "last_name"=>"Dingari", "scopus_author_id"=>"36656951500"}, {"first_name"=>"Michael S.", "last_name"=>"Feld", "scopus_author_id"=>"7102163536"}, {"first_name"=>"Ramachandra R.", "last_name"=>"Dasari", "scopus_author_id"=>"35481707100"}, {"first_name"=>"Maryann", "last_name"=>"Fitzmaurice", "scopus_author_id"=>"35474789300"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84856405874", "sgr"=>"84856405874", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0030887", "pmid"=>"22303465", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pui"=>"364167971"}, "id"=>"f67cb50e-09ac-313a-baaf-4b4963c2fd5a", "abstract"=>"There continues to be a significant clinical need for rapid and reliable intraoperative margin assessment during cancer surgery. Here we describe a portable, quantitative, optical fiber probe-based, spectroscopic tissue scanner designed for intraoperative diagnostic imaging of surgical margins, which we tested in a proof of concept study in human tissue for breast cancer diagnosis. The tissue scanner combines both diffuse reflectance spectroscopy (DRS) and intrinsic fluorescence spectroscopy (IFS), and has hyperspectral imaging capability, acquiring full DRS and IFS spectra for each scanned image pixel. Modeling of the DRS and IFS spectra yields quantitative parameters that reflect the metabolic, biochemical and morphological state of tissue, which are translated into disease diagnosis. The tissue scanner has high spatial resolution (0.25 mm) over a wide field of view (10 cm×10 cm), and both high spectral resolution (2 nm) and high spectral contrast, readily distinguishing tissues with widely varying optical properties (bone, skeletal muscle, fat and connective tissue). Tissue-simulating phantom experiments confirm that the tissue scanner can quantitatively measure spectral parameters, such as hemoglobin concentration, in a physiologically relevant range with a high degree of accuracy (<5% error). Finally, studies using human breast tissues showed that the tissue scanner can detect small foci of breast cancer in a background of normal breast tissue. This tissue scanner is simpler in design, images a larger field of view at higher resolution and provides a more physically meaningful tissue diagnosis than other spectroscopic imaging systems currently reported in literatures. We believe this spectroscopic tissue scanner can provide real-time, comprehensive diagnostic imaging of surgical margins in excised tissues, overcoming the sampling limitation in current histopathology margin assessment. As such it is a significant step in the development of a platform technology for intraoperative management of cancer, a clinical problem that has been inadequately addressed to date.", "link"=>"http://www.mendeley.com/research/portable-optical-fiber-probebased-spectroscopic-scanner-rapid-cancer-diagnosis-new-tool-intraoperati", "reader_count"=>55, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>13, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>2, "Student > Master"=>11, "Other"=>2, "Lecturer > Senior Lecturer"=>2, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>13, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>21, "Student > Postgraduate"=>2, "Student > Master"=>11, "Other"=>2, "Lecturer > Senior Lecturer"=>2, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>19, "Unspecified"=>2, "Agricultural and Biological Sciences"=>4, "Medicine and Dentistry"=>14, "Neuroscience"=>1, "Physics and Astronomy"=>13, "Chemistry"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>19}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Neuroscience"=>{"Neuroscience"=>1}, "Chemistry"=>{"Chemistry"=>2}, "Physics and Astronomy"=>{"Physics and Astronomy"=>13}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Japan"=>1, "United Kingdom"=>1, "India"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/687627"], "description"=>"<p>T-test of the null hypothesis that means of normal and cancer DRS/IFS parameters are not equal.</p>", "links"=>[], "tags"=>["null", "means", "cancer", "parameters"], "article_id"=>358115, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.t002", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_T_test_of_the_null_hypothesis_that_means_of_normal_and_cancer_DRS_IFS_parameters_are_not_equal_/358115", "title"=>"T-test of the null hypothesis that means of normal and cancer DRS/IFS parameters are not equal.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 09:29:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/686923"], "description"=>"<p>Fifteen liquid phantoms composed of 2% intralipid and varying Hb concentrations in glass vials (A); O-rings filled with liquid phantoms and Spectralon standards (10% and 20%) on the glass plate, with the scanning field of view marked with yellow tape (B); 2D DRS scan of the phantoms and Spectralon standards at 490 nm (field of view = 10 cm×10 cm) (C).</p>", "links"=>[], "tags"=>["simulating"], "article_id"=>357413, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g003", "stats"=>{"downloads"=>1, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DRS_Tissue_Simulating_Phantoms_/357413", "title"=>"DRS Tissue Simulating Phantoms.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:25:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/687504"], "description"=>"<p>Scatter plot of decision algorithm using DRS β-carotene and IFS collagen parameters for selective regions in normal and cancer breast tissues (A); Diagnostic map of normal and breast cancer tissues using the decision algorithm (B). Please note that: 1) regions denoted as cancer at the border of the grossly cancerous and normal tissues (white arrows) are most likely an artifact due to inadvertent gaps between the two tissues; and 2) regions denoted as cancer at the outer edges of the tissues (black arrows) are most likely due to the presence of black colloidal ink applied to the margin of the surgical specimen prior to harvesting for research use.</p>", "links"=>[], "tags"=>["diagnostic"], "article_id"=>357990, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g009", "stats"=>{"downloads"=>1, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DRS_IFS_Diagnostic_Algorithm_/357990", "title"=>"DRS-IFS Diagnostic Algorithm.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:28:38"}
  • {"files"=>["https://ndownloader.figshare.com/files/687033"], "description"=>"<p>DRS spectra from a liquid phantom with 1.8 mg/ml Hb (blue), corresponding model fit (red) and residual (black) (A); Bar chart showing the Hb concentration curve results (B).</p>", "links"=>[], "tags"=>["hb", "quantitation", "drs", "simulating"], "article_id"=>357513, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g004", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_Hb_Quantitation_in_DRS_Tissue_Simulating_Phantoms_/357513", "title"=>"Validation of Hb Quantitation in DRS Tissue Simulating Phantoms.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:26:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/687449"], "description"=>"<p>Bar chart of pixel-to-pixel means DRS and IFS parameters in normal and breast cancer tissues.</p>", "links"=>[], "tags"=>["parameters", "cancer"], "article_id"=>357933, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g008", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fitting_Parameters_in_Normal_and_Breast_Cancer_Tissue_/357933", "title"=>"Fitting Parameters in Normal and Breast Cancer Tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:28:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/687352"], "description"=>"<p>DRS spectral intensity map of normal and cancer tissues at 545 nm (A); IFS spectral intensity map at 425 nm (B); DRS parameter maps for scattering parameters A, B and C, Hb and β-carotene, resp. (C–G); IFS parameter map for collagen (H).</p>", "links"=>[], "tags"=>["parameter", "maps"], "article_id"=>357838, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g007", "stats"=>{"downloads"=>1, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spectral_Intensity_and_Parameter_Maps_of_Breast_Tissue_/357838", "title"=>"Spectral Intensity and Parameter Maps of Breast Tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:27:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/687107"], "description"=>"<p>DRS (a) and IFS spectra(b) of phantoms with varying furan concentration (phantom 1 and 2 furan = 0.8 µg/mL); phantom 3 and 4 furan = 0.3 µg/mL).</p>", "links"=>[], "tags"=>["fluorescence", "ifs", "simulating"], "article_id"=>357588, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g005", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_Fluorescence_Measurements_in_IFS_Tissue_Simulating_Phantoms_/357588", "title"=>"Validation of Fluorescence Measurements in IFS Tissue Simulating Phantoms.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:26:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/686806"], "description"=>"<p>A photo of the resolution target (A) and a randomly selected 2D 2.5 cm×2.5 cm DRS spectral intensity map of zoomed target at 510 nm (B); a gross photograph of the porcine lower leg tissue cross section that was scanned (C); a photograph of the tissue cross section on the glass plate during scanning (D); and 9 cm×9 cm DRS images of the tissue cross section at different wavelengths (E–H). Note that the color bar is for all DRS images and is in arbitrary units.</p>", "links"=>[], "tags"=>["spectral"], "article_id"=>357302, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g002", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Spatial_Resolution_and_Spectral_Contrast_/357302", "title"=>"Spatial Resolution and Spectral Contrast.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:24:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/686667"], "description"=>"<p>Schematic diagram of the tissue scanner and photographs of the unit from different views.</p>", "links"=>[], "tags"=>["biotechnology", "pathology", "physics"], "article_id"=>357146, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Tissue_Scanner_/357146", "title"=>"Tissue Scanner.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:24:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/687595"], "description"=>"<p>IFS tissue simulating phantom mixtures of furan, intralipid and blood.</p>", "links"=>[], "tags"=>["simulating", "phantom", "mixtures", "intralipid"], "article_id"=>358075, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.t001", "stats"=>{"downloads"=>4, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_IFS_tissue_simulating_phantom_mixtures_of_furan_intralipid_and_blood_/358075", "title"=>"IFS tissue simulating phantom mixtures of furan, intralipid and blood.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 09:29:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/687204"], "description"=>"<p>Diagram of normal and breast cancer tissues placed on glass plate during scanning (A); Gross photograph of breast tissues (B); Composite photomicrograph of histopathology of breast tissues (C)(top insert: ductal carcinoma <i>in situ</i>; bottom insert: invasive ductal carcinoma); DRS (D) and IFS (E) spectra of breast tissues.</p>", "links"=>[], "tags"=>["ifs", "cancer"], "article_id"=>357694, "categories"=>["Physics", "Biotechnology", "Cell Biology"], "users"=>["Niyom Lue", "Jeon Woong Kang", "Chung-Chieh Yu", "Ishan Barman", "Narahara Chari Dingari", "Michael S. Feld", "Ramachandra R. Dasari", "Maryann Fitzmaurice"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0030887.g006", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DRS_and_IFS_of_breast_cancer_and_normal_breast_tissue_/357694", "title"=>"DRS and IFS of breast cancer and normal breast tissue.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 09:27:02"}

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Relative Metric

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