High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting
- Publication Date
- January 25, 2012
- Journal
- PLOS ONE
- Authors
- Michelle Cronin, Ali R. Akin, Sara A. Collins, Jeff Meganck, et al
- Volume
- 7
- Issue
- 1
- Pages
- e30940
- DOI
- https://dx.plos.org/10.1371/journal.pone.0030940
- Publisher URL
- http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0030940
- PubMed
- http://www.ncbi.nlm.nih.gov/pubmed/22295120
- PubMed Central
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266281
- Europe PMC
- http://europepmc.org/abstract/MED/22295120
- Web of Science
- 000301640600065
- Scopus
- 84856245757
- Mendeley
- http://www.mendeley.com/research/high-resolution-vivo-bioluminescent-imaging-study-bacterial-tumour-targeting
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Mendeley | Further Information
{"title"=>"High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting", "type"=>"journal", "authors"=>[{"first_name"=>"Michelle", "last_name"=>"Cronin", "scopus_author_id"=>"7203085007"}, {"first_name"=>"Ali R.", "last_name"=>"Akin", "scopus_author_id"=>"12241395900"}, {"first_name"=>"Sara A.", "last_name"=>"Collins", "scopus_author_id"=>"57191796006"}, {"first_name"=>"Jeff", "last_name"=>"Meganck", "scopus_author_id"=>"8563859400"}, {"first_name"=>"Jae Beom", "last_name"=>"Kim", "scopus_author_id"=>"50161608800"}, {"first_name"=>"Chwanrow K.", "last_name"=>"Baban", "scopus_author_id"=>"37021302500"}, {"first_name"=>"Susan A.", "last_name"=>"Joyce", "scopus_author_id"=>"7007076890"}, {"first_name"=>"Gooitzen M.", "last_name"=>"van Dam", "scopus_author_id"=>"7005713258"}, {"first_name"=>"Ning", "last_name"=>"Zhang", "scopus_author_id"=>"57193817412"}, {"first_name"=>"Douwe", "last_name"=>"van Sinderen", "scopus_author_id"=>"7005771022"}, {"first_name"=>"Gerald C.", "last_name"=>"O'Sullivan", "scopus_author_id"=>"35077445900"}, {"first_name"=>"Noriyuki", "last_name"=>"Kasahara", "scopus_author_id"=>"7005566886"}, {"first_name"=>"Cormac G.", "last_name"=>"Gahan", "scopus_author_id"=>"7004069227"}, {"first_name"=>"Kevin P.", "last_name"=>"Francis", "scopus_author_id"=>"7103208601"}, {"first_name"=>"Mark", "last_name"=>"Tangney", "scopus_author_id"=>"35595935100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84856245757", "pui"=>"364145961", "pmid"=>"22295120", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0030940", "sgr"=>"84856245757"}, "id"=>"a33bc26b-9499-3ccd-bd7c-323224c56fa2", "abstract"=>"The ability to track microbes in real time in vivo is of enormous value for preclinical investigations in infectious disease or gene therapy research. Bacteria present an attractive class of vector for cancer therapy, possessing a natural ability to grow preferentially within tumours following systemic administration. Bioluminescent Imaging (BLI) represents a powerful tool for use with bacteria engineered to express reporter genes such as lux. BLI is traditionally used as a 2D modality resulting in images that are limited in their ability to anatomically locate cell populations. Use of 3D diffuse optical tomography can localize the signals but still need to be combined with an anatomical imaging modality like micro-Computed Tomography (μCT) for interpretation.In this study, the non-pathogenic commensal bacteria E. coli K-12 MG1655 and Bifidobacterium breve UCC2003, or Salmonella Typhimurium SL7207 each expressing the luxABCDE operon were intravenously (i.v.) administered to mice bearing subcutaneous (s.c) FLuc-expressing xenograft tumours. Bacterial lux signal was detected specifically in tumours of mice post i.v.-administration and bioluminescence correlated with the numbers of bacteria recovered from tissue. Through whole body imaging for both lux and FLuc, bacteria and tumour cells were co-localised. 3D BLI and μCT image analysis revealed a pattern of multiple clusters of bacteria within tumours. Investigation of spatial resolution of 3D optical imaging was supported by ex vivo histological analyses. In vivo imaging of orally-administered commensal bacteria in the gastrointestinal tract (GIT) was also achieved using 3D BLI. This study demonstrates for the first time the potential to simultaneously image multiple BLI reporter genes three dimensionally in vivo using approaches that provide unique information on spatial locations.", "link"=>"http://www.mendeley.com/research/high-resolution-vivo-bioluminescent-imaging-study-bacterial-tumour-targeting", "reader_count"=>128, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>34, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>35, "Student > Postgraduate"=>1, "Other"=>12, "Student > Master"=>20, "Student > Bachelor"=>10, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>5, "Librarian"=>1, "Researcher"=>34, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>35, "Student > Postgraduate"=>1, "Other"=>12, "Student > Master"=>20, "Student > Bachelor"=>10, "Lecturer"=>2, "Lecturer > Senior Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Agricultural and Biological Sciences"=>67, "Arts and Humanities"=>1, "Veterinary Science and Veterinary Medicine"=>3, "Chemistry"=>7, "Engineering"=>12, "Biochemistry, Genetics and Molecular Biology"=>12, "Materials Science"=>1, "Medicine and Dentistry"=>12, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Physics and Astronomy"=>3, "Psychology"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Physics and Astronomy"=>{"Physics and Astronomy"=>3}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>4}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>12}, "Chemistry"=>{"Chemistry"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>67}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>12}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>3}}, "reader_count_by_country"=>{"Sweden"=>1, "Netherlands"=>1, "United States"=>3, "Mexico"=>2, "United Kingdom"=>2, "Italy"=>1, "Germany"=>1}, "group_count"=>10}CrossRef
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Scopus | Further Information
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Wikipedia | Further Information
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- {"month"=>"10", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"105"}
- {"month"=>"11", "year"=>"2017", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"163"}
- {"month"=>"12", "year"=>"2017", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"127"}
- {"month"=>"1", "year"=>"2018", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"86"}
- {"month"=>"2", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"64"}
- {"month"=>"3", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"55"}
- {"month"=>"4", "year"=>"2018", "pdf_views"=>"23", "xml_views"=>"1", "html_views"=>"53"}
- {"month"=>"5", "year"=>"2018", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"40"}
- {"month"=>"6", "year"=>"2018", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"37"}
- {"month"=>"7", "year"=>"2018", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"21"}
- {"month"=>"8", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"2", "html_views"=>"35"}
- {"month"=>"9", "year"=>"2018", "pdf_views"=>"19", "xml_views"=>"1", "html_views"=>"31"}
- {"month"=>"10", "year"=>"2018", "pdf_views"=>"14", "xml_views"=>"3", "html_views"=>"29"}
- {"month"=>"11", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"23"}
- {"month"=>"12", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"50"}
- {"month"=>"1", "year"=>"2019", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"51"}
- {"month"=>"2", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"45"}
- {"month"=>"3", "year"=>"2019", "pdf_views"=>"25", "xml_views"=>"0", "html_views"=>"35"}
- {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"28"}
- {"month"=>"5", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"52"}
- {"month"=>"6", "year"=>"2019", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"61"}
- {"month"=>"7", "year"=>"2019", "pdf_views"=>"34", "xml_views"=>"0", "html_views"=>"37"}
- {"month"=>"8", "year"=>"2019", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"46"}
- {"month"=>"9", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"41"}
- {"month"=>"10", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"11", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"42"}
- {"month"=>"12", "year"=>"2019", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"34"}
- {"month"=>"1", "year"=>"2020", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"39"}
- {"month"=>"2", "year"=>"2020", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"37"}
- {"month"=>"3", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"9"}
- {"month"=>"4", "year"=>"2020", "pdf_views"=>"27", "xml_views"=>"0", "html_views"=>"28"}
- {"month"=>"5", "year"=>"2020", "pdf_views"=>"32", "xml_views"=>"1", "html_views"=>"21"}
- {"month"=>"6", "year"=>"2020", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"18"}
- {"month"=>"7", "year"=>"2020", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"25"}
- {"month"=>"8", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"17"}
- {"month"=>"9", "year"=>"2020", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"24"}
- {"month"=>"10", "year"=>"2020", "pdf_views"=>"24", "xml_views"=>"0", "html_views"=>"32"}
- {"month"=>"11", "year"=>"2020", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"16"}
- {"month"=>"12", "year"=>"2020", "pdf_views"=>"7", "xml_views"=>"3", "html_views"=>"16"}
- {"month"=>"1", "year"=>"2021", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"23"}
PMC Usage Stats | Further Information
- {"month"=>"2", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"120", "year"=>"2012", "pdf"=>"96", "unique-ip"=>"108", "figure"=>"60", "scanned-summary"=>"0", "supp-data"=>"6"}
- {"scanned-page-browse"=>"0", "month"=>"3", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"74", "unique-ip"=>"69", "pdf"=>"60", "year"=>"2012", "figure"=>"41", "scanned-summary"=>"0", "supp-data"=>"9"}
- {"month"=>"4", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"2", "full-text"=>"62", "year"=>"2012", "pdf"=>"46", "unique-ip"=>"62", "figure"=>"24", "scanned-summary"=>"0", "supp-data"=>"5"}
- {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"44", "unique-ip"=>"40", "pdf"=>"26", "year"=>"2012", "figure"=>"22", "scanned-summary"=>"0", "supp-data"=>"12"}
- {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"43", "year"=>"2012", "pdf"=>"33", "unique-ip"=>"44", "figure"=>"11", "scanned-summary"=>"0", "supp-data"=>"0"}
- {"unique-ip"=>"36", "full-text"=>"33", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
- {"unique-ip"=>"31", "full-text"=>"36", "pdf"=>"20", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
- {"unique-ip"=>"32", "full-text"=>"44", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
- {"unique-ip"=>"48", "full-text"=>"44", "pdf"=>"21", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"30", "supp-data"=>"14", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
- {"unique-ip"=>"43", "full-text"=>"43", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"8", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
- {"unique-ip"=>"41", "full-text"=>"40", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
- {"unique-ip"=>"48", "full-text"=>"60", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
- {"unique-ip"=>"38", "full-text"=>"43", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
- {"unique-ip"=>"42", "full-text"=>"47", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
- {"unique-ip"=>"50", "full-text"=>"57", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"9", "cited-by"=>"1", "year"=>"2012", "month"=>"11"}
- {"unique-ip"=>"39", "full-text"=>"34", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
- {"unique-ip"=>"31", "full-text"=>"27", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
- {"unique-ip"=>"20", "full-text"=>"13", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
- {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"241", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
- {"unique-ip"=>"26", "full-text"=>"21", "pdf"=>"235", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
- {"unique-ip"=>"27", "full-text"=>"20", "pdf"=>"5", "abstract"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"13", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
- {"unique-ip"=>"21", "full-text"=>"18", "pdf"=>"7", "abstract"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
- {"unique-ip"=>"17", "full-text"=>"19", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
- {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
- {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
- {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"18", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
- {"unique-ip"=>"15", "full-text"=>"17", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
- {"unique-ip"=>"19", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
- {"unique-ip"=>"20", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
- {"unique-ip"=>"32", "full-text"=>"29", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
- {"unique-ip"=>"14", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
- {"unique-ip"=>"22", "full-text"=>"26", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
- {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"7"}
- {"unique-ip"=>"28", "full-text"=>"30", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"15", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
- {"unique-ip"=>"15", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
- {"unique-ip"=>"29", "full-text"=>"24", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
- {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
- {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
- {"unique-ip"=>"18", "full-text"=>"15", "pdf"=>"5", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
- {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
- {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"7", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
- {"unique-ip"=>"24", "full-text"=>"19", "pdf"=>"7", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"14", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
- {"unique-ip"=>"28", "full-text"=>"27", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
- {"unique-ip"=>"19", "full-text"=>"14", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"113", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
- {"unique-ip"=>"19", "full-text"=>"15", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
- {"unique-ip"=>"29", "full-text"=>"29", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
- {"unique-ip"=>"24", "full-text"=>"21", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
- {"unique-ip"=>"26", "full-text"=>"28", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
- {"unique-ip"=>"25", "full-text"=>"23", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
- {"unique-ip"=>"23", "full-text"=>"29", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
- {"unique-ip"=>"33", "full-text"=>"34", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"16", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
- {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
- {"unique-ip"=>"27", "full-text"=>"31", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
- {"unique-ip"=>"17", "full-text"=>"17", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
- {"unique-ip"=>"20", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
- {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
- {"unique-ip"=>"24", "full-text"=>"25", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
- {"unique-ip"=>"16", "full-text"=>"16", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
- {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
- {"unique-ip"=>"25", "full-text"=>"27", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
- {"unique-ip"=>"22", "full-text"=>"24", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
- {"unique-ip"=>"22", "full-text"=>"21", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
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Relative Metric
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