Uncovering the Molecular Machinery of the Human Spindle—An Integration of Wet and Dry Systems Biology
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Mendeley | Further Information

{"title"=>"Uncovering the molecular machinery of the human spindle-an integration of wet and dry systems biology", "type"=>"journal", "authors"=>[{"first_name"=>"Ana M.", "last_name"=>"Rojas", "scopus_author_id"=>"57143751600"}, {"first_name"=>"Anna", "last_name"=>"Santamaria", "scopus_author_id"=>"7102375902"}, {"first_name"=>"Rainer", "last_name"=>"Malik", "scopus_author_id"=>"57197900620"}, {"first_name"=>"Thomas Skøt", "last_name"=>"Jensen", "scopus_author_id"=>"57196558902"}, {"first_name"=>"Roman", "last_name"=>"Körner", "scopus_author_id"=>"7003672380"}, {"first_name"=>"Ian", "last_name"=>"Morilla", "scopus_author_id"=>"36523269400"}, {"first_name"=>"David", "last_name"=>"de Juan", "scopus_author_id"=>"23492288400"}, {"first_name"=>"Martin", "last_name"=>"Krallinger", "scopus_author_id"=>"8508138400"}, {"first_name"=>"Daniel Aaen", "last_name"=>"Hansen", "scopus_author_id"=>"23466861600"}, {"first_name"=>"Robert", "last_name"=>"Hoffmann", "scopus_author_id"=>"56854843600"}, {"first_name"=>"Jonathan", "last_name"=>"Lees", "scopus_author_id"=>"9636068500"}, {"first_name"=>"Adam", "last_name"=>"Reid", "scopus_author_id"=>"15760716800"}, {"first_name"=>"Corin", "last_name"=>"Yeats", "scopus_author_id"=>"55991503600"}, {"first_name"=>"Anja", "last_name"=>"Wehner", "scopus_author_id"=>"8948232300"}, {"first_name"=>"Sabine", "last_name"=>"Elowe", "scopus_author_id"=>"6505861943"}, {"first_name"=>"Andrew B.", "last_name"=>"Clegg", "scopus_author_id"=>"36146926700"}, {"first_name"=>"Søren", "last_name"=>"Brunak", "scopus_author_id"=>"7005477388"}, {"first_name"=>"Erich A.", "last_name"=>"Nigg", "scopus_author_id"=>"35433130400"}, {"first_name"=>"Christine", "last_name"=>"Orengo", "scopus_author_id"=>"7006781333"}, {"first_name"=>"Alfonso", "last_name"=>"Valencia", "scopus_author_id"=>"16308427600"}, {"first_name"=>"Juan A.G.", "last_name"=>"Ranea", "scopus_author_id"=>"7801487448"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84857982256", "doi"=>"10.1371/journal.pone.0031813", "issn"=>"19326203", "pui"=>"364394753", "isbn"=>"2003505520", "pmid"=>"22427808", "scopus"=>"2-s2.0-84857982256"}, "id"=>"a023d6f0-192f-3b89-87f5-3060df91cc16", "abstract"=>"The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments. However, because of its dynamic organization and complex regulation it is difficult to obtain a complete description of its molecular composition. We have implemented an integrated computational approach to characterize novel human spindle components and have analysed in detail the individual candidates predicted to be spindle proteins, as well as the network of predicted relations connecting known and putative spindle proteins. The subsequent experimental validation of a number of predicted novel proteins confirmed not only their association with the spindle apparatus but also their role in mitosis. We found that 75% of our tested proteins are localizing to the spindle apparatus compared to a success rate of 35% when expert knowledge alone was used. We compare our results to the previously published MitoCheck study and see that our approach does validate some findings by this consortium. Further, we predict so-called \"hidden spindle hub\", proteins whose network of interactions is still poorly characterised by experimental means and which are thought to influence the functionality of the mitotic spindle on a large scale. Our analyses suggest that we are still far from knowing the complete repertoire of functionally important components of the human spindle network. Combining integrated bio-computational approaches and single gene experimental follow-ups could be key to exploring the still hidden regions of the human spindle system.", "link"=>"http://www.mendeley.com/research/uncovering-molecular-machinery-human-spindlean-integration-wet-dry-systems-biology", "reader_count"=>37, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>4, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. 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Student"=>10, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>8, "Agricultural and Biological Sciences"=>22, "Medicine and Dentistry"=>2, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>22}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>8}, "Unspecified"=>{"Unspecified"=>1}, "Environmental Science"=>{"Environmental Science"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>3, "Portugal"=>1, "Spain"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/671274"], "description"=>"<p>Hidden spindle hubs (rectangular nodes) and associated known spindle proteins (pink circle nodes). Enriched functional classes related to spindle clusters are indicated – see Methods (black labels). For the spindle interacting proteins IDs see <b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031813#pone.0031813.s020\" target=\"_blank\">Table S10</a></b>.</p>", "links"=>[], "tags"=>["spindle"], "article_id"=>341741, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.g005", "stats"=>{"downloads"=>2, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Network_model_of_the_hidden_spindle_hubs_/341741", "title"=>"Network model of the hidden spindle hubs.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-09 00:29:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/342891", "https://ndownloader.figshare.com/files/342902", "https://ndownloader.figshare.com/files/342923", "https://ndownloader.figshare.com/files/342933", "https://ndownloader.figshare.com/files/342946", "https://ndownloader.figshare.com/files/342956", "https://ndownloader.figshare.com/files/342964", "https://ndownloader.figshare.com/files/342975", "https://ndownloader.figshare.com/files/342987", "https://ndownloader.figshare.com/files/343000", "https://ndownloader.figshare.com/files/343012", "https://ndownloader.figshare.com/files/343022", "https://ndownloader.figshare.com/files/343034", "https://ndownloader.figshare.com/files/343041", "https://ndownloader.figshare.com/files/343049", "https://ndownloader.figshare.com/files/343094", "https://ndownloader.figshare.com/files/343116", "https://ndownloader.figshare.com/files/343124", "https://ndownloader.figshare.com/files/343134", "https://ndownloader.figshare.com/files/343145", "https://ndownloader.figshare.com/files/343155", "https://ndownloader.figshare.com/files/343167"], "description"=>"<div><p>The mitotic spindle is an essential molecular machine involved in cell division, whose composition has been studied extensively by detailed cellular biology, high-throughput proteomics, and RNA interference experiments. However, because of its dynamic organization and complex regulation it is difficult to obtain a complete description of its molecular composition. We have implemented an integrated computational approach to characterize novel human spindle components and have analysed in detail the individual candidates predicted to be spindle proteins, as well as the network of predicted relations connecting known and putative spindle proteins. The subsequent experimental validation of a number of predicted novel proteins confirmed not only their association with the spindle apparatus but also their role in mitosis. We found that 75% of our tested proteins are localizing to the spindle apparatus compared to a success rate of 35% when expert knowledge alone was used. We compare our results to the previously published MitoCheck study and see that our approach does validate some findings by this consortium. Further, we predict so-called “hidden spindle hub”, proteins whose network of interactions is still poorly characterised by experimental means and which are thought to influence the functionality of the mitotic spindle on a large scale. Our analyses suggest that we are still far from knowing the complete repertoire of functionally important components of the human spindle network. Combining integrated bio-computational approaches and single gene experimental follow-ups could be key to exploring the still hidden regions of the human spindle system.</p> </div>", "links"=>[], "tags"=>["uncovering", "molecular", "machinery", "systems"], "article_id"=>127771, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0031813.s001", "https://dx.doi.org/10.1371/journal.pone.0031813.s002", "https://dx.doi.org/10.1371/journal.pone.0031813.s003", "https://dx.doi.org/10.1371/journal.pone.0031813.s004", "https://dx.doi.org/10.1371/journal.pone.0031813.s005", "https://dx.doi.org/10.1371/journal.pone.0031813.s006", "https://dx.doi.org/10.1371/journal.pone.0031813.s007", "https://dx.doi.org/10.1371/journal.pone.0031813.s008", "https://dx.doi.org/10.1371/journal.pone.0031813.s009", "https://dx.doi.org/10.1371/journal.pone.0031813.s010", "https://dx.doi.org/10.1371/journal.pone.0031813.s011", "https://dx.doi.org/10.1371/journal.pone.0031813.s012", "https://dx.doi.org/10.1371/journal.pone.0031813.s013", "https://dx.doi.org/10.1371/journal.pone.0031813.s014", "https://dx.doi.org/10.1371/journal.pone.0031813.s015", "https://dx.doi.org/10.1371/journal.pone.0031813.s016", "https://dx.doi.org/10.1371/journal.pone.0031813.s017", "https://dx.doi.org/10.1371/journal.pone.0031813.s018", "https://dx.doi.org/10.1371/journal.pone.0031813.s019", "https://dx.doi.org/10.1371/journal.pone.0031813.s020", "https://dx.doi.org/10.1371/journal.pone.0031813.s021", "https://dx.doi.org/10.1371/journal.pone.0031813.s022"], "stats"=>{"downloads"=>170, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Uncovering_the_Molecular_Machinery_of_the_Human_Spindle_An_Integration_of_Wet_and_Dry_Systems_Biology/127771", "title"=>"Uncovering the Molecular Machinery of the Human Spindle—An Integration of Wet and Dry Systems Biology", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-03-09 02:09:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/670797"], "description"=>"<p>Validation of the predictions using the text mined, manually curated dataset, EXPERT, as true positives. (A) ROC curves: Sensitivity (also called Recall; y-axis) versus 1-Specificity (x-axis). And (B) PR curves: Precision (y-axis) versus Recall (x-axis) retrieved by each method.</p>", "links"=>[], "tags"=>["spindle"], "article_id"=>341260, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.g002", "stats"=>{"downloads"=>0, "page_views"=>10, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Validation_of_the_performance_of_the_spindle_prediction_platform_SPIP_in_the_human_proteome_/341260", "title"=>"Validation of the performance of the spindle prediction platform (SPIP) in the human proteome.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-09 00:21:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/671431"], "description"=>"<p>The scheme, output, benchmark, validation and results are shown.</p>", "links"=>[], "tags"=>["benchmarks", "conducted", "corresponding"], "article_id"=>341897, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_benchmarks_conducted_in_this_study_and_the_corresponding_findings_/341897", "title"=>"Summary of the benchmarks conducted in this study and the corresponding findings.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-09 00:31:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/671505"], "description"=>"<p>nd = not determined. The protein name, accession number, whether it has been successfully cloned in this study or not, the mitotic localization, whether they localize or not to the spindle apparatus, the reported siRNA phenotype is specified (nd = not determined), and the target rank in the SPIP list of functionally unknown proteins (<b><a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031813#pone.0031813.s016\" target=\"_blank\">Table S6</a></b>).</p>", "links"=>[], "tags"=>["validation", "mitotic", "localization", "sirna"], "article_id"=>341966, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.t003", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Targets_selected_for_experimental_validation_and_summary_of_mitotic_localization_and_siRNA_phenotypes_/341966", "title"=>"Targets selected for experimental validation and summary of mitotic localization and siRNA phenotypes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-09 00:32:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/671627"], "description"=>"<p>Number of predictions retrieved by each method.</p>", "links"=>[], "tags"=>["predictions"], "article_id"=>342095, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.t005", "stats"=>{"downloads"=>4, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Number_of_predictions_retrieved_by_each_method_/342095", "title"=>"Number of predictions retrieved by each method.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-09 00:34:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/671566"], "description"=>"<p>From right to left: Spindle hidden hub clusters, Spindle hidden hub proteins considered in each cluster; Functional composition; enriched functional classes in each cluster; %, coverage of the functional classes over the total number of interacting spindle proteins; Spindle partners IDs, the accession numbers in Uniprot of the interacting spindle proteins annotated under each enriched functional class. Proteins repeated in different functional classes within the same cluster are labeled in bold.</p>", "links"=>[], "tags"=>["spindle", "sub-network"], "article_id"=>342030, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.t004", "stats"=>{"downloads"=>5, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_results_of_the_hidden_spindle_hubs_sub_network_functional_analysis_/342030", "title"=>"Summary of the results of the ‘<i>hidden spindle hubs</i>’ sub-network functional analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-09 00:33:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/670645"], "description"=>"<p>Left panel, “Prediction”: describes three different approaches (dashed boxes, NNI, DGC, LM) which include seven independent methods for predicting spindle associated proteins from all proteins in the human proteome. Each method has its own associated confidence score (red: the less confident). NNI group of methods includes the MLNN method that integrates different spindle protein features to predict new spindle proteins using Neural Network technology; The DGC approach includes the following methods: DORA that searches for domains characteristic of known spindle proteins in target proteins; hiPPI that scores potential interactions between putative and spindle proteins based on their homology to known interacting protein pairs; CODA that scores putative spindle proteins if there is a homologous domain fused to a homologue of a domain typically associated with spindle proteins; the GOSS method that measures semantic similarity of the GO terms for known and putative spindle proteins, and finally the GECO method that measures the correlation of gene expression profiles between known and putative spindle proteins. The LM approach includes the COCITE method that detects pairs of spindle and target proteins co-cited in the literature. The left panel of the figure represents the following: For a given set of proteins (labelled with numbers) each method scores the same protein at a different rank, for example protein 1 is top-ranked in NNI but ranked in second place by Hippi i.e. depending on the method we could have different rankings for the same protein. Central box, “Integration”: The scores within each prediction dataset were translated into p-values and combined in a target prediction matrix. The prediction p-values from the 3 approaches, LM, NNI and DGC were then integrated into the Spindle Prediction Integrated Platform score (SPIP) for every protein target, again using Fisher's method (for more details see the Material and Methods section). Upper box, Validation”: SPIP was validated using two different schemes, a computational one using the whole human proteome, and an experimental one using a subset of selected “unknown proteins” to conduct experimental validation (see the text). Lower box, “Context analyses”: to identify relevant targets potentially involved in “hidden hubs”.</p>", "links"=>[], "tags"=>["spindle"], "article_id"=>341116, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.g001", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_Spindle_Prediction_Integrated_Platform_SPIP_workflow_/341116", "title"=>"The Spindle Prediction Integrated Platform (SPIP) workflow.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-09 00:18:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/671372"], "description"=>"<p>The class, method, type and laboratory where the methods were developed is shown.</p>", "links"=>[], "tags"=>["methods"], "article_id"=>341846, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.t001", "stats"=>{"downloads"=>0, "page_views"=>45, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Summary_of_the_methods_used_in_this_study_/341846", "title"=>"Summary of the methods used in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-03-09 00:30:46"}
  • {"files"=>["https://ndownloader.figshare.com/files/671090"], "description"=>"<p>(<b>A</b>) HeLa S3 cells were treated for 48 h with control (GL2) or <i>KIAA0841</i>-and <i>Nup88</i> specific siRNAs, respectively, then fixed and stained with α-Tubulin (green). DNA was visualized using DAPI (blue). Bar = 10 µm. (<b>B</b>) HeLa S3 cells were treated for 48 h with control (<i>GL2</i>) and p59Fyn specific siRNAs, respectively, then fixed and stained with α-Tubulin (green). DNA was visualized using DAPI (blue). Bar = 10 µm. (<b>C–G</b>) Stills of representative movies of H2B-GFP expressing HeLa S3 cells treated with control (<i>GL2</i>), <i>KIAA0841</i>, <i>Nup88</i>, <i>p59Fyn</i> and <i>WD75</i> siRNAs for 36 h before filming. Time points are indicated in h:min.</p>", "links"=>[], "tags"=>["phenotype", "observed", "depletion", "sirna", "spindle"], "article_id"=>341550, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.g004", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mitotic_phenotype_observed_upon_depletion_by_siRNA_of_the_selected_predicted_spindle_proteins_/341550", "title"=>"Mitotic phenotype observed upon depletion by siRNA of the selected predicted spindle proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-09 00:25:50"}
  • {"files"=>["https://ndownloader.figshare.com/files/670898"], "description"=>"<p>HeLa S3 cells were transfected with the indicated myc-tagged constructs, fixed and analyzed by indirect immunofluorescence. Cells were stained with 9E10 anti-myc antibody (red) and with α-Tubulin (green). DNA was visualized using DAPI (blue). Arrows indicate positive kinetochore staining. Bar = 10 µm.</p>", "links"=>[], "tags"=>["localization", "spindle"], "article_id"=>341362, "categories"=>["Biological Sciences", "Cell Biology"], "users"=>["Ana M. Rojas", "Anna Santamaria", "Rainer Malik", "Thomas Skøt Jensen", "Roman Körner", "Ian Morilla", "David de Juan", "Martin Krallinger", "Daniel Aaen Hansen", "Robert Hoffmann", "Jonathan Lees", "Adam Reid", "Corin Yeats", "Anja Wehner", "Sabine Elowe", "Andrew B. Clegg", "Søren Brunak", "Erich A. Nigg", "Christine Orengo", "Alfonso Valencia", "Juan A. G. Ranea"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0031813.g003", "stats"=>{"downloads"=>3, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mitotic_localization_of_selected_predicted_candidate_spindle_proteins_/341362", "title"=>"Mitotic localization of selected predicted candidate spindle proteins.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-03-09 00:22:42"}

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  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
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  • {"unique-ip"=>"17", "full-text"=>"6", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"5", "cited-by"=>"1", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"10", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
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  • {"unique-ip"=>"5", "full-text"=>"1", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"2", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
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  • {"unique-ip"=>"5", "full-text"=>"8", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"8", "full-text"=>"14", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"9", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"29", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"8", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"16", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"10", "full-text"=>"13", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"13", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"6", "full-text"=>"6", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"88", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"42", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"44", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"4", "full-text"=>"2", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"17", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"12", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"1", "full-text"=>"0", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
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Relative Metric

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