In Vitro Study of the Effects of Angiostrongylus cantonensis Larvae Extracts on Apoptosis and Dysfunction in the Blood-Brain Barrier (BBB)
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{"title"=>"In vitro study of the effects of angiostrongylus cantonensis larvae extracts on apoptosis and dysfunction in the blood-brain barrier (bbb)", "type"=>"journal", "authors"=>[{"first_name"=>"Xin", "last_name"=>"Hu", "scopus_author_id"=>"57199989958"}, {"first_name"=>"Jiang Hui", "last_name"=>"Li", "scopus_author_id"=>"55277537000"}, {"first_name"=>"Lan", "last_name"=>"Lan", "scopus_author_id"=>"55276713800"}, {"first_name"=>"Fei Fei", "last_name"=>"Wu", "scopus_author_id"=>"7403465305"}, {"first_name"=>"Er Peng", "last_name"=>"Zhang", "scopus_author_id"=>"55043578700"}, {"first_name"=>"Zeng Mei", "last_name"=>"Song", "scopus_author_id"=>"55042851500"}, {"first_name"=>"Hui Cong", "last_name"=>"Huang", "scopus_author_id"=>"14024302100"}, {"first_name"=>"Fang Jun", "last_name"=>"Luo", "scopus_author_id"=>"54903210400"}, {"first_name"=>"Chang Wang", "last_name"=>"Pan", "scopus_author_id"=>"16302180400"}, {"first_name"=>"Feng", "last_name"=>"Tan", "scopus_author_id"=>"35938055700"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203", "pui"=>"364355250", "sgr"=>"84863299096", "pmid"=>"22393387", "scopus"=>"2-s2.0-84863299096", "doi"=>"10.1371/journal.pone.0032161"}, "id"=>"9478e78a-ea46-3597-b76e-81a3f6f1347b", "abstract"=>"It has been hypothesized that blood-brain barrier (BBB) dysfunction in Angiostrongylus cantonensis infection might be due to the apoptosis of the hosts' BBB cells. Here, we evaluated this hypothesis through several methods, all based on an in vitro mouse BBB model consisting of primary culture brain microvascular endothelial cells (BMECs) and brain astrocytic cells (BACs). In the present study, a four-hour percolation and HRP permeability experiment showed that A. cantonensis larvae extracts can increase the permeability of the BBB. Apoptosis among BMECs and BACs after exposure to larvae extracts was monitored by TUNEL and annexin-V-FITC/PI double staining. A. cantonensis larvae extracts were found to induce apoptosis in both BMECs and BACs. For this reason, we concluded that the induction of apoptosis might participate in the BBB dysfunction observed during angiostrongyliasis. Improved fundamental understanding of how A. cantonensis induces apoptosis may lead to new approaches to the treatment or prevention of this parasitic disease.", "link"=>"http://www.mendeley.com/research/vitro-study-effects-angiostrongylus-cantonensis-larvae-extracts-apoptosis-dysfunction-bloodbrain-bar", "reader_count"=>11, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>5, "Neuroscience"=>1, "Physics and Astronomy"=>1, "Computer Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Czech Republic"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/673600"], "description"=>"<p>No positive signal was detected in alone (A–D) cultured BMECs or (I–L) cultured BACs. With larvae extract, however, positive signals were observed in (E–H) BMECs and (M–P) BACs. The same microscopic field was observed by (A, E, I, M) differential interference contrast, (B, E, H and K) FITC channel, and (C, G, K, O) PI channel. This figure shows a representative example of three independent experiments that all gave similar results.</p>", "links"=>[], "tags"=>["immunofluorescence", "images", "staining", "larvae"], "article_id"=>344086, "categories"=>["Neuroscience", "Infectious Diseases", "Immunology"], "users"=>["Xin Hu", "Jiang-Hui Li", "Lan Lan", "Fei-Fei Wu", "Er-Peng Zhang", "Zeng-Mei Song", "Hui-Cong Huang", "Fang-Jun Luo", "Chang-Wang Pan", "Feng Tan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032161.g004", "stats"=>{"downloads"=>2, "page_views"=>116, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Confocal_immunofluorescence_images_of_annexin_V_FITC_PI_double_staining_during_in_vitro_culture_with_or_without_A_cantonensis_larvae_extracts_/344086", "title"=>"Confocal immunofluorescence images of annexin-V-FITC/PI double staining during <i>in vitro</i> culture with or without <i>A. cantonensis</i> larvae extracts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:15:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/673201"], "description"=>"<p>Samples were collected from the donor and receiver tanks to calculate HRP permeability at 0.5, 1, 2, 3, 4, 8 h after larvae extracts were added to the BBB cell model, showing that the HRP permeability started to increase significantly in larvae extract group after 1 hour. Data are presented as the mean ± SD of three experiments. * <i>P</i><0.01, larvae extract group vs. control group at each point in time.</p>", "links"=>[], "tags"=>["hrp", "permeability", "bbb", "larvae"], "article_id"=>343681, "categories"=>["Neuroscience", "Infectious Diseases", "Immunology"], "users"=>["Xin Hu", "Jiang-Hui Li", "Lan Lan", "Fei-Fei Wu", "Er-Peng Zhang", "Zeng-Mei Song", "Hui-Cong Huang", "Fang-Jun Luo", "Chang-Wang Pan", "Feng Tan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032161.g002", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_on_HRP_Permeability_of_BBB_model_with_or_with_A_cantonesis_larvae_extracts_/343681", "title"=>"Analysis on HRP Permeability of BBB model with or with <i>A. cantonesis</i> larvae extracts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:13:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/673112"], "description"=>"<p>After larvae extracts were added to the BBB cell model, the time that the fluid level in the donor tank of Transwell started to drop was reported within 4 hours. The fluid level began to decrease significantly sooner in the larvae extract group. Data are presented as the mean ± SD of three experiments. * <i>P</i><0.01, larvae extract group vs. Control group.</p>", "links"=>[], "tags"=>["percolation", "bbb", "larvae"], "article_id"=>343586, "categories"=>["Neuroscience", "Infectious Diseases", "Immunology"], "users"=>["Xin Hu", "Jiang-Hui Li", "Lan Lan", "Fei-Fei Wu", "Er-Peng Zhang", "Zeng-Mei Song", "Hui-Cong Huang", "Fang-Jun Luo", "Chang-Wang Pan", "Feng Tan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032161.g001", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Analysis_of_percolation_ability_of_BBB_model_with_or_without_A_cantonesis_larvae_extracts_/343586", "title"=>"Analysis of percolation ability of BBB model with or without <i>A. cantonesis</i> larvae extracts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:12:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/673402"], "description"=>"<p>No positive signal was detected in (A) BMECs cultured alone or (C) BACs cultured alone. After the addition with larvae extract, positive signals were observed in both (B) BMECs and (D) BACs. This figure shows a representative example of three independent experiments that all gave similar results.</p>", "links"=>[], "tags"=>["detection", "apoptosis", "bmecs", "bacs", "larvae"], "article_id"=>343881, "categories"=>["Neuroscience", "Infectious Diseases", "Immunology"], "users"=>["Xin Hu", "Jiang-Hui Li", "Lan Lan", "Fei-Fei Wu", "Er-Peng Zhang", "Zeng-Mei Song", "Hui-Cong Huang", "Fang-Jun Luo", "Chang-Wang Pan", "Feng Tan"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032161.g003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TUNEL_detection_of_apoptosis_in_BMECs_and_BACs_with_and_without_A_cantonesis_larvae_extracts_/343881", "title"=>"TUNEL detection of apoptosis in BMECs and BACs with and without <i>A. cantonesis</i> larvae extracts.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 08:14:34"}

PMC Usage Stats | Further Information

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Relative Metric

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