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{"title"=>"A common HLA-DPA1 variant is associated with hepatitis b virus infection but fails to distinguish active from inactive caucasian carriers", "type"=>"journal", "authors"=>[{"first_name"=>"Johannes", "last_name"=>"Vermehren", "scopus_author_id"=>"24823201900"}, {"first_name"=>"Jörn", "last_name"=>"Lötsch", "scopus_author_id"=>"7004589758"}, {"first_name"=>"Simone", "last_name"=>"Susser", "scopus_author_id"=>"24448363600"}, {"first_name"=>"Sabine", "last_name"=>"Wicker", "scopus_author_id"=>"12785187200"}, {"first_name"=>"Annemarie", "last_name"=>"Berger", "scopus_author_id"=>"7402970321"}, {"first_name"=>"Stefan", "last_name"=>"Zeuzem", "scopus_author_id"=>"7103125178"}, {"first_name"=>"Christoph", "last_name"=>"Sarrazin", "scopus_author_id"=>"7004249751"}, {"first_name"=>"Alexandra", "last_name"=>"Doehring", "scopus_author_id"=>"22949784600"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22448225", "sgr"=>"84858625881", "doi"=>"10.1371/journal.pone.0032605", "scopus"=>"2-s2.0-84858625881", "pui"=>"364479949", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"ef5b60f9-958c-317b-8d7e-c5e491590756", "abstract"=>"Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians.", "link"=>"http://www.mendeley.com/research/common-hladpa1-variant-associated-hepatitis-b-virus-infection-fails-distinguish-active-inactive-cauc", "reader_count"=>13, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Master"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Master"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>0}

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• http://doi.org/10.1128/JVI.02073-13
• http://doi.org/10.1371/journal.pone.0080445
• http://doi.org/10.1517/14712598.2014.907784
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• http://doi.org/10.1155/2016/9069375

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Figshare

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• {"files"=>["https://ndownloader.figshare.com/files/664917"], "description"=>"*<p>controls include either healthy subjects with negative serological HBV markers (vs. HBV patients) or inactive HBsAg carriers in the subgroup analysis of patients with HBV infection (vs. active CHB patients);</p>**<p>to sustain the conventional gene description from the 5′ end to the 3′ end we changed the SNP denomination in comparison to previous publications. That is, the rs3077T/C alleles in our study correspond to the A/G alleles, respectively, in previously published studies <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032605#pone.0032605-Kamatani1\" target=\"_blank\">[9]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032605#pone.0032605-Guo1\" target=\"_blank\">[11]</a>.</p>", "links"=>[], "tags"=>["variant", "rs3077", "rs9277535", "hbv"], "article_id"=>335395, "categories"=>["Biotechnology", "Chemistry", "Genetics", "Infectious Diseases"], "users"=>["Johannes Vermehren", "Jörn Lötsch", "Simone Susser", "Sabine Wicker", "Annemarie Berger", "Stefan Zeuzem", "Christoph Sarrazin", "Alexandra Doehring"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0032605.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_HLA_DPA1_variant_rs3077_and_HLA_DPB1_variant_rs9277535_with_HBV_infection_/335395", "title"=>"Association of <i>HLA-DPA1</i> variant rs3077 and <i>HLA-DPB1</i> variant rs9277535 with HBV infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:29:51"}

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• {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[319, 556, 679, 785, 881, 970, 1062, 1149, 1236, 1323, 1402, 1474, 1545, 1617, 1681, 1754, 1822, 1892, 1963, 2031, 2099, 2165, 2233, 2299, 2359]}, {"subject_area"=>"/Biology and life sciences/Genetics", "average_usage"=>[333, 576, 707, 814, 908, 1004, 1104, 1197, 1280, 1370, 1449, 1531, 1603, 1673, 1742, 1817, 1886, 1954, 2025, 2098, 2171, 2234, 2304, 2365, 2431]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[312, 555, 680, 785, 880, 965, 1057, 1142, 1230, 1312, 1394, 1471, 1547, 1613, 1681, 1743, 1805, 1871, 1941, 2010, 2071, 2128, 2202, 2266, 2323]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[307, 545, 668, 765, 855, 943, 1029, 1113, 1202, 1285, 1361, 1439, 1506, 1571, 1636, 1706, 1772, 1837, 1901, 1969, 2031, 2096, 2160, 2228, 2287]}, {"subject_area"=>"/People and places", "average_usage"=>[330, 562, 680, 783, 875, 964, 1062, 1152, 1240, 1327, 1406, 1483, 1561, 1632, 1701, 1770, 1849, 1922, 1993, 2059, 2131, 2197, 2271, 2335, 2403]}, {"subject_area"=>"/People and places/Geographical locations", "average_usage"=>[318, 550, 661, 755, 847, 941, 1034, 1126, 1222, 1320, 1395, 1476, 1573, 1629, 1693, 1751, 1832, 1910, 1975, 2037, 2106, 2172, 2235, 2309, 2388]}]}

F1000Prime