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{"title"=>"A common HLA-DPA1 variant is associated with hepatitis b virus infection but fails to distinguish active from inactive caucasian carriers", "type"=>"journal", "authors"=>[{"first_name"=>"Johannes", "last_name"=>"Vermehren", "scopus_author_id"=>"24823201900"}, {"first_name"=>"Jörn", "last_name"=>"Lötsch", "scopus_author_id"=>"7004589758"}, {"first_name"=>"Simone", "last_name"=>"Susser", "scopus_author_id"=>"24448363600"}, {"first_name"=>"Sabine", "last_name"=>"Wicker", "scopus_author_id"=>"12785187200"}, {"first_name"=>"Annemarie", "last_name"=>"Berger", "scopus_author_id"=>"7402970321"}, {"first_name"=>"Stefan", "last_name"=>"Zeuzem", "scopus_author_id"=>"7103125178"}, {"first_name"=>"Christoph", "last_name"=>"Sarrazin", "scopus_author_id"=>"7004249751"}, {"first_name"=>"Alexandra", "last_name"=>"Doehring", "scopus_author_id"=>"22949784600"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22448225", "sgr"=>"84858625881", "doi"=>"10.1371/journal.pone.0032605", "scopus"=>"2-s2.0-84858625881", "pui"=>"364479949", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"ef5b60f9-958c-317b-8d7e-c5e491590756", "abstract"=>"Chronic infection with the hepatitis B virus (HBV) is a major health issue worldwide. Recently, single nucleotide polymorphisms (SNPs) within the human leukocyte antigen (HLA)-DP locus were identified to be associated with HBV infection in Asian populations. Most significant associations were observed for the A alleles of HLA-DPA1 rs3077 and HLA-DPB1 rs9277535, which conferred a decreased risk for HBV infection. We assessed the implications of these variants for HBV infection in Caucasians.", "link"=>"http://www.mendeley.com/research/common-hladpa1-variant-associated-hepatitis-b-virus-infection-fails-distinguish-active-inactive-cauc", "reader_count"=>13, "reader_count_by_academic_status"=>{"Researcher"=>5, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Master"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>5, "Student > Ph. D. Student"=>2, "Other"=>2, "Student > Master"=>1, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>0}

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• http://doi.org/10.1128/JVI.02073-13
• http://doi.org/10.1371/journal.pone.0080445
• http://doi.org/10.1517/14712598.2014.907784
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Figshare

• {"files"=>["https://ndownloader.figshare.com/files/664874"], "description"=>"<p>Characteristics are shown for all patients as well as inactive HBsAg carriers (n = 48) and active CHB patients (n = 46) in whom longitudinal data were available.</p><p>IC, inactive HBsAg carriers; CHB, active chronic hepatitis B;</p>*<p>HBV genotype was available in 67 patients (25 in IC and 18 in CHB).</p>", "links"=>[], "tags"=>["characteristics", "patients", "persistent", "hbv"], "article_id"=>335350, "categories"=>["Biotechnology", "Chemistry", "Genetics", "Infectious Diseases"], "users"=>["Johannes Vermehren", "Jörn Lötsch", "Simone Susser", "Sabine Wicker", "Annemarie Berger", "Stefan Zeuzem", "Christoph Sarrazin", "Alexandra Doehring"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0032605.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_characteristics_of_patients_with_persistent_HBV_infection_n_8202_8202_201_/335350", "title"=>"Clinical characteristics of patients with persistent HBV infection (n = 201).", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:29:36"}
• {"files"=>["https://ndownloader.figshare.com/files/664917"], "description"=>"*<p>controls include either healthy subjects with negative serological HBV markers (vs. HBV patients) or inactive HBsAg carriers in the subgroup analysis of patients with HBV infection (vs. active CHB patients);</p>**<p>to sustain the conventional gene description from the 5′ end to the 3′ end we changed the SNP denomination in comparison to previous publications. That is, the rs3077T/C alleles in our study correspond to the A/G alleles, respectively, in previously published studies <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032605#pone.0032605-Kamatani1\" target=\"_blank\">[9]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0032605#pone.0032605-Guo1\" target=\"_blank\">[11]</a>.</p>", "links"=>[], "tags"=>["variant", "rs3077", "rs9277535", "hbv"], "article_id"=>335395, "categories"=>["Biotechnology", "Chemistry", "Genetics", "Infectious Diseases"], "users"=>["Johannes Vermehren", "Jörn Lötsch", "Simone Susser", "Sabine Wicker", "Annemarie Berger", "Stefan Zeuzem", "Christoph Sarrazin", "Alexandra Doehring"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0032605.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_HLA_DPA1_variant_rs3077_and_HLA_DPB1_variant_rs9277535_with_HBV_infection_/335395", "title"=>"Association of <i>HLA-DPA1</i> variant rs3077 and <i>HLA-DPB1</i> variant rs9277535 with HBV infection.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:29:51"}

PMC Usage Stats | Further Information

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Relative Metric

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F1000Prime