Epithelial Proinflammatory Response and Curcumin-Mediated Protection from Staphylococcal Toxic Shock Syndrome Toxin-1
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Mendeley | Further Information

{"title"=>"Epithelial proinflammatory response and curcumin-mediated protection from staphylococcal toxic shock syndrome toxin-1", "type"=>"journal", "authors"=>[{"first_name"=>"Matthew M.", "last_name"=>"Schaefers", "scopus_author_id"=>"25923132400"}, {"first_name"=>"Laura M.", "last_name"=>"Breshears", "scopus_author_id"=>"22940440600"}, {"first_name"=>"Michele J.", "last_name"=>"Anderson", "scopus_author_id"=>"55276207600"}, {"first_name"=>"Ying Chi", "last_name"=>"Lin", "scopus_author_id"=>"56301481800"}, {"first_name"=>"Alex E.", "last_name"=>"Grill", "scopus_author_id"=>"32867651500"}, {"first_name"=>"Jayanth", "last_name"=>"Panyam", "scopus_author_id"=>"6602498359"}, {"first_name"=>"Peter J.", "last_name"=>"Southern", "scopus_author_id"=>"7005920505"}, {"first_name"=>"Patrick M.", "last_name"=>"Schlievert", "scopus_author_id"=>"7103254042"}, {"first_name"=>"Marnie L.", "last_name"=>"Peterson", "scopus_author_id"=>"35609719200"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84863274002", "sgr"=>"84863274002", "pui"=>"364433910", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22431984", "doi"=>"10.1371/journal.pone.0032813"}, "id"=>"9aeb26e8-dd10-3952-91bb-369ef7623c72", "abstract"=>"Staphylococcus aureus initiates infections and produces virulence factors, including superantigens (SAgs), at mucosal surfaces. The SAg, Toxic Shock Syndrome Toxin-1 (TSST-1) induces cytokine secretion from epithelial cells, antigen presenting cells (APCs) and T lymphocytes, and causes toxic shock syndrome (TSS). This study investigated the mechanism of TSST-1-induced secretion of proinflammatory cytokines from human vaginal epithelial cells (HVECs) and determined if curcumin, an anti-inflammatory agent, could reduce TSST-1-mediated pathology in a rabbit vaginal model of TSS. TSST-1 caused a significant increase in NF-κB-dependent transcription in HVECs that was associated with increased expression of TNF- α, MIP-3α, IL-6 and IL-8. Curcumin, an antagonist of NF-κB-dependent transcription, inhibited IL-8 production from ex vivo porcine vaginal explants at nontoxic doses. In a rabbit model of TSS, co-administration of curcumin with TSST-1 intravaginally reduced lethality by 60% relative to 100% lethality in rabbits receiving TSST-1 alone. In addition, TNF-α was undetectable from serum or vaginal tissue of curcumin treated rabbits that survived. These data suggest that the inflammatory response induced at the mucosal surface by TSST-1 is NF-κB dependent. In addition, the ability of curcumin to prevent TSS in vivo by co-administration with TSST-1 intravaginally suggests that the vaginal mucosal proinflammatory response to TSST-1 is important in the progression of mTSS.", "link"=>"http://www.mendeley.com/research/epithelial-proinflammatory-response-curcuminmediated-protection-staphylococcal-toxic-shock-syndrome", "reader_count"=>20, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Student > Master"=>3, "Other"=>3, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Ph. D. Student"=>5, "Student > Postgraduate"=>4, "Student > Master"=>3, "Other"=>3, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Social Sciences"=>1, "Computer Science"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Computer Science"=>{"Computer Science"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Canada"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/668027"], "description"=>"<p>(A) Curcumin protects rabbit from lethal TSS. TSST-1 (10 µg) in 3% DMSO was administered intravaginally with or without curcumin (1.62 µmol) (n = 8 rabbits per group). Four hours later LPS (0.1 µg/kg) was administered via ear marginal vein and animals monitored for survival. Curcumin significantly reduced TSS-induced mortality compared to untreated (p<.0028, Log-rank test). Four rabbits (given curcumin only, triangles) displayed no signs of disease and survived the entirety of the experiment. Curcumin decreases TNF-α in serum (B) and vaginal tissue (C) from surviving rabbits in a lethal model of TSS. TNF-α in serum and homogenized vaginal tissue was determined using ELISA. Each data point corresponds to data from 1 rabbit measured in duplicate. Data presented as mean ± SEM.</p>", "links"=>[], "tags"=>["tsst-1-induced"], "article_id"=>338512, "categories"=>["Infectious Diseases"], "users"=>["Matthew M. Schaefers", "Laura M. Breshears", "Michele J. Anderson", "Ying-Chi Lin", "Alex E. Grill", "Jayanth Panyam", "Peter J. Southern", "Patrick M. Schlievert", "Marnie L. Peterson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032813.g005", "stats"=>{"downloads"=>3, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curcumin_reduces_TSST_1_induced_death_in_a_rabbit_model_of_TSS_/338512", "title"=>"Curcumin reduces TSST-1-induced death in a rabbit model of TSS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:46:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/667732"], "description"=>"<p>HVECs were exposed to TSST-1 (50 and 100 µg/ml) or media only controls (0 µg/ml) for 6 h, then RNA was harvested and supernates collected. (A) changes in expression of proinflammatory genes were measured by real time RT-PCR, and (B–E) secreted cytokines were measured via multiplex cytokine array. Data presented in 2A are representative of three independent experiments conducted in triplicate, data presented in 2B–E are from one experiment conducted in triplicate, mean ± SD. * denotes p<0.05 compared to media only control.</p>", "links"=>[], "tags"=>["induces", "cytokines", "immortalized"], "article_id"=>338214, "categories"=>["Infectious Diseases"], "users"=>["Matthew M. Schaefers", "Laura M. Breshears", "Michele J. Anderson", "Ying-Chi Lin", "Alex E. Grill", "Jayanth Panyam", "Peter J. Southern", "Patrick M. Schlievert", "Marnie L. Peterson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032813.g002", "stats"=>{"downloads"=>1, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TSST_1_induces_cytokines_from_immortalized_HVEC_/338214", "title"=>"TSST-1 induces cytokines from immortalized HVEC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:44:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/667859"], "description"=>"<p>HVECs were transfected with plasmids containing NF-κB response elements or a basal promoter (negative control), which control expression of luciferase. Transfected cells were then treated with TSST-1 (250 µg/ml) or left untreated for 4 h, then luciferase activity was measured. Data presented are from 15 replicates obtained from three independent experiments, mean ± SD. * denotes p<0.001 compared to corresponding media only control.</p>", "links"=>[], "tags"=>["activates"], "article_id"=>338343, "categories"=>["Infectious Diseases"], "users"=>["Matthew M. Schaefers", "Laura M. Breshears", "Michele J. Anderson", "Ying-Chi Lin", "Alex E. Grill", "Jayanth Panyam", "Peter J. Southern", "Patrick M. Schlievert", "Marnie L. Peterson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032813.g003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TSST_1_activates_NF_954_B_in_HVEC_/338343", "title"=>"TSST-1 activates NF-κB in HVEC.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:45:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/668166"], "description"=>"<p>Primers used in reverse transcription polymerase chain reaction.</p>", "links"=>[], "tags"=>["transcription", "polymerase"], "article_id"=>338650, "categories"=>["Infectious Diseases"], "users"=>["Matthew M. Schaefers", "Laura M. Breshears", "Michele J. Anderson", "Ying-Chi Lin", "Alex E. Grill", "Jayanth Panyam", "Peter J. Southern", "Patrick M. Schlievert", "Marnie L. Peterson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032813.t001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Primers_used_in_reverse_transcription_polymerase_chain_reaction_/338650", "title"=>"Primers used in reverse transcription polymerase chain reaction.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:46:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/667638"], "description"=>"<p>HVEC were exposed to TSST-1 (10–500 µg/ml) for 6 h, then cell viability (A) and IL-8 production (B) were determined. Viability was determined using an MTT assay. IL-8 was measured from culture supernatants by ELISA and expressed as fold increase in IL-8 production compared to media only control (TSST-1 0 µg/ml). Data presented are representative of three independent experiments done in triplicate, mean ± SD. * denotes p<0.05 compared to media only control.</p>", "links"=>[], "tags"=>["induces", "il-8", "activates", "hvec"], "article_id"=>338107, "categories"=>["Infectious Diseases"], "users"=>["Matthew M. Schaefers", "Laura M. Breshears", "Michele J. Anderson", "Ying-Chi Lin", "Alex E. Grill", "Jayanth Panyam", "Peter J. Southern", "Patrick M. Schlievert", "Marnie L. Peterson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032813.g001", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_TSST_1_induces_IL_8_and_activates_NF_954_B_from_HVEC_with_minimal_toxicity_/338107", "title"=>"TSST-1 induces IL-8 and activates NF-κB from HVEC with minimal toxicity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:43:55"}
  • {"files"=>["https://ndownloader.figshare.com/files/667953"], "description"=>"<p>(A) Porcine vaginal explants (5 mm) were treated with curcumin in 5 µl of 100% DMSO and incubated for 18 h. Tissue viability was measured using a MTT assay and normalized to tissue left untreated (media only: no DMSO or curcumin). * denotes p<0.05 compared to vehicle control (0 nmol curcumin in 100% DMSO) by ANOVA. Curcumin inhibits IL-8 production. Porcine vaginal explants were left unstimulated (B) or stimulated with filtered <i>S. aureus</i> culture supernates for 1 h (C) and then exposed to curcumin (5 µl/explant in 10% DMSO) and incubated for an additional 6 h. Tissue was disrupted and IL-8 was measured by ELISA. * denotes p<0.05 compared to vehicle control (0 nmol curcumin in 10% DMSO) by ANOVA. Data presented are representative of three independent experiments done in triplicate, mean ± SD.</p>", "links"=>[], "tags"=>["inhibits", "exoprotein-induced"], "article_id"=>338431, "categories"=>["Infectious Diseases"], "users"=>["Matthew M. Schaefers", "Laura M. Breshears", "Michele J. Anderson", "Ying-Chi Lin", "Alex E. Grill", "Jayanth Panyam", "Peter J. Southern", "Patrick M. Schlievert", "Marnie L. Peterson"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0032813.g004", "stats"=>{"downloads"=>0, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Curcumin_inhibits_S_aureus_exoprotein_induced_IL_8_/338431", "title"=>"Curcumin inhibits <i>S. aureus</i> exoprotein-induced IL-8.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:45:42"}

PMC Usage Stats | Further Information

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Relative Metric

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