Genetic Resistance to Rhabdovirus Infection in Teleost Fish Is Paralleled to the Derived Cell Resistance Status
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{"title"=>"Genetic resistance to rhabdovirus infection in teleost fish is paralleled to the derived cell resistance status", "type"=>"journal", "authors"=>[{"first_name"=>"Eloi R.", "last_name"=>"Verrier", "scopus_author_id"=>"54682512500"}, {"first_name"=>"Christelle", "last_name"=>"Langevin", "scopus_author_id"=>"8747722700"}, {"first_name"=>"Corinne", "last_name"=>"Tohry", "scopus_author_id"=>"55184048400"}, {"first_name"=>"Armel", "last_name"=>"Houel", "scopus_author_id"=>"54684214200"}, {"first_name"=>"Vincent", "last_name"=>"Ducrocq", "scopus_author_id"=>"7004135528"}, {"first_name"=>"Abdenour", "last_name"=>"Benmansour", "scopus_author_id"=>"7003632705"}, {"first_name"=>"Edwige", "last_name"=>"Quillet", "scopus_author_id"=>"55990333700"}, {"first_name"=>"Pierre", "last_name"=>"Boudinot", "scopus_author_id"=>"6602494911"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "sgr"=>"84859706288", "doi"=>"10.1371/journal.pone.0033935", "scopus"=>"2-s2.0-84859706288", "pui"=>"364617708", "pmid"=>"22514610"}, "id"=>"8dca54d0-e6d3-3144-9353-b8497f168b7c", "abstract"=>"Genetic factors of resistance and predisposition to viral diseases explain a significant part of the clinical variability observed within host populations. Predisposition to viral diseases has been associated to MHC haplotypes and T cell immunity, but a growing repertoire of innate/intrinsic factors are implicated in the genetic determinism of the host susceptibility to viruses. In a long-term study of the genetics of host resistance to fish rhabdoviruses, we produced a collection of double-haploid rainbow trout clones showing a wide range of susceptibility to Viral Hemorrhagic Septicemia Virus (VHSV) waterborne infection. The susceptibility of fibroblastic cell lines derived from these clonal fish was fully consistent with the susceptibility of the parental fish clones. The mechanisms determining the host resistance therefore did not associate with specific host immunity, but rather with innate or intrinsic factors. One cell line was resistant to rhabdovirus infection due to the combination of an early interferon IFN induction - that was not observed in the susceptible cells - and of yet unknown factors that hamper the first steps of the viral cycle. The implication of IFN was well consistent with the wide range of resistance of this genetic background to VSHV and IHNV, to the birnavirus IPNV and the orthomyxovirus ISAV. Another cell line was even more refractory to the VHSV infection through different antiviral mechanisms. This collection of clonal fish and isogenic cell lines provides an interesting model to analyze the relative contribution of antiviral pathways to the resistance to different viruses.", "link"=>"http://www.mendeley.com/research/genetic-resistance-rhabdovirus-infection-teleost-fish-paralleled-derived-cell-resistance-status", "reader_count"=>44, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Researcher"=>17, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>10, "Student > Master"=>3, "Other"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>1, "Student > Postgraduate"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Researcher"=>17, "Student > Doctoral Student"=>4, "Student > Ph. D. Student"=>10, "Student > Master"=>3, "Other"=>1, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>2, "Professor"=>1, "Student > Postgraduate"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>28, "Medicine and Dentistry"=>2, "Veterinary Science and Veterinary Medicine"=>2, "Business, Management and Accounting"=>1, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>28}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>5}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Colombia"=>2, "Austria"=>1, "United States"=>1, "Norway"=>2, "Italy"=>1, "France"=>1, "Portugal"=>1}, "group_count"=>3}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/653750"], "description"=>"<p>(A): The expression of shIFNφ1 transcript in A22 and B57 cells after VHSV infection was measured by qPCR 4, 8 and 24 hours post infection by VHSV or in mock infected cells (ctrl). mRNA copy numbers were normalized on ß-actin expression (measured ratio of shIFNφ1 mRNA/actin mRNA). The mean of three experiments is shown. (B): Expression of N viral gene in cells after VHSV 07-71 infection at different time. Expression of gene is measured by qPCR after 4, 8 and 24 hours of infection by VHSV 07-71 or without viral infection (ctrl). Gene expression is evaluated relative to ß-actin expression (measured ratio of VHSV N mRNA/actin mRNA). The mean of three experiments is shown. (C): Viral genomic RNA (strand+ plus strand−) was quantified using qPCR. The virus replication was assessed by the ratio of virus genome at 6 h versus 2 h post-inoculation. (D): The mRNA encoding the viral N protein was quantified in parallel and the ratio N mRNA 6 hours post inoculation/N mRNA 2 hours post inoculation is represented.</p>", "links"=>[], "tags"=>["ifn-", "viral", "inhibition", "b57"], "article_id"=>324231, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.g006", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Early_IFN_dependent_and_independent_viral_inhibition_in_B57_cells_/324231", "title"=>"Early IFN- dependent and independent viral inhibition in B57 cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-13 01:10:31"}
  • {"files"=>["https://ndownloader.figshare.com/files/653359"], "description"=>"<p>(A) Kaplan-Meier estimation of survival function for every fish clone. This estimation is calculated from the 9 independent waterborne infections with VHSV corresponding to 5166 infected fish (including data from (49)). (B) Relative risks relative to the B57 clone (R = 1). Relative risks are estimated from the same dataset as above using the “Survival kit” software. The program also computes a chi<sup>2</sup> test between each clone pair. Letters above each column design a clone significantly different from all the others. All paired tests indicated statistically significant differences between clones. (C) Correlation between risks of fish clones and viral production 96 hours post infection. Linear regression: R = 0.99. (D) Correlation between risks of fish clones and N viral gene expression 4 hours post infection in cell lines. Linear regression: R = 0.85.</p>", "links"=>[], "tags"=>["susceptibilities", "clones", "lines", "vhsv"], "article_id"=>323846, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_susceptibilities_of_fish_clones_and_cell_lines_to_VHSV_infection_are_highly_correlated_/323846", "title"=>"The susceptibilities of fish clones and cell lines to VHSV infection are highly correlated.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-13 01:04:06"}
  • {"files"=>["https://ndownloader.figshare.com/files/335690", "https://ndownloader.figshare.com/files/335739", "https://ndownloader.figshare.com/files/335784"], "description"=>"<div><p>Genetic factors of resistance and predisposition to viral diseases explain a significant part of the clinical variability observed within host populations. Predisposition to viral diseases has been associated to MHC haplotypes and T cell immunity, but a growing repertoire of innate/intrinsic factors are implicated in the genetic determinism of the host susceptibility to viruses. In a long-term study of the genetics of host resistance to fish rhabdoviruses, we produced a collection of double-haploid rainbow trout clones showing a wide range of susceptibility to Viral Hemorrhagic Septicemia Virus (VHSV) waterborne infection. The susceptibility of fibroblastic cell lines derived from these clonal fish was fully consistent with the susceptibility of the parental fish clones. The mechanisms determining the host resistance therefore did not associate with specific host immunity, but rather with innate or intrinsic factors. One cell line was resistant to rhabdovirus infection due to the combination of an early interferon IFN induction - that was not observed in the susceptible cells - and of yet unknown factors that hamper the first steps of the viral cycle. The implication of IFN was well consistent with the wide range of resistance of this genetic background to VSHV and IHNV, to the birnavirus IPNV and the orthomyxovirus ISAV. Another cell line was even more refractory to the VHSV infection through different antiviral mechanisms. This collection of clonal fish and isogenic cell lines provides an interesting model to analyze the relative contribution of antiviral pathways to the resistance to different viruses.</p> </div>", "links"=>[], "tags"=>["rhabdovirus", "teleost", "paralleled", "derived"], "article_id"=>126324, "categories"=>["Cancer", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0033935.s001", "https://dx.doi.org/10.1371/journal.pone.0033935.s002", "https://dx.doi.org/10.1371/journal.pone.0033935.s003"], "stats"=>{"downloads"=>3, "page_views"=>11, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Genetic_Resistance_to_Rhabdovirus_Infection_in_Teleost_Fish_Is_Paralleled_to_the_Derived_Cell_Resistance_Status/126324", "title"=>"Genetic Resistance to Rhabdovirus Infection in Teleost Fish Is Paralleled to the Derived Cell Resistance Status", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-04-13 01:45:24"}
  • {"files"=>["https://ndownloader.figshare.com/files/653129"], "description"=>"<p>(A). Fibroblast-like cells from the B57 line. Bar 50 µm. (B): Monolayer destruction 3 days post infection with different MOI of VHSV. Cells were incubated 3 days with the virus inoculum, then fixed and colored with crystal violet. (C) Quantification of CPE after VHSV infection (MOI 1): cells were infected as indicated in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033935#s2\" target=\"_blank\">Materials and Methods</a>, colored with DAPI 3 days post infection, and nuclei counted using the ImageJ software. Three independent infections were performed. <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033935#s3\" target=\"_blank\">Results</a> are shown as ratios of cell counts in infected wells to cell counts before infection. This ratio may be >1 when cell growth occurs after infection in the absence of cytopathic effect.</p>", "links"=>[], "tags"=>["lines", "haploid", "clones", "susceptibilities", "vhsv"], "article_id"=>323618, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.g001", "stats"=>{"downloads"=>1, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Fibroblastic_cell_lines_from_double_haploid_fish_clones_show_different_susceptibilities_to_VHSV_infection_/323618", "title"=>"Fibroblastic cell lines from double haploid fish clones show different susceptibilities to VHSV infection.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-13 01:00:18"}
  • {"files"=>["https://ndownloader.figshare.com/files/653610"], "description"=>"<p>(A): Expression of the functional IFNφ1 (shIFNφ1) in cell lines. Gene expression was measured by qPCR 4 hours post infection by VHSV (MOI 1) or in mock infected cells (ctrl). shIFNφ1 transcript copy numbers were normalized on the ß-actin expression (measured ratio of mRNA of interest/ß-actin mRNA). The mean of three experiments is shown. (B): Expression of IFN φ1, MxI and Mx3 interferon induced genes and viral N mRNA in B57 and A22 cell lines. Expression was measured by qPCR 4 hours post infection or in control cells. Higher amount of template was used, allowing detection of the basic expression levels of the different genes. Primers used are presented in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033935#pone-0033935-t001\" target=\"_blank\">Table 1</a>.</p>", "links"=>[], "tags"=>["resistant", "phenotype", "b57", "cells", "intrinsic"], "article_id"=>324093, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.g005", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_The_resistant_phenotype_of_B57_cells_results_from_combined_early_IFN_966_1_and_intrinsic_immunity_/324093", "title"=>"The resistant phenotype of B57 cells results from combined early IFNφ1 and intrinsic immunity.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-13 01:08:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/653824"], "description"=>"<p>qPCR primers sequences.</p>", "links"=>[], "tags"=>["primers"], "article_id"=>324313, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.t001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_qPCR_primers_sequences_/324313", "title"=>"qPCR primers sequences.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-04-13 01:11:53"}
  • {"files"=>["https://ndownloader.figshare.com/files/653242"], "description"=>"<p>(A) The viral titer in cell supernatant 2, 3 and 4 days post infection with VHSV at MOI 1 was measured by plaque assay using EPC cells. Two independent lines for each genetic background were tested in the experiment, and the plaque assays operated in duplicates. (B) Expression of the N viral transcript 4 hours post infection by VHSV at MOI 1 was measured using qPCR. Transcript copy numbers were normalized to the ß-actin expression (measured ratio of VHSV N mRNA/actin mRNA). Mean values of triplicates are shown. (C) Visualization of the N viral protein by Western Blotting. Infected cell lysates were treated with anti-N<sub>SHV</sub> monoclonal antibody (34F5). <b>1 hour</b>: cells were incubated with VHSV 07-71 during only one hour and lysates prepared for western blotting. (1): B57 (2): A2 (3): B45 (4): A22 (5): A3 (6): RTG. <b>48 hours</b>: cells were infected as described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0033935#s2\" target=\"_blank\">Material and Methods</a>, and lysates prepared 48 hours post infection for western blotting. (7): B57 (8): A2 (9): B45 (10): A22 (11): A3 (12): RTG. <b>Ctrl</b>: EPC cells transfected with NSHV cDNA.</p>", "links"=>[], "tags"=>["transcripts"], "article_id"=>323736, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.g002", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Viral_titer_production_of_N_transcripts_and_protein_by_the_different_cell_lines_/323736", "title"=>"Viral titer, production of N transcripts and protein by the different cell lines.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-13 01:02:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/653468"], "description"=>"<p>(A): viral production in cells infected by VHSV at MOI 4. Two independent infections were performed. Viral titer was estimated by plaque assay on EPC cells in duplicates. (B): CPE after VHSV infection at MOI 1 and MOI 4. Cells were fixed 3 days post infection and colored with crystal violet.</p>", "links"=>[], "tags"=>["resistant", "phenotypes", "lines", "a2"], "article_id"=>323955, "categories"=>["Virology", "Microbiology", "Immunology"], "users"=>["Eloi R. Verrier", "Christelle Langevin", "Corinne Tohry", "Armel Houel", "Vincent Ducrocq", "Abdenour Benmansour", "Edwige Quillet", "Pierre Boudinot"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0033935.g004", "stats"=>{"downloads"=>3, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Different_resistant_phenotypes_of_cell_lines_A2_and_B57_/323955", "title"=>"Different resistant phenotypes of cell lines A2 and B57.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-13 01:05:55"}

PMC Usage Stats | Further Information

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Relative Metric

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