Virulence Potential and Genomic Mapping of the Worldwide Clone Escherichia coli ST131
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{"title"=>"Virulence potential and genomic mapping of the worldwide clone Escherichia coli ST131", "type"=>"journal", "authors"=>[{"first_name"=>"Jean Philippe", "last_name"=>"Lavigne", "scopus_author_id"=>"24531297400"}, {"first_name"=>"Annette C.", "last_name"=>"Vergunst", "scopus_author_id"=>"6603387233"}, {"first_name"=>"Lucie", "last_name"=>"Goret", "scopus_author_id"=>"9739017100"}, {"first_name"=>"Albert", "last_name"=>"Sotto", "scopus_author_id"=>"7006249763"}, {"first_name"=>"Christophe", "last_name"=>"Combescure", "scopus_author_id"=>"6701580156"}, {"first_name"=>"Jorge", "last_name"=>"Blanco", "scopus_author_id"=>"7402720990"}, {"first_name"=>"David", "last_name"=>"O'Callaghan", "scopus_author_id"=>"7103410216"}, {"first_name"=>"Marie Hélène", "last_name"=>"Nicolas-Chanoine", "scopus_author_id"=>"7003940043"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"364494649", "sgr"=>"84858775420", "issn"=>"19326203", "pmid"=>"22457832", "scopus"=>"2-s2.0-84858775420", "doi"=>"10.1371/journal.pone.0034294", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)"}, "id"=>"fec1bf4b-2153-3345-a419-892811ce93d5", "abstract"=>"Recently, the worldwide propagation of clonal CTX-M-15-producing Escherichia coli isolates, namely ST131 and O25b:H4, has been reported. Like the majority of extra-intestinal pathogenic E. coli isolates, the pandemic clone ST131 belongs to phylogenetic group B2, and has recently been shown to be highly virulent in a mouse model, even though it lacks several genes encoding key virulence factors (Pap, Cnf1 and HlyA). Using two animal models, Caenorhabditis elegans and zebrafish embryos, we assessed the virulence of three E. coli ST131 strains (2 CTX-M-15- producing urine and 1 non-ESBL-producing faecal isolate), comparing them with five non-ST131 B2 and a group A uropathogenic E. coli (UPEC). In C. elegans, the three ST131 strains showed intermediate virulence between the non virulent group A isolate and the virulent non-ST131 B2 strains. In zebrafish, the CTX-M-15-producing ST131 UPEC isolates were also less virulent than the non-ST131 B2 strains, suggesting that the production of CTX-M-15 is not correlated with enhanced virulence. Amongst the non-ST131 B2 group isolates, variation in pathogenic potential in zebrafish embryos was observed ranging from intermediate to highly virulent. Interestingly, the ST131 strains were equally persistent in surviving embryos as the non-ST131-group B2 strains, suggesting similar mechanisms may account for development of persistent infection. Optical maps of the genome of the ST131 strains were compared with those of 24 reference E. coli strains. Although small differences were seen within the ST131 strains, the tree built on the optical maps showed that these strains belonged to a specific cluster (86% similarity) with only 45% similarity with the other group B2 strains and 25% with strains of group A and D. Thus, the ST131 clone has a genetic composition that differs from other group B2 strains, and appears to be less virulent than previously suspected.", "link"=>"http://www.mendeley.com/research/virulence-potential-genomic-mapping-worldwide-clone-escherichia-coli-st131", "reader_count"=>70, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>7, "Researcher"=>17, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>10, "Student > Bachelor"=>6, "Professor"=>4}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>2, "Librarian"=>1, "Student > Doctoral Student"=>7, "Researcher"=>17, "Student > Ph. D. Student"=>16, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>10, "Student > Bachelor"=>6, "Professor"=>4}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>4, "Agricultural and Biological Sciences"=>36, "Medicine and Dentistry"=>14, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Computer Science"=>3, "Immunology and Microbiology"=>6, "Linguistics"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>14}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>36}, "Computer Science"=>{"Computer Science"=>3}, "Linguistics"=>{"Linguistics"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>4}, "Environmental Science"=>{"Environmental Science"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"United States"=>3, "Chile"=>1, "France"=>1, "Spain"=>2}, "group_count"=>4}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/663647"], "description"=>"<p>A. Survival probability of zebrafish embryos following infection with three ST131 strains and two non-ST131 strains. Thirty hour post fertilization (hpf) embryos were microinjected with an average inoculum size of 1.9×10<sup>3</sup>.CFU. The data represent the average of 5 independent experiments (n = 20 for each strain per experiment). NEC20 and NECS81153 were analysed twice. A Mantel-Cox test was performed (between strains p<0.001). NECS81153 and NEC20 did not differ significantly (p = 0.08) from each other in virulence. The non-ST131 group B2 strains NEC20 and NECS81153 induced a significantly higher rate of embryo mortality than the two ST131 strains MECB5 (p<0.001) and FV7563 (p = 0.002). MECB5 was significantly less virulent than S250 (p<0.001), but did not differ from FV7563 (p = 0.73). Although S250 and NECS81153 did not differ in virulence (p = 0.82), S250 was less virulent than NEC20 (p = 0.009). In this model, NEC20 was significantly (p<0.05) more virulent than all the other group B2 strains except for NECS81153(p = 0.08). B. Survival probability of zebrafish embryos following injection of ST131 strain MECB5 compared with group A strain NEC3, and non-ST131 group B2 control strains CFT073, 536 and ED1a. Thirty hour post fertilization (hpf) embryos were microinjected with an average inoculum size of 1.4×10<sup>3</sup>.CFU. The data represent the average of 2 independent experiments (n = 20 for each strain per experiment) in this context, but each strain was analysed at least 5 times. A Mantel-Cox test was performed. MECB5 was significantly less virulent than the strains CFT073, 536 and NEC3 (p<0.0001). ED1a was significantly less virulent than MECB5 (p = 0.047). Within the group of fast killing strains, strain 536 was less virulent than CFT073 (p = 0.011) and NEC3 (p = 0.020), whereas NEC3 and CFT073 were not significantly different (p = 0.079). C. Infection kinetics after microinjection with the following inocula: FV7563 (300 CFU), S250 (520 CFU), MECB5 (1760 CFU), NECS81153 (2200 CFU) and NEC20 (880 CFU). Bacterial counts were performed in 5 individual embryos per time point per strain (geometric mean ± SEM, n = 5), however, dead embryos were not included in the counts as explained in the text. Shown is a typical experiment. The experiment was repeated 5 times. D. Bright field and fluorescence overlay of a NEC20 infected embryo, 48 hpi, showing a close up of bacteria in a phagocytic cell. Inset shows an enlargement of the phagocytic cell (arrow). n = notochord, arrowhead marks an erythrocyte. E. Fluorescent image of an embryo, 24 hpi, infected with NEC20-DSRed showing bacteria have multiplied in the vasculature. A non-infected control embryo does not show any fluorescence with similar camera settings (not shown). Inset: corresponding bright field image. F. Embryo, 24 hpi, microinjected with MECB5-DSRed. Fluorescence and bright field overlay image of central nervous system infection.</p>", "links"=>[], "tags"=>["st131", "b2", "strains", "zebrafish", "embryos", "compared", "non-st131"], "article_id"=>334112, "categories"=>["Microbiology", "Biological Sciences", "Virology", "Infectious Diseases"], "users"=>["Jean-Philippe Lavigne", "Annette C. Vergunst", "Lucie Goret", "Albert Sotto", "Christophe Combescure", "Jorge Blanco", "David O'Callaghan", "Marie-Hélène Nicolas-Chanoine"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034294.g001", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Virulence_of_ST131_B2_group_Escherichia_coli_strains_in_zebrafish_embryos_compared_to_other_non_ST131_B2_group_strains_/334112", "title"=>"Virulence of ST131 B2 group <i>Escherichia coli</i> strains in zebrafish embryos compared to other non-ST131 B2 group strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:23:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/664178"], "description"=>"<p>Main characteristics of the <i>E. coli</i> clinical isolates used in this study.</p>", "links"=>[], "tags"=>["characteristics", "isolates"], "article_id"=>334659, "categories"=>["Microbiology", "Biological Sciences", "Virology", "Infectious Diseases"], "users"=>["Jean-Philippe Lavigne", "Annette C. Vergunst", "Lucie Goret", "Albert Sotto", "Christophe Combescure", "Jorge Blanco", "David O'Callaghan", "Marie-Hélène Nicolas-Chanoine"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034294.t001", "stats"=>{"downloads"=>2, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Main_characteristics_of_the_E_coli_clinical_isolates_used_in_this_study_/334659", "title"=>"Main characteristics of the <i>E. coli</i> clinical isolates used in this study.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:26:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/664091"], "description"=>"<p>The results are representative of at least five independent trials for each group of strains. p: Pairwise comparison using a log rank tests. NS: non significant.</p>", "links"=>[], "tags"=>["lethal", "infected", "st131", "strains", "non-st131"], "article_id"=>334571, "categories"=>["Microbiology", "Biological Sciences", "Virology", "Infectious Diseases"], "users"=>["Jean-Philippe Lavigne", "Annette C. Vergunst", "Lucie Goret", "Albert Sotto", "Christophe Combescure", "Jorge Blanco", "David O'Callaghan", "Marie-Hélène Nicolas-Chanoine"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034294.t002", "stats"=>{"downloads"=>3, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_50_Lethal_Time_LT50_of_Caenorhabditis_elegans_infected_by_the_E_coli_ST131_strains_and_non_ST131_strains_/334571", "title"=>"50% Lethal Time (LT50) of <i>Caenorhabditis elegans</i> infected by the <i>E. coli</i> ST131 strains and non-ST131 strains.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:25:34"}
  • {"files"=>["https://ndownloader.figshare.com/files/663814"], "description"=>"<p>Alignment software highlights <i>Nco</i>I restricted fragment polymorphisms between strains by using white color and homologous regions by using blue color. Vertical lines in each bacterial genome represent matching <i>Nco</i>I restriction sites. PAIs present in the genome of strain CFT073 are represented by different colors: PAI I: green, PAI II: pink, PAI III: red, PAI IV: yellow. Red lines under the genome of S250, FV7563 and MECB5 indicate four insertions only observed in this strain. Red frame on the genome of strain MECB5 indicates the insertion only observed in this strain. A close up view of this region is shown under the genome optical maps.</p>", "links"=>[], "tags"=>["optical", "maps", "st131", "strains", "fv7563", "upec"], "article_id"=>334295, "categories"=>["Microbiology", "Biological Sciences", "Virology", "Infectious Diseases"], "users"=>["Jean-Philippe Lavigne", "Annette C. Vergunst", "Lucie Goret", "Albert Sotto", "Christophe Combescure", "Jorge Blanco", "David O'Callaghan", "Marie-Hélène Nicolas-Chanoine"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034294.g002", "stats"=>{"downloads"=>1, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Overview_of_optical_maps_of_the_E_coli_ST131_strains_S250_FV7563_and_MECB5_and_reference_UPEC_CFT073_/334295", "title"=>"Overview of optical maps of the <i>E. coli</i> ST131 strains S250, FV7563 and MECB5, and reference UPEC CFT073.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:24:10"}
  • {"files"=>["https://ndownloader.figshare.com/files/664132"], "description"=>"<p>Evaluation of CFU in the <i>C. elegans</i> digestive tract obtained from 3 experiments for each strain.</p>", "links"=>[], "tags"=>["cfu", "digestive", "tract", "experiments"], "article_id"=>334616, "categories"=>["Microbiology", "Biological Sciences", "Virology", "Infectious Diseases"], "users"=>["Jean-Philippe Lavigne", "Annette C. Vergunst", "Lucie Goret", "Albert Sotto", "Christophe Combescure", "Jorge Blanco", "David O'Callaghan", "Marie-Hélène Nicolas-Chanoine"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034294.t003", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Evaluation_of_CFU_in_the_C_elegans_digestive_tract_obtained_from_3_experiments_for_each_strain_/334616", "title"=>"Evaluation of CFU in the <i>C. elegans</i> digestive tract obtained from 3 experiments for each strain.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 07:25:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/663954"], "description"=>"<p>The scale indicates the percentage of genetic difference.</p>", "links"=>[], "tags"=>["unweighted-pair", "arithmetic", "averages", "optical", "maps", "performed"], "article_id"=>334433, "categories"=>["Microbiology", "Biological Sciences", "Virology", "Infectious Diseases"], "users"=>["Jean-Philippe Lavigne", "Annette C. Vergunst", "Lucie Goret", "Albert Sotto", "Christophe Combescure", "Jorge Blanco", "David O'Callaghan", "Marie-Hélène Nicolas-Chanoine"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0034294.g003", "stats"=>{"downloads"=>1, "page_views"=>22, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Map_similarity_cluster_using_unweighted_pair_group_method_using_arithmetic_averages_UPGMA_tree_of_optical_maps_performed_on_different_Escherichia_coli_strains_/334433", "title"=>"Map similarity cluster using unweighted-pair group method using arithmetic averages (UPGMA) tree of optical maps performed on different <i>Escherichia coli</i> strains.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 07:24:52"}

PMC Usage Stats | Further Information

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Relative Metric

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