Modulation of Human Muscle Spindle Discharge by Arterial Pulsations - Functional Effects and Consequences
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{"title"=>"Modulation of human muscle spindle discharge by arterial pulsations - functional effects and consequences", "type"=>"journal", "authors"=>[{"first_name"=>"Ingvars", "last_name"=>"Birznieks", "scopus_author_id"=>"7801456419"}, {"first_name"=>"Tjeerd W.", "last_name"=>"Boonstra", "scopus_author_id"=>"8975028000"}, {"first_name"=>"Vaughan G.", "last_name"=>"Macefield", "scopus_author_id"=>"7004510758"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84859808405", "sgr"=>"84859808405", "pui"=>"364638438", "isbn"=>"1932-6203", "doi"=>"10.1371/journal.pone.0035091"}, "id"=>"0ad2173d-c395-383e-b2e2-90f6bc41870b", "abstract"=>"Arterial pulsations are known to modulate muscle spindle firing;\\nhowever, the physiological significance of such synchronised modulation\\nhas not been investigated. Unitary recordings were made from 75 human\\nmuscle spindle afferents innervating the pretibial muscles. The\\nmodulation of muscle spindle discharge by arterial pulsations was\\nevaluated by R-wave triggered averaging and power spectral analysis. We\\ndescribe various effects arterial pulsations may have on muscle spindle\\nafferent discharge. Afferents could be ``driven{''} by arterial\\npulsations, e. g., showing no other spontaneous activity than spikes\\ngenerated with cardiac rhythmicity. Among afferents showing ongoing\\ndischarge that was not primarily related to cardiac rhythmicity we\\nillustrate several mechanisms by which individual spikes may become\\nphase-locked. However, in the majority of afferents the discharge rate\\nwas modulated by the pulse wave without spikes being phase locked. Then\\nwe assessed whether these influences changed in two physiological\\nconditions in which a sustained increase in muscle sympathetic nerve\\nactivity was observed without activation of fusimotor neurones: a\\nmaximal inspiratory breath-hold, which causes a fall in systolic\\npressure, and acute muscle pain, which causes an increase in systolic\\npressure. The majority of primary muscle spindle afferents displayed\\npulse-wave modulation, but neither apnoea nor pain had any significant\\neffect on the strength of this modulation, suggesting that the\\nphysiological noise injected by the arterial pulsations is robust and\\nrelatively insensitive to fluctuations in blood pressure. Within the\\nafferent population there was a similar number of muscle spindles that\\nwere inhibited and that were excited by the arterial pulse wave,\\nindicating that after signal integration at the population level,\\narterial pulsations of opposite polarity would cancel each other out. We\\nspeculate that with close-to-threshold stimuli the arterial pulsations\\nmay serve as an endogenous noise source that may synchronise the\\nsporadic discharge within the afferent population and thus facilitate\\nthe detection of weak stimuli.", "link"=>"http://www.mendeley.com/research/modulation-human-muscle-spindle-discharge-arterial-pulsations-functional-effects-consequences", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Librarian"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>3, "Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1, "Psychology"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Social Sciences"=>{"Social Sciences"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>2}

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/652597"], "description"=>"<p>Modulation of discharge rate is normalized to the variance in discharge rate over the whole recording and plotted as a function of time, measured from the R-wave of ECG signal. Afferents are grouped according to whether the initial modulatory peak in response to the upbeat of the pulse wave is positive (graphs in left column) or negative (graphs in right column), as revealed by the sign of the eigenvector coefficient (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035091#pone-0035091-g006\" target=\"_blank\">Fig. 6<b>B</b></a>). <b>A</b> & <b>B</b>, changes in discharge rate modulation during inspiratory-capacity apnoea. <b>C</b> & <b>D</b>, changes in discharge rate modulation during muscle pain. <b>E</b> & <b>F</b>, changes in discharge rate modulation during skin pain. <b>G</b> & <b>H</b>, discharge rate modulation during active voluntary contraction.</p>", "links"=>[], "tags"=>["r-wave", "triggered", "discharge", "averages", "physiological"], "article_id"=>323091, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g007", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_R_wave_triggered_discharge_rate_averages_between_different_physiological_conditions_/323091", "title"=>"Comparison of R-wave triggered discharge rate averages between different physiological conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:24:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/652052"], "description"=>"<p>For further details see text and legend of <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035091#pone-0035091-g002\" target=\"_blank\">Fig. 2</a>.</p>", "links"=>[], "tags"=>["resetting", "spindle"], "article_id"=>322546, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g003", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phase_locking_and_resetting_of_ongoing_muscle_spindle_discharge_/322546", "title"=>"Phase-locking and resetting of ongoing muscle spindle discharge.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:22:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/652421"], "description"=>"<p>Top panels display the first principal component of the time-domain analysis (explained variance = 48%), i.e. R-wave triggered discharge rate averages, extracting the modulation pattern common across afferents. Panel <b>A</b> shows the projection of the data with characteristic regions that are stable (p<0.01) across recordings depicted in gray. The time axis is normalized to the average RR-interval for each afferent before performing PCA. Panel <b>B</b> shows the histogram of the eigenvector coefficients representing the strength of this pattern in each afferent. Afferents with significant pulse wave modulation are depicted in black, non-significant afferents in grey. Lower panels display the first principal component of the frequency-domain analysis (explained variance = 43%), representing the common power spectrum across afferents (Panel <b>C</b>). The frequency axis is normalized to the average heart rate for each afferent before performing PCA. Panels <b>D</b> shows the histogram of the corresponding eigenvector coefficients.</p>", "links"=>[], "tags"=>["55", "spontaneously", "afferents"], "article_id"=>322915, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g006", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Principal_component_analysis_PCA_of_55_spontaneously_active_afferents_in_control_resting_conditions_/322915", "title"=>"Principal component analysis (PCA) of 55 spontaneously active afferents in control (resting) conditions.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:24:04"}
  • {"files"=>["https://ndownloader.figshare.com/files/651901"], "description"=>"<p>Each panel shows post stimulus time histogram at the bottom and raster sweeps of single cardiac cycles on top. <b>A–C</b>, Afferents typically responded with one single spike phase-locked to the cardiac cycle. <b>D–F</b>, Afferents responding with two spikes at the time corresponding to the pulse wave upbeat. A third spike corresponding to the time of dicrotic notch is generated by afferents depicted in <b>E</b> and <b>F</b> (see also <b>B</b>&<b>D</b>). Each bar indicates total count of spikes falling within corresponding 0.02 s time bin. Each dot in raster plot indicates one spike.</p>", "links"=>[], "tags"=>["driven"], "article_id"=>322405, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g002", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Pulse_wave_driven_muscle_spindles_/322405", "title"=>"Pulse-wave driven muscle spindles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:21:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/651805"], "description"=>"<p>This afferent responded with one single spike at the early part of the upbeat of pulse wave and about ∼250 ms following R-wave in ECG signal. Note also muscle sympathetic burst activity in nerve signal.</p>", "links"=>[], "tags"=>["spindle", "discharge", "locked", "arterial"], "article_id"=>322291, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Example_of_muscle_spindle_discharge_locked_to_the_arterial_pulsations_/322291", "title"=>"Example of muscle spindle discharge locked to the arterial pulsations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:21:01"}
  • {"files"=>["https://ndownloader.figshare.com/files/652322"], "description"=>"<p>The gray shaded area shows the distribution of spectral power represented as a percentage of total power. Mean heart rate (HR) is indicated by the left dashed vertical line and numeric value. The right dashed vertical line indicates the frequency twice that of the heart rate. The thin black line indicates the 95% confidence interval, determined using the surrogate power spectrum distribution.</p>", "links"=>[], "tags"=>["spectral", "analyses", "afferents", "illustrated"], "article_id"=>322811, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g005", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_spectral_analyses_for_the_same_ten_afferents_illustrated_in_figure_4_A_8211_J_respectively_/322811", "title"=>"Examples of spectral analyses for the same ten afferents illustrated in <b>figure 4 A–J</b>, respectively.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:23:33"}
  • {"files"=>["https://ndownloader.figshare.com/files/652196"], "description"=>"<p>Panels on the left (<b>A</b>–<b>E</b>) illustrate five afferents showing positive peak (excitatory response to the upbeat of pulse wave). Panels on the right (<b>F</b>–<b>J</b>) show five afferents displaying an initial negative peak (inhibitory effect). Discharge rate modulation is expressed as % difference from mean discharge rate. Time elapsed after R-wave is shown on the x-axis. Text box indicates the relative amount of variance explained by arterial pulsations (EV). Black thick lines represent averages. Gray thin lines show overlay of individual discharge rate traces in every cardiac cycle.</p>", "links"=>[], "tags"=>["r-wave", "triggered", "discharge", "averages", "pulse-wave", "modulated"], "article_id"=>322684, "categories"=>["Physiology", "Biological Sciences", "Neuroscience"], "users"=>["Ingvars Birznieks", "Tjeerd W. Boonstra", "Vaughan G. Macefield"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035091.g004", "stats"=>{"downloads"=>1, "page_views"=>14, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Examples_of_R_wave_triggered_discharge_rate_averages_in_pulse_wave_modulated_muscle_spindles_/322684", "title"=>"Examples of R-wave triggered discharge rate averages in pulse-wave modulated muscle spindles.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:22:56"}

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Relative Metric

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