DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder
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Mendeley | Further Information

{"title"=>"DCLK1 Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder", "type"=>"journal", "authors"=>[{"first_name"=>"Bjarte", "last_name"=>"Håvik"}, {"first_name"=>"Franziska A.", "last_name"=>"Degenhardt"}, {"first_name"=>"Stefan", "last_name"=>"Johansson"}, {"first_name"=>"Carla P. D.", "last_name"=>"Fernandes"}, {"first_name"=>"Anke", "last_name"=>"Hinney"}, {"first_name"=>"André", "last_name"=>"Scherag"}, {"first_name"=>"Helle", "last_name"=>"Lybæk"}, {"first_name"=>"Srdjan", "last_name"=>"Djurovic"}, {"first_name"=>"Andrea", "last_name"=>"Christoforou"}, {"first_name"=>"Kari M.", "last_name"=>"Ersland"}, {"first_name"=>"Sudheer", "last_name"=>"Giddaluru"}, {"first_name"=>"Michael C.", "last_name"=>"O'Donovan"}, {"first_name"=>"Michael J.", "last_name"=>"Owen"}, {"first_name"=>"Nick", "last_name"=>"Craddock"}, {"first_name"=>"Thomas W.", "last_name"=>"Mühleisen"}, {"first_name"=>"Manuel", "last_name"=>"Mattheisen"}, {"first_name"=>"Benno G.", "last_name"=>"Schimmelmann"}, {"first_name"=>"Tobias", "last_name"=>"Renner"}, {"first_name"=>"Andreas", "last_name"=>"Warnke"}, {"first_name"=>"Beate", "last_name"=>"Herpertz-Dahlmann"}, {"first_name"=>"Judith", "last_name"=>"Sinzig"}, {"first_name"=>"Özgür", "last_name"=>"Albayrak"}, {"first_name"=>"Marcella", "last_name"=>"Rietschel"}, {"first_name"=>"Markus M.", "last_name"=>"Nöthen"}, {"first_name"=>"Clive R.", "last_name"=>"Bramham"}, {"first_name"=>"Thomas", "last_name"=>"Werge"}, {"first_name"=>"Johannes", "last_name"=>"Hebebrand"}, {"first_name"=>"Jan", "last_name"=>"Haavik"}, {"first_name"=>"Ole A.", "last_name"=>"Andreassen"}, {"first_name"=>"Sven", "last_name"=>"Cichon"}, {"first_name"=>"Vidar M.", "last_name"=>"Steen"}, {"first_name"=>"Stéphanie", "last_name"=>"Le Hellard"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"1932-6203", "pmid"=>"22539971", "doi"=>"10.1371/journal.pone.0035424"}, "id"=>"be8e23cb-6be2-3cbf-ac80-0c054fda4c9a", "abstract"=>"Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in DCLK1 are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of DCLK1 variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the DCLK1 region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several DCLK1 variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4 × 10(-5) and 4 × 10(-6), respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3'UTR (SCZ+BP). Our results suggest that genetic variants in DCLK1 are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that DCLK1 variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.", "link"=>"http://www.mendeley.com/research/dclk1-variants-associated-across-schizophrenia-attention-deficithyperactivity-disorder-1", "reader_count"=>16, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Ph. D. Student"=>6, "Student > Master"=>3, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Ph. D. Student"=>6, "Student > Master"=>3, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>1, "Neuroscience"=>3, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>3}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United States"=>1, "Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/649922"], "description"=>"<p>Analyses are presented for both the allelic regression and the genotypic regression for which the genotypes were recoded under an additive genotypic model; age, sex and country/study were used as covariates. The Norwegian (NO) sample consists of 466 cases and 515 controls; the German (GE) sample consists of 500 cases and 1300 controls. The 12 markers that were typed or extracted in the 2 samples are presented (966 cases and 1815 controls); see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424.s007\" target=\"_blank\">Tables S6</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424.s008\" target=\"_blank\">S7</a> for results from all markers in each sample.</p>*<p>indicates significant P-values (<0.05).</p>", "links"=>[], "tags"=>["adhd", "cases"], "article_id"=>320379, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035424.t004", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_results_for_the_ADHD_cases_and_control_samples_/320379", "title"=>"Association results for the ADHD cases and control samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-04-23 00:06:19"}
  • {"files"=>["https://ndownloader.figshare.com/files/649783"], "description"=>"<p>Analyses are presented for both the allelic regression and the genotypic regression for which the genotypes were recoded under an additive genotypic model; age, sex and country/study were used as covariates. The German sample consists of 682 cases and 1300 controls; the replication sample consists of 1814 cases and 2407 controls. The 16 markers that were typed or extracted in the 2 samples are presented (2496 cases and 3707 controls); see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424.s005\" target=\"_blank\">Tables S4</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424.s006\" target=\"_blank\">S5</a> for results from all markers in each sample.</p>*<p>indicates significant P-values (<0.05).</p>", "links"=>[], "tags"=>["bp", "cases"], "article_id"=>320236, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035424.t003", "stats"=>{"downloads"=>5, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_results_for_the_BP_cases_and_control_samples_/320236", "title"=>"Association results for the BP cases and control samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-04-23 00:03:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/649999"], "description"=>"<p>For ADHD+BP, 3462 cases versus 4222 controls were analyzed; for ADHD+SCZ, 3621 cases versus 4793 controls were analyzed; for BP+SCZ, 2092 cases versus 2901 controls were analyzed; for ADHD+BP+SCZ, 4587 cases versus 5308 controls were analyzed. The 11 markers typed in all the samples are presented.</p>*<p>indicates significant P-values (<0.05).</p>", "links"=>[], "tags"=>["analyses", "scz", "bp"], "article_id"=>320457, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035424.t005", "stats"=>{"downloads"=>3, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_analyses_across_ADHD_SCZ_and_BP_phenotypes_/320457", "title"=>"Association analyses across ADHD, SCZ and BP phenotypes.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-04-23 00:07:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/649714"], "description"=>"<p>Analyses are presented for both the allelic regression and the genotypic regression for which the genotypes were recoded under an additive genotypic model; age, sex and country/study were used as covariates. The German sample consists of 484 cases and 1300 controls. The Scandinavian SCOPE (Scandinavian Collaboration on Psychiatric Etiology) sample (Scand.) consists of 641 cases and 1086 controls and was created by merging the Danish and Norwegian samples, which were shown previously to be similar <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424-Hansen1\" target=\"_blank\">[32]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424-LeHellard2\" target=\"_blank\">[41]</a>. The 15 markers that were typed or extracted in the 2 samples are presented (1125 cases and 2386 controls); see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424.s003\" target=\"_blank\">Tables S2</a> and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424.s004\" target=\"_blank\">S3</a> for results from all markers in each sample. In <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone-0035424-t002\" target=\"_blank\">Tables 2</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone-0035424-t003\" target=\"_blank\">3</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone-0035424-t004\" target=\"_blank\">4</a>, and <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone-0035424-t005\" target=\"_blank\">5</a>, the position (hg18, NCBI36) of each marker is given below its rsID, the minor alleles and their frequencies in cases and controls are given, together with the odds ratio, the 95% confidence interval and the genotype success (call rate).</p>*<p>indicates significant P-values (<0.05).</p>", "links"=>[], "tags"=>["scz", "cases"], "article_id"=>320167, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035424.t002", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_results_for_the_SCZ_cases_and_control_samples_/320167", "title"=>"Association results for the SCZ cases and control samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-04-23 00:02:47"}
  • {"files"=>["https://ndownloader.figshare.com/files/334813", "https://ndownloader.figshare.com/files/334879", "https://ndownloader.figshare.com/files/334994", "https://ndownloader.figshare.com/files/335109", "https://ndownloader.figshare.com/files/335231", "https://ndownloader.figshare.com/files/335317", "https://ndownloader.figshare.com/files/335431", "https://ndownloader.figshare.com/files/335523", "https://ndownloader.figshare.com/files/335586", "https://ndownloader.figshare.com/files/335667", "https://ndownloader.figshare.com/files/335762"], "description"=>"<div><p>Doublecortin and calmodulin like kinase 1 (DCLK1) is implicated in synaptic plasticity and neurodevelopment. Genetic variants in <em>DCLK1</em> are associated with cognitive traits, specifically verbal memory and general cognition. We investigated the role of <em>DCLK1</em> variants in three psychiatric disorders that have neuro-cognitive dysfunctions: schizophrenia (SCZ), bipolar affective disorder (BP) and attention deficit/hyperactivity disorder (ADHD). We mined six genome wide association studies (GWASs) that were available publically or through collaboration; three for BP, two for SCZ and one for ADHD. We also genotyped the <em>DCLK1</em> region in additional samples of cases with SCZ, BP or ADHD and controls that had not been whole-genome typed. In total, 9895 subjects were analysed, including 5308 normal controls and 4,587 patients (1,125 with SCZ, 2,496 with BP and 966 with ADHD). Several <em>DCLK1</em> variants were associated with disease phenotypes in the different samples. The main effect was observed for rs7989807 in intron 3, which was strongly associated with SCZ alone and even more so when cases with SCZ and ADHD were combined (P-value = 4×10<sup>−5</sup> and 4×10<sup>−6</sup>, respectively). Associations were also observed with additional markers in intron 3 (combination of SCZ, ADHD and BP), intron 19 (SCZ+BP) and the 3′UTR (SCZ+BP). Our results suggest that genetic variants in <em>DCLK1</em> are associated with SCZ and, to a lesser extent, with ADHD and BP. Interestingly the association is strongest when SCZ and ADHD are considered together, suggesting common genetic susceptibility. Given that <em>DCLK1</em> variants were previously found to be associated with cognitive traits, these results are consistent with the role of DCLK1 in neurodevelopment and synaptic plasticity.</p> </div>", "links"=>[], "tags"=>["variants", "are", "schizophrenia"], "article_id"=>126127, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0035424.s001", "https://dx.doi.org/10.1371/journal.pone.0035424.s002", "https://dx.doi.org/10.1371/journal.pone.0035424.s003", "https://dx.doi.org/10.1371/journal.pone.0035424.s004", "https://dx.doi.org/10.1371/journal.pone.0035424.s005", "https://dx.doi.org/10.1371/journal.pone.0035424.s006", "https://dx.doi.org/10.1371/journal.pone.0035424.s007", "https://dx.doi.org/10.1371/journal.pone.0035424.s008", "https://dx.doi.org/10.1371/journal.pone.0035424.s009", "https://dx.doi.org/10.1371/journal.pone.0035424.s010", "https://dx.doi.org/10.1371/journal.pone.0035424.s011"], "stats"=>{"downloads"=>27, "page_views"=>8, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_DCLK1_Variants_Are_Associated_across_Schizophrenia_and_Attention_Deficit_Hyperactivity_Disorder/126127", "title"=>"<em>DCLK1</em> Variants Are Associated across Schizophrenia and Attention Deficit/Hyperactivity Disorder", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-04-23 01:42:07"}
  • {"files"=>["https://ndownloader.figshare.com/files/649855"], "description"=>"<p>The number of cases and controls, number of markers mined/genotyped and the genotyping technology is shown. The covariate code takes into consideration the possible effect of country of origin and platform used in the genotypic analysis.</p>*<p>Same control samples used,</p>**<p>same control samples used. n.a., not applicable as the sample was not used for the merged analyses.</p>", "links"=>[], "tags"=>["samples", "GWAS", "genotyped", "replication"], "article_id"=>320317, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035424.t001", "stats"=>{"downloads"=>5, "page_views"=>3, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Origin_of_the_samples_used_either_in_the_GWAS_mining_or_genotyped_in_the_replication_samples_/320317", "title"=>"Origin of the samples used either in the GWAS mining, or genotyped in the replication samples.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-04-23 00:05:17"}
  • {"files"=>["https://ndownloader.figshare.com/files/649579"], "description"=>"<p>Markers are ordered from 5′ to 3′ of the gene, anti-sense to the reference sequence. <b>A.</b> Representation of the genomic region covered and of 6 <i>DCLK1</i> transcripts (from top to bottom: <i>DCL</i>, <i>CARP</i>, 2 short variants and 2 long variants). In addition to alternative start sites, the transcripts can be alternatively spliced for part of exon 9, for exon 19 and in the 3′UTR. <b>B.</b> All markers showing nominal association to psychiatric traits in this study or to cognitive traits in our previous study <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424-LeHellard1\" target=\"_blank\">[16]</a> are displayed. Color code: yellow, P-value between 0.05 and 0.001; orange, P-value between 0.001 and 0.0001; red, P-value<0.0001; white, P-value>0.05; grey, marker not tested in this sample. The markers used in the cross-phenotype analyses are highlighted in red. <b>C.</b> LD between the markers used in the cross-phenotype analyses, and the markers associated with cognitive traits in our previous study <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424-LeHellard1\" target=\"_blank\">[16]</a>. LD is displayed using a r<sup>2</sup> scale ranging from r<sup>2</sup> = 1 in black to r<sup>2</sup> = 0 in white.</p>", "links"=>[], "tags"=>["variants", "psychiatric"], "article_id"=>320031, "categories"=>["Biological Sciences", "Neuroscience", "Mental Health"], "users"=>["Bjarte Håvik", "Franziska A. Degenhardt", "Stefan Johansson", "Carla P. D. Fernandes", "Anke Hinney", "André Scherag", "Helle Lybæk", "Srdjan Djurovic", "Andrea Christoforou", "Kari M. Ersland", "Sudheer Giddaluru", "Michael C. O'Donovan", "Michael J. Owen", "Nick Craddock", "Thomas W. Mühleisen", "Manuel Mattheisen", "Benno G. Schimmelmann", "Tobias Renner", "Andreas Warnke", "Beate Herpertz-Dahlmann", "Judith Sinzig", "Özgür Albayrak", "Marcella Rietschel", "Markus M. Nöthen", "Clive R. Bramham", "Thomas Werge", "Johannes Hebebrand", "Jan Haavik", "Ole A. Andreassen", "Sven Cichon", "Vidar M. Steen", "Stéphanie Le Hellard"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035424.g001", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Association_of_DCKL1_genetic_variants_with_psychiatric_and_cognitive_traits_/320031", "title"=>"Association of <i>DCKL1</i> genetic variants with psychiatric and cognitive traits.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-04-23 00:00:31"}

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  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
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  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
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  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
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  • {"unique-ip"=>"6", "full-text"=>"5", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
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  • {"unique-ip"=>"13", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"10", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
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  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
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  • {"unique-ip"=>"8", "full-text"=>"5", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}
  • {"unique-ip"=>"10", "full-text"=>"8", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"2"}
  • {"unique-ip"=>"3", "full-text"=>"2", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"3"}
  • {"unique-ip"=>"2", "full-text"=>"5", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"4"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"5"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2020", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"8"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2020", "month"=>"12"}
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Relative Metric

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