Comprehensive Evaluation of Corticospinal Tract Metabolites in Amyotrophic Lateral Sclerosis Using Whole-Brain 1H MR Spectroscopy
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{"title"=>"Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy", "type"=>"journal", "authors"=>[{"first_name"=>"Varan", "last_name"=>"Govind", "scopus_author_id"=>"7006413178"}, {"first_name"=>"Khema R.", "last_name"=>"Sharma", "scopus_author_id"=>"7402096333"}, {"first_name"=>"Andrew A.", "last_name"=>"Maudsley", "scopus_author_id"=>"7006771472"}, {"first_name"=>"Kristopher L.", "last_name"=>"Arheart", "scopus_author_id"=>"7003660038"}, {"first_name"=>"Gaurav", "last_name"=>"Saigal", "scopus_author_id"=>"6602106285"}, {"first_name"=>"Sulaiman", "last_name"=>"Sheriff", "scopus_author_id"=>"36246751100"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0035607", "sgr"=>"84859945812", "scopus"=>"2-s2.0-84859945812", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22539984", "pui"=>"364662445"}, "id"=>"42d75b95-5119-3a9d-ba8e-1d8d3d01bc59", "abstract"=>"Changes in the distribution of the proton magnetic resonance spectroscopy (MRS) observed metabolites N-acetyl aspartate (NAA), total-choline (Cho), and total-creatine (Cre) in the entire intracranial corticospinal tract (CST) including the primary motor cortex were evaluated in patients with amyotrophic lateral sclerosis (ALS). The study included 38 sporadic definite-ALS subjects and 70 age-matched control subjects. All received whole-brain MR imaging and spectroscopic imaging scans at 3T and clinical neurological assessments including percentage maximum forced vital capacity (FVC) and upper motor neuron (UMN) function. Differences in each individual metabolite and its ratio distributions were evaluated in the entire intracranial CST and in five segments along the length of the CST (at the levels of precentral gyrus (PCG), centrum semiovale (CS), corona radiata (CR), posterior limb of internal capsule (PLIC) and cerebral peduncle (CP)). Major findings included significantly decreased NAA and increased Cho and Cho/NAA in the entire intracranial CST, with the largest differences for Cho/NAA in all the groups. Significant correlations between Cho/NAA in the entire intracranial CST and the right finger tap rate were noted. Of the ten bilateral CST segments, significantly decreased NAA in 4 segments, increased Cho in 5 segments and increased Cho/NAA in all the segments were found. Significant left versus right CST asymmetries were found only in ALS for Cho/NAA in the CS. Among the significant correlations found between Cho/NAA and the clinical assessments included the left-PCG versus FVC and right finger tap rate, left -CR versus FVC and right finger tap rate, and left PLIC versus FVC and right foot tap rate. These results demonstrate that a significant and bilaterally asymmetric alteration of metabolites occurs along the length of the entire intracranial CST in ALS, and the MRS metrics in the segments correlate with measures of disease severity and UMN function.", "link"=>"http://www.mendeley.com/research/comprehensive-evaluation-corticospinal-tract-metabolites-amyotrophic-lateral-sclerosis-using-wholebr-2", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Other"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>6, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>3, "Student > Master"=>3, "Other"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Unspecified"=>2, "Medicine and Dentistry"=>11, "Agricultural and Biological Sciences"=>1, "Neuroscience"=>3, "Chemistry"=>1, "Psychology"=>3, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Psychology"=>{"Psychology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Computer Science"=>{"Computer Science"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"United States"=>2, "Brazil"=>1, "Australia"=>2, "Spain"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/648906"], "description"=>"<p><sup>1</sup>H-MR spectra obtained at 3T from six anatomical regions (square boxes on the MRIs) along the length of the corticospinal tract in the brain of a patient with ALS (male, 43 years) are shown. (a: medulla; b: pons/midbrain, c: left internal capsule; d: left corona radiata; e: left centrum semiovale; f: left precentral gyrus/subcortical white matter). The spectra shown were obtained by averaging spectra from 2.7 mL to 6.0 mL contiguous voxels in that region.</p>", "links"=>[], "tags"=>["spectra"], "article_id"=>319390, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.g001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_1_H_MR_spectra_in_the_brain_of_a_patient_with_ALS_/319390", "title"=>"Representative <sup>1</sup>H-MR spectra in the brain of a patient with ALS.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:05:35"}
  • {"files"=>["https://ndownloader.figshare.com/files/649150"], "description"=>"<p>Comparisons of the left (A) and right (B) entire intracranial corticospinal tract (CST) metabolite values (mean ± SD) in the ALS (n = 38) and control (n = 70) groups (age range: 34–65 years) using ANCOVA. The green and orange histograms indicate the metabolite values of the entire intracranial CST in the ALS and control groups, respectively. The asterisks indicate significant group differences with *p<0.05, **p<0.005 and ***p<0.0001. The significant percent differences found were: −8.9 (left) and −6.2 (right) in NAA, +8.1 (left) and +7.5 (right) in Cho, and +20.0 (left) and +15.7 (right) in Cho/NAA. The abbreviations used indicate as NAA: N-acetyl aspartate; Cre: total-creatine; Cho: total-choline; I. U.: institutional units.</p>", "links"=>[], "tags"=>["intracranial", "corticospinal", "tract", "metabolite", "als"], "article_id"=>319637, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.g003", "stats"=>{"downloads"=>1, "page_views"=>15, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Comparison_of_intracranial_corticospinal_tract_CST_metabolite_values_between_the_ALS_and_control_groups_/319637", "title"=>"Comparison of intracranial corticospinal tract (CST) metabolite values between the ALS and control groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:06:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/649248"], "description"=>"<p>The probabilistic corticospinal tract (CST) atlas is overlaid onto the coronal orientation T1-MRI template (Montreal Neurological Institute). The color bar indicates the full range of the probability values in the CST atlas. The horizontal lines indicate the approximate anatomical levels at which the five segments were made along the length of the CST. PCG: Precentral gyrus, CS: Centrum semiovale, CR: Corona radiata, PLIC: Posterior limb of the internal capsule, CP: Cerebral peduncle and R: Right side of the subject. The blue, green and purple lines indicate the somatotopic arrangement within the primary motor cortex that are associated with the face and lower and upper limb parts, respectively.</p>", "links"=>[], "tags"=>["intracranial", "corticospinal", "tract", "atlas", "somatotopic"], "article_id"=>319735, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.g004", "stats"=>{"downloads"=>6, "page_views"=>267, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Segmented_intracranial_corticospinal_tract_CST_atlas_and_the_somatotopic_arrangement_within_the_primary_motor_cortex_/319735", "title"=>"Segmented intracranial corticospinal tract (CST) atlas and the somatotopic arrangement within the primary motor cortex.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:07:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/649604"], "description"=>"<p>Significant p-values (<0.05) are indicated by asterisks (*). Out of a total of 40 possible comparisons, 24 and 17 between-segment comparisons were found to be significant in the left and right CST, respectively. The abbreviations used are: CST: corticospinal tract, PCG: precentral gyrus, CS: centrum semiovale, CR: corona radiate, PLIC: posterior limb of internal capsule, and CP: cerebral peduncle, NAA: N-acetyl aspartate, Cho: total-choline, Cre: total-creatine.</p>", "links"=>[], "tags"=>["metabolite", "comparisons", "intracranial", "cst", "segments", "hemisphere", "als"], "article_id"=>320085, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.t004", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_values_of_the_metabolite_comparisons_between_the_intracranial_CST_segments_in_each_hemisphere_in_the_ALS_group_/320085", "title"=>"P-values of the metabolite comparisons between the intracranial CST segments in each hemisphere in the ALS group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 06:09:26"}
  • {"files"=>["https://ndownloader.figshare.com/files/649525"], "description"=>"*<p>Rates are provided in s<sup>−1</sup>;</p>**<p>mean of <i>la-la</i> and <i>pa-pa</i> syllable repeat rates.</p>", "links"=>[], "tags"=>["measures", "neuron", "als"], "article_id"=>320016, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.t002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Clinical_measures_of_motor_neuron_function_in_the_ALS_group_/320016", "title"=>"Clinical measures of motor neuron function in the ALS group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 06:09:02"}
  • {"files"=>["https://ndownloader.figshare.com/files/649070"], "description"=>"<p>The full-range probabilistic atlas is shown in green. We modified this atlas (shown in red) for our use by including only voxels with probability values greater than 0.20 and by excluding voxels inferior to the cerebral peduncle. The axial MRI image is included to provide anatomical context.</p>", "links"=>[], "tags"=>["corticospinal", "tract"], "article_id"=>319563, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.g002", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Intracranial_corticospinal_tract_atlas_/319563", "title"=>"Intracranial corticospinal tract atlas.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:06:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/649375"], "description"=>"<p>Metabolite metrics along the length of the intracranial corticospinal tracts (CST) in patients with ALS (blue; n = 38) and control (red; n = 70) groups in the age range of 34–65 years using ANCOVA. The asterisks indicate significant group differences with *p<0.05, **p<0.005 and ***p<0.0001. The abbreviations used indicate as NAA: N-acetyl aspartate, Cho: total-choline, Cre: total-creatine, PCG: precentral gyrus, CS: centrum semiovale, CR: corona radiata, PLIC: posterior limb of internal capsule, CP: cerebral peduncle, and I.U.: institutional units.</p>", "links"=>[], "tags"=>["metrics", "intracranial", "corticospinal", "tracts", "als"], "article_id"=>319863, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.g005", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Metabolite_metrics_in_the_length_of_the_intracranial_corticospinal_tracts_in_the_ALS_and_control_groups_/319863", "title"=>"Metabolite metrics in the length of the intracranial corticospinal tracts in the ALS and control groups.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 06:08:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/649482"], "description"=>"<p>Significant p-values (<0.05) are indicated by asterisks (*). Out of a total of 40 possible comparisons, 34 and 30 between-segment comparisons were found to be significant in the left and right CST, respectively. The abbreviations used are: CST: corticospinal tract, PCG: precentral gyrus, CS: centrum semiovale, CR: corona radiate, PLIC: posterior limb of internal capsule, and CP: cerebral peduncle, NAA: N-acetyl aspartate, Cho: total-choline, Cre: total-creatine.</p>", "links"=>[], "tags"=>["metabolite", "comparisons", "intracranial", "cst", "segments", "hemisphere"], "article_id"=>319972, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.t003", "stats"=>{"downloads"=>1, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_P_values_of_the_metabolite_comparisons_between_the_intracranial_CST_segments_in_each_hemisphere_in_the_control_group_/319972", "title"=>"P-values of the metabolite comparisons between the intracranial CST segments in each hemisphere in the control group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 06:08:48"}
  • {"files"=>["https://ndownloader.figshare.com/files/649562"], "description"=>"*<p>Amyotrophic lateral sclerosis functional rating scale-revised.</p>", "links"=>[], "tags"=>["duration", "severity", "patients", "als"], "article_id"=>320050, "categories"=>["Neuroscience", "Cell Biology"], "users"=>["Varan Govind", "Khema R. Sharma", "Andrew A. Maudsley", "Kristopher L. Arheart", "Gaurav Saigal", "Sulaiman Sheriff"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0035607.t001", "stats"=>{"downloads"=>4, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Disease_duration_and_severity_of_the_patients_in_the_ALS_group_/320050", "title"=>"Disease duration and severity of the patients in the ALS group.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 06:09:13"}

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Relative Metric

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