Screening Estrogenic Activities of Chemicals or Mixtures In Vivo Using Transgenic (cyp19a1b-GFP) Zebrafish Embryos
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{"title"=>"Screening estrogenic activities of chemicals or mixtures in vivo using transgenic (cyp19a1b-GFP) zebrafish embryos", "type"=>"journal", "authors"=>[{"first_name"=>"François", "last_name"=>"Brion", "scopus_author_id"=>"23011355300"}, {"first_name"=>"Yann", "last_name"=>"Le Page", "scopus_author_id"=>"57142085300"}, {"first_name"=>"Benjamin", "last_name"=>"Piccini", "scopus_author_id"=>"23035986700"}, {"first_name"=>"Olivier", "last_name"=>"Cardoso", "scopus_author_id"=>"56576134700"}, {"first_name"=>"Sok Keng", "last_name"=>"Tong", "scopus_author_id"=>"57141622500"}, {"first_name"=>"Bon chu", "last_name"=>"Chung", "scopus_author_id"=>"24372354300"}, {"first_name"=>"Olivier", "last_name"=>"Kah", "scopus_author_id"=>"7006567539"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84860642434", "pui"=>"364751089", "doi"=>"10.1371/journal.pone.0036069", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84860642434", "pmid"=>"22586461"}, "id"=>"db664bde-db09-3732-b88b-58af22464ce0", "abstract"=>"The tg(cyp19a1b-GFP) transgenic zebrafish expresses GFP (green fluorescent protein) under the control of the cyp19a1b gene, encoding brain aromatase. This gene has two major characteristics: (i) it is only expressed in radial glial progenitors in the brain of fish and (ii) it is exquisitely sensitive to estrogens. Based on these properties, we demonstrate that natural or synthetic hormones (alone or in binary mixture), including androgens or progestagens, and industrial chemicals induce a concentration-dependent GFP expression in radial glial progenitors. As GFP expression can be quantified by in vivo imaging, this model presents a very powerful tool to screen and characterize compounds potentially acting as estrogen mimics either directly or after metabolization by the zebrafish embryo. This study also shows that radial glial cells that act as stem cells are direct targets for a large panel of endocrine disruptors, calling for more attention regarding the impact of environmental estrogens and/or certain pharmaceuticals on brain development. Altogether these data identify this in vivo bioassay as an interesting alternative to detect estrogen mimics in hazard and risk assessment perspective.", "link"=>"http://www.mendeley.com/research/screening-estrogenic-activities-chemicals-mixtures-vivo-using-transgenic-cyp19a1bgfp-zebrafish-embry", "reader_count"=>72, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Professor > Associate Professor"=>2, "Researcher"=>19, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>1, "Student > Master"=>11, "Other"=>6, "Student > Bachelor"=>5, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Professor > Associate Professor"=>2, "Researcher"=>19, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>20, "Student > Postgraduate"=>1, "Student > Master"=>11, "Other"=>6, "Student > Bachelor"=>5, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>8, "Environmental Science"=>17, "Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>33, "Medicine and Dentistry"=>3, "Chemistry"=>2, "Computer Science"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>33}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}, "Unspecified"=>{"Unspecified"=>8}, "Environmental Science"=>{"Environmental Science"=>17}}, "reader_count_by_country"=>{"United States"=>3, "Italy"=>1, "France"=>1, "Spain"=>1}, "group_count"=>2}

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Figshare

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  • {"files"=>["https://ndownloader.figshare.com/files/643486"], "description"=>"<p>\n <i>Results are expressed as mean ± confidence interval at 95% (CI 95).</i></p>", "links"=>[], "tags"=>["concentrations", "e1", "genistein", "transgenic", "cyp19a1b-gfp", "zebrafish", "gfp", "pcr"], "article_id"=>313972, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.t001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Calculated_Effective_concentrations_EC_50_for_E2_EE2_E1_and_Genistein_in_transgenic_cyp19a1b_GFP_zebrafish_line_based_on_measurement_of_either_cyp19a1b_or_GFP_gene_expression_by_PCR_and_by_image_analysis_/313972", "title"=>"Calculated Effective concentrations EC<sub>50</sub> for E2, EE2, E1 and Genistein in transgenic cyp19a1b-GFP zebrafish line based on measurement of either <i>cyp19a1b</i> or GFP gene expression by PCR and by image analysis.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 05:37:29"}
  • {"files"=>["https://ndownloader.figshare.com/files/643222"], "description"=>"<p>Results are expressed as fold induction above control (means ± SEM).</p>", "links"=>[], "tags"=>["zebrafish", "embryos", "exposed", "ee2", "tcdd"], "article_id"=>313713, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.g006", "stats"=>{"downloads"=>4, "page_views"=>12, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GFP_expression_in_zebrafish_embryos_exposed_to_EE2_and_TCDD_0_05_nM_alone_or_in_combination_/313713", "title"=>"GFP expression in zebrafish embryos exposed to EE2 and TCDD (0.05 nM) alone or in combination.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:36:13"}
  • {"files"=>["https://ndownloader.figshare.com/files/643021"], "description"=>"<p>Results are expressed as fold induction above control (means ± SEM, n = indicates the number of 5-dpf old zebrafish examined).</p>", "links"=>[], "tags"=>["zebrafish", "embryos", "exposed", "ar", "pr", "ligands"], "article_id"=>313506, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.g004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_GFP_expression_in_zebrafish_embryos_exposed_to_various_ER_AR_and_PR_ligands_alone_or_in_combination_with_ICI_/313506", "title"=>"GFP expression in zebrafish embryos exposed to various ER, AR and PR ligands alone or in combination with ICI.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:35:09"}
  • {"files"=>["https://ndownloader.figshare.com/files/642561"], "description"=>"<p>(<i>a</i>) Dorsal view of a zebrafish larva treated with 10 nM E2 showing that GFP signal is visible in the brain, notably in the telencephalon (tel), preoptic area (poa), and in the nucleus recessus posterioris (nrp) of the caudal hypothalamus; ob: olfactory bulb. (<i>b</i>) High resolution confocal image showing the RGCs in the telencephalon (tel), preoptic area (poa), nucleus recessus lateralis (nrl) and nucleus recessus posterioris (nrp) of the caudal hypothalamus. (c) High power view of the area shown in (<i>b</i>). Soma (s) are located along the midline except in the case of newborn cells (nb) undergoing migration (see <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0036069#pone-0036069-g002\" target=\"_blank\">Figure 2</a>). RGCs have long cytoplasmic radial processes (rp) terminating by end-feet (ef) at the brain surface. (<i>a</i>) Bar = 200 µm; (<i>b</i>) Bar = 100 µm (c) Bar = 20 µm.</p>", "links"=>[], "tags"=>["embryos", "zebrafish", "expresses", "gfp", "radial", "glial"], "article_id"=>313038, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.g001", "stats"=>{"downloads"=>0, "page_views"=>13, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Upon_exposure_of_embryos_to_estradiol_the_tg_cyp19a1b_GFP_zebrafish_expresses_GFP_only_in_radial_glial_cells_/313038", "title"=>"Upon exposure of embryos to estradiol, the tg(<i>cyp19a1b</i>-GFP) zebrafish expresses GFP only in radial glial cells.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:32:39"}
  • {"files"=>["https://ndownloader.figshare.com/files/643328"], "description"=>"<p>The combined effects of mixture of E1+E2 (ratio 1∶10) and E2+EE2 (ratio 1∶1) induced GFP expression in a concentration-dependent manner. Mixture means (green) is the mean of two independent assays, Mixture assays 1 (pale blue) and 2 (red). CA: dose response curve generated by the CA model (black). IA: dose response curve generated by the IA model (blue).</p>", "links"=>[], "tags"=>["binary", "mixtures", "estrogens", "cyp19a1b-gfp"], "article_id"=>313817, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.g007", "stats"=>{"downloads"=>0, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effects_of_binary_mixtures_of_estrogens_on_cyp19a1b_GFP_expression_/313817", "title"=>"Effects of binary mixtures of estrogens on cyp19a1b-GFP expression.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:36:44"}
  • {"files"=>["https://ndownloader.figshare.com/files/642934"], "description"=>"<p>(a) Natural estrogens and pharmaceutical compounds: EE2: 17α-ethinylestradiol; E2: 17β-estradiol; E1: estrone; E3: estriol; DES: diethylstilbestrol; HEX: hexestrol; GEN: genistein; α-ZEA: α-zearalenol; α-ZEE: α-zearalanol; β-ZEE: β-zearalanol. The hexestrol curve in red is hardly visible because it is very similar to that of DES. (b) Industrial chemicals: BPA: bisphenol A; 4-t-PP: 4-t-pentylphenol; 4-t-OP, 4-t octylphenol; NPmix: mixture of nonylphenol. (c) Insecticides: o,p’DDT: 1,1,1-Trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane; MXC: methoxychlor; HPTE 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane. (d) Androgens: Testo: testosterone; DHT: dihydotestosterone; 17α-MT: 17α-methyltestosterone; 17β-Trenb: 17β-trenbolone; Noreth.: 17α-Ethynyl-19-nortestosterone (norethindrone); D(-)N: 13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one (levonogestrel), ICI (ICI 182-780); R1881 (metribolone): androgen receptor agonist.</p>", "links"=>[], "tags"=>["curves", "gfp", "induction", "transgenic", "cyp19a1b-gfp", "embryos", "ligands"], "article_id"=>313418, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.g003", "stats"=>{"downloads"=>1, "page_views"=>18, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Dose_response_curves_of_GFP_induction_in_transgenic_cyp19a1b_GFP_embryos_by_various_ligands_17_945_ethinylestradiol_is_used_as_a_reference_/313418", "title"=>"Dose-response curves of GFP induction in transgenic cyp19a1b-GFP embryos by various ligands (17α-ethinylestradiol is used as a reference).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:34:40"}
  • {"files"=>["https://ndownloader.figshare.com/files/643444"], "description"=>"<p>Results are expressed as mean ± standard deviation (SD).</p><p>N = number of independent experiments, n.e.: no effect, CV(%) = coefficient of variation inter-assay for EC<sub>50</sub>. For each experiment, 10–15 transgenic zebrafish embryos were analyzed per condition.</p>", "links"=>[], "tags"=>["concentrations", "induction", "solvent", "estrogenic", "potencies", "compounds", "belonging"], "article_id"=>313925, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.t002", "stats"=>{"downloads"=>1, "page_views"=>37, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Effective_concentrations_EC_50_maximum_fold_of_induction_measured_above_solvent_control_and_relative_estrogenic_potencies_REP_of_various_compounds_belonging_to_different_chemical_families_/313925", "title"=>"Effective concentrations (EC<sub>50</sub>), maximum fold of induction measured above solvent control and relative estrogenic potencies (REP) of various compounds belonging to different chemical families.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2013-02-20 05:37:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/642727"], "description"=>"<p>Dorsal views (anterior to the top) of the telencephalon (tel), preoptic area (poa), and nucleus recessus posterioris (nrp) of the caudal hypothalamus. For each chemical the concentration used is indicated. CTRL: solvent control, EE2: 17α-ethinylestradiol, E2: 17β-estradiol, E1: estrone, E3: estriol, DES: diethystilbestrol, HEX: hexestrol, GEN: genistein, α-ZEA: α-zearalenol, α-ZEE: α-zearalanol, β-ZEE: β-zearalanol, BPA: bisphenol A, 4-t-PP: 4-t-pentylphenol, 4-t-OP, 4-t octylphenol, NPmix: mixture of nonylphenol, o,p’DDT: 1,1,1-Trichloro-2-(2-chlorophenyl)-2-(4-chlorophenyl)ethane, MXC: methoxychlor, HPTE 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane, Testo: testosterone, DHT: dihydotestosterone, 17α-MT: 17α-methyltestosterone, 17β-Trenb: 17β-trenbolone, Noreth.: 17α-Ethynyl-19-nortestosterone, D(-)N: 13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one, ICI (ICI 182-780).</p>", "links"=>[], "tags"=>["imaging", "5-dpf", "transgenic", "zebrafish", "embryos", "exposed", "chemicals", "inducing", "gfp", "radial", "glial"], "article_id"=>313202, "categories"=>["Biochemistry", "Neuroscience", "Ecology", "Developmental Biology"], "users"=>["François Brion", "Yann Le Page", "Benjamin Piccini", "Olivier Cardoso", "Sok-Keng Tong", "Bon-chu Chung", "Olivier Kah"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036069.g002", "stats"=>{"downloads"=>1, "page_views"=>70, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_In_vivo_imaging_of_5_dpf_old_live_transgenic_cyp19a1b_GFP_zebrafish_embryos_exposed_to_chemicals_inducing_GFP_expression_in_radial_glial_progenitors_/313202", "title"=>"<i>In vivo</i> imaging of 5-dpf old live transgenic <i>cyp19a1b</i>-GFP zebrafish embryos exposed to chemicals inducing GFP expression in radial glial progenitors.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2013-02-20 05:33:33"}

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Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Developmental biology", "average_usage"=>[313, 562, 690, 796, 893, 986, 1079, 1173, 1257, 1349, 1429, 1506, 1586, 1661, 1730, 1803, 1876, 1945, 2017, 2091, 2163, 2225, 2294, 2362, 2430]}]}
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