Association between the ERCC5 Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis
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{"title"=>"Association between the ERCC5 asp1104his polymorphism and cancer risk: A meta-analysis", "type"=>"journal", "authors"=>[{"first_name"=>"Mei Ling", "last_name"=>"Zhu", "scopus_author_id"=>"54584677000"}, {"first_name"=>"Mengyun", "last_name"=>"Wang", "scopus_author_id"=>"55058835800"}, {"first_name"=>"Zhi Gang", "last_name"=>"Cao", "scopus_author_id"=>"56883558100"}, {"first_name"=>"Jing", "last_name"=>"He", "scopus_author_id"=>"34769976900"}, {"first_name"=>"Ting Yan", "last_name"=>"Shi", "scopus_author_id"=>"35211822100"}, {"first_name"=>"Kai Qin", "last_name"=>"Xia", "scopus_author_id"=>"55232832400"}, {"first_name"=>"Li Xin", "last_name"=>"Qiu", "scopus_author_id"=>"35201578000"}, {"first_name"=>"Qing Yi", "last_name"=>"Wei", "scopus_author_id"=>"7201691656"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"22815677", "pui"=>"365274739", "scopus"=>"2-s2.0-84864000719", "doi"=>"10.1371/journal.pone.0036293", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "sgr"=>"84864000719"}, "id"=>"ca9e4e99-58ad-3c07-996a-d010fd033894", "abstract"=>"Excision repair cross complementing group 5 (ERCC5 or XPG) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessive syndrome, and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity phenotype and cancer risk. However, a series of epidemiological studies on the association between the ERCC5 Asp1104His polymorphism (rs17655, G>C) and cancer susceptibility generated conflicting results.", "link"=>"http://www.mendeley.com/research/association-between-ercc5-asp1104his-polymorphism-cancer-risk-metaanalysis", "reader_count"=>10, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Pakistan"=>1}, "group_count"=>0}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/606939"], "description"=>"<p>For each study, the estimates of OR and its 95% CI were plotted with a box and a horizontal line. The symbol filled diamond indicates pooled OR and its 95% CI.</p>", "links"=>[], "tags"=>["cancer", "types", "asp1104his", "polymorphism", "44", "published"], "article_id"=>277421, "categories"=>["Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Mei-Ling Zhu", "Mengyun Wang", "Zhi-Gang Cao", "Jing He", "Ting-Yan Shi", "Kai-Qin Xia", "Li-Xin Qiu", "Qing-Yi Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036293.g002", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Forest_plot_of_overall_cancer_risk_of_different_cancer_types_associated_with_ERCC5_Asp1104His_polymorphism_His_His_vs_Asp_His_Asp_Asp_by_the_fixed_effects_for_each_of_the_44_published_studies_/277421", "title"=>"Forest plot of overall cancer risk of different cancer types associated with <i>ERCC5</i> Asp1104His polymorphism (His/His vs. Asp/His + Asp/Asp) by the fixed effects for each of the 44 published studies.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-18 02:03:41"}
  • {"files"=>["https://ndownloader.figshare.com/files/606844"], "description"=>"<p>(A) Human ERCC5 protein harbors the N- and I-nuclease domains (blue) and 600 amino acid spacer region (Orange). Conserved residues (Glu77, Glu791 and Asp812) located in the active site (red). Interaction regions with TFIIH, RPA, and PCNA (PIP) and the ubiquitin-binding domain (UBM) are indicated. (B) ERCC5 cleaves 5′ flap, splayed-arm and bubble substrates at ss/dsDNA junctions and makes the 3′ incision in NER. (C) ERCC5 protein plays versatile roles in cellular processes including DNA repair, genomic integrity maintenance and modulation of gene transcription.</p>", "links"=>[], "tags"=>["characteristics", "modified"], "article_id"=>277335, "categories"=>["Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Mei-Ling Zhu", "Mengyun Wang", "Zhi-Gang Cao", "Jing He", "Ting-Yan Shi", "Kai-Qin Xia", "Li-Xin Qiu", "Qing-Yi Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036293.g001", "stats"=>{"downloads"=>0, "page_views"=>1, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Structural_characteristics_and_function_of_ERCC5_protein_modified_from_the_picture_in_the_reference_14_/277335", "title"=>"Structural characteristics and function of <i>ERCC5</i> protein modified from the picture in the reference [14].", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-18 02:02:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/607027"], "description"=>"<p>: CEU, 90 Utah residents from northern and western Europe; <b>B</b>: Asians, 45 unrelated Han Chinese in Beijing (CHB) and 45 unrelated Japanese in Tokyo (JPT); <b>C</b>: YRI, 90 Yoruba in Ibadan, Nigeria.</p>", "links"=>[], "tags"=>["asp1104his", "mrna"], "article_id"=>277515, "categories"=>["Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Mei-Ling Zhu", "Mengyun Wang", "Zhi-Gang Cao", "Jing He", "Ting-Yan Shi", "Kai-Qin Xia", "Li-Xin Qiu", "Qing-Yi Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036293.g003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_Asp1104His_and_ERCC5_mRNA_expression_for_different_populations_A_/277515", "title"=>"Correlation between Asp1104His and <i>ERCC5</i> mRNA expression for different populations. A", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-07-18 02:05:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/607098"], "description"=>"a<p><i>P</i> value of the Z-test for odds ration test.</p>b<p><i>P</i> value of the Q-test for heterogeneity test.</p>c<p>Fixed effects model.</p>", "links"=>[], "tags"=>["asp1104his", "polymorphism", "cancer", "xp", "recessive", "49"], "article_id"=>277581, "categories"=>["Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Mei-Ling Zhu", "Mengyun Wang", "Zhi-Gang Cao", "Jing He", "Ting-Yan Shi", "Kai-Qin Xia", "Li-Xin Qiu", "Qing-Yi Wei"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036293.t001", "stats"=>{"downloads"=>0, "page_views"=>2, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Meta_analysis_of_the_association_between_the_ERCC5_Asp1104His_polymorphism_and_cancer_risk_under_the_XP_recessive_genetic_model_for_49_studies_/277581", "title"=>"Meta-analysis of the association between the <i>ERCC5</i> Asp1104His polymorphism and cancer risk under the XP recessive genetic model for 49 studies.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-07-18 02:06:21"}
  • {"files"=>["https://ndownloader.figshare.com/files/316923", "https://ndownloader.figshare.com/files/316946", "https://ndownloader.figshare.com/files/316982", "https://ndownloader.figshare.com/files/317013", "https://ndownloader.figshare.com/files/317067", "https://ndownloader.figshare.com/files/317118"], "description"=>"<div><h3>Background</h3><p>Excision repair cross complementing group 5 (<em>ERCC5</em> or <em>XPG</em>) plays an important role in regulating DNA excision repair, removal of bulky lesions caused by environmental chemicals or UV light. Mutations in this gene cause a rare autosomal recessive syndrome, and its functional single nucleotide polymorphisms (SNPs) may alter DNA repair capacity phenotype and cancer risk. However, a series of epidemiological studies on the association between the <em>ERCC5</em> Asp1104His polymorphism (rs17655, G>C) and cancer susceptibility generated conflicting results.</p> <h3>Methodology/Principal Findings</h3><p>To derive a more precise estimation of the association between the <em>ERCC5</em> Asp1104His polymorphism and overall cancer risk, we performed a meta-analysis of 44 published case-control studies, in which a total of 23,490 cases and 27,168 controls were included. To provide additional biological plausibility, we also assessed the genotype-gene expression correlation from the HapMap phase II release 23 data with 270 individuals from 4 ethnic populations. When all studies were pooled, we found no statistical evidence for a significantly increased cancer risk in the recessive genetic models (His/His vs. Asp/Asp: OR = 0.99, 95% CI: 0.92–1.06, <em>P</em> = 0.242 for heterogeneity or His/His vs. Asp/His + Asp/Asp: OR = 0.98, 95% CI: 0.93–1.03, <em>P</em> = 0.260 for heterogeneity), nor in further stratified analyses by cancer type, ethnicity, source of controls and sample size. In the genotype-phenotype correlation analysis from 270 individuals, we consistently found no significant correlation of the Asp1104His polymorphism with <em>ERCC5</em> mRNA expression.</p> <h3>Conclusions/Significance</h3><p>This meta-analysis suggests that it is unlikely that the <em>ERCC5</em> Asp1104His polymorphism may contribute to individual susceptibility to cancer risk.</p> </div>", "links"=>[], "tags"=>["asp1104his", "polymorphism", "cancer", "meta-analysis"], "article_id"=>122551, "categories"=>["Biological Sciences", "Genetics", "Biotechnology", "Evolutionary Biology"], "users"=>["Mei-Ling Zhu", "Mengyun Wang", "Zhi-Gang Cao", "Jing He", "Ting-Yan Shi", "Kai-Qin Xia", "Li-Xin Qiu", "Qing-Yi Wei"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0036293.s001", "https://dx.doi.org/10.1371/journal.pone.0036293.s002", "https://dx.doi.org/10.1371/journal.pone.0036293.s003", "https://dx.doi.org/10.1371/journal.pone.0036293.s004", "https://dx.doi.org/10.1371/journal.pone.0036293.s005", "https://dx.doi.org/10.1371/journal.pone.0036293.s006"], "stats"=>{"downloads"=>35, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Association_between_the_ERCC5_Asp1104His_Polymorphism_and_Cancer_Risk_A_Meta_Analysis/122551", "title"=>"Association between the <em>ERCC5</em> Asp1104His Polymorphism and Cancer Risk: A Meta-Analysis", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-07-18 00:42:31"}

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Relative Metric

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