Effectiveness of a Prevention of Mother-to-Child HIV Transmission Programme in an Urban Hospital in Angola
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{"title"=>"Effectiveness of a prevention of mother-to-child HIV transmission programme in an urban hospital in Angola", "type"=>"journal", "authors"=>[{"first_name"=>"Cristina", "last_name"=>"Lussiana", "scopus_author_id"=>"54954945900"}, {"first_name"=>"Sofiada Lôa", "last_name"=>"van Clemente", "scopus_author_id"=>"55203633800"}, {"first_name"=>"Angelo", "last_name"=>"Ghelardi", "scopus_author_id"=>"55204020000"}, {"first_name"=>"Magda", "last_name"=>"Lonardi", "scopus_author_id"=>"55203634200"}, {"first_name"=>"Ivan Alejandro", "last_name"=>"Tarquino", "scopus_author_id"=>"53872093200"}, {"first_name"=>"Marco", "last_name"=>"Floridia", "scopus_author_id"=>"8580776400"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84860459528", "sgr"=>"84860459528", "pui"=>"364721033", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pmid"=>"22558455", "doi"=>"10.1371/journal.pone.0036381"}, "id"=>"2e160d82-e07f-30ed-b6cd-cfaea16e7bb2", "abstract"=>"BACKGROUND: Antiretroviral therapy is effective in reducing rates of mother-to child transmission of HIV to low levels in resource-limited contexts but the applicability and efficacy of these programs in the field are scarcely known. In order to explore such issues, we performed a descriptive study on retrospective data from hospital records of HIV-infected pregnant women who accessed in 2007-2010 the Luanda Municipal Hospital service for prevention of mother-to-child transmission (PMTCT). The main outcome measure was infant survival and HIV transmission. Our aim was to evaluate PMTCT programme in a local hospital setting in Africa.\\n\\nRESULTS: Data for 104 pregnancies and 107 infants were analysed. Sixty-eight women (65.4%) had a first visit before or during pregnancy and received combination antiretroviral treatment (ART) in pregnancy. The remaining 36 women (34.6%) presented after delivery and received no ART during pregnancy. Across a median cohort follow-up time of 73 weeks, mortality among women with and without ART in pregnancy was 4.4% and 16.7%, respectively (death hazard ratio: 0.30, 95% CI 0.07-1.20, p = 0.089). The estimated rates of HIV transmission or death in the infants over a median follow up time of 74 weeks were 8.5% with maternal ART during pregnancy and 38.9% without maternal ART during pregnancy. Following adjustment for use of oral zidovudine in the newborn and exposure to maternal milk, no ART in pregnancy remained associated with a 5-fold higher infant risk of HIV transmission or death (adjusted odds ratio: 5.13, 95% CI: 1.31-20.15, p = 0.019).\\n\\nCONCLUSIONS: Among the women and infants adhering to the PMTCT programme, HIV transmission and mortality were low. However, many women presented too late for PMTCT, and about 20% of infants did not complete follow up. This suggests the need of targeted interventions that maintain the access of mothers and infants to prevention and care services for HIV.", "link"=>"http://www.mendeley.com/research/effectiveness-prevention-mothertochild-hiv-transmission-programme-urban-hospital-angola", "reader_count"=>82, "reader_count_by_academic_status"=>{"Unspecified"=>5, "Researcher"=>8, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>8, "Student > Master"=>31, "Other"=>4, "Student > Bachelor"=>5, "Lecturer"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>5, "Researcher"=>8, "Student > Doctoral Student"=>5, "Student > Ph. D. Student"=>13, "Student > Postgraduate"=>8, "Student > Master"=>31, "Other"=>4, "Student > Bachelor"=>5, "Lecturer"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Environmental Science"=>2, "Nursing and Health Professions"=>7, "Medicine and Dentistry"=>41, "Agricultural and Biological Sciences"=>4, "Business, Management and Accounting"=>2, "Psychology"=>4, "Social Sciences"=>11, "Computer Science"=>1, "Immunology and Microbiology"=>2, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>41}, "Social Sciences"=>{"Social Sciences"=>11}, "Psychology"=>{"Psychology"=>4}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>7}, "Business, Management and Accounting"=>{"Business, Management and Accounting"=>2}, "Unspecified"=>{"Unspecified"=>7}, "Environmental Science"=>{"Environmental Science"=>2}}, "reader_count_by_country"=>{"Iran"=>1, "Sudan"=>1, "Nigeria"=>1, "Kenya"=>2, "Peru"=>1, "Ethiopia"=>1, "Spain"=>1}, "group_count"=>8}

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PMC Usage Stats | Further Information

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Relative Metric

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