Cluster Analysis of Obesity and Asthma Phenotypes
Publication Date
May 11, 2012
Journal
PLOS ONE
Authors
E. Rand Sutherland, Elena Goleva, Tonya S. King, Erik Lehman, et al
Volume
7
Issue
5
Pages
e36631
DOI
https://dx.plos.org/10.1371/journal.pone.0036631
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0036631
PubMed
http://www.ncbi.nlm.nih.gov/pubmed/22606276
PubMed Central
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350517
Europe PMC
http://europepmc.org/abstract/MED/22606276
Web of Science
000305338200035
Scopus
84861008611
Mendeley
http://www.mendeley.com/research/cluster-analysis-obesity-asthma-phenotypes-4
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Cluster analysis of obesity and asthma phenotypes", "type"=>"journal", "authors"=>[{"first_name"=>"E. Rand", "last_name"=>"Sutherland", "scopus_author_id"=>"55666159800"}, {"first_name"=>"Elena", "last_name"=>"Goleva", "scopus_author_id"=>"6602407605"}, {"first_name"=>"Tonya S.", "last_name"=>"King", "scopus_author_id"=>"7403270844"}, {"first_name"=>"Erik", "last_name"=>"Lehman", "scopus_author_id"=>"19836077200"}, {"first_name"=>"Allen D.", "last_name"=>"Stevens", "scopus_author_id"=>"7202107805"}, {"first_name"=>"Leisa P.", "last_name"=>"Jackson", "scopus_author_id"=>"36059217200"}, {"first_name"=>"Amanda R.", "last_name"=>"Stream", "scopus_author_id"=>"54585980600"}, {"first_name"=>"John V.", "last_name"=>"Fahy", "scopus_author_id"=>"7006313500"}, {"first_name"=>"Donald Y.M.", "last_name"=>"Leung", "scopus_author_id"=>"35411672600"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84861008611", "sgr"=>"84861008611", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0036631", "pmid"=>"22606276", "isbn"=>"1932-6203 (Electronic) 1932-6203 (Linking)", "pui"=>"364803131"}, "id"=>"f8114382-605f-3189-86f6-3d754ad3283d", "abstract"=>"BACKGROUND Asthma is a heterogeneous disease with variability among patients in characteristics such as lung function, symptoms and control, body weight, markers of inflammation, and responsiveness to glucocorticoids (GC). Cluster analysis of well-characterized cohorts can advance understanding of disease subgroups in asthma and point to unsuspected disease mechanisms. We utilized an hypothesis-free cluster analytical approach to define the contribution of obesity and related variables to asthma phenotype. METHODOLOGY AND PRINCIPAL FINDINGS In a cohort of clinical trial participants (n = 250), minimum-variance hierarchical clustering was used to identify clinical and inflammatory biomarkers important in determining disease cluster membership in mild and moderate persistent asthmatics. In a subset of participants, GC sensitivity was assessed via expression of GC receptor alpha (GCRα) and induction of MAP kinase phosphatase-1 (MKP-1) expression by dexamethasone. Four asthma clusters were identified, with body mass index (BMI, kg/m(2)) and severity of asthma symptoms (AEQ score) the most significant determinants of cluster membership (F = 57.1, p<0.0001 and F = 44.8, p<0.0001, respectively). Two clusters were composed of predominantly obese individuals; these two obese asthma clusters differed from one another with regard to age of asthma onset, measures of asthma symptoms (AEQ) and control (ACQ), exhaled nitric oxide concentration (F(E)NO) and airway hyperresponsiveness (methacholine PC(20)) but were similar with regard to measures of lung function (FEV(1) (%) and FEV(1)/FVC), airway eosinophilia, IgE, leptin, adiponectin and C-reactive protein (hsCRP). Members of obese clusters demonstrated evidence of reduced expression of GCRα, a finding which was correlated with a reduced induction of MKP-1 expression by dexamethasone CONCLUSIONS AND SIGNIFICANCE Obesity is an important determinant of asthma phenotype in adults. There is heterogeneity in expression of clinical and inflammatory biomarkers of asthma across obese individuals. Reduced expression of the dominant functional isoform of the GCR may mediate GC insensitivity in obese asthmatics.", "link"=>"http://www.mendeley.com/research/cluster-analysis-obesity-asthma-phenotypes-4", "reader_count"=>74, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>3, "Researcher"=>18, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Student > Master"=>14, "Other"=>4, "Student > Bachelor"=>5, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>3, "Researcher"=>18, "Student > Doctoral Student"=>11, "Student > Ph. D. Student"=>14, "Student > Postgraduate"=>2, "Student > Master"=>14, "Other"=>4, "Student > Bachelor"=>5, "Lecturer"=>1, "Lecturer > Senior Lecturer"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Agricultural and Biological Sciences"=>13, "Arts and Humanities"=>1, "Computer Science"=>1, "Engineering"=>3, "Environmental Science"=>3, "Biochemistry, Genetics and Molecular Biology"=>2, "Nursing and Health Professions"=>2, "Mathematics"=>7, "Medicine and Dentistry"=>33, "Sports and Recreations"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>33}, "Social Sciences"=>{"Social Sciences"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Mathematics"=>{"Mathematics"=>7}, "Unspecified"=>{"Unspecified"=>5}, "Environmental Science"=>{"Environmental Science"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Arts and Humanities"=>{"Arts and Humanities"=>1}, "Engineering"=>{"Engineering"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>13}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Colombia"=>1, "Canada"=>1, "Korea (South)"=>1, "United Kingdom"=>1, "France"=>2, "Australia"=>1, "Portugal"=>2, "Germany"=>1, "Spain"=>1}, "group_count"=>4}

CrossRef

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84861008611"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84861008611?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84861008611&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84861008611&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84861008611", "dc:identifier"=>"SCOPUS_ID:84861008611", "eid"=>"2-s2.0-84861008611", "dc:title"=>"Cluster analysis of obesity and asthma phenotypes", "dc:creator"=>"Sutherland E.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"5", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-05-11", "prism:coverDisplayDate"=>"11 May 2012", "prism:doi"=>"10.1371/journal.pone.0036631", "citedby-count"=>"112", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"National Jewish Health", "affiliation-city"=>"Denver", "affiliation-country"=>"United States"}, {"@_fa"=>"true", "affilname"=>"University of Colorado School of Medicine", "affiliation-city"=>"Denver", "affiliation-country"=>"United States"}], "pubmed-id"=>"22606276", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e36631", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0036631", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"5", "year"=>"2012", "pdf_views"=>"136", "xml_views"=>"7", "html_views"=>"565"}
  • {"month"=>"6", "year"=>"2012", "pdf_views"=>"51", "xml_views"=>"0", "html_views"=>"114"}
  • {"month"=>"7", "year"=>"2012", "pdf_views"=>"42", "xml_views"=>"0", "html_views"=>"105"}
  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"27", "xml_views"=>"6", "html_views"=>"60"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"36", "xml_views"=>"0", "html_views"=>"96"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"117"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"62"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"84"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"72"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"27", "xml_views"=>"1", "html_views"=>"107"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"24", "xml_views"=>"1", "html_views"=>"124"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"44", "xml_views"=>"0", "html_views"=>"128"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"80"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"83"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"71"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"21", "xml_views"=>"2", "html_views"=>"89"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"18", "xml_views"=>"1", "html_views"=>"81"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"41"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"65"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"2", "html_views"=>"94"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"106"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"59"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"78"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"2", "html_views"=>"36"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"56"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"55"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"26", "xml_views"=>"1", "html_views"=>"73"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"67"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"58"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"77"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"20", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"23", "xml_views"=>"0", "html_views"=>"46"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"51"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"49"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"12", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"21", "xml_views"=>"1", "html_views"=>"70"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"61"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"60"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"67"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"69"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"26", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"54"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"22", "xml_views"=>"0", "html_views"=>"57"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"53"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"14", "xml_views"=>"1", "html_views"=>"40"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"29", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"13", "xml_views"=>"0", "html_views"=>"73"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"70"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"52"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"2", "html_views"=>"51"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"61"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"16", "xml_views"=>"2", "html_views"=>"58"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"53"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"51"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"46", "xml_views"=>"2", "html_views"=>"69"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"162", "xml_views"=>"0", "html_views"=>"95"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"226", "xml_views"=>"1", "html_views"=>"58"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"148", "xml_views"=>"0", "html_views"=>"38"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"0", "html_views"=>"35"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"50"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"39"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"12", "xml_views"=>"3", "html_views"=>"24"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"1", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"31"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"10", "xml_views"=>"1", "html_views"=>"30"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"46", "xml_views"=>"1", "html_views"=>"39"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"19", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"18", "xml_views"=>"0", "html_views"=>"36"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"2", "html_views"=>"32"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"20", "xml_views"=>"1", "html_views"=>"31"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"17", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"16", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"39", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"15", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/639742"], "description"=>"<p>Results of discriminant analysis demonstrating relative contribution of variables in determining cluster membership.</p>", "links"=>[], "tags"=>["discriminant", "demonstrating", "variables", "determining"], "article_id"=>310225, "categories"=>["Medicine", "Cell Biology", "Genetics", "Pharmacology"], "users"=>["E. Rand Sutherland", "Elena Goleva", "Tonya S. King", "Erik Lehman", "Allen D. Stevens", "Leisa P. Jackson", "Amanda R. Stream", "John V. Fahy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036631.t002", "stats"=>{"downloads"=>0, "page_views"=>6, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Results_of_discriminant_analysis_demonstrating_relative_contribution_of_variables_in_determining_cluster_membership_/310225", "title"=>"Results of discriminant analysis demonstrating relative contribution of variables in determining cluster membership.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-11 00:03:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/639691"], "description"=>"<p>Table p values from Pearson chi-square test (Exact or CMH test) or analysis of variance comparing all 4 clusters.</p>*<p>indicates p<0.05 for comparison of clusters 3 and 4.</p><p>Numeric data presented as Mean (Standard Deviation), except.</p>†<p>Geometric Mean (Coefficient of Variation), log-transformed for analysis.</p><p>ACQ: asthma control questionnaire score after 4 weeks of HFA-BDP, AEQ: asthma evaluation questionnaire score after 4 weeks of HFA-BDP.</p>", "links"=>[], "tags"=>["asthma"], "article_id"=>310179, "categories"=>["Medicine", "Cell Biology", "Genetics", "Pharmacology"], "users"=>["E. Rand Sutherland", "Elena Goleva", "Tonya S. King", "Erik Lehman", "Allen D. Stevens", "Leisa P. Jackson", "Amanda R. Stream", "John V. Fahy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036631.t003", "stats"=>{"downloads"=>0, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_asthma_disease_clusters_/310179", "title"=>"Characteristics of asthma disease clusters.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-11 00:02:59"}
  • {"files"=>["https://ndownloader.figshare.com/files/639551"], "description"=>"<p>Correlation between expression of GCRα in PBMC and serum hsCRP concentrations of (both log-transformed).</p>", "links"=>[], "tags"=>["pbmc", "serum", "hscrp", "concentrations"], "article_id"=>310036, "categories"=>["Medicine", "Cell Biology", "Genetics", "Pharmacology"], "users"=>["E. Rand Sutherland", "Elena Goleva", "Tonya S. King", "Erik Lehman", "Allen D. Stevens", "Leisa P. Jackson", "Amanda R. Stream", "John V. Fahy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036631.g002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_expression_of_GCR_945_in_PBMC_and_serum_hsCRP_concentrations_of_both_log_transformed_/310036", "title"=>"Correlation between expression of GCRα in PBMC and serum hsCRP concentrations of (both log-transformed).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-05-11 00:00:36"}
  • {"files"=>["https://ndownloader.figshare.com/files/330707"], "description"=>"<div><h3>Background</h3><p>Asthma is a heterogeneous disease with variability among patients in characteristics such as lung function, symptoms and control, body weight, markers of inflammation, and responsiveness to glucocorticoids (GC). Cluster analysis of well-characterized cohorts can advance understanding of disease subgroups in asthma and point to unsuspected disease mechanisms. We utilized an hypothesis-free cluster analytical approach to define the contribution of obesity and related variables to asthma phenotype.</p> <h3>Methodology and Principal Findings</h3><p>In a cohort of clinical trial participants (n = 250), minimum-variance hierarchical clustering was used to identify clinical and inflammatory biomarkers important in determining disease cluster membership in mild and moderate persistent asthmatics. In a subset of participants, GC sensitivity was assessed via expression of GC receptor alpha (GCRα) and induction of MAP kinase phosphatase-1 (MKP-1) expression by dexamethasone. Four asthma clusters were identified, with body mass index (BMI, kg/m<sup>2</sup>) and severity of asthma symptoms (AEQ score) the most significant determinants of cluster membership (F = 57.1, p<0.0001 and F = 44.8, p<0.0001, respectively). Two clusters were composed of predominantly obese individuals; these two obese asthma clusters differed from one another with regard to age of asthma onset, measures of asthma symptoms (AEQ) and control (ACQ), exhaled nitric oxide concentration (F<sub>E</sub>NO) and airway hyperresponsiveness (methacholine PC<sub>20</sub>) but were similar with regard to measures of lung function (FEV<sub>1</sub> (%) and FEV<sub>1</sub>/FVC), airway eosinophilia, IgE, leptin, adiponectin and C-reactive protein (hsCRP). Members of obese clusters demonstrated evidence of reduced expression of GCRα, a finding which was correlated with a reduced induction of MKP-1 expression by dexamethasone</p> <h3>Conclusions and Significance</h3><p>Obesity is an important determinant of asthma phenotype in adults. There is heterogeneity in expression of clinical and inflammatory biomarkers of asthma across obese individuals. Reduced expression of the dominant functional isoform of the GCR may mediate GC insensitivity in obese asthmatics.</p> </div>", "links"=>[], "tags"=>["obesity", "asthma", "phenotypes"], "article_id"=>125308, "categories"=>["Medicine", "Cell Biology", "Genetics", "Pharmacology"], "users"=>["E. Rand Sutherland", "Elena Goleva", "Tonya S. King", "Erik Lehman", "Allen D. Stevens", "Leisa P. Jackson", "Amanda R. Stream", "John V. Fahy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036631", "stats"=>{"downloads"=>1, "page_views"=>7, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Cluster_Analysis_of_Obesity_and_Asthma_Phenotypes/125308", "title"=>"Cluster Analysis of Obesity and Asthma Phenotypes", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-11 01:28:28"}
  • {"files"=>["https://ndownloader.figshare.com/files/639414"], "description"=>"<p>Correlation between expression of GCRα and baseline expression of MKP-1 in PBMC (both log-transformed).</p>", "links"=>[], "tags"=>["baseline", "mkp-1", "pbmc"], "article_id"=>309900, "categories"=>["Medicine", "Cell Biology", "Genetics", "Pharmacology"], "users"=>["E. Rand Sutherland", "Elena Goleva", "Tonya S. King", "Erik Lehman", "Allen D. Stevens", "Leisa P. Jackson", "Amanda R. Stream", "John V. Fahy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036631.g001", "stats"=>{"downloads"=>1, "page_views"=>5, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Correlation_between_expression_of_GCR_945_and_baseline_expression_of_MKP_1_in_PBMC_both_log_transformed_/309900", "title"=>"Correlation between expression of GCRα and baseline expression of MKP-1 in PBMC (both log-transformed).", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-05-11 02:45:00"}
  • {"files"=>["https://ndownloader.figshare.com/files/639658"], "description"=>"<p>Numeric data presented as mean (standard deviation), except <sup>†</sup>geometric mean (coefficient of variation), log-transformed for analysis.</p>", "links"=>[], "tags"=>["genetics and genomics", "pharmacology", "pathology", "respiratory medicine"], "article_id"=>310141, "categories"=>["Medicine", "Cell Biology", "Genetics", "Pharmacology"], "users"=>["E. Rand Sutherland", "Elena Goleva", "Tonya S. King", "Erik Lehman", "Allen D. Stevens", "Leisa P. Jackson", "Amanda R. Stream", "John V. Fahy"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036631.t001", "stats"=>{"downloads"=>1, "page_views"=>4, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characteristics_of_study_population_/310141", "title"=>"Characteristics of study population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-11 00:02:21"}

PMC Usage Stats | Further Information

  • {"scanned-page-browse"=>"0", "month"=>"5", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"74", "unique-ip"=>"71", "pdf"=>"55", "year"=>"2012", "figure"=>"4", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"month"=>"6", "scanned-page-browse"=>"0", "cited-by"=>"0", "abstract"=>"0", "full-text"=>"89", "year"=>"2012", "pdf"=>"67", "unique-ip"=>"87", "figure"=>"10", "scanned-summary"=>"0", "supp-data"=>"0"}
  • {"unique-ip"=>"60", "full-text"=>"67", "pdf"=>"45", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"7"}
  • {"unique-ip"=>"49", "full-text"=>"50", "pdf"=>"22", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"10", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"8"}
  • {"unique-ip"=>"44", "full-text"=>"52", "pdf"=>"24", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"72", "full-text"=>"74", "pdf"=>"40", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"38", "full-text"=>"39", "pdf"=>"18", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"42", "full-text"=>"47", "pdf"=>"28", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"35", "full-text"=>"37", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"36", "full-text"=>"35", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"40", "full-text"=>"42", "pdf"=>"20", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"63", "full-text"=>"73", "pdf"=>"41", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"36", "full-text"=>"32", "pdf"=>"21", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"29", "full-text"=>"27", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"21", "full-text"=>"26", "pdf"=>"16", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"31", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"14", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"26", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"25", "full-text"=>"24", "pdf"=>"19", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"30", "full-text"=>"35", "pdf"=>"23", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"24", "full-text"=>"29", "pdf"=>"17", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"16", "full-text"=>"13", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"38", "full-text"=>"34", "pdf"=>"19", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"24", "full-text"=>"28", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"11", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"16", "full-text"=>"17", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"21", "full-text"=>"21", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"15", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"25", "full-text"=>"19", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"23", "full-text"=>"17", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"3", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"17", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"18", "full-text"=>"18", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"25", "full-text"=>"22", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"10", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"17", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"13", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"18", "full-text"=>"16", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"13", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"17", "full-text"=>"14", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"14", "full-text"=>"14", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"1", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"9", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"8", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"16", "full-text"=>"14", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"15", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"5", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"6", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"11", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"13", "full-text"=>"15", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"14", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"12", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"2"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"9", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"7", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"12", "full-text"=>"30", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"2", "cited-by"=>"2", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"19", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"3", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"12", "pdf"=>"6", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"9", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"11", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"2", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"19", "full-text"=>"8", "pdf"=>"11", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"23", "full-text"=>"10", "pdf"=>"15", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"11", "full-text"=>"10", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"15", "full-text"=>"16", "pdf"=>"8", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"19", "full-text"=>"11", "pdf"=>"12", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[316, 541, 663, 766, 856, 950, 1041, 1128, 1218, 1302, 1382, 1456, 1526, 1593, 1657, 1729, 1796, 1862, 1930, 1999, 2065, 2132, 2202, 2261, 2319]}, {"subject_area"=>"/Biology and life sciences/Cell biology", "average_usage"=>[319, 556, 679, 785, 881, 970, 1062, 1149, 1236, 1323, 1402, 1474, 1545, 1617, 1681, 1754, 1822, 1892, 1963, 2031, 2099, 2165, 2233, 2299, 2359]}, {"subject_area"=>"/Biology and life sciences/Immunology", "average_usage"=>[312, 555, 680, 785, 880, 965, 1057, 1142, 1230, 1312, 1394, 1471, 1547, 1613, 1681, 1743, 1805, 1871, 1941, 2010, 2071, 2128, 2202, 2266, 2323]}, {"subject_area"=>"/Biology and life sciences/Physiology", "average_usage"=>[307, 536, 653, 753, 839, 926, 1017, 1103, 1189, 1268, 1348, 1425, 1492, 1557, 1620, 1686, 1759, 1825, 1891, 1950, 2014, 2079, 2141, 2200, 2255]}, {"subject_area"=>"/Medicine and health sciences", "average_usage"=>[312, 547, 668, 769, 861, 953, 1046, 1135, 1224, 1307, 1388, 1464, 1536, 1606, 1676, 1744, 1812, 1882, 1954, 2020, 2089, 2155, 2218, 2282, 2344]}, {"subject_area"=>"/Medicine and health sciences/Immunology", "average_usage"=>[307, 545, 668, 765, 855, 943, 1029, 1113, 1202, 1285, 1361, 1439, 1506, 1571, 1636, 1706, 1772, 1837, 1901, 1969, 2031, 2096, 2160, 2228, 2287]}, {"subject_area"=>"/Medicine and health sciences/Pathology and laboratory medicine", "average_usage"=>[321, 553, 683, 785, 880, 973, 1072, 1162, 1249, 1336, 1425, 1504, 1574, 1642, 1711, 1785, 1852, 1923, 1987, 2050, 2129, 2192, 2259, 2325, 2393]}, {"subject_area"=>"/Medicine and health sciences/Physiology", "average_usage"=>[308, 535, 653, 754, 847, 930, 1020, 1103, 1188, 1268, 1351, 1420, 1487, 1550, 1614, 1679, 1757, 1830, 1898, 1961, 2024, 2086, 2150, 2216, 2266]}, {"subject_area"=>"/Medicine and health sciences/Pulmonology", "average_usage"=>[311, 554, 688, 795, 893, 992, 1073, 1157, 1250, 1327, 1407, 1478, 1557, 1610, 1684, 1749, 1812, 1890, 1978, 2054, 2134, 2210, 2280, 2346, 2425]}, {"subject_area"=>"/People and places/Population groupings", "average_usage"=>[325, 565, 687, 787, 880, 971, 1065, 1156, 1244, 1339, 1424, 1502, 1582, 1654, 1724, 1794, 1855, 1925, 1997, 2058, 2132, 2207, 2285, 2347, 2412]}]}

F1000Prime | Further Information

Loading … Spinner
There are currently no alerts