Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population
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{"title"=>"Investigation of host candidate malaria-associated risk/protective snps in a Brazilian Amazonian population", "type"=>"journal", "authors"=>[{"first_name"=>"Simone", "last_name"=>"da Silva Santos", "scopus_author_id"=>"55222134600"}, {"first_name"=>"Taane G.", "last_name"=>"Clark", "scopus_author_id"=>"7403216793"}, {"first_name"=>"Susana", "last_name"=>"Campino", "scopus_author_id"=>"14827794400"}, {"first_name"=>"Martha Cecília", "last_name"=>"Suarez-Mutis", "scopus_author_id"=>"14026234300"}, {"first_name"=>"Kirk A.", "last_name"=>"Rockett", "scopus_author_id"=>"7003949633"}, {"first_name"=>"Dominic P.", "last_name"=>"Kwiatkowski", "scopus_author_id"=>"7102780531"}, {"first_name"=>"Octavio", "last_name"=>"Fernandes", "scopus_author_id"=>"7004906161"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"22615793", "sgr"=>"84861217211", "doi"=>"10.1371/journal.pone.0036692", "scopus"=>"2-s2.0-84861217211", "pui"=>"364837280", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "issn"=>"19326203"}, "id"=>"eea0d33b-0743-3081-912c-efc72f59ff8e", "abstract"=>"The Brazilian Amazon is a hypo-endemic malaria region with nearly 300,000 cases each year. A variety of genetic polymorphisms, particularly in erythrocyte receptors and immune response related genes, have been described to be associated with susceptibility and resistance to malaria. In order to identify polymorphisms that might be associated with malaria clinical outcomes in a Brazilian Amazonian population, sixty-four human single nucleotide polymorphisms in 37 genes were analyzed using a Sequenom massARRAY iPLEX platform. A total of 648 individuals from two malaria endemic areas were studied, including 535 malaria cases (113 individuals with clinical mild malaria, 122 individuals with asymptomatic infection and 300 individuals with history of previous mild malaria) and 113 health controls with no history of malaria. The data revealed significant associations (p<0.003) between one SNP in the IL10 gene (rs1800896) and one SNP in the TLR4 gene (rs4986790) with reduced risk for clinical malaria, one SNP in the IRF1 gene (rs2706384) with increased risk for clinical malaria, one SNP in the LTA gene (rs909253) with protection from clinical malaria and one SNP in the TNF gene (RS1800750) associated with susceptibility to clinical malaria. Also, a new association was found between a SNP in the CTL4 gene (rs2242665), located at the major histocompatibility complex III region, and reduced risk for clinical malaria. This study represents the first association study from an Amazonian population involving a large number of host genetic polymorphisms with susceptibility or resistance to Plasmodium infection and malaria outcomes. Further studies should include a larger number of individuals, refined parameters and a fine-scale map obtained through DNA sequencing to increase the knowledge of the Amazonian population genetic diversity.", "link"=>"http://www.mendeley.com/research/investigation-host-candidate-malariaassociated-riskprotective-snps-brazilian-amazonian-population", "reader_count"=>38, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>8, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>3, "Professor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Doctoral Student"=>3, "Researcher"=>8, "Student > Ph. D. Student"=>9, "Student > Postgraduate"=>2, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>3, "Lecturer"=>3, "Professor"=>3}, "reader_count_by_subject_area"=>{"Environmental Science"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>24, "Immunology and Microbiology"=>2, "Earth and Planetary Sciences"=>1, "Economics, Econometrics and Finance"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Earth and Planetary Sciences"=>{"Earth and Planetary Sciences"=>1}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>24}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Environmental Science"=>{"Environmental Science"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Burkina Faso"=>1, "United States"=>1, "Brazil"=>2, "United Kingdom"=>3, "France"=>1, "Indonesia"=>1}, "group_count"=>2}

Scopus | Further Information

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Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/638093"], "description"=>"<p><i>Any_</i>malaria group consisted of: clinical malaria, asymptomatic infection and previous history of malaria; <i>Asymptomatic</i> group: asymptomatic infection; <i>Clinical_Malaria</i> group: clinical mild malaria (current or previous mild malaria); <i>Never_malaria</i> group: no history of malaria; Ref: reference; MinA: minor allele; MajA: major allele; MAF: minor allele frequency; HWEP: Hardy-Weinberg p-value; OR: odds ratio; 95% Confidence interval (LCL- UCL).</p>", "links"=>[], "tags"=>["frequencies"], "article_id"=>308585, "categories"=>["Biological Sciences", "Genetics", "Microbiology", "Immunology"], "users"=>["Simone da Silva Santos", "Taane G. Clark", "Susana Campino", "Martha Cecília Suarez-Mutis", "Kirk A. Rockett", "Dominic P. Kwiatkowski", "Octavio Fernandes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036692.t002", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Allele_frequencies_and_tests_of_association_for_the_most_significant_SNPs_/308585", "title"=>"Allele frequencies and tests of association for the most significant SNPs.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-16 02:23:05"}
  • {"files"=>["https://ndownloader.figshare.com/files/638202"], "description"=>"<p><i>Any_malaria</i> group consisted of: clinical malaria, asymptomatic infection and previous history of malaria; <i>Asymptomatic</i> group: asymptomatic infection; <i>Clinical_Malaria</i> group: clinical mild malaria (current or previous history of mild malaria ); <i>Never_malaria</i> group: no history of malaria; Ref: reference; MAF: minor allele frequency; OR  =  odds ratio; 95% Confidence interval (LCL, UCL).</p>", "links"=>[], "tags"=>["ratios", "duffy", "hbs"], "article_id"=>308698, "categories"=>["Biological Sciences", "Genetics", "Microbiology", "Immunology"], "users"=>["Simone da Silva Santos", "Taane G. Clark", "Susana Campino", "Martha Cecília Suarez-Mutis", "Kirk A. Rockett", "Dominic P. Kwiatkowski", "Octavio Fernandes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036692.t004", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Odds_ratios_for_the_Duffy_antigen_HbS_rs334_ABO_and_G6PD_202_/308698", "title"=>"Odds ratios for the Duffy antigen, HbS (rs334), ABO, and G6PD-202.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-16 02:24:58"}
  • {"files"=>["https://ndownloader.figshare.com/files/638135"], "description"=>"<p><i>Any_</i>malaria group consisted of: clinical malaria, asymptomatic infection and previous history of malaria; <i>Asymptomatic</i> group: asymptomatic infection; <i>Clinical_Malaria</i> group: clinical mild malaria (current or previous mild malaria); <i>Never_malaria</i> group: no history of malaria: Haplotypes are for rs3024500, rs1800896,and rs1800890; Freq: frequency; OR: odds ratio; 95% Confidence interval (LCL- UCL); df : degrees of freedom.</p>", "links"=>[], "tags"=>["il10"], "article_id"=>308625, "categories"=>["Biological Sciences", "Genetics", "Microbiology", "Immunology"], "users"=>["Simone da Silva Santos", "Taane G. Clark", "Susana Campino", "Martha Cecília Suarez-Mutis", "Kirk A. Rockett", "Dominic P. Kwiatkowski", "Octavio Fernandes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036692.t003", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Haplotype_analysis_of_IL10_gene_/308625", "title"=>"Haplotype analysis of IL10 gene.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-16 02:23:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/638169"], "description"=>"*<p>these individuals were not infected at the moment of blood collection but recorded as having previously mild malaria; Controls were healthy individuals with no history of previous malaria; For some statistical analysis we have grouped clinical malaria patients, asymptomatic infected individuals and individuals with previous history of malaria (<i>any_malaria</i> group) and clinical malaria patients previous history of mild malaria (<i>clinical_malaria</i> group).</p>", "links"=>[], "tags"=>["characteristics", "studied"], "article_id"=>308656, "categories"=>["Biological Sciences", "Genetics", "Microbiology", "Immunology"], "users"=>["Simone da Silva Santos", "Taane G. Clark", "Susana Campino", "Martha Cecília Suarez-Mutis", "Kirk A. Rockett", "Dominic P. Kwiatkowski", "Octavio Fernandes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036692.t001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Baseline_and_clinical_characteristics_of_the_studied_population_/308656", "title"=>"Baseline and clinical characteristics of the studied population.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-05-16 02:24:16"}
  • {"files"=>["https://ndownloader.figshare.com/files/329063", "https://ndownloader.figshare.com/files/329086", "https://ndownloader.figshare.com/files/329115", "https://ndownloader.figshare.com/files/329133", "https://ndownloader.figshare.com/files/329157", "https://ndownloader.figshare.com/files/329188", "https://ndownloader.figshare.com/files/329216"], "description"=>"<div><p>The Brazilian Amazon is a hypo-endemic malaria region with nearly 300,000 cases each year. A variety of genetic polymorphisms, particularly in erythrocyte receptors and immune response related genes, have been described to be associated with susceptibility and resistance to malaria. In order to identify polymorphisms that might be associated with malaria clinical outcomes in a Brazilian Amazonian population, sixty-four human single nucleotide polymorphisms in 37 genes were analyzed using a Sequenom massARRAY iPLEX platform. A total of 648 individuals from two malaria endemic areas were studied, including 535 malaria cases (113 individuals with clinical mild malaria, 122 individuals with asymptomatic infection and 300 individuals with history of previous mild malaria) and 113 health controls with no history of malaria. The data revealed significant associations (p<0.003) between one SNP in the IL10 gene (rs1800896) and one SNP in the TLR4 gene (rs4986790) with reduced risk for clinical malaria, one SNP in the IRF1 gene (rs2706384) with increased risk for clinical malaria, one SNP in the LTA gene (rs909253) with protection from clinical malaria and one SNP in the TNF gene (RS1800750) associated with susceptibility to clinical malaria. Also, a new association was found between a SNP in the CTL4 gene (rs2242665), located at the major histocompatibility complex III region, and reduced risk for clinical malaria. This study represents the first association study from an Amazonian population involving a large number of host genetic polymorphisms with susceptibility or resistance to <em>Plasmodium</em> infection and malaria outcomes. Further studies should include a larger number of individuals, refined parameters and a fine-scale map obtained through DNA sequencing to increase the knowledge of the Amazonian population genetic diversity.</p> </div>", "links"=>[], "tags"=>["malaria-associated", "snps", "brazilian", "amazonian"], "article_id"=>124983, "categories"=>["Biological Sciences", "Genetics", "Microbiology", "Immunology"], "users"=>["Simone da Silva Santos", "Taane G. Clark", "Susana Campino", "Martha Cecília Suarez-Mutis", "Kirk A. Rockett", "Dominic P. Kwiatkowski", "Octavio Fernandes"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0036692.s001", "https://dx.doi.org/10.1371/journal.pone.0036692.s002", "https://dx.doi.org/10.1371/journal.pone.0036692.s003", "https://dx.doi.org/10.1371/journal.pone.0036692.s004", "https://dx.doi.org/10.1371/journal.pone.0036692.s005", "https://dx.doi.org/10.1371/journal.pone.0036692.s006", "https://dx.doi.org/10.1371/journal.pone.0036692.s007"], "stats"=>{"downloads"=>24, "page_views"=>9, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Investigation_of_Host_Candidate_Malaria_Associated_Risk_Protective_SNPs_in_a_Brazilian_Amazonian_Population/124983", "title"=>"Investigation of Host Candidate Malaria-Associated Risk/Protective SNPs in a Brazilian Amazonian Population", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-05-16 01:23:03"}
  • {"files"=>["https://ndownloader.figshare.com/files/637999"], "description"=>"<p>any malaria: <i>Any_malaria</i> group (clinical malaria, asymptomatic infection and previous history of malaria); asym: <i>Asymptomatic</i> group (individuals with asymptomatic infection); malaria: <i>Clinical_Malaria</i> group (current or previous history of mild malaria); never: <i>never_malaria</i> group (no history of previous malaria); genotypic tests of dominant, recessive, general, heterozygous advantage, and additive models, adjusted for gender; the dashed line represents a <i>p-value</i> of 0.003.</p>", "links"=>[], "tags"=>["p-values", "autosomal"], "article_id"=>308485, "categories"=>["Biological Sciences", "Genetics", "Microbiology", "Immunology"], "users"=>["Simone da Silva Santos", "Taane G. Clark", "Susana Campino", "Martha Cecília Suarez-Mutis", "Kirk A. Rockett", "Dominic P. Kwiatkowski", "Octavio Fernandes"], "doi"=>"https://dx.doi.org/10.1371/journal.pone.0036692.g001", "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Minimum_p_values_from_tests_of_association_for_the_autosomal_SNPs_/308485", "title"=>"Minimum p-values from tests of association for the autosomal SNPs.*", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-05-16 02:21:25"}

PMC Usage Stats | Further Information

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Relative Metric

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