Segregation of LIPG, CETP, and GALNT2 Mutations in Caucasian Families with Extremely High HDL Cholesterol
Events
Loading … Spinner

Mendeley | Further Information

{"title"=>"Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol", "type"=>"journal", "authors"=>[{"first_name"=>"Ian", "last_name"=>"Tietjen", "scopus_author_id"=>"8578183500"}, {"first_name"=>"G. Kees", "last_name"=>"Hovingh", "scopus_author_id"=>"6602780482"}, {"first_name"=>"Roshni R.", "last_name"=>"Singaraja", "scopus_author_id"=>"6603726053"}, {"first_name"=>"Chris", "last_name"=>"Radomski", "scopus_author_id"=>"6602383377"}, {"first_name"=>"Amina", "last_name"=>"Barhdadi", "scopus_author_id"=>"14031107300"}, {"first_name"=>"Jason", "last_name"=>"McEwen", "scopus_author_id"=>"56247603700"}, {"first_name"=>"Elden", "last_name"=>"Chan", "scopus_author_id"=>"49860897600"}, {"first_name"=>"Maryanne", "last_name"=>"Mattice", "scopus_author_id"=>"35074528600"}, {"first_name"=>"Annick", "last_name"=>"Legendre", "scopus_author_id"=>"38661517300"}, {"first_name"=>"Patrick L.", "last_name"=>"Franchini", "scopus_author_id"=>"6603948558"}, {"first_name"=>"Marie Pierre", "last_name"=>"Dubé", "scopus_author_id"=>"7103243627"}, {"first_name"=>"John J P", "last_name"=>"Kastelein", "scopus_author_id"=>"36044888200"}, {"first_name"=>"Michael R.", "last_name"=>"Hayden", "scopus_author_id"=>"55765887300"}], "year"=>2012, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84865406477", "doi"=>"10.1371/journal.pone.0037437", "issn"=>"19326203", "pui"=>"365513965", "isbn"=>"1932-6203 (Electronic)\\r1932-6203 (Linking)", "pmid"=>"22952570", "scopus"=>"2-s2.0-84865406477"}, "id"=>"8b3d2dcd-625a-3178-bcd7-6c069c09067b", "abstract"=>"To date, few mutations are described to underlie highly-elevated HDLc levels in families. Here we sequenced the coding regions and adjacent sequence of the LIPG, CETP, and GALNT2 genes in 171 unrelated Dutch Caucasian probands with HDLc≥90th percentile and analyzed segregation of mutations with lipid phenotypes in family members. In these probands, mutations were most frequent in LIPG (12.9%) followed by GALNT2 (2.3%) and CETP (0.6%). A total of 6 of 10 mutations in these three genes were novel (60.0%), and mutations segregated with elevated HDLc in families. Interestingly, the LIPG mutations N396S and R476W, which usually result in elevated HDLc, were unexpectedly found in 6 probands with low HDLc (i.e., ≤10th percentile). However, 5 of these probands also carried mutations in ABCA1, LCAT, or LPL. Finally, no CETP and GALNT2 mutations were found in 136 unrelated probands with low HDLc. Taken together, we show that rare coding and splicing mutations in LIPG, CETP, and GALNT2 are enriched in persons with hyperalphalipoproteinemia and segregate with elevated HDLc in families. Moreover, LIPG mutations do not overcome low HDLc in individuals with ABCA1 and possibly LCAT and LPL mutations, indicating that LIPG affects HDLc levels downstream of these proteins.", "link"=>"http://www.mendeley.com/research/segregation-lipg-cetp-galnt2-mutations-caucasian-families-extremely-high-hdl-cholesterol", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>2, "Researcher"=>6, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>4, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>7, "Medicine and Dentistry"=>6, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>7}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Brazil"=>1, "Spain"=>1}, "group_count"=>1}

Scopus | Further Information

{"@_fa"=>"true", "link"=>[{"@_fa"=>"true", "@ref"=>"self", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84865406477"}, {"@_fa"=>"true", "@ref"=>"author-affiliation", "@href"=>"https://api.elsevier.com/content/abstract/scopus_id/84865406477?field=author,affiliation"}, {"@_fa"=>"true", "@ref"=>"scopus", "@href"=>"https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84865406477&origin=inward"}, {"@_fa"=>"true", "@ref"=>"scopus-citedby", "@href"=>"https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84865406477&origin=inward"}], "prism:url"=>"https://api.elsevier.com/content/abstract/scopus_id/84865406477", "dc:identifier"=>"SCOPUS_ID:84865406477", "eid"=>"2-s2.0-84865406477", "dc:title"=>"Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol", "dc:creator"=>"Tietjen I.", "prism:publicationName"=>"PLoS ONE", "prism:eIssn"=>"19326203", "prism:volume"=>"7", "prism:issueIdentifier"=>"8", "prism:pageRange"=>nil, "prism:coverDate"=>"2012-08-27", "prism:coverDisplayDate"=>"27 August 2012", "prism:doi"=>"10.1371/journal.pone.0037437", "citedby-count"=>"21", "affiliation"=>[{"@_fa"=>"true", "affilname"=>"Xenon Pharmaceuticals Inc.", "affiliation-city"=>"Burnaby", "affiliation-country"=>"Canada"}], "pubmed-id"=>"22952570", "prism:aggregationType"=>"Journal", "subtype"=>"ar", "subtypeDescription"=>"Article", "article-number"=>"e37437", "source-id"=>"10600153309", "openaccess"=>"1", "openaccessFlag"=>true}

Facebook

  • {"url"=>"http%3A%2F%2Fjournals.plos.org%2Fplosone%2Farticle%3Fid%3D10.1371%252Fjournal.pone.0037437", "share_count"=>0, "like_count"=>0, "comment_count"=>0, "click_count"=>0, "total_count"=>0}

Counter

  • {"month"=>"8", "year"=>"2012", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"56"}
  • {"month"=>"9", "year"=>"2012", "pdf_views"=>"33", "xml_views"=>"0", "html_views"=>"123"}
  • {"month"=>"10", "year"=>"2012", "pdf_views"=>"21", "xml_views"=>"0", "html_views"=>"43"}
  • {"month"=>"11", "year"=>"2012", "pdf_views"=>"15", "xml_views"=>"1", "html_views"=>"35"}
  • {"month"=>"12", "year"=>"2012", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"1", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"2", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"3", "year"=>"2013", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"4", "year"=>"2013", "pdf_views"=>"13", "xml_views"=>"1", "html_views"=>"37"}
  • {"month"=>"5", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"36"}
  • {"month"=>"6", "year"=>"2013", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"7", "year"=>"2013", "pdf_views"=>"14", "xml_views"=>"0", "html_views"=>"42"}
  • {"month"=>"8", "year"=>"2013", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"9", "year"=>"2013", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"28"}
  • {"month"=>"10", "year"=>"2013", "pdf_views"=>"7", "xml_views"=>"5", "html_views"=>"41"}
  • {"month"=>"11", "year"=>"2013", "pdf_views"=>"4", "xml_views"=>"2", "html_views"=>"23"}
  • {"month"=>"12", "year"=>"2013", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"1", "year"=>"2014", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2014", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"34"}
  • {"month"=>"3", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"3", "html_views"=>"32"}
  • {"month"=>"4", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"5", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"22"}
  • {"month"=>"6", "year"=>"2014", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"23"}
  • {"month"=>"7", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"34"}
  • {"month"=>"8", "year"=>"2014", "pdf_views"=>"7", "xml_views"=>"2", "html_views"=>"25"}
  • {"month"=>"9", "year"=>"2014", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"18"}
  • {"month"=>"10", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"29"}
  • {"month"=>"11", "year"=>"2014", "pdf_views"=>"4", "xml_views"=>"1", "html_views"=>"22"}
  • {"month"=>"12", "year"=>"2014", "pdf_views"=>"11", "xml_views"=>"2", "html_views"=>"22"}
  • {"month"=>"1", "year"=>"2015", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"25"}
  • {"month"=>"2", "year"=>"2015", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"3", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"4", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"5", "year"=>"2015", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"23"}
  • {"month"=>"6", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"7", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2015", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"11"}
  • {"month"=>"9", "year"=>"2015", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"30"}
  • {"month"=>"10", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"9"}
  • {"month"=>"11", "year"=>"2015", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"12", "year"=>"2015", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"20"}
  • {"month"=>"1", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"2", "year"=>"2016", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"3", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"4", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"5", "year"=>"2016", "pdf_views"=>"9", "xml_views"=>"0", "html_views"=>"14"}
  • {"month"=>"6", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"11"}
  • {"month"=>"7", "year"=>"2016", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2016", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"10", "year"=>"2016", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"15"}
  • {"month"=>"11", "year"=>"2016", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"24"}
  • {"month"=>"12", "year"=>"2016", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"18"}
  • {"month"=>"1", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"16"}
  • {"month"=>"2", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"19"}
  • {"month"=>"3", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"4", "year"=>"2017", "pdf_views"=>"7", "xml_views"=>"1", "html_views"=>"24"}
  • {"month"=>"5", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"1", "html_views"=>"33"}
  • {"month"=>"6", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"27"}
  • {"month"=>"7", "year"=>"2017", "pdf_views"=>"3", "xml_views"=>"2", "html_views"=>"13"}
  • {"month"=>"8", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"12"}
  • {"month"=>"9", "year"=>"2017", "pdf_views"=>"6", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"10", "year"=>"2017", "pdf_views"=>"1", "xml_views"=>"1", "html_views"=>"17"}
  • {"month"=>"11", "year"=>"2017", "pdf_views"=>"11", "xml_views"=>"0", "html_views"=>"37"}
  • {"month"=>"12", "year"=>"2017", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"14"}
  • {"month"=>"1", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"9"}
  • {"month"=>"2", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2018", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"4", "year"=>"2018", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"8"}
  • {"month"=>"5", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"6", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"7", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"4", "html_views"=>"2"}
  • {"month"=>"8", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"6"}
  • {"month"=>"9", "year"=>"2018", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"10", "year"=>"2018", "pdf_views"=>"2", "xml_views"=>"1", "html_views"=>"5"}
  • {"month"=>"11", "year"=>"2018", "pdf_views"=>"0", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"12", "year"=>"2018", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"1", "year"=>"2019", "pdf_views"=>"4", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"2", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"3", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"4", "year"=>"2019", "pdf_views"=>"6", "xml_views"=>"0", "html_views"=>"6"}
  • {"month"=>"5", "year"=>"2019", "pdf_views"=>"7", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"6", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"7", "year"=>"2019", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"7"}
  • {"month"=>"8", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"4"}
  • {"month"=>"9", "year"=>"2019", "pdf_views"=>"1", "xml_views"=>"0", "html_views"=>"3"}
  • {"month"=>"10", "year"=>"2019", "pdf_views"=>"3", "xml_views"=>"0", "html_views"=>"1"}
  • {"month"=>"11", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"5"}
  • {"month"=>"12", "year"=>"2019", "pdf_views"=>"8", "xml_views"=>"0", "html_views"=>"2"}
  • {"month"=>"1", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"1", "html_views"=>"2"}
  • {"month"=>"2", "year"=>"2020", "pdf_views"=>"5", "xml_views"=>"0", "html_views"=>"4"}

Figshare

  • {"files"=>["https://ndownloader.figshare.com/files/307571", "https://ndownloader.figshare.com/files/307626", "https://ndownloader.figshare.com/files/307684", "https://ndownloader.figshare.com/files/307732", "https://ndownloader.figshare.com/files/307777", "https://ndownloader.figshare.com/files/307834", "https://ndownloader.figshare.com/files/307884", "https://ndownloader.figshare.com/files/307931", "https://ndownloader.figshare.com/files/307979"], "description"=>"<div><p>To date, few mutations are described to underlie highly-elevated HDLc levels in families. Here we sequenced the coding regions and adjacent sequence of the <em>LIPG</em>, <em>CETP</em>, and <em>GALNT2</em> genes in 171 unrelated Dutch Caucasian probands with HDLc≥90th percentile and analyzed segregation of mutations with lipid phenotypes in family members. In these probands, mutations were most frequent in <em>LIPG</em> (12.9%) followed by <em>GALNT2</em> (2.3%) and <em>CETP</em> (0.6%). A total of 6 of 10 mutations in these three genes were novel (60.0%), and mutations segregated with elevated HDLc in families. Interestingly, the <em>LIPG</em> mutations N396S and R476W, which usually result in elevated HDLc, were unexpectedly found in 6 probands with low HDLc (i.e., ≤10th percentile). However, 5 of these probands also carried mutations in <em>ABCA1</em>, <em>LCAT</em>, or <em>LPL</em>. Finally, no <em>CETP</em> and <em>GALNT2</em> mutations were found in 136 unrelated probands with low HDLc. Taken together, we show that rare coding and splicing mutations in <em>LIPG</em>, <em>CETP</em>, and <em>GALNT2</em> are enriched in persons with hyperalphalipoproteinemia and segregate with elevated HDLc in families. Moreover, <em>LIPG</em> mutations do not overcome low HDLc in individuals with <em>ABCA1</em> and possibly <em>LCAT</em> and <em>LPL</em> mutations, indicating that <em>LIPG</em> affects HDLc levels downstream of these proteins.</p> </div>", "links"=>[], "tags"=>["segregation", "mutations", "caucasian", "hdl"], "article_id"=>120692, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.s001", "https://dx.doi.org/10.1371/journal.pone.0037437.s002", "https://dx.doi.org/10.1371/journal.pone.0037437.s003", "https://dx.doi.org/10.1371/journal.pone.0037437.s004", "https://dx.doi.org/10.1371/journal.pone.0037437.s005", "https://dx.doi.org/10.1371/journal.pone.0037437.s006", "https://dx.doi.org/10.1371/journal.pone.0037437.s007", "https://dx.doi.org/10.1371/journal.pone.0037437.s008", "https://dx.doi.org/10.1371/journal.pone.0037437.s009"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/Segregation_of_LIPG_CETP_and_GALNT2_Mutations_in_Caucasian_Families_with_Extremely_High_HDL_Cholesterol/120692", "title"=>"Segregation of <em>LIPG</em>, <em>CETP</em>, and <em>GALNT2</em> Mutations in Caucasian Families with Extremely High HDL Cholesterol", "pos_in_sequence"=>0, "defined_type"=>4, "published_date"=>"2012-08-27 00:11:32"}
  • {"files"=>["https://ndownloader.figshare.com/files/585508"], "description"=>"<p>A) Overview of the study design. <b>B–D</b>) Predicted mutation effects on <b>B</b>) LIPG, <b>C</b>) CETP, and <b>D</b>) GALNT2 proteins. Red sequence changes are novel, blue are previously described <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone.0037437-Edmondson1\" target=\"_blank\">[17]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone.0037437-deLemos1\" target=\"_blank\">[23]</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone.0037437-Holleboom1\" target=\"_blank\">[28]</a>, and black is previously described in a subset of this cohort <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone.0037437-vanderSteeg1\" target=\"_blank\">[16]</a>.</p>", "links"=>[], "tags"=>["probands"], "article_id"=>255991, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.g001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mutations_identified_in_probands_with_high_or_low_HDLc_/255991", "title"=>"Mutations identified in probands with high or low HDLc.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-27 01:39:51"}
  • {"files"=>["https://ndownloader.figshare.com/files/585632"], "description"=>"<p><b>A, B</b>) Segregation of (<b>A</b>) <i>LIPG</i> L130F-FS and (<b>B</b>) <i>GALNT2</i> D314A with elevated HDLc. For each individual, the individual ID, HDLc (in mmol/L) plus [HDLc percentile], and genotype are shown. Squares, Males; Circles, Females; Arrow, proband. Filled shape, HDLc≥90<sup>th</sup> percentile; half-filled, HDLc between 80–89<sup>th</sup> percentiles; empty shape, HDLc<80<sup>th</sup> percentile. Slash = deceased. <b>C</b>) Percent of individuals in families with mutations at given HDLc percentiles or higher.</p>", "links"=>[], "tags"=>["segregation", "mutations"], "article_id"=>256117, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.g002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Representative_segregation_of_mutations_in_families_/256117", "title"=>"Representative segregation of mutations in families.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-27 01:41:57"}
  • {"files"=>["https://ndownloader.figshare.com/files/585792"], "description"=>"<p><b>A</b>) Representative segregation of <i>LIPG</i> N396S and <i>ABCA1</i> IVS24+1G>C mutations. Filled shape, HDLc<15<sup>th</sup> percentile; empty shape, HDLc≥15<sup>th</sup> percentile. <b>B</b>) HDLc levels of individuals with <i>LIPG</i>+/−<i>ABCA1</i>, <i>LCAT</i>, or <i>LPL</i> mutations. Individuals with <i>LIPG</i> mutations alone are described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone-0037437-t004\" target=\"_blank\">Table 4</a>. Individuals with single <i>ABCA1</i>, <i>LCAT</i>, and <i>LPL</i> mutations are from an independent Dutch-Caucasian population (<a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone.0037437.s003\" target=\"_blank\">Tables S1</a>, <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone.0037437.s004\" target=\"_blank\">S2</a>, and S3 and data not shown). <b>C</b>) HDLc levels of individuals with mutations in <i>LIPG</i>, <i>GALNT2</i>, or <i>LIPG+GALNT2</i>. Individuals with single <i>LIPG</i> or <i>GALNT2</i> mutations are described in <a href=\"http://www.plosone.org/article/info:doi/10.1371/journal.pone.0037437#pone-0037437-t004\" target=\"_blank\">Table 4</a>.</p>", "links"=>[], "tags"=>["probands"], "article_id"=>256277, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.g003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Characterization_of_probands_and_families_with_multiple_mutations_/256277", "title"=>"Characterization of probands and families with multiple mutations.", "pos_in_sequence"=>0, "defined_type"=>1, "published_date"=>"2012-08-27 01:44:37"}
  • {"files"=>["https://ndownloader.figshare.com/files/585875"], "description"=>"a<p>, Average (SD) shown;</p>b<p>, N (%) shown.</p>", "links"=>[], "tags"=>["members"], "article_id"=>256356, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.t004"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Phenotypes_of_family_members_with_single_LIPG_CETP_and_GALNT2_mutations_/256356", "title"=>"Phenotypes of family members with single <i>LIPG, CETP, and GALNT2</i> mutations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-27 01:45:56"}
  • {"files"=>["https://ndownloader.figshare.com/files/585916"], "description"=>"<p>Additional mutations in individuals with <i>LIPG</i> mutations and low HDLc.</p>", "links"=>[], "tags"=>["mutations", "individuals"], "article_id"=>256405, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.t005"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Additional_mutations_in_individuals_with_LIPG_mutations_and_low_HDLc_/256405", "title"=>"Additional mutations in individuals with <i>LIPG</i> mutations and low HDLc.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-27 01:46:45"}
  • {"files"=>["https://ndownloader.figshare.com/files/585964"], "description"=>"a<p>, Average (SD);</p>b<p>, N (%);</p>c<p>, Average (95% confidence interval).</p>", "links"=>[], "tags"=>["unrelated", "probands"], "article_id"=>256447, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.t001"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Demographics_of_unrelated_probands_with_extreme_HDLc_/256447", "title"=>"Demographics of unrelated probands with extreme HDLc.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-27 01:47:27"}
  • {"files"=>["https://ndownloader.figshare.com/files/586015"], "description"=>"a<p>, Two probands have rare <i>LIPG</i>+<i>GALNT2</i> variants.</p>", "links"=>[], "tags"=>["frequencies"], "article_id"=>256495, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.t002"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_Mutation_frequencies_and_burden_effects_in_probands_/256495", "title"=>"Mutation frequencies and burden effects in probands.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-27 01:48:15"}
  • {"files"=>["https://ndownloader.figshare.com/files/586057"], "description"=>"<p><i>LIPG</i>, <i>CETP</i>, and <i>GALNT2</i> mutations.</p>", "links"=>[], "tags"=>["genetics and genomics", "Computational biology"], "article_id"=>256542, "categories"=>["Biological Sciences", "Genetics"], "users"=>["Ian Tietjen", "G. Kees Hovingh", "Roshni R. Singaraja", "Chris Radomski", "Amina Barhdadi", "Jason McEwen", "Elden Chan", "Maryanne Mattice", "Annick Legendre", "Patrick L. Franchini", "Marie-Pierre Dubé", "John J. P. Kastelein", "Michael R. Hayden"], "doi"=>["https://dx.doi.org/10.1371/journal.pone.0037437.t003"], "stats"=>{"downloads"=>0, "page_views"=>0, "likes"=>0}, "figshare_url"=>"https://figshare.com/articles/_LIPG_CETP_and_GALNT2_mutations_/256542", "title"=>"<i>LIPG</i>, <i>CETP</i>, and <i>GALNT2</i> mutations.", "pos_in_sequence"=>0, "defined_type"=>3, "published_date"=>"2012-08-27 01:49:02"}

PMC Usage Stats | Further Information

  • {"unique-ip"=>"34", "full-text"=>"29", "pdf"=>"23", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2012", "month"=>"9"}
  • {"unique-ip"=>"39", "full-text"=>"42", "pdf"=>"14", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2012", "month"=>"10"}
  • {"unique-ip"=>"19", "full-text"=>"20", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2012", "month"=>"12"}
  • {"unique-ip"=>"30", "full-text"=>"34", "pdf"=>"16", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"1"}
  • {"unique-ip"=>"17", "full-text"=>"18", "pdf"=>"13", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2013", "month"=>"3"}
  • {"unique-ip"=>"23", "full-text"=>"25", "pdf"=>"7", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"2"}
  • {"unique-ip"=>"21", "full-text"=>"20", "pdf"=>"9", "abstract"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"4"}
  • {"unique-ip"=>"33", "full-text"=>"33", "pdf"=>"15", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2012", "month"=>"11"}
  • {"unique-ip"=>"22", "full-text"=>"22", "pdf"=>"6", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2013", "month"=>"5"}
  • {"unique-ip"=>"17", "full-text"=>"15", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"6"}
  • {"unique-ip"=>"12", "full-text"=>"15", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"9", "supp-data"=>"9", "cited-by"=>"1", "year"=>"2013", "month"=>"7"}
  • {"unique-ip"=>"18", "full-text"=>"19", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"8", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"8"}
  • {"unique-ip"=>"12", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2013", "month"=>"9"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"11", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"6", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"10"}
  • {"unique-ip"=>"24", "full-text"=>"27", "pdf"=>"10", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2013", "month"=>"11"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2013", "month"=>"12"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"7", "cited-by"=>"0", "year"=>"2014", "month"=>"1"}
  • {"unique-ip"=>"10", "full-text"=>"14", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"2"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"7", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"8", "pdf"=>"3", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"6"}
  • {"unique-ip"=>"10", "full-text"=>"7", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"4"}
  • {"unique-ip"=>"13", "full-text"=>"13", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"4"}
  • {"unique-ip"=>"10", "full-text"=>"10", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"5"}
  • {"unique-ip"=>"13", "full-text"=>"11", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"6"}
  • {"unique-ip"=>"6", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"7"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"3"}
  • {"unique-ip"=>"17", "full-text"=>"16", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"2"}
  • {"unique-ip"=>"11", "full-text"=>"8", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"8"}
  • {"unique-ip"=>"9", "full-text"=>"9", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"9"}
  • {"unique-ip"=>"26", "full-text"=>"22", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"5", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"10"}
  • {"unique-ip"=>"18", "full-text"=>"14", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"2", "cited-by"=>"0", "year"=>"2014", "month"=>"7"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"4", "abstract"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"8"}
  • {"unique-ip"=>"23", "full-text"=>"16", "pdf"=>"6", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"16", "cited-by"=>"0", "year"=>"2014", "month"=>"9"}
  • {"unique-ip"=>"22", "full-text"=>"12", "pdf"=>"10", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"10"}
  • {"unique-ip"=>"13", "full-text"=>"12", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"1"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"2"}
  • {"unique-ip"=>"15", "full-text"=>"15", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"4", "cited-by"=>"0", "year"=>"2014", "month"=>"11"}
  • {"unique-ip"=>"16", "full-text"=>"12", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2014", "month"=>"12"}
  • {"unique-ip"=>"9", "full-text"=>"6", "pdf"=>"5", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"1"}
  • {"unique-ip"=>"19", "full-text"=>"18", "pdf"=>"8", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2015", "month"=>"11"}
  • {"unique-ip"=>"9", "full-text"=>"7", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2015", "month"=>"12"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"3"}
  • {"unique-ip"=>"16", "full-text"=>"11", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"4", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2016", "month"=>"4"}
  • {"unique-ip"=>"9", "full-text"=>"10", "pdf"=>"4", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"5"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"6"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"7"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"8"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"10"}
  • {"unique-ip"=>"3", "full-text"=>"4", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"11"}
  • {"unique-ip"=>"3", "full-text"=>"5", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2016", "month"=>"12"}
  • {"unique-ip"=>"11", "full-text"=>"6", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"1"}
  • {"unique-ip"=>"3", "full-text"=>"3", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"2"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"3"}
  • {"unique-ip"=>"9", "full-text"=>"14", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"2", "supp-data"=>"5", "cited-by"=>"0", "year"=>"2017", "month"=>"4"}
  • {"unique-ip"=>"1", "full-text"=>"1", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"5"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"6"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"7"}
  • {"unique-ip"=>"4", "full-text"=>"5", "pdf"=>"1", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"8"}
  • {"unique-ip"=>"19", "full-text"=>"12", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"3", "cited-by"=>"0", "year"=>"2017", "month"=>"9"}
  • {"unique-ip"=>"8", "full-text"=>"9", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"10"}
  • {"unique-ip"=>"9", "full-text"=>"8", "pdf"=>"2", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2017", "month"=>"11"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"3", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2017", "month"=>"12"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"3", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"1"}
  • {"unique-ip"=>"2", "full-text"=>"2", "pdf"=>"0", "abstract"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"3"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"1"}
  • {"unique-ip"=>"11", "full-text"=>"9", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"5"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"6"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"8"}
  • {"unique-ip"=>"14", "full-text"=>"16", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"11", "cited-by"=>"0", "year"=>"2018", "month"=>"7"}
  • {"unique-ip"=>"2", "full-text"=>"1", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"1", "supp-data"=>"9", "cited-by"=>"0", "year"=>"2018", "month"=>"11"}
  • {"unique-ip"=>"7", "full-text"=>"7", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"4"}
  • {"unique-ip"=>"4", "full-text"=>"4", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"10"}
  • {"unique-ip"=>"6", "full-text"=>"7", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"12"}
  • {"unique-ip"=>"5", "full-text"=>"5", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2018", "month"=>"9"}
  • {"unique-ip"=>"14", "full-text"=>"15", "pdf"=>"0", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"2"}
  • {"unique-ip"=>"7", "full-text"=>"10", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"3"}
  • {"unique-ip"=>"5", "full-text"=>"6", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"4"}
  • {"unique-ip"=>"11", "full-text"=>"12", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"5"}
  • {"unique-ip"=>"8", "full-text"=>"6", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"8"}
  • {"unique-ip"=>"4", "full-text"=>"3", "pdf"=>"1", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"9"}
  • {"unique-ip"=>"7", "full-text"=>"6", "pdf"=>"4", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2019", "month"=>"10"}
  • {"unique-ip"=>"5", "full-text"=>"4", "pdf"=>"3", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"1", "cited-by"=>"0", "year"=>"2019", "month"=>"12"}

Relative Metric

{"start_date"=>"2012-01-01T00:00:00Z", "end_date"=>"2012-12-31T00:00:00Z", "subject_areas"=>[{"subject_area"=>"/Biology and life sciences", "average_usage"=>[322, 550, 671, 773, 864, 955, 1048, 1135, 1223, 1308, 1387, 1465, 1534, 1602, 1673, 1744, 1813, 1885, 1955, 2026, 2093, 2160, 2228, 2290, 2349]}, {"subject_area"=>"/Biology and life sciences/Biochemistry", "average_usage"=>[316, 541, 663, 766, 856, 950, 1041, 1128, 1218, 1302, 1382, 1456, 1526, 1593, 1657, 1729, 1796, 1862, 1930, 1999, 2065, 2132, 2202, 2261, 2319]}, {"subject_area"=>"/Biology and life sciences/Computational biology", "average_usage"=>[375, 629, 760, 889, 1000, 1110, 1203, 1298, 1399, 1492, 1603, 1699, 1774, 1855, 1918, 1998, 2062, 2152, 2227, 2312, 2378, 2461, 2528, 2600, 2664]}, {"subject_area"=>"/Biology and life sciences/Molecular biology", "average_usage"=>[324, 551, 679, 782, 879, 971, 1064, 1154, 1245, 1328, 1406, 1476, 1541, 1617, 1683, 1754, 1818, 1893, 1962, 2025, 2092, 2164, 2227, 2294, 2355]}, {"subject_area"=>"/Medicine and health sciences/Anatomy and physiology", "average_usage"=>[308, 539, 659, 759, 852, 941, 1028, 1113, 1197, 1275, 1353, 1423]}]}
Loading … Spinner
There are currently no alerts